Superparamagnetic iron oxide nanoparticles (SPIONs): Development, surface modification and applications in chemotherapy

Advanced Drug Delivery Reviews

Volumn 63, Issue 1-2, 2011, Pages 24-46

  Mahmoudi, Morteza ^a,b   Sant, Shilpa ^c,d   Wang, Ben ^c,d   Laurent, Sophie ^e   Sen, Tapas ^f  

^a PASTEUR INSTITUTE OF IRAN   (Iran)

^b SHARIF UNIVERSITY OF TECHNOLOGY   (Iran)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^e UNIVERSITY OF MONS   (Belgium)

^f UNIVERSITY OF CENTRAL LANCASHIRE   (United Kingdom)

Author keywords

Coatings; Drug delivery; SPIONs; Superparamagnetic iron oxide nanoparticles; Surfaces; Toxicity

Indexed keywords

BIOMEDICAL APPLICATIONS; CANCER THERAPY; DRUG DELIVERY APPLICATIONS; SIDE EFFECT; SPIONS; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES; SURFACE ARCHITECTURES; SURFACE MODIFICATION; SYNTHETIC ROUTES;

CHEMOTHERAPY; COATINGS; DRUG DELIVERY; NANOPARTICLES; SUPERPARAMAGNETISM; TOXICITY;

IRON OXIDES;

ACETYLSALICYLIC ACID; ALPHA2B INTERFERON; CAMPTOTHECIN; CARUBICIN; CISPLATIN; DEXAMETHASONE ACETATE; DOXORUBICIN; EPIRUBICIN; FERRIC OXIDE; IBUPROFEN; MAGNETIC NANOPARTICLE; MAGNETITE; MITOXANTRONE; PACLITAXEL; RUBOMYCIN; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE; TAMOXIFEN;

ANTIINFLAMMATORY ACTIVITY; BLOOD BRAIN BARRIER; CHEMICAL COMPOSITION; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; CHEMOTHERAPY; CHILL; COLLOID; CRYSTALLIZATION; CYTOTOXICITY; DRUG BIOAVAILABILITY; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG RELEASE; DRUG RESEARCH; DRUG TARGETING; DRUG TOLERABILITY; GLIOMA; HUMAN; ISOTOPE LABELING; MAGNETIC FIELD; MOLECULAR IMAGING; MOLECULAR STABILITY; NANOENCAPSULATION; NONHUMAN; OSTEOSARCOMA; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN INTERACTION; REVIEW; SOLID TUMOR; SQUAMOUS CELL CARCINOMA; SURFACE CHARGE; SURFACE PROPERTY; SYNTHESIS; TOXICITY TESTING; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; ANTINEOPLASTIC AGENTS; DRUG DELIVERY SYSTEMS; HUMANS; MAGNETITE NANOPARTICLES;

EID: 78649522496     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.addr.2010.05.006     Document Type: Review

References (281)

