Mutation of Asn-391 within the conserved NPXXY motif of the cholecystokinin B receptor abolishes G(q) protein activation without affecting its association with the receptor

Journal of Biological Chemistry

Volumn 275, Issue 23, 2000, Pages 17321-17327

  Galés, Céline ^a   Kowalski Chauvel, Aline ^a   Dufour, Marie Noelle ^b   Seva, Catherine ^a   Moroder, Luis ^c   Pradayrol, Lucien ^a   Vaysse, Nicole ^a   Fourmy, Daniel ^a   Silvente Poirot, Sandrine ^a  

^a CHU RANGUEIL   (France)

^b CCIPE   (France)

^c MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; ASPARAGINE; CHOLECYSTOKININ B RECEPTOR; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOLIPASE C;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; ENZYME ACTIVATION; GENE EXPRESSION; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; RECEPTOR AFFINITY; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ASPARAGINE; ASPARTIC ACID; BINDING SITES; CHOLECYSTOKININ; CONSERVED SEQUENCE; COS CELLS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; GTP-BINDING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); INOSITOL PHOSPHATES; MITOGEN-ACTIVATED PROTEIN KINASES; MUTAGENESIS, SITE-DIRECTED; PEPTIDE FRAGMENTS; PHOSPHOLIPASE C; PROTEIN KINASE C; RATS; RECEPTOR, CHOLECYSTOKININ B; RECEPTORS, CHOLECYSTOKININ; RECOMBINANT PROTEINS; TRANSFECTION;

EID: 0034625358     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M909801199     Document Type: Article

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