Development of superparamagnetic iron oxide nanoparticles (SPIONS) for translation to clinical applications

IEEE Transactions on Nanobioscience

Volumn 7, Issue 4, 2008, Pages 298-305

  Lin, Meng Meng ^a   Kim, Do Kyung ^a   El Haj, Alicia J ^a   Dobson, Jon ^a  

^a KEELE UNIVERSITY   (United Kingdom)

Author keywords

Biomagnetics; Biomedical; Gene therapy; MRI; Nanoparticles; SPION; Surface coatings

Indexed keywords

BIOMAGNETICS; BIOMEDICAL; GENE THERAPY; MRI; SPION; SURFACE COATINGS;

COATINGS; GENE TRANSFER; GENETIC ENGINEERING; IRON OXIDES; IRON RESEARCH; MAGNETIC FIELD EFFECTS; MAGNETIC FIELDS; MAGNETIC MATERIALS; MAGNETIC PROPERTIES; MAGNETIC RESONANCE IMAGING; MAGNETIC SEPARATION; MAGNETISM; MEDICAL NANOTECHNOLOGY; NANOPARTICLES; PLASTIC COATINGS; SUPERPARAMAGNETISM; SURFACE PROPERTIES; SURFACE TREATMENT;

APPLICATIONS;

CONTRAST MEDIA; DRUG DELIVERY SYSTEMS; FERROSOFERRIC OXIDE; MAGNETIC RESONANCE IMAGING; NANOMEDICINE; NANOPARTICLES; TRANSFECTION;

EID: 60149091554     PISSN: 15361241     EISSN: None     Source Type: Journal    
DOI: 10.1109/TNB.2008.2011864     Document Type: Review

References (68)