1. Poizot P., Laruelle S., Grugeon S., Dupont L., Tarascon J.M. Nano-sized transition-metaloxides as negative-electrode materials for lithium-ion batteries. Nature 2000, 407(6803):496-499.
2. 4 particles. Physica B & C 1979, 97(1):57-64.
3. Mahmoudi M., Simchi A., Imani M., Stroeve P., Sohrabi A. Templated growth of superparamagnetic iron oxide nanoparticles by temperature programming in the presence of poly(vinyl alcohol). Thin Solid Films 2010, 518(15):4281-4289.
4. Langer R. Drug delivery and targeting. Nature 1998, 392(6679):5-10.
5. Kodama R.H. Magnetic nanoparticles. Journal of Magnetism and Magnetic Materials 1999, 200(1- 3):359-372.
6. Freeman M.W., Arrott A., Watson J.H.L. Magnetism in medicine. Journal of Applied Physics 1960, 31(5):S404-S405.
7. Alexiou C., Arnold W., Klein R.J., Parak F.G., Hulin P., Bergemann C., Erhardt W., Wagenpfeil S., Lubbe A.S. Locoregional cancer treatment with magnetic drug targeting. Cancer Research 2000, 60(23):6641-6648.
8. Senyei A., Widder K., Czerlinski G. Magnetic guidance of drug-carrying microspheres. Journal of Applied Physics 1978, 49(6):3578-3583.
9. Mosbach K., Schroder U. Preparation and application of magnetic polymers for targeting of drugs. FEBS Letters 1979, 102(1):112-116.
10. Hans M.L., Lowman A.M. Biodegradable nanoparticles for drug delivery and targeting. Current Opinion in Solid State & Materials Science 2002, 6(4):319-327.
11. Koneracka M., Kopcansky P., Antalik M., Timko M., Ramchand C.N., Lobo D., Mehta R.V., Upadhyay R.V. Immobilization of proteins and enzymes to fine magnetic particles. Journal of Magnetism and Magnetic Materials 1999, 201:427-430.
12. Mehta R.V., Upadhyay R.V., Charles S.W., Ramchand C.N. Direct binding of protein to magnetic particles. Biotechnology Techniques 1997, 11(7):493-496.
13. Koneracka M., Kopcansky P., Timko M., Ramchand C.N., de Sequeira A., Trevan M. Direct binding procedure of proteins and enzymes to fine magnetic particles. Journal of Molecular Catalysis. B, Enzymatic 2002, 18(1- 3):13-18.
14. Widder K.J., Senyei A.E., Scarpelli D.G. Magnetic microspheres - model system for site specific drug delivery invivo. Proceedings of the Society for Experimental Biology and Medicine 1978, 158(2):141-146.
15. Cunningham C.H., Arai T., Yang P.C., McConnell M.V., Pauly J.M., Conolly S.M. Positive contrast magnetic resonance imaging of cells labeled with magnetic nanoparticles. Magnetic Resonance in Medicine 2005, 53(5):999-1005.
16. Anderson S.A., Rader R.K., Westlin W.F., Null C., Jackson D., Lanza C.M., Wickline S.A., Kotyk J.J. Magnetic resonance contrast enhancement of neovasculature with alpha(v)beta(3)-targeted nanoparticles. Magnetic Resonance in Medicine 2000, 44(3):433-439.
17. Polyak B., Friedman G. Magnetic targeting for site-specific drug delivery: applications and clinical potential. Expert Opinion on Drug Delivery 2009, 6(1):53-70.
18. Jalilian A.R., Panahifar A., Mahmoudi M., Akhlaghi M., Simchi A. Preparation and biological evaluation of [67Ga]-labeled- superparamagnetic nanoparticles in normal rats. Radiochimica Acta 2009, 97(1):51-56.
19. Talelli M., Rijcken C.J.F., Lammers T., Seevinck P.R., Storm G., van Nostrum C.F., Hennink W.E. Superparamagnetic iron oxide nanoparticles encapsulated in biodegradable thermosensitive polymeric micelles: toward a targeted nanomedicine suitable for image-guided drug delivery. Langmuir 2009, 25(4):2060-2067.
20. Bartolozzi C., Lencioni R., Donati F., Cioni D. Abdominal MR: liver and pancreas. European Radiology 1999, 9(8):1496-1512.
21. Meng J., Fan J., Galiana G., Branca R.T., Clasen P.L., Ma S., Zhou J., Leuschner C., Kumar C.S.S.R., Hormes J., Otiti T., Beye A.C., Harmer M.P., Kiely C.J., Warren W., Haataja M.P., Soboyejo W.O. LHRH-functionalized superparamagnetic iron oxide nanoparticles for breast cancer targeting and contrast enhancement in MRI. Materials Science and Engineering C 2009, 29(4):1467-1479.
22. Shubayev V.I., Pisanic Ii T.R., Jin S. Magnetic nanoparticles for theragnostics. Advanced Drug Delivery Reviews 2009, 61(6):467-477.
23. Arbab A.S., Janic B., Haller J., Pawelczyk E., Liu W., Frank J.A. In vivo cellular imaging for translational medical research. Current Medical Imaging Reviews 2009, 5(1):19-38.
24. Tartaj P., Serna C.J. Synthesis of monodisperse superparamagnetic Fe/silica nanospherical composites. Journal of the American Chemical Society 2003, 125(51):15754-15755.
25. Zhang Y., Kohler N., Zhang M. Surface modification of superparamagnetic magnetite nanoparticles and their interacellular uptake. Biomaterials 2002, 23(7):9.
26. Teja A.S., Koh P.Y. Synthesis, properties, and applications of magnetic iron oxide nanoparticles. Progress in Crystal Growth and Characterization of Materials 2009, 55(1- 2):22-45.
27. Lin M.M., Kim D.K., El Haj A.J., Dobson J. Development of superparamagnetic iron oxide nanoparticles (SPIONS) for translation to clinical applications. IEEE Transactions on Nanobioscience 2008, 7(4):298-305.
28. Kim J., Piao Y., Hyeon T. Multifunctional nanostructured materials for multimodal imaging, and simultaneous imaging and therapy. Chemical Society Reviews 2009, 38(2):372-390.
29. Spaldin N. Magnetic Materials: Fundamentals and Device Applications 2003, Cambridge University Press, Cambridge, UK.
30. O'Handley R.C. Modern magnetic materials: Principles and Applications 2000, Wiley, New York.
31. Kaiser R., Miskolcz G. Some applications of ferrofluid magnetic colloids. IEEE Transactions on Magnetics 1970, MAG6(3):694.
32. Sugimoto T., Matijevic E. Formation of uniform spherical magnetite particles by crystallization from ferrous hydroxide gels. Journal of Colloid and Interface Science 1980, 74(1):227-243.
33. Itoh H., Sugimoto T. Systematic control of size, shape, structure, and magnetic properties of uniform magnetite and maghemite particles. Journal of Colloid and Interface Science 2003, 265(2):283-295.
34. Sugimoto T. Fine Particles: Synthesis, Characterisation and Mechanism of Growth 2000, Marcel Dekker, New York.
35. Nielsen N.E. Kinetics of Precipitation 1964, Pergamon Press, New York.
36. Walton A.G. The Formation and Properties of Precipitates 1979, Robert Krieger, New York, (reprint).
37. Denouden C.J.J., Thompson R.W. Analysis of the formation of monodisperse populations by homogeneous nucleation. Journal of Colloid and Interface Science 1991, 143(1):77-84.
38. Ocana M., Rodriguezclemente R., Serna C.J. Uniform colloidal particles in solution - formation mechanisms. Advanced Materials 1995, 7(2):212-216.
39. 3 monodispersed particles in solution. Journal of Materials Research 1992, 7(9):2538-2545.
40. Turnbull D. Acta Metallurgica 1953, 32:1493.
41. Massart R. Preparation of aqueous magnetic liquids in alkaline and acidic media. IEEE Transactions on Magnetics 1981, 17(2):1247-1248.
42. Sen T., Magdassi S., Nizri G., Bruce I.J. Dispersion of magnetic nanoparticles in suspension. Micro & Nano Letters 2006, 1(1):39-42.
43. Inouye K., Endo R., Otsuka Y., Miyashiro K., Kaneko K., Ishikawa T. Oxygenation of ferrous-ions in reversed micelle and reversed micro-emulsion. The Journal of Physical Chemistry 1982, 86(8):1465-1469.
44. Muller B.W., Muller R.H. Particle-size distributions and particle-size alterations in microemulsions. Journal of Pharmaceutical Sciences 1984, 73(7):919-922.
45. Gupta A.K., Wells S. Surface-modified superparamagnetic nanoparticles for drug delivery: preparation, characterization, and cytotoxicity studies. IEEE Transactions on Nanobioscience 2004, 3(1):66-73.
46. 4 nanospheres in a microemulsion. Materials Letters 2008, 62(24):4053-4055.
47. Lee Y., Lee J., Bae C.J., Park J.G., Noh H.J., Park J.H., Hyeon T. Large-scale synthesis of uniform and crystalline magnetite nanoparticles using reverse micelles as nanoreactors under reflux conditions. Advanced Functional Materials 2005, 15(3):503-509.
48. Sun S.H., Zeng H. Size-controlled synthesis of magnetite nanoparticies. Journal of the American Chemical Society 2002, 124(28):8204-8205.
