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For biomedical applications, it is important to have a hydrophilic surface. Thus, the use of methods based on the decomposition at high temperatures of iron precursors in the presence of organic surfactants (see for example: Hyeon, T.; Lee, S. S.; Park, J.; Chung, Y.; Na, H. J. Am. Chem. Soc. 2001, 123, 12798) is excluded because they produce highly hydrophobic surfaces.
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Having this particular microstructure instead of the typical core-shell microstructure (a magnetic core surrounded by a silica shell) could be beneficial in some applications because we can have a similar load of magnetic material with a lower number of particles, that is, reduce the probability of collision between particles.
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This microemulsion method can be considered as a confined sol-gel method. Thus, spherical colloids are formed in ammonia-base-catalyzed conditions, while in acidic conditions we can expect gel-like structures.
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22
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2 (Fe/Si molar ratio set to 0.2), based on values described in ref 10 to obtain monodisperse nanospherical silica particles.
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