1. T. Neuberger, B. Schopf, H. Hofmann, M. Hofmann, and B. von Rechenberg, "Superparamagnetic nanoparticle for biomedical applications: Possibility and limitations of a new drug delivery system," J. Magn. Magn. Mater., vol. 293, pp. 483-496, 2005.
2. H. Lin, Y.Watanabe, M. Kimura, Y. Hanabusa, and H. Shirai, "Preparation of magnetic poly(vinyl alcohol) (PVA) materials by in situ synthesis of magnetite in a PVA matrix," J. Appl. Polym. Sci., vol. 87, pp. 1239-1247, 2003.
3. A. K. Gupta and S. Wells, "Surface-modified superparamagnetic nanoparticles for drug delivery: Preparation, characterization, and cytotoxicity studies," IEEE Trans. Nanobiosci., vol. 3, pp. 66-73, 2004.
4. Y. Deng, L. Wang, W. Yang, S. Fu, and A. Elaissari, "Preparation of magnetic polymeric particles via inverse microemulsion polymerization process," J. Magn. Magn. Mater., vol. 257, pp. 69-78, 2003.
5. S. Sun and H. Zeng, "Size-controlled synthesis of magnetite nanoparticles," J. Amer. Chem. Soc., vol. 124, pp. 8204-8205, 2002.
6. T. Hyeon, S. S. Lee, J. Park, and Y. Chung, "Synthesis of highly crystalline and monodisperse maghemite nanocrystallites without a sizeselection process," J. Amer. Chem. Soc., vol. 123, pp. 12798-12801, 2001.
7. J. Park, E. Lee, N. M. Hwang, M. S. Kang, S. C. Kim, Y. Hwang, J. G. Park, H. J. Noh, J. Y. Kini, J. H. Park, and T. Hyeon, "One-nanometerscale size-controlled synthesis of monodisperse magnetic iron oxide nanoparticles," Angew. Chem.-Int. Ed., vol. 44, pp. 2872-2877, 2005.
8. J. Park, K. An, Y. S.Hwang, J. G. Park, H. J. Noh, J. K. Kim, J. H. Park, N. M. Hwang, and Y. Hyeon, "Ultra-large-scale syntheses of monodisperse nanocrystals," Nature Mater., vol. 3, pp. 891-895, 2004.
9. Z. Li, L. Wei, M. Gao, and H. Lei, "One-pot reaction to synthesize biocompatible magnetic nanoparticles," Adv. Mater., vol. 17, pp. 1001-1005, 2005.
10. K. Woo and J. W. Hong, "Surface modification of hydrophobic iron oxide nanoparticles for clinical applications," IEEE Trans. Magn., vol. 41, pp. 4137-4139, 2005.
11. T. K. Jain, M. A. Morales, S. K. Sahoo, D. L. Leslie-Pelecky, and V. Labbasetwar, "Iron oxide nanoparticles for sustained delivery of anticancer agents," Mol. Phar., 2005.
12. C. C. Berry, S. Wells, S. Charles, G. Aitchison, and A. S. G. Curtis, "Cell response to dextran-derivatised iron oxide nanoparticles post internalisation," Biomaterials, vol. 25, pp. 5405-5413, 2004.
13. A. K. Gupta and M. Gupta, "Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications," Biomaterials, vol. 26, pp. 3995-4021, 2005.
14. R. Mevhar, "Dextrans for targeted and sustained delivery of therapeutic and imaging agents," J. Controlled Release, vol. 69, pp. 1-25, 2000.
15. F. Sonvico, S. Mornet, S. Vasseur, C. Dubernet, D. Jaillard, J. Degrouard, J. Hoebeke, E. Duguet, P. Colombo, and P. Couvreur, "Folate-conjugated iron oxide nanoparticles for solid tumor targeting as potential specific magnetic hyperthermia mediators: Synthesis, physicochemical characterization, and in vitro experiments," Bioconjugate Chem., vol. 16, pp. 1181-1188, 2005.
16. H. Choi, S. R. Choi, R. Zhou, F. R. Kung, and I. Chen, "Iron oxide nanoparticles as magnetic resonance contrast agent for tumor imaging via folate receptor-targeted delivery," Acad. Radiol., vol. 11, pp. 996-1004, 2004.
17. M. Lewin, N. Carlesso, C. Tung, X. Tang, D. Cory, D. T. Scadden, and R. Weissleder, "Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells," Nature Biotechnol., vol. 18, pp. 410-414, 2000.
18. R. A. A. Muzzarelli and C. Muzzarelli, "Chitosan chemistry: Relevance to the biomedical sciences," in Polysaccharides 1: Structure, Characterization and Use, 2005, vol. 186, pp. 151-209, Advances in Polymer Science.
19. H. Lee, H. P. Shao, Y. Q. Huang, and K. B. , "Synthesis of MRI contrast agent by coating superparamagnetic iron oxide with chitosan," IEEE Trans. Magn., vol. 41, pp. 4102-4104, 2005.