49. Kumar R.V., Koltypin Y., Xu X.N., Yeshurun Y., Gedanken A., Felner I. Fabrication of magnetite nanorods by ultrasound irradiation. Journal of Applied Physics 2001, 89(11):6324-6328.
50. 4 particles. Materials Science and Engineering A- Structural Materials Properties Microstructure and Processing 2000, 286(1):101-105.
51. Dang F., Enomoto N., Hojo J., Enpuku K. A novel method to synthesize monodispersed magnetite nanoparticles. Chemistry Letters 2008, 37(5):530-531.
52. 3 nanoparticle size. Morphology, microstructure, and magnetic behavior. Chemistry of Materials 1999, 11(1):141-147.
53. 4)powders. Materials Letters 2002, 56(4):571-577.
54. Grzeta B., Ristic M., Nowik I., Music S. Formation of nanocrystalline magnetite by thermal decomposition of iron choline citrate. Journal of Alloys and Compounds 2002, 334:304-312.
55. Narasimhan B.R.V., Prabhakar S., Manohar P., Gnanam F.D. Synthesis of gamma ferric oxide by direct thermal decomposition of ferrous carbonate. Materials Letters 2002, 52(4- 5):295-300.
56. Yu W.W., Falkner J.C., Yavuz C.T., Colvin V.L. Synthesis of monodisperse iron oxide nanocrystals by thermal decomposition of iron carboxylate salts. Chemical Communications 2004, (20):2306-2307.
57. Liu X.M., Kim J.K. Solvothermal synthesis and magnetic properties of magnetite nanoplatelets. Materials Letters 2009, 63(3- 4):428-430.
58. Maity D., Choo S.G., Yi J.B., Ding J., Xue J.M. Synthesis of magnetite nanoparticles via a solvent-free thermal decomposition route. Journal of Magnetism and Magnetic Materials 2009, 321(9):1256-1259.
59. Amemiya Y., Arakaki A., Staniland S.S., Tanaka T., Matsunaga T. Controlled formation of magnetite crystal by partial oxidation of ferrous hydroxide in the presence of recombinant magnetotactic bacterial protein Mms6. Biomaterials 2007, 28(35):5381-5389.
60. Philipse A.P., Maas D. Magnetic colloids from magnetotactic bacteria: chain formation and colloidal stability. Langmuir 2002, 18(25):9977-9984.
61. Prozorov T., Mallapragada S.K., Narasimhan B., Wang L.J., Palo P., Nilsen-Hamilton M., Williams T.J., Bazylinski D.A., Prozorov R., Canfield P.C. Protein-mediated synthesis of uniform superparamagnetic magnetite nanocrystals. Advanced Functional Materials 2007, 17(6):951-957.
62. Bharde A.A., Parikh R.Y., Baidakova M., Jouen S., Hannoyer B., Enoki T., Prasad B.L.V., Shouche Y.S., Ogale S., Sastry M. Bacteria-mediated precursor-dependent biosynthesis of superparamagnetic iron oxide and iron sulfide nanoparticles. Langmuir 2008, 24(11):5787-5794.
63. Bharde A., Rautaray D., Bansal V., Ahmad A., Sarkar I., Yusuf S.M., Sanyal M., Sastry M. Extracellular biosynthesis of magnetite using fungi. Small 2006, 2(1):135-141.
64. Coker V.S., Telling N.D., van der Laan G., Pattrick R.A.D., Pearce C.I., Arenholz E., Tuna F., Winpenny R.E.P., Lloyd J.R. Harnessing the extracellular bacterial production of nanoscale cobalt ferrite with exploitable magnetic properties. ACS Nano 2009, 3(7):1922-1928.
65. Kim D., Lee N., Park M., Kim B.H., An K., Hyeon T. Synthesis of uniform ferrimagnetic magnetite nanocubes. Journal of the American Chemical Society 2009, 131(2). 454-+.
66. Peng Z.M., Wu M.Z., Xiong Y., Wang J., Chen Q.W. Synthesis of magnetite nanorods through reduction of beta-FeOOH. Chemistry Letters 2005, 34(5):636-637.
67. Jia C.J., Sun L.D., Luo F., Han X.D., Heyderman L.J., Yan Z.G., Yan C.H., Zheng K., Zhang Z., Takano M., Hayashi N., Eltschka M., Klaui M., Rudiger U., Kasama T., Cervera-Gontard L., Dunin-Borkowski R.E., Tzvetkov G., Raabe J. Large-scale synthesis of single-crystalline iron oxide magnetic nanorings. Journal of the American Chemical Society 2008, 130(50):16968-16977.
68. Hamley I.W. Nanotechnology with soft materials. Angewandte Chemie. International Edition 2003, 42(15):1692-1712.
69. Sebastianelli A., Sen T., Bruce I.J. Extraction of DNA from soil using nanoparticles by magnetic bioseparation. Letters in Applied Microbiology 2008, 46(4):488-491.
70. Zhao X.L., Shi Y.L., Wang T., Cai Y.Q., Jiang G.B. Preparation of silica-magnetite nanoparticle mixed hemimicelle sorbents for extraction of several typical phenolic compounds from environmental water samples. Journal of Chromatography. A 2008, 1188(2):140-147.
71. Chiang C.L., Sung C.S., Chen C.Y. Application of silica-magnetite nanocomposites to the isolation of ultrapure plasmid DNA from bacterial cells. Journal of Magnetism and Magnetic Materials 2006, 305(2):483-490.
72. del Campo A., Sen T., Lellouche J.P., Bruce I.J. Multifunctional magnetite and silica-magnetite nanoparticles: Synthesis, surface activation and applications in life sciences. Journal of Magnetism and Magnetic Materials 2005, 293(1):33-40.
73. Son S.J., Reichel J., He B., Schuchman M., Bai X., Lee S.B. Magnetic-field-assisted bioseparation and drug delivery by magnetic silica/magnetite composite nanotubes. Abstracts of Papers of the American Chemical Society 2005, 230:152-ANYL.
74. Bruce I.J., Taylor J., Todd M., Davies M.J., Borioni E., Sangregorio C., Sen T. Synthesis, characterisation and application of silica-magnetite nanocomposites. Journal of Magnetism and Magnetic Materials 2004, 284:145-160.
75. Taylor J.I., Hurst C.D., Davies M.J., Sachsinger N., Bruce I.J. Application of magnetite and silica-magnetite composites to the isolation of genomic DNA. Journal of Chromatography. A 2000, 890(1):159-166.
76. Souza K.C., Ardisson J.D., Sousa E.M.B. Study of mesoporous silica/magnetite systems in drug controlled release. Journal of Materials Science: Materials in Medicine 2009, 20(2):507-512.
77. Qu L.L., Tie S.L. Mesoporous silica-coated superparamagnetic magnetite functionalized with CuO and its application as a desulfurizer. Microporous and Mesoporous Materials 2009, 117(1- 2):402-405.
78. Sen T., Bruce I.J. Mesoporous silica- magnetite nanocomposites: fabrication, characterisation and applications in biosciences. Microporous and Mesoporous Materials 2009, 120(3):246-251.
79. Yang P.P., Quan Z.W., Hou Z.Y., Li C.X., Kang X.J., Cheng Z.Y., Lin J. A magnetic, luminescent and mesoporous core- shell structured composite material as drug carrier. Biomaterials 2009, 30(27):4786-4795.
80. Kim J., Kim H.S., Lee N., Kim T., Kim H., Yu T., Song I.C., Moon W.K., Hyeon T. Multifunctional uniform nanoparticles composed of a magnetite nanocrystal core and a mesoporous silica shell for magnetic resonance and fluorescence imaging and for drug delivery. Angewandte Chemie. International Edition 2008, 47(44):8438-8441.
81. Sen T., Sebastianelli A., Bruce I.J. Mesoporous silica- magnetite nanocomposite: fabrication and applications in magnetic bioseparations. Journal of the American Chemical Society 2006, 128(22):7130-7131.
82. Sun C., Veiseh O., Gunn J., Fang C., Hansen S., Lee D., Sze R., Ellenbogen R.G., Olson J., Zhang M. In vivo MRI detection of gliomas by chlorotoxin-conjugated superparamagnetic nanoprobes. Small 2008, 4(3):372-379.
83. Lee H., Yu M.K., Park S., Moon S., Min J.J., Jeong Y.Y., Kang H.W., Jon S. Thermally cross-linked superparamagnetic iron oxide nanoparticles: synthesis and application as a dual imaging probe for cancer in vivo. Journal of the American Chemical Society 2007, 129:12739-12745.
84. Suzuki M., Shimizu W., Kosugi Y., Honda H., Kobayashi T. Magnetic characterization of magnetite particles for MR contrast agents. Bulletin. Chemical Society of Japan 1996, 69(4):1143-1148.
85. Mahmoudi M., Simchi A., Imani M., Milani A.S., Stroeve P. Optimal design and characterization of superparamagnetic iron oxide nanoparticles coated with polyvinyl alcohol for targeted delivery and imaging. The Journal of Physical Chemistry. B 2008, 112(46):14470-14481.
86. Chastellain M., Petri A., Hofmann H. Superparamagnetic iron oxide nanoarticles for biomedical applications: a focus on PVA as a coating. Quantum Dots, Nanoparticles and Nanowires 2004, 789:269-272.
87. 4 nanoparticles for biomedical applications. Journal of Magnetism and Magnetic Materials 2007, 310(2):E815-E817.
88. Lee H.Y., Lim N.H., Seo J.A., Khang G., Kim J., Lee H.B., Cho S.H. Preparation of poly(vinylpyrrolidone) coated iron oxide nanoparticles for contrast agent. Polymer-Korea 2005, 29(3):266-270.
