Hydrogels: From controlled release to pH-responsive drug delivery

Drug Discovery Today

Volumn 7, Issue 10, 2002, Pages 569-579

  Gupta, Piyush ^a   Vermani, Kavita ^a   Garg, Sanjay ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

[No Author keywords available]

Indexed keywords

1 VINYL 2 PYRROLIDINONE; AMOXICILLIN; AQUAMERE; AQUATRIX; CALCITONIN; CARBOMER; CHITOSAN DERIVATIVE; CLONIDINE; DRUG CARRIER; ETHINYLESTRADIOL; ETHYLENE VINYL ACETATE COPOLYMER; ETHYLENE VINYL ALCOHOL COPOLYMER; FLUOROURACIL; GELATIN; HEPARIN; HYCORE R; HYCORE V; HYDROCORTISONE; HYPAN; INSULIN; MACROGOL; MACROGOL DERIVATIVE; METRONIDAZOLE; MORPHINE SULFATE; NALTREXONE; NICOTINAMIDE; POLYACRYLIC ACID; POLYMACON; PREDNISOLONE; PROPRANOLOL; PROSTAGLANDIN E2; RIBOFLAVIN; SALICYLAMIDE; SALICYLIC ACID; SMART HYDROGEL; SQZ GEL; TERBINAFINE; THEOPHYLLINE; UNINDEXED DRUG; DRUG;

CONTROLLED DRUG RELEASE; DRUG DELIVERY SYSTEM; GEL; HYDROGEL; HYDROPHILICITY; HYDROPHOBICITY; IONIC STRENGTH; IONIZATION; PH; PHYSICAL CHEMISTRY; PKA; PULSATILE DRUG RELEASE; REVIEW; CHEMISTRY; DELAYED RELEASE FORMULATION; HUMAN; THEORETICAL MODEL;

DELAYED-ACTION PREPARATIONS; HUMAN; HYDROGELS; HYDROGEN-ION CONCENTRATION; MODELS, THEORETICAL; PHARMACEUTICAL PREPARATIONS; HUMANS;

EID: 0037092619     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(02)02255-9     Document Type: Review

References (70)

1. Chronopharmacokinetics: Current status
2. Hydrophilic gels for biological use
3. Hydrogels for biomedical applications
4. Hydrogels in pharmaceutical formulations
5. Intelligent gels
6. Smart materials
7. Intelligent drug delivery systems
8. Synthesis and properties of hydrogels used for drug delivery
9. Gels and jellies
10. Hydrogels for drug delivery systems
11. Network deformation in flow
12. Hydrogels
13. Polymeric delivery systems for controlled drug release
14. Macromolecular and modeling aspects of swelling-controlled systems
15. Hydrogels
16. Novel crosslinking methods to design hydrogels
17. Probing the mechanisms of drug release from hydrogels
18. In vitro and in vivo studies of enzyme-digestible hydrogels for oral drug delivery
19. In vitro evaluation of a pH-sensitive hydrogel for control of GI drug delivery from silicone-based matrices
20. Design of insulin delivery devices based on glucose sensitive membranes
21. Pulsatile local delivery of thrombolytic and antithrombotic agents using poly (N-isopropylacrylamide-co-methacrylic acid) hydrogels
22. Development of a morphine-triggered naltrexone delivery system
23. Rate-controlled rectal drug delivery in man with a hydrogel preparation
24. 2
25. Swelling-controlled release system for the vaginal delivery of miconazole
26. Swelling controlled-release systems: Recent developments and applications
27. A simple equation for description of solute release I. Fickian and non-Fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs
28. The swelling interface number as a criterion for prediction of diffusional solute release mechanisms in swellable polymers
29. Diffusion of water soluble drugs from initially dry hydrogels
30. Hydrogels
31. Triggered drug delivery systems
32. Stimuli-modulated delivery systems
33. Squeezing hydrogels for controlled oral drug delivery
34. Dual-stimuli-responsive drug release from interpenetrating polymer network-structured hydrogels of gelatin and dextran
35. Secretory functions of the alimentary tract
36. Intravaginal drug delivery
37. Preparation and characterization of freeze-dried chitosan-poly(ethylene oxide) hydrogels for site-specific antibiotic delivery in the stomach
38. Investigation of compressed coating tablet swelling with water as a new dosage form for elderly patients
39. Chemically modified polyacrylamide-g-guar gum-based crosslinked anionic microgels as pH-sensitive drug delivery systems: Preparation and characterization
40. Controlled drug release by polymer dissolution II: Enzyme mediated delivery device
41. Preparation of thermally denatured albumin gel and its pH-sensitive swelling
42. Examination of self-crosslinked gelatin as a hydrogel for controlled release
43. Controlled release of amylase from a thermal and pH-sensitive, macroporous hydrogel
44. PH/temperature-sensitive polymers for macromolecular drug loading and release
45. Temperature and pH sensitive polymers for human calcitonin delivery
46. Graft copolymers that exhibit temperature induced phase transitions over a wide range of pH
47. PH-dependent equilibrium swelling properties of hydrophobic polyelectrolyte copolymer gels
48. Kinetics and mechanism of water sorption in hydrophobic, ionizable copolymer gels
49. Buffer effects on swelling kinetics in polybasic gels
50. Temporally controlled drug delivery systems: Coupling of pH oscillators with membrane diffusion
51. PH-sensitive freeze-dried chitosan-polyvinyl pyrrolidone hydrogels as controlled release system for antibiotic delivery
52. Solubility effects on drug transport through pH-sensitive, swelling-controlled release systems: Transport of theophylline and metoclopramide monohydrochloride
53. Transport of ionizable drugs and proteins in crosslinked poly(acrylic acid) and poly(acrylic acid-co-2-hydroxyethylmethacrylate) hydrogels. II. Diffusion and release studies
54. Analysis of crosslinked structure of hydrogels
55. Biochemical and mechanical characterization of enzyme-digestible hydrogels
56. Multiple phases of polymer gels
57. Synthesis and characterization of superporous hydrogel composites
58. Gastric retention properties of superporous hydrogel composites
59. Analysis of drug distribution in hydrogels using Fourier transform infrared microscopy
60. A study of the hydrophilic cellulose matrix: Effect of indomethacin and a water-soluble additive on swelling properties
61. Influence of beta-cyclodextrin concentration and polyacrylic acid molecular weight on swelling and release characteristics of metoclopramide-containing hydrogels
62. One month of sustained release of insulin from a polymer implant
63. An electrically modulated drug delivery device: I
64. Characterization of glucose-mediated insulin release from implantable polymers
65. Controlled drug release by polymer dissolution. I. Partial esters of maleic anhydride copolymers - Properties and theory
66. Gelatin-poly(ethylene oxide) semi-interpenetrating polymer network with pH-sensitive swelling and enzyme-degradable properties for oral drug delivery
67. Evaluation of poly(2-hydroxyethyl methacrylate) gels as drug delivery systems at different pH values
68. Controlled release of terbinafine hydrochloride from pH sensitive poly(acrylamide/maleic acid) hydrogels
69. Preparation and in vitro evaluation of poly(N-vinyl-2-pyrrolidone-polyethylene glycol diacrylate)-chitosan interpolymeric pH-responsive hydrogels for oral drug delivery
70. Heparin release from thermosensitive hydrogels