20. L. Q. Wu, K. Lee, X. Wang, D. S. English, W. Losert, and P. G. F. , "Chitosan-mediated and spatially selective electrodeposition of nanoscale particles," Langmuir, vol. 21, pp. 3641-3646, 2005.
21. D. K. Kim, M. Mikhaylova, Y. Zhang, and M. Muhammed, "Protective coating of superparamagnetic iron oxide nanoparticles," Chem. Mater., vol. 15, pp. 1617-1627, 2003.
22. D. K. Kim, M. Mikhaylova, F. H. Wang, J. Kehr, B. Bjelke, Y. Zhang, T. Tsakalakos, and M. Muhammed, "Starch-coated superparamagnetic nanoparticles as MR contrast agents," Chem. Mater., vol. 15, pp. 4343-4351, 2003.
23. M. Mikhaylova, D. K. Kim, N. Bobrysheva, M. Osmolowsky, V. Semenov, T. Tsakalakos, and M. Muhammed, "Superparamagnetism of magnetite nanoparticles: Dependence on surface modification," Langmuir, vol. 20, pp. 2472-2477, 2004.
24. A. K. Gupta and M. Gupta, "Cytotoxicity suppression and cellular uptake enhancement of surface modified magnetic nanoparticles," Biomaterials, vol. 26, pp. 1565-1573, 2004.
25. D. K. Kim, M. Toprak, M. Mikhailova, Y. Zhang, B. Bjelke, J. Kehr, and M. Muhammed, "Surface modification of superparamagnetic nanoparticles for in-vivo bio-medical applications," in Mat. Res. Soc. Symp. Proc., 2002, vol. 704, pp. W11.2.1-W11.2.6.
26. N.Kohler,G. E. Fryxell, and M. Zhang, "A biofunctional poly(ethylene glycol) silane immobilized on metallic oxide-based nanoparticles for conjugation with cell targeting agents," J. Amer. Chem. Soc., vol. 126, pp. 7206-7211, 2004.
27. L. A. Harris, J. D. Goff, A. Y. Carmihael, J. S. Riffe, J. J. Harburn, T. G. St Pierre, and M. Saunders, "Magnetite nanoparticle dispersions stablized with triblock copolymers," Chem. Mater., vol. 15, pp. 1367-1377, 2003.
28. A. F. Thunemann, D. Schutt, L. Kaufner, U. Pison, and H. Mohwald, "Maghemite nanoparticles protectively coated with poly(ethylene imine) and poly(ethylene oxide)-block-poly(glutamic acid)," Langmuir, vol. 22, pp. 2351-2357, 2006.
29. H. Pardoe, W. Chua-anusorm, T. G. St Pierre, and J. Dobson, "Structural and magnetic properties of nanoscale iron oxide particles synthesized in the presence of dextran or polyvinyl alcohol," J. Magn. Magn. Mater., vol. 225, pp. 41-46, 2001.
30. A. Petri-Fink, M. Chastellain, L. Juillerat-Jeanneret, A. Ferrari, and H. Hofmann, "Development of functionalized superparamagnetic iron oxide nanoparticles for interaction with human cancer cells," Biomaterials, vol. 26, pp. 2685-2694, 2005.
31. B. Schopf, T. Neuberger, K. Schulze, A. Petri, M. Chastellain, M. Hofmann, H. Hofmann, and B. von Rechenberg, "Methodology description for detection of cellular uptake of PVA coated superparamagnetic iron oxide nanoparticles (SPION) in synovial cells of sheep," J. Magn. Magn. Mater., vol. 293, pp. 411-418, 2005.
32. S. H. Im, T. Herricks, Y. T. Lee, and Y. Xia, "Syntehsis and chracterization of monodisperse silica colloids loaded with superparamagnetic iro oxide nanoparticles," Chem. Phys. Lett., vol. 401, pp. 19-23, 2004.
33. C. Lu, Y. Hung, J. Hsiao, Y. Lin, S. Wu, S. Hsu, H. Liu, C. Mou, C. Yang, D. Huang, and Y. Chen, "Bifunctional magnetic silica nanoparticles for highly efficient human stem cell labeling," Nano Lett., vol. 7, pp. 149-154, 2007.
34. K. Dormer, C. Seeney, K. Lewelling, G. Lian, D. Gibson, and M. Johnson, "Epithelial internalization of superparamagnetic nanoparticles and response to external field," Biomaterials, vol. 26, pp. 2061-2072, 2005.
35. J. L. Lyon, D. A. Fleming, M. B. Stone, P. Schiffer, and M. E.Williams, "Synthesis of Fe oxide core/Au shell nanoparticles by iterative hydroxylamine seeding," Nano Lett., vol. 4, pp. 719-723, 2004.