89. Ma Y.H., Wu S.Y., Wu T., Chang Y.J., Hua M.Y., Chen J.P. Magnetically targeted thrombolysis with recombinant tissue plasminogen activator bound to polyacrylic acid-coated nanoparticles. Biomaterials 2009, 30(19):3343-3351.
90. Xu F.H., Cheng C.M., Xu F.J., Zhang C.F., Xu H., Xie X., Yin D.Z., Gu H.C. Superparamagnetic magnetite nanocrystal clusters: a sensitive tool for MR cellular imaging. Nanotechnology 2009, 20(40).
91. Lellouche J.P., Senthil G., Joseph A., Buzhansky L., Bruce I., Bauminger E.R., Schlesinger J. Magnetically responsive carboxylated magnetite-polydipyrrole/polydicarbazole nanocomposites of core- shell morphology. Preparation, characterization, and use in DNA hybridization. Journal of the American Chemical Society 2005, 127(34):11998-12006.
92. 4/PMMA)/SiO2 nanoparticles with core- shell structure. Abstracts of Papers American Chemical Society 2006, 231:162-ANYL.
93. Ma D.C., Wasylaschuk W.R., Beasley C., Zhao Z.X., Harmon P.A., Ballard J.M., Pitzenberger S.M., Varga S.L., Reed R.A. Identification and quantitation of extractables from cellulose acetate butyrate (CAB) and estimation of their in vivo exposure levels. Journal of Pharmaceutical and Biomedical Analysis 2004, 35(4):779-788.
94. Kato T., Nemoto R., Mori H. Magnetic microcapsules for targeted delivery of anticancer drugs. Applied Biochemistry and Biotechnology 1984, 10:199-211.
95. Juang J.H., Shen C.R., Wang J.J., Kuo C.H., Chien Y.W., Kuo H.Y., Tsai Z.T., Yen T.C. Magnetic resonance imaging of transplanted mouse islets labeled with chitosan-coated superparamagnetic iron oxide nanoparticles. Diabetes 2009, 58:A501-A501.
96. Bravo-Osuna I., Ponchel G., Vauthier C. Tuning of shell and core characteristics of chitosan-decorated acrylic nanoparticles. European Journal of Pharmaceutical Sciences 2007, 30(2):143-154.
97. Yu L.M.Y., Kazazian K., Shoichet M.S. Peptide surface modification of methacrylamide chitosan for neural tissue engineering applications. Journal of Biomedical Materials Research. Part A 2007, 82A(1):243-255.
98. Chang Y.C., Chen D.H. Recovery of gold(III) ions by a chitosan-coated magnetic nano-adsorbent. Gold Bulletin 2006, 39(3):98-102.
99. Zhuang Q., Sun X., Zhou S., Guan W., Ye Z. Application of dextran coated magnetic iron oxide nanoparticles in delivering target gene into cells in vitro. Wuhan Daxue Xuebao (Yixue Ban) 2007, 28(3):270-273. 286.
100. Jarrett B.R., Frendo M., Vogan J., Louie A.Y. Size-controlled synthesis of dextran sulfate coated iron oxide nanoparticles for magnetic resonance imaging. Nanotechnology 2007, 18(3):35603.
101. Lacava L.M., Lacava Z.G.M., Da Silva M.F., Silva O., Chaves S.B., Azevedo R.B., Pelegrini F., Gansau C., Buske N., Sabolovic D., Morais P.C. Magnetic resonance of a dextran-coated magnetic fluid intravenously administered in mice. Biophysical Journal 2001, 80(5):2483-2486.
102. Saboktakin M.R., Maharramov A., Ramazanov M.A. Synthesis and characterization of superparamagnetic nanoparticles coated with carboxymethyl starch (CMS) for magnetic resonance imaging technique. Carbohydrate Polymers 2009, 78(2):292-295.
103. Kim D.K., Mikhaylova M., Wang F.H., Kehr J., Bjelke B., Zhang Y., Tsakalakos T., Muhammed M. Starch-coated superparamagnetic nanoparticles as MR contrast agents. Chemistry of Materials 2003, 15(23):4343-4351.
104. Meincke M., Schlorf T., Kossel E., Jansen O., Glueer C.C., Mentlein R. Iron oxide - loaded liposomes for MR imaging. Frontiers in Bioscience 2008, 13:4002-4008.
105. Pradhan P., Giri J., Banerjee R., Bellare J., Bahadur D. Preparation and characterization of manganese ferrite-based magnetic liposomes for hyperthermia treatment of cancer. Journal of Magnetism and Magnetic Materials 2007, 311(1):208-215.
106. Pauser S., Reszka R., Wagner S., Wolf K.J., Buhr H.J., Berger G. Liposome-encapsulated superparamagnetic iron oxide particles as markers in an MRI-guided search for tumor-specific drug carriers. Anti-Cancer Drug Design 1997, 12(2):125-135.
107. Torchilin V.P., Trubetskoy V.S. In vivo visualizing of organs and tissues with liposomes. Journal of Liposome Research 1995, 5(4):795-812.
108. Sato T., Sunamoto J. Recent aspects in the use of liposomes in biotechnology and medicine. Progress in Lipid Research 1992, 31(4):345-372.
109. Kandzia J., Anderson M.J.D., Mullerruchholtz W. Antibody-coated magnetic albumin microspheres - preparation conditions and analysis of their efficiency in cell-separation. Immunobiology 1983, 165(3- 4):289-290.
110. Miltenyi S., Muller W., Weichel W., Radbruch A. High gradient magnetic cell separation with MACS. Cytometry 1990, 11(2):231-238.
111. Antonelli A., Sfara C., Mosca L., Manuali E., Magnani M. New biomimetic constructs for improved in vivo circulation of superparamagnetic nanoparticles. Journal of Nanoscience and Nanotechnology 2008, 8(5):2270-2278.
112. Brahler M., Georgieva R., Buske N., Muller A., Muller S., Pinkernelle J., Teichgraber U., Voigt A., Baumler H. Magnetite-loaded carrier erythrocytes as contrast agents for magnetic resonance imaging. Nano Letters 2006, 6(11):2505-2509.
113. Gaihre B., Khil M.S., Lee D.R., Kim H.Y. Gelatin-coated magnetic iron oxide nanoparticles as carrier system: drug loading and in vitro drug release study. International Journal of Pharmaceutics 2009, 365(1- 2):180-189.
114. Intorasoot S., Srirung R., Intorasoot A., Ngamratanapaiboon S. Application of gelatin-coated magnetic particles for isolation of genomic DNA from bacterial cells. Analytical Biochemistry 2009, 386(2):291-292.
115. Sahoo Y., Pizem H., Fried T., Golodnitsky D., Burstein L., Sukenik C.N., Markovich G. Alkyl phosphonate/phosphate coating on magnetite nanoparticles: a comparison with fatty acids. Langmuir 2001, 17(25):7907-7911.
116. Wang Y., Wong J.F., Teng X.W., Lin X.Z., Yang H. "Pulling" nanoparticles into water: phase transfer of oleic acid stabilized monodisperse nanoparticles into aqueous solutions of alpha-cyclodextrin. Nano Letters 2003, 3(11):1555-1559.
117. Pellegrino T., Manna L., Kudera S., Liedl T., Koktysh D., Rogach A.L., Keller S., Radler J., Natile G., Parak W.J. Hydrophobic nanocrystals coated with an amphiphilic polymer shell: a general route to water soluble nanocrystals. Nano Letters 2004, 4(4):703-707.
118. Zhao X., Harris J.M. Novel degradable poly(ethylene glycol) hydrogels for controlled release of protein. Journal of Pharmaceutical Sciences 1998, 87(11):1450-1458.
119. Euliss L.E., Grancharov S.G., O'Brien S., Deming T.J., Stucky G.D., Murray C.B., Held G.A. Cooperative assembly of magnetic nanoparticles and block copolypeptides in aqueous media. Nano Letters 2003, 3(11):1489-1493.
120. Park K.C., Wang F., Morimoto S., Fujishige M., Morisako A., Liu X.X., Kim Y.J., Jung Y.C., Jang I.Y., Endo M. One-pot synthesis of iron oxide-carbon core- shell particles in supercritical water. Materials Research Bulletin 2009, 44(7):1443-1450.
121. Philipse A.P., Vanbruggen M.P.B., Pathmamanoharan C. Magnetic silica dispersions - preparation and stability of surface-modified silica particles with a magnetic core. Langmuir 1994, 10(1):92-99.
122. Bruce I.J., Sen T. Surface modification of magnetic nanoparticles with alkoxysilanes and their application in magnetic bioseparations. Langmuir 2005, 21(15):7029-7035.
123. Deng Y.H., Deng C.H., Qi D.W., Liu C., Liu J., Zhang X.M., Zhao D.Y. Synthesis of core/shell colloidal magnetic zeolite microspheres for the immobilization of trypsin. Advanced Materials 2009, 21(13):1377-1382.
124. 3 @ polystyrene core- shell nanoparticles. Nano Letters 2003, 3(6):789-793.
125. Li G.F., Fan J.D., Jiang R., Gao Y. Cross-linking the linear polymeric chains in the ATRP synthesis of iron oxide/polystyrene core/shell nanoparticles. Chemistry of Materials 2004, 16(10):1835-1837.
126. 4 nanoparticles coated with homopolymers of glycerol mono(meth) acrylate and their block copolymers. Journal of Materials Chemistry 2005, 15(33):3424-3430.
127. Harris L.A., Goff J.D., Carmichael A.Y., Riffle J.S., Harburn J.J., St Pierre T.G., Saunders M. Magnetite nanoparticle dispersions stabilized with triblock copolymers. Chemistry of Materials 2003, 15(6):1367-1377.
128. Gomez-Lopera S.A., Plaza R.C., Delgado A.V. Synthesis and characterization of spherical magnetite/biodegradable polymer composite particles. Journal of Colloid and Interface Science 2001, 240(1):40-47.
129. Voit W., Kim D.K., Zapka W., Muhammed M., Rao K.V. Magnetic behaviour of coated superparamagnetic iron oxide nanoparticles in ferrofluids. Mater Res Soc Symp Proc 2001, Y7.8.1-Y7.8.6.
130. Kim D.K., Mikhailova M., Toprak M., Zhang Y., Bjelke B., Kehr J., Muhammed M. In-situ gold coating of superparamagnetic nanoparticles by microemulsion method. Nanoparticulate Materials 2002, 704:137-142.
131. Goon I.Y., Lai L.M.H., Lim M., Munroe P., Gooding J.J., Amal R. Fabrication and dispersion of gold-shell-protected magnetite nanoparticles: systematic control using polyethyleneimine. Chemistry of Materials 2009, 21(4):673-681.
132. Nagao D., Yokoyama M., Saeki S., Kobayashi Y., Konno M. Preparation of composite particles with magnetic silica core and fluorescent polymer shell. Colloid and Polymer Science 2008, 286(8- 9):959-964.
133. Mahmoudi M., Shokrgozar M.A., Simchi A., Imani M., Milani A.S., Stroeve P., Vali H., Hafeli U.O., Bonakdar S. Multiphysics flow modeling and in vitro toxicity of iron oxide nanoparticles coated with poly(vinyl alcohol). Journal of Physical Chemistry C 2009, 113(6):2322-2331.
134. Varanda L.C., Jafelicci M., Tartaj P., O' Grady K., Gonzalez-Carreno T., Morales M.P., Munoz T., Serna C.J. Structural and magnetic transformation of monodispersed iron oxide particles in a reducing atmosphere. Journal of Applied Physics 2002, 92(4):2079-2085.
135. Barratt G., Courraze G., Couvreur P. Polymeric Biomaterials 2002, 753. Headquarters, Marcel Dekker, Inc., New York. 2nd ed. S. Dumitriu (Ed.).
136. Moghimi S.M., Hunter A.C., Murray J.C. Long-circulating and target-specific nanoparticles: theory to practice. Pharmacological Reviews 2001, 53(2):283-318.
137. Gupta A.K., Gupta M. Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials 2005, 26(18):3995-4021.
138. Sun Z.X., Su F.W., Forsling W., Samskog P.O. Surface characteristics of magnetite in aqueous suspension. Journal of Colloid and Interface Science 1998, 197(1):151-159.
139. Fleet M.E. The structure of magnetite. Acta Crystallographica Section B-Structural Science APR 1981, 37:917-920.
140. Coey J.M.D., Shvets I.V., Wiesendanger R., Guntherodt H.J. Charge freezing and surface anisotropy on magnetite(100). Journal of Applied Physics 1993, 73(10):6742-6744.
141. Chouly C., Pouliquen D., Lucet I., Jeune J.J., Jallet P. Development of superparamagnetic nanoparticles for MRI: effect of particle size, charge and surface nature on biodistribution. Journal of Microencapsulation 1996, 13(3):245-255.
142. Osaka T., Nakanishi T., Shanmugam S., Takahama S., Zhang H. Effect of surface charge of magnetite nanoparticles on their internalization into breast cancer and umbilical vein endothelial cells. Colloids and Surfaces. B: Biointerfaces 2009, 71(2):325-330.
143. Armstrong T.I., Davies M.C., Illum L. Human serum albumin as a probe for protein adsorption to nanoparticles: relevance to biodistribution. Journal of Drug Targeting 1997, 4(6):389-398.
144. Norman M.E., Williams P., Illum L. Influence of block copolymers on the adsorption of plasma-proteins to microspheres. Biomaterials 1993, 14(3):193-202.
145. Zhang Y., Kohler N., Zhang M.Q. Surface modification of superparamagnetic magnetite nanoparticles and their intracellular uptake. Biomaterials 2002, 23(7):1553-1561.
146. Lee H., Lee E., Kim D.K., Jang N.K., Jeong Y.Y., Jon S. Antibiofouling polymer-coated superparamagnetic iron oxide nanoparticles as potential magnetic resonance contrast agents for in vivo cancer imaging. Journal of the American Chemical Society 2006, 128(22):7383-7389.
147. Mahmoudi M., Simchi A., Milani A.S., Stroeve P. Cell toxicity of superparamagnetic iron oxide nanoparticles. Journal of Colloidal and Interface Science 2009, 336(2):510-518.
148. Karlsson H.L., Cronholm P., Gustafsson J., Muller L. Copper oxide nanoparticles are highly toxic: a comparison between metal oxide nanoparticles and carbon nanotubes. Chemical Research in Toxicology 2008, 21(9):1726-1732.
149. Mahmoudi M., Simchi A., Imani M. Cytotoxicity of uncoated and polyvinyl alcohol coated superparamagnetic iron oxide nanoparticles. The Journal of Physical Chemistry C 2009, 113(22):9573-9580.
150. Mahmoudi M., Simchi A., Imani M., Shokrgozar M.A., Azadmanesh K., Azari F. Cytotoxicity and cell cycle effects of bare and polyvinyl alcohol coated iron oxide nanoparticles in mouse fibroblasts. Advanced Engineering Materials 2009, 11(12):B243-B250.
151. Mahmoudi M., Simchi A., Imani M., Shokrgozar M.A., Milani A.S., Hafeli U., Stroeve P. A new approach for the in vitro identification of the cytotoxicity of superparamagnetic iron oxide nanoparticles. Colloids and Surfaces. B: Biointerfaces 2010, 75:300-309.
152. Mahmoudi M., Simchi A., Imani M., Milani A.S., Stroeve P. An in vitro study of bare and poly(ethylene glycol)-co-fumarate-coated superparamagnetic iron oxide nanoparticles: a new toxicity identification procedure. Nanotechnology 2009, 20(22).
153. Lynch I. Are there generic mechanisms governing interactions between nanoparticles and cells? Epitope mapping the outer layer of the protein- material interface. Physica A 2007, 373:511-520.
154. Lynch I., Dawson K.A. Protein- nanoparticle interactions. Nano Today 2008, 3(1- 2):40-47.
155. Nel A., Xia T., Madler L., Li N. Toxic potential of materials at the nanolevel. Science 2006, 311:622-627.
156. Nel A.E., Madler I., Velegol D., Xia T., Hoek E.M.V., Somasundaran P., Klaessig F., Castranova V., Thompson M. Understanding biophysicochemical interactions at the nano-bio interface. Nature Materials 2009, 8:543-557.
157. Cedervall T., Lynch I., Lindman S., Nilsson H., Thulin E., Linse S., Dawson K.A. Understanding the nanoparticle protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles. Proceedings of the National Academy of Sciences of the United States of America 2007, 104:2050-2055.
158. Lynch I., Cedervall T., Lundqvist M., Cabaleiro-Lago C., Linse S., Dawson K.A. The nanoparticle-protein complex as a biological entity; a complex fluids and surface science challenge for the 21st century. Advances in Colloid and Interface Science 2007, 134- 135:167-174.
159. Walczyk D., Bombelli F.B., Monopoli M.P., Lynch I., Dawson K.A. What the cell "sees" in bionanoscience. Journal of the American Chemical Society 2010, 132(16):5761-5768.
160. Gerber D., Maerkl S.J., Quake S.R. An in vitro microfluidic approach to generating protein-interaction networks. Nature Methods 2009, 6:71-74.
161. Neuberger T., Schopf B., Hofmann H., Hofmann M., Von Rechenberg B. Superparamagnetic nanoparticles for biomedical applications: possibilities and limitations of a new drug delivery system. Journal of Magnetism and Magnetic Materials 2005, 293(1):483-496.
162. Arruebo M., Fernández-Pacheco R., Ibarra M.R., Santamariá J. Magnetic nanoparticles for drug delivery. Nano Today 2007, 2(3):22-32.
163. Farokhzad O.C., Langer R. Impact of nanotechnology on drug delivery. ACS Nano 2009, 3(1):16-20.
164. McCarthy J.R., R.W. Multifonctional magnetic nanoparticles for targeted imaging and therapy. Advanced Drug Delivery Reviews 2008, 60:1241-1251.
165. McCarthy J.R., Kelly K.A., Sun E.Y., R.W. Targeted delivery of multifunctional magnetic nanoparticles. Nanomedicine 2007, 2(2):153-167.
166. Laurent S., Forge D., Port M., Roch A., Robic C., Vander Elst L., Muller R.N. Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physico-chemical characterizations and biological applications. Chemical Reviews 2008, 108(6):2064-2110.
167. Mahmoudi M., Simchi A., Imani M. Recent advances in surface engineering of superparamagnetic iron oxide nanoparticles for biomedical applications. Journal of Iranian Chemical Society 2010, 7(3):S1-S27.