36. S. Seino, T. Kusunose, T. Sekino, T. Kinoshita, T. Nakagawa, Y. Kakimi, Y. Kawabe, J. Iida, T. A. Yamamoto, and Y. Mizukoshi, "Synthesis of gold/magnetic iron oxide composite nanoparticles for biomedical applications with good dispersibility," J. Appl. Phys., vol. 99, 2006.
37. L. Wang, J. Luo, Q. Fan, M. Suzuki, I. S. Suzuki, M. H. Engelhard, Y. Lin, N. Kim, J. Q. Wang, and C. J. Zhong, "Monodispersed core-shell Fe O Au nanoparticles," J. Phys. Chem. B., vol. 109, pp. 21593-21601, 2005.
38. D. Caruntu, B. L. Cushing, G. Caruntu, and C. J. O'Connor, "Attachment of gold nanograins onto colloidal magnetite nanocrystals," Chem. Mater., vol. 17, pp. 3398-3402, 2005.
39. C. C. Berry, S. Charles, S.Wells, M. J. Dalby, and A. S. G. Curtis, "The influence of transferrin stabilized magnetic nanoparticles on human dermal fibroblasts in culture," Int. J. Pharm., vol. 269, pp. 211-225, 2004.
40. J. Zhou, C. Leuschner, C. Kumar, J. F. Hormones, and W. O. Soboyejo, "Subecellular accumulation of magnetic nanoparticles in breast tumors and metastases," Biomaterials, vol. 27, pp. 2001-2008, 2006.
41. C. Zhang, M. Jugold, E. C. Woenne, T. Lammers, B. Morgenstern, M. M. Mueller, H. Zentgraf, M. Bock, M. Eisenhut, W. Semmler, and F. Kiessling, "Specific targeting of tumor angiogenesis by RGD-conjugated ultrasmall superparamagnetic iron oxide particles using a clinical 1.5-T magnetic resonance scanner," Cancer Res., vol. 67, pp. 1555-1572, 2007.
42. A. G. Tkachenko, H. L. Xie, Y. D. Coleman, J. Ryan, W. R. Glomm, M. K. Shipton, S. Franzen, and D. L. Felheim, "Cellular rajectories of peptide modified gold particle complexes comparison of nuclear localization signals and peptide transduction domians," Bioconjugate Chem., vol. 15, pp. 482-490, 2004.
43. Q. A. Pankhurst, J. Connolly, S.K. Jones, and J. Dobson, "Applications of magnetic nanoparticles in biomedicine," J. Phys. D: Appl. Phys., vol. 36, pp. R167-R181, 2003.
44. U. Gneveckow, A. Jordan, R. Scholz, V. Bruss, N.Waldofner, J. Ricke, A. Feussner, B. Hildebrandt, B. Rau, and P. Wust, "Description and characterization of the novel hyperthermia- and thermoablation-system MFH (R) 300F for clinical magnetic fluid hyperthermia," Med. Phys., vol. 31, pp. 1444-1451, 2004.
45. A. Ito, Y. Kuga, H. Honda, H. Kikkawa, A. Horiuchi, Y.Watanabe, and T. Kobayashi, "Magnetite nanoparticle-loaded anti-HER2 immunoliposomes for combination of antibody therapy with hyperthermia," Cancer Lett., vol. 212, pp. 167-175, 2004.
46. I. Hilger, R. Hergt, and W. A. Kaiser, "Towards breast cancer treatment by magnetic heating," J. Magn. Magn. Mater., vol. 293, pp. 314-319, 2005.
47. A. Bjornerud and L. Johansson, "The utility of superparamagnetic contrast agents in MRI: Theoretical consideration and applications in the cardiovascular system," NMR Biomed., vol. 17, pp. 465-477, 2004.
48. P. Wunderbaldinger, L. Josephson, C. Bremer, A. Moore, and R. Weissleder, "Detection of lymph node metastases by contrast-enhanced MRI in an experimental model," Magn. Resonance Med., vol. 47, pp. 292-297, 2002.
49. R. Sigal, T. Vogl, J. Casselman, G. Moulin, F. Veillon, R. Hermans, F. Dubrulle, J. Viala, J. Bosq, M. Mack, M. Depondt, C. Mattelaer, P. Petit, P. Champsaur, S. Reihm, Y. Dadashitazehozi, T. de Jaegere, G. Marchal, D. Chevalier, L. Lemaitre, C. Kubiak, R. Helmberger, and P. Halimi, "Lymph node metastases from head and neck squamous cell carcinoma: MR imaging with ultrasmall superparamagnetic iron oxide particles (Sinerem MR)-Results of a phase-III multicenter clinical trial," Eur. Radiol., vol. 12, pp. 1104-1132, 2002.
50. C. Alexiou, R. Jurgons, R. J. Schmid, C. Bergemann, J. Henke, W. Erthardt, E. Huenges, and F. Parak, "Magnetic drug targeting: Biodistribution of the magnetic carrier and the chemotherapeutic agnet mitoxantrone after locoregional cancer treatment," J. Drug Targeting, vol. 11, pp. 139-149, 2003.