168. Burtea C., Laurent S., Roch A., Vander Elst L., Muller R.N. C-MALISA (cellular magnetic-linked immunosorbent assay), a new application of cellular ELISA for MRI. Journal of Inorganic Biochemistry 2005, 99(5):1135-1144.
169. Boutry S., Laurent S., Vander Elst L., Muller R.N. Specific E-selectin targeting with a superparamagnetic MRI contrast agent. Contrast Media & Molecular Imaging 2006, 1(1):15-22.
170. Quinti L., Weissleder R., Tung C.H. A fluorescent nanosensor for apoptotic cells. Nano Letters 2006, 6(3):488-490.
171. W.S.E., B.S., P.G.B., N.N., M.P., A.B., T.J.B., R.W. MR imaging of slow axonal transport in vivo. Experimental Neurology 1993, 123:235-242.
172. Enochs W.S., R.W. MR imaging of the peripheral nervous system. Journal of Magnetic Resonance Imaging 1994, 4:251-257.
173. Petropoulos A.E., Schaffer B.K., Cheney M.L., Enochs S., Zimmer C., Weissleder R. MR imaging of neuronal transport in the guinea pig facial nerve: initial findings. Acta Otolaryngologica 1995, 115:512-516.
174. Van Everdingen K.J., Enochs W.S., Bhide P.G., Nossiff N., Papisov M., Bogdanov A., Brady T.J., Weissleder R. Determinants of in vivo MR imaging of slow axonal transport. Radiology 1994, 193:485-491.
175. O. Mykhaylyk, A. Cherchenko, A. Ilkin, N. Dudchenko, V. Ruditsa, M. Novoseletz, Y. Zozulya, In Glial brain tumor targeting of magnetite nanoparticles in rats, Journal of Magnetism and Magnetic Materials 225 (2001) 241- 247.
176. Remsen L.G., McCormick C.I., Roman-Goldstein S., Nilaver G., Weissleder R., Bogdanov A., Hellström K.E., Hellström I., Kroll R.A., Neuwelt E.A. MR of carcinoma-specific monoclonal antibody conjugated to monocrystalline iron oxide nanoparticles: the potential for noninvasive diagnosis. American Journal of Neuroradiology 1996, 17(3):411-418.
177. Sykova E., Jendelova P., Urdzikova L., Lesny P., Hejcl A. Bone marrow stem cells and polymer hydrogels - two strategies for spinal cord injury repair. Cellular and Molecular Neurobiology 2006, 26(7- 8):1113-1129.
178. Zhao M., Beauregard D.A., Loizou L., Davletov B., Brindle K.M. Non-invasive detection of apoptosis using magnetic resonance imaging and a targeted contrast agent. Natural Medicines 2001, 7:1241-1244.
179. Pirko I., Johnson A., Ciric B., Gamez J., Macura S.I., Pease L., Rodriguez M. In vivo magnetic resonance imaging of immune cells in the central nervous system with superparamagnetic antibodies. FASEB 2004, 18:179-182.
180. Wadghiri Y.Z., Sigurdsson E.M., Sadowski M., Elliott J.I., Li Y., Scholtzova H., Tang C.Y., Aguinaldo G., Pappolla M., Duff K., Wisniewski T., Turnbull D.H. Detection of Alzheimer's amyloid in transgenic mice using magnetic resonance microimaging. Magnetic Resonance in Medicine 2003, 50:293-302.
181. Hogemann D., Josephson L., Weissleder R., Basilion J.P. Improvement of MRI probes to allow efficient detection of gene expression. Bioconjugate Chemistry 2000, 11(6):941-946.
182. Funovics M.A., Kapeller B., Hoeller C., Su H.S., Kunstfeld R., Puig S., Macfelda K. MR imaging of the her2/neu and 9.2.27 tumor antigens using immunospecific contrast agents. Magnetic Resonance Imaging 2004, 22:843-850.
183. Papisov M.I., Bogdanov A., Schaffer B., Nossiff N., Shen T., Weissleder R., Brady T.J. Colloidal magnetic resonance contrast agents: effect of particle surface on biodistribution. Journal of Magnetism and Magnetic Materials 1993, 122:383-386.
184. Renshaw P.F., Owen C.S., Evans A.E., Leigh J.S. Immunospecific NMR contrast agents. Magnetic Resonance Imaging 1986, 4:351-357.
185. Suzuki M., Shinkai M., Kamihira M., Kobayashi T. Antibody-conjugated magnetoliposomes for targeting cancer cells and their application in hyperthermia. Biotechnology and Applied Biochemistry 1995, 21:125-137.
186. Reimer P., Weissleder R., Shen T., Knoefel W.T., Brady T.J. Pancreatic receptors: initial feasibility studies with a targeted contrast agent for MR imaging. Radiology 1994, 193:527-531.
187. Cerdan S., Lotscher H.R., Kunnecke B., Seelig J. Monoclonal antibody-coated magnetite particles as contrast agents in magnetic resonance imaging of tumors. Magnetic Resonance in Medicine 1989, 12(2):151-163.
188. Suwa T., Ozawa S., Ueda M., Ando N., Kitajima M. Magnetic resonance imaging of esophageal squamous cell carcinoma using magnetite particles coated with anti-epidermal growth factor receptor antibody. International Journal of Cancer 1998, 75:626-634.
189. Li Z., Wei L., Gao M., Lei H. One-pot reaction to synthesize biocompatible magnetite nanoparticles. Advanced Materials 2005, 8:1001-1005.
190. Zhang C., Jugold M., Woenne E.C., Lammers T., Morgenstern B., Mueller M.M., Zentgraf H., Bock M., Eisenhut M., Semmler W., Kiessling F. Specific targeting of tumor angiogenesis by RGD-conjugated ultrasmall superparamagnetic iron oxide particles using a clinical 1.5-T magnetic resonance scanner. Cancer Research 2007, 67(4):148-157.
191. Bulte J.W., Hoekstra Y., Kamman R.L., Magin R.L., Webb A.G., Briggs R.W., Go K.G., Hulstaert C.E., Miltenyi S., The T.H., De Leij L. Specific MR imaging of human lymphocytes by monoclonal antibody-guided dextran- magnetite particles. Magnetic Resonance in Medicine 1992, 25(1):148-157.
192. Go K.G., Bulte J.W., de Ley L., The T.H., Kamman R.L., Hulstaert C.E., Blaauw E.H., Ma L.D. Our approach towards developing a specific tumour-targeted MRI contrast agent for the brain. European Journal of Radiology 1993, 16(3):171-175.
193. Hogemann-Savellano D., Bos E., Blondet C., Sato F., Abe T., Josephson L., Weissleder R., Gaudet J., Sgroi D., P.J.P., Basilion J.P. The transferrin receptor: a potential molecular imaging marker for human cancer. Neoplasia 2003, 5(6):495-506.
194. Kang H.W., Josephson L., Petrovsky A., Weissleder R., Bogdanov A.J. Magnetic resonance imaging of inducible E-selectin expression in human endothelial cell culture. Bioconjugate Chemistry 2002, 13:122-127.
195. Schellenberger E.A., Bogdanov A.J., Hogemann D., Tait J., Weissleder R., Josephson L. Annexin V-CLIO: a nanoparticle for detecting apoptosis by MRI. Molecular Imaging 2002, 1:102-107.
196. Schellenberger E.A., Sosnovik D.E., Weissleder R., Josephson L. Magneto/optical annexin V, a multimodal protein. Bioconjugate Chemistry 2004, 15:1062-1067.
197. Sosnovik D.E., Schellenberger E.A., Nahrendorf M., Novikov M.S., Matsui T., Dai G., Reynolds F., Grazette L., Rosenzweig A., Weissleder R., Josephson L. Magnetic resonance imaging of cardiomyocyte apoptosis with a novel magneto-optical nanoparticle. Magnetic Resonance in Medicine 2005, 54:718-724.
198. Tsourkas A., Shinde-Patil V.R., Kelly K.A., Patel P., Wolley A., Allport J.R., Weissleder R. In vivo imaging of activated endothelium using an anti-VCAM-1 magnetooptical probe. Bioconjugate Chemistry 2005, 16:576-581.
199. Montet X., Weissleder R., Josephson L. Imaging pancreatic cancer with a peptide- nanoparticle conjugate targeted to normal pancreas. Bioconjugate Chemistry 2006, 17(4):905-911.
200. Kircher M.F., Mahmood U., King R.S., Weissleder R., Josephson L. A multimodal nanoparticle for preoperative magnetic resonance imaging and intraoperative optical brain tumor delineation. Cancer Research 2003, 63(23):8122-8125.
201. Jun Y.W., Huh Y.M., Choi J.S., Lee J.H., Song H.T., Kim S., Yoon S., Kim K.S., Shin J.S., Suh J.S., Cheon J. Nanoscale size effect of magnetic nanocrystals and their utilization for cancer diagnosis via magnetic resonance imaging. Journal of the American Chemical Society 2005, 127(16):5732-5733.
202. Huh Y.M., Jun Y.W., Song H.T., Kim S., Choi J.S., Lee J.H., Yoon S., Kim J.S., Shin J.S., Suh J.S., Cheon J. In vivo magnetic resonance detection of cancer by using multifunctional magnetic nanocrystals. Journal of the American Chemical Society 2005, 7:12387-12391.
203. Halbreich A., Sabolovic D., Sestier C., Amri A., Pons J.N., Roger J., Geldwerth D. Annexin V binding to mouse erythrocytes following infection with Plasmodium parasites. Parasitology Today 1996, 12(7):292-293.
204. Fauconnier N., Pons J.N., Roger J., Bee A. Thiolation of maghemite nanoparticles by dimercaptosuccinic acid. Journal of Colloid and Interface Science 1997, 194:427-433.
205. Sestier C., Sabolovic D., Geldwerth D., Moumaris M., Roger J., Pons J.N., Halbreich A. Use of annexin V-ferrofluid to enumerate erythrocytes damaged in various pathologies or during storage in vitro. Comptes rendus de l'Académie des sciences. Série 3, Sciences de la vie 1995, 318(11):1141-1146.
206. J.R., J.N.P., Massart R., Halbreich A., Bacri J.C. Some biomedical applications of ferrofluids. European Physical Journal. Applied physics 1999, 5:321-325.
207. Lee J.H., Huh Y.M., Jun Y.W., Seo J.W., Jang J.T., Song H.T., Kim S., Cho E.J., Yoon H.G., Suh J.S., Cheon J. Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging. Natural Medicines 2007, 13(1):95-99.
208. Neuberger T., Schopf B., Hofmann H., Hofmann M., Rechenberg B. Superparamagnetic nanoparticles for biomedical applications: possibilities and limitations of a new drug delivery system. Journal of Magnetism and Magnetic Materials 2005, 293:483-496.
209. Sykova E., Jendelova P. Migration, fate and in vivo imaging of adult stem cells in the CNS. Cell Death and Differentiation 2007, 14:1336-1342.
210. Lubbe A.S., Alexiou C., Bergemann C. Clinical applications of magnetic drug targeting. The Journal of Surgical Research 2001, 95(2):200-206.
211. Rudge S., Peterson C., Vessely C., Koda J., Stevens S., Catterall L. Adsorption and desorption of chemotherapeutic drugs from a magnetically targeted carrier (MTC). Journal of Controlled Release 2001, 74(1- 3):335-340.
212. Mahmoudi M., Simchi A., Imani M., Hafeli U.O. Superparamagnetic iron oxide nanoparticles with rigid cross-linked polyethylene glycol fumarate coating for application in imaging and drug delivery. Journal of Physical Chemistry C 2009, 113(19):8124-8131.
213. Gupta A.K., Naregalkar R.R., Vaidya V.D., Gupta M. Recent advances on surface engineering of magnetic iron oxide nanoparticles and their biomedical applications. Nanomedicine 2007, 2(1):23-39.
214. Hergt R., Dutz S., Röder M. Effects of size distribution on hysteresis losses of magnetic nanoparticles for hyperthermia. Journal of Physics Condensed Matter 2008, 20(38).
215. Narayanan T.N., Reena Mary A.P., Shaijumon M.M., Ci L., Ajayan P.M., Anantharaman M.R. On the synthesis and magnetic properties of multiwall carbon nanotube-superparamagnetic iron oxide nanoparticle nanocomposites. Nanotechnology 2009, 20(5).
216. Jones R.A.L. Soft Mashines: Nanotechnology and Life 2004, Oxford University Press.
217. Hong R., Li H.H., Wang H., Li H.Z. China Particuology 2007, 5:6.
218. Bacri J.C., Perzynski R., Salin D. Journal of Magnetism and Magnetic Materials 1990, 85.
219. Douziech-Eyrolles L., Marchais H., Herve K., Munnier E., Souce M., Linassier C., Dubois P., Chourpa I. Nanovectors for anticancer agents based on superparamagnetic iron oxide nanoparticles. International Journal of Nanomedicine 2007, 2(4):541-550.
220. Akerman M.E., Chan W.C.W., Laakkonen P., Bhatia S.N., Ruoslahti E. Nanocrystal targeting in vivo. Proceedings of the National Academy of Sciences of the United States of America 2002, 99(20):12617-12621.
221. LaVan D.A., McGuire T., Langer R. Small-scale systems for in vivo drug delivery. Nature Biotechnology 2003, 21(10):1184-1191.
222. Lubbe A.S., Bergemann C., Brock J., McClure D.G. Physiological aspects in magnetic drug-targeting. Journal of Magnetism and Magnetic Materials 1999, 194:7.
223. Gupta P., Vermani K., Garg S. Hydrogels: from controlled release to pH-responsive drug delivery. Drug Discovery Today 2002, 7(10):569-579.
224. Cengelli F., Maysinger D., Tschudi-Monnet F., Montet X., Corot C., Petri-Fink A., Hofmann H., Juillerat-Jeanneret L. Interaction of functionalized superparamagnetic iron oxide nanoparticles with brain structures. The Journal of Pharmacology and Experimental Therapeutics 2006, 318(1):108-116.
225. Guo S., Li D., Zhang L., Li J., Wang E. Monodisperse mesoporous superparamagnetic single-crystal magnetite nanoparticles for drug delivery. Biomaterials 2009, 30:9.
226. Kubo T., Sugita T., Shimose S., Nitta Y., Ikuta Y., Murakami T. Targeted systemic chemotherapy using magnetic liposomes with incorporated adriamycin for osteosarcoma in hamsters. International Journal of Oncology 2001, 18(1):121-125.
227. Gonzales M., Krishnan K.M. Synthesis of magnetoliposomes with monodisperse iron oxide nanocrystal cores for hyperthermia. Journal of Magnetism and Magnetic Materials 2005, 293:265-270.
228. Meyers P.H., Cronic F., Nice C.M. Experimental approach in the use and magnetic control of metallic iron particles in the lymphatic and vascular system of dogs as a contrast and isotopic agent. The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine 1963, 90:1068-1077.
229. Alksne J.F., Fingerhut A.G. Magnetically controlled metallic thrombosis of intracranial aneurysms. A preliminary report. Bulletin of the Los Angeles Neurological Societies 1965, 30(3):153-155.
230. Turner R.D., Rand R.W., Bentson J.R., Mosso J.A. Ferromagnetic silicone necrosis of hypernephromas by selective vascular occlusion to the tumor: a new technique. Journal d'Urologie 1975, 113(4):455-459.
231. Widder K.J., Senyei A.E., Ranney D.F. Magnetically responsive microspheres and other carriers for the biophysical targeting of antitumor agents. Advances in Pharmacology and Chemotherapy 1979, 16:213-271.
232. Cheng Y., Zak O., Alsen P., Harrison S.C., Walz T. Structure of the human transferrin receptor- transferrin complex. Cell 2004, 116(4):565-576.
233. Lubbe A.S., Bergemann C., Huhnt W., Fricke T., Riess H., Brock J.W., Huhn D. Preclinical experiences with magnetic drug targeting: tolerance and efficacy. Cancer Research 1996, 56(20):4694-4701.
234. Lubbe A.S., Bergemann C., Riess H., Schriever F., Reichardt P., Possinger K., Matthias M., Dorken B., Herrmann F., Gurtler R., Hohenberger P., Haas N., Sohr R., Sander B., Lemke A.J., Ohlendorf D., Huhnt W., Huhn D. Clinical experiences with magnetic drug targeting: a phase I study with 4'-epidoxorubicin in 14 patients with advanced solid tumors. Cancer Research 1996, 56(20):4686-4693.
235. Widder K.J., Morris R.M., Howard D.P., Senyei A.E. Tumor remission in Yoshida sarcoma-bearing rats by selective targeting of magnetic albumin microspheres containing doxorubicin. Proceedings of the National Academy of Sciences of the United States of America 1981, 78:579-581.
236. Widder K.J., Morris R.M., Poore G.A., et al. Selective targeting of magnetic albumin microspheres containing lowdose doxorubicin: total remission in Yoshida sarcoma-bearing rats. European Journal of Cancer & Clinical Oncology 1983, 19:135-139.
237. Senyei A.E., Reich S.D., Gonczy C., Widder K.J. In vivo kinetics of magnetically targeted low-dose doxorubicin. Journal of Pharmaceutical Sciences 1981, 70:39-41.
238. S. Goodwin, C. Peterson, C. Hoh, C. Bittner. In Targeting and retention of magnetic targeted carriers (MTCs) enhancing intra-arterial chemotherapy, 1999, pp 132- 139.
239. Goodwin S.C., Bittner C.A., Peterson C.L., Wong G. Single-dose toxicity study of hepatic intra-arterial infusion of doxorubicin coupled to a novel magnetically targeted drug carrier. Toxicological Sciences 2001, 60(1):177-183.
240. A.S. Lubbe, C. Bergemann, J. Brock, D.G. McClure. In Physiological aspects in magnetic drug-targeting, 1999, pp 149- 155.
241. Pulfer S.K., Gallo J.M. Enhanced brain tumor selectivity of cationic magnetic polysaccharide microspheres. Journal of Drug Targeting 1998, 6(3):215-227.
242. Pulfer S.K., Ciccotto S.L., Gallo J.M. Distribution of small magnetic particles in brain tumor-bearing rats. Journal of Neuro-Oncology 1999, 41(2):99-105.
243. Kubo T., Sugita T., Shimose S., Nitta Y., Ikuta Y., Murakami T. Targeted delivery of anticancer drugs with intravenously administered magnetic liposomes in osteosarcoma-bearing hamsters. International Journal of Oncology 2000, 17(2):309-315.
244. Khurshid H., Kim S.H., Bonder M.J., Colak L., Ali B., Shah S.I., Kiick K.L., Hadjipanayis G.C. Development of heparin-coated magnetic nanoparticles for targeted drug delivery applications. Journal of Applied Physics 2009, 105(7).