51. A. J. Lemke, M. von Pilsach, A. S. Lubbe, C. Bergemann, H. Riess, and R. Felix, "MRI after magnetic drug targeting in patients with advanced solid maglinant tumors," Eur. Radiol., vol. 14, pp. 1949-1955, 2004.
52. A. S. Lubbe, C. Alexiou, and C. Bergemann, "Clinical applications of magnetic drug targeting," J. Surg. Res., vol. 95, pp. 200-206, 2000.
53. A. J. Rosengart, M. D. Kaminski, H. Chen, P. L. Caviness, A. D. Ebner, and R. J. A. , "Magnetizable implants and functionlized magnetic cariers: A novel approch for nonivasive yet targeted drug delivery," J. Magn. Magn. Mater., vol. 293, pp. 633-638, 2005.
54. J. Dobson, "Magnetic nanoparticle-based targeting for drug and gene delivery," NanoMedicine, vol. 1, pp. 31-37, 2006.
55. J. Dobson, "Magnetic nanoparticles for drug delivery," Drug Development Res., vol. 67, pp. 55-60, 2006.
56. J. Dobson, "Magnetic nanoparticle-based gene delivery," Gene Therapy, vol. 13, pp. 283-287, 2006.
57. C. Mah, I. Zolotukhin, T. J. Fraites, J. Dobson, C. Batich, and B. J. Byrne, "Microsphere-mediated delivery of recombinant AAV vectors in vitro and in vivo," Mol. Therapy, vol. 1, p. S239, 2002.
58. C. Mah, T. J. Fraites, I. Zolotukhin, S. H. Song, T. R. Flotte, J. Dobson, C. Batich, and B. J. Byrne, "Improved method of recombinant AAV2 delivery for systemic targeted gene therapy," Mol. Therapy, vol. 6, pp. 106-112, 2002.
59. C. Plank, U. Schillinger, F. Scherer, C. Bergemann, J. S. Remy, F. Krotz, M. Anton, J. Lausier, and J. Rosenecker, "The magnetofection method: Using magnetic force to enhance gene delivery," Biol. Chem., vol. 384, pp. 737-747, 2003.
60. F. Scherer, M. Arton, U. Schillinger, J. Henke, C. Bergemann, A. Kruger, and B. Gansbacher, "Magnetofection: Enhancing and targeting gene delivery by magnetic force in vitro and in vivo," Gene Therapy, vol. 9, pp. 102-109, 2002.
61. H. Kalish, A. S. Arbab, B. R. Miller, B. K. Lewis, H. A. Zywicke, J. W. M. Bulte, L. H. Bryant, and J. A. Frank, "Combination of transfection agents and magnetic resonance contrast agents for cellular imaging: Relationship between relaxivities, electrostatic forces, and chemical composition," Magn. Resonance Med, vol. 50, pp. 275-282, Aug. 2003.
62. J. A. Frank, B. R. Miller, A. S. Arbab, H. A. Zywicke, E. K. Jordan, B. K. Lewis, L. H. Byrant, Jr., and J. W. M. Bulte, "Clinically applicable labeling of mammalian and stem cells by combining superparamagnetic iron oxides and transfection agents," Radiology, vol. 228, pp. 480-487, 2003.
63. J. Dobson, "Remote control of cellular behavior with magnetic nanoparticles," Nature Nanotechnol., vol. 3, pp. 139-143, 2008.
64. S. H. Cartmell, J. Dobson, S. B. Verschueren, and A. J. El Haj, "Development of magnetic particle techniques for long term culture of bone cells with intermittent mechanical activation," IEEE Trans. NanoBiosci., vol. 1, pp. 92-97, 2002.
65. J. Dobson, S. H. Cartmell, A. Keramane, and A. J. El Haj, "Principles and design of a novel magnetic force mechanical conditioning Bioreactor for tissue engineering, stem cell conditioning, and dynamic in vitro screening," IEEE Trans. NanoBiosci., vol. 5, pp. 173-177, Sep. 2006.
66. S. Hughes, S. McBain, J. Dobson, and A. J. El Haj, "Selective activation of mechanosensitive ion channels using magnetic particles," J. Roy. Soc. Interface, vol. 5, pp. 855-863, 2008.
67. A. Ito, Y. Takizawa, H. Honda, K. I. Hata, H. Kagami, M. Ueda, and T. Kobayashi, "Tissue engineering using magnetite nanoparticles and magnetic force: Heterotypic layers of cocultured hepatocytes and endothelial cells," Tissue Eng., vol. 10, pp. 833-840, May 2004.
68. A. Ito, K. Ino, M. Hayashida, T. Kobayashi, H. Matsunuma, H. Kagami, M. Ueda, and H. Honda, "Novel methodology for fabrication of tissue-engineered tubular constructs using magnetite nanoparticles and magnetic force," Tissue Eng., vol. 11, pp. 1553-1561, Sep. 2005.