245. Butoescu N., Seemayer C.A., Palmer G., Guerne P.-A., Gabay C., Doelker E., Jordan O. Magnetically retainable microparticles for drug delivery to the joint: efficacy studies in an antigen-induced arthritis model in mice. Arthritis Research & Therapy 2009, 11(3).
246. Peppas N.A., Hilt J.Z., Khademhosseini A., Langer R. Hydrogels in biology and medicine: from molecular principles to bionanotechnology. Advanced Materials 2006, 18:1345-1360.
247. Babincova M., Cicmanec P., Altanerova V., et al. AC magnetic field controlled drug release from magnetoliposomes: design of a method for site-specific chemotherapy. Bioelectrochemistry 2002, 55:17-19.
248. Viroonchatapan E., Sato H., Ueno M., et al. Microdialysis assessment of 5-fluorouracil release from thermosensitive magnetoliposomes induced by an electromagnetic field in tumor-bearing mice. Journal of Drug Targeting 1998, 5:379-390.
249. Butoescu N., Jordan O., Burdet P., Stadelmann P., Petri-Fink A., Hofmann H., Doelker E. Dexamethasone-containing biodegradable superparamagnetic microparticles for intra-articular administration: physicochemical and magnetic properties, in vitro and in vivo drug release. European Journal of Pharmaceutics and Biopharmaceutics 2009, 72:529-538.
250. Nasongkla N., Bey E., Ren J., Ai H., Khemtong C., Guthi J.S., Chin S.-F., Sherry A.D., Boothman D.A., Gao J. Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems. Nano Letters 2006, 6(11):2427-2430.
251. Jain T.K., Richey J., Strand M., Leslie-Pelecky D.L., Flask C.A., Labhasetwar V. Magnetic nanoparticles with dual functional properties: drug delivery and magnetic resonance imaging. Biomaterials 2008, 29:4012-4021.
252. Jain T.K., Morales M.A., Sahoo S.K., Leslie-Pelecky D.L., Labhasetwar V. Iron oxide nanoparticles for sustained delivery of anticancer agents. Molecular Pharmaceutics 2005, 2(3):194-205.
253. Santra S., Kaittanis C., Grimm J., Perez J.M. Drug/dye-loaded, multifunctional iron oxide nanoparticles for combined targeted cancer therapy and dual optical/magnetic resonance imaging. Small 2009, 5(16):1862-1868.
254. 4 nanoparticles for targeted delivery and controlled release of cisplatin. Journal of the American Chemical Society 2009, 131(30):10637-10644.
255. 4 nanoparticles for camptothecin loading and release. Acta Biomaterialia 2009, 5(5):1489-1498.
256. Zhou S., Sun J., Sun L., Dai Y., Liu L., Li X., Wang J., Weng J., Jia W., Zhang Z. Preparation and characterization of interferon-loaded magnetic biodegradable microspheres. Journal of Biomedical Materials Research. Part B: Applied Biomaterials 2008, 87B:189-196.
257. Zhao W., Chen H., Li Y., Li L., Lang M., Shi J. Uniform rattle-type hollow magnetic mesoporous spheres as drug delivery carriers and their sustained-release property. Advanced Functional Materials 2008, 18:2780-2788.
258. Gong X., Peng S., Wen W., Sheng P., Li W. Design and fabrication of magnetically functionalized core/shell microspheres for smart drug delivery. Advanced Functional Materials 2009, 19:292-297.
259. Rossin R., Pan D., Qi K., Turner J.L., Sun X., Wooley K.L., Welch M.J. 64Cu-labeled folate-conjugated shell cross-linked nanoparticles for tumor imaging and radiotherapy: synthesis, radiolabeling, and biologic evaluation. Journal of Nuclear Medicine 2005, 46(7):1210-1218.
260. Bao A., Phillips W.T., Goins B., Zheng X., Sabour S., Natarajan M., Ross Woolley F., Zavaleta C., Otto R.A. Potential use of drug carried-liposomes for cancer therapy via direct intratumoral injection. International Journal of Pharmaceutics 2006, 316(1- 2):162-169.
261. Hafeli U.O. Radioactive microspheres for medical applications. Physics and Chemistry Basis of Biotechnology 2001, 213-248. Kluwer Academic Publishers, Dordrecht, Holland. J. Bulte, M. de Kuyper (Eds.).
262. + and in vivo biodistribution evaluation using microSPECT/CT imaging. Bioconjugate Chemistry 2009, 20(6):1209-1217.
263. Voltairas P.A., Fotiadis D.I., Michalis L.K. Hydrodynamics of magnetic drug targeting. Journal of Biomechanics 2002, 35(6):813-821.
264. Richardson T.P., Peters M.C., Ennett A.B., Mooney D.J. Polymeric system for dual growth factor delivery. Nature Biotechnology 2001, 19(11):1029-1034.
265. Aviles M.O., Ebner A.D., Chen H.T., Rosengart A.J., Kaminski M.D., Ritter J.A. Theoretical analysis of a transdermal ferromagnetic implant for retention of magnetic drug carrier particles. Journal of Magnetism and Magnetic Materials 2005, 293(1):605-615.
266. Ritter J.A., Ebner A.D., Daniel K.D., Stewart K.L. Application of high gradient magnetic separation principles to magnetic drug targeting. Journal of Magnetism and Magnetic Materials 2004, 280(2- 3):184-201.
267. Grief A.D., Richardson G. Mathematical modelling of magnetically targeted drug delivery. Journal of Magnetism and Magnetic Materials 2005, 293(1):455-463.
268. Nishijima S., Mishima F., Tabata Y., Iseki H., Muragaki Y., Sasaki A., Saho N. Research and development of magnetic drug delivery system using bulk high temperature superconducting magnet. IEEE Transactions on Applied Superconductivity 2009, 19(3):2257-2260.
269. Nishijima S., Takeda S.I., Mishima F., Tabata Y., Yamamoto M., Joh J.I., Iseki H., Muragaki Y., Sasaki A., Jun K., Saho N. A study of magnetic drug delivery system using bulk high temperature superconducting magnet. IEEE Transactions on Applied Superconductivity 2008, 18(2):874-877.
270. Mishima F., Takeda S., Izumi Y., Nishijima S. Development of magnetic field control for magnetically targeted drug delivery system using a superconducting magnet. IEEE Transactions on Applied Superconductivity 2007, 17(2):2303-2306.
271. Takeda S., Mishima F., Fujimoto S., Izumi Y., Nishijima S. Development of magnetically targeted drug delivery system using superconducting magnet. Journal of Magnetism and Magnetic Materials 2007, 311(1):367-371.
272. Rotariu O., Strachan N.J.C. Modelling magnetic carrier particle targeting in the tumor microvasculature for cancer treatment. Journal of Magnetism and Magnetic Materials 2005, 293(1):639-646.
273. Iacob G., Rotariu O., Strachan N.J.C., Häfeli U.O. Magnetizable needles and wires - modeling an efficient way to target magnetic microspheres in vivo. Biorheology 2004, 41(5):599-612.
274. Yellen B.B., Forbes Z.G., Halverson D.S., Fridman G., Barbee K.A., Chorny M., Levy R., Friedman G. Targeted drug delivery to magnetic implants for therapeutic applications. Journal of Magnetism and Magnetic Materials 2005, 293(1):647-654.
275. Rosengart A.J., Kaminski M.D., Chen H., Caviness P.L., Ebner A.D., Ritter J.A. Magnetizable implants and functionalized magnetic carriers: a novel approach for noninvasive yet targeted drug delivery. Journal of Magnetism and Magnetic Materials 2005, 293(1):633-638.
276. Aviles M.O., Chen H.T., Ebner A.D., Rosengart A.J., Kaminski M.D., Ritter J.A. In vitro study of ferromagnetic stents for implant assisted-magnetic drug targeting. Journal of Magnetism and Magnetic Materials 2007, 311(1):306-311.
277. Forbes Z.G., Yellen B.B., Halverson D.S., Fridman G., Barbee K.A., Friedman G. Validation of high gradient magnetic field based drug delivery to magnetizable implants under flow. IEEE Transactions on Biomedical Engineering 2008, 55(2):643-649.
278. Chen H.T., Ebner A.D., Kaminski M.D., Rosengart A.J., Ritter J.A. Analysis of magnetic drug carrier particle capture by a magnetizable intravascular stent-2: parametric study with multi-wire two-dimensional model. Journal of Magnetism and Magnetic Materials 2005, 293(1):616-632.
279. Chen H.T., Ebner A.D., Rosengart A.J., Kaminski M.D., Ritter J.A. Analysis of magnetic drug carrier particle capture by a magnetizable intravascular stent: 1. Parametric study with single wire correlation. Journal of Magnetism and Magnetic Materials 2004, 284:181-194.
280. Furlani E.P., Ng K.C. Analytical model of magnetic nanoparticle transport and capture in the microvasculature. Physical Review E 2006, 73(6).
281. Milton Harris J., Chess R.B. Effect of pegylation on pharmaceuticals. Nature Reviews. Drug Discovery 2003, 2(3):214-221.