-
1
-
-
0028845877
-
Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
-
Maffei M, Halaas J, Ravussin E, et al: Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1995;1:1155-1161.
-
(1995)
Nat. Med.
, vol.1
, pp. 1155-1161
-
-
Maffei, M.1
Halaas, J.2
Ravussin, E.3
-
2
-
-
13344295079
-
Serum immunoreactive-leptin concentrations in normal-weight and obese humans
-
Considine RV, Sinha MK, Heiman ML, et al: Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 1996;334:292-295.
-
(1996)
N. Engl. J. Med.
, vol.334
, pp. 292-295
-
-
Considine, R.V.1
Sinha, M.K.2
Heiman, M.L.3
-
3
-
-
0028793697
-
Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action
-
Frederich RC, Hamann A, Anderson S, et al: Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat Med 1995;1:1311-1314.
-
(1995)
Nat. Med.
, vol.1
, pp. 1311-1314
-
-
Frederich, R.C.1
Hamann, A.2
Anderson, S.3
-
4
-
-
0029048408
-
Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural net works
-
Campfield LA, Smith FJ, Guisez Y, et al: Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural net works. Science 1995;269:546-549.
-
(1995)
Science
, vol.269
, pp. 546-549
-
-
Campfield, L.A.1
Smith, F.J.2
Guisez, Y.3
-
5
-
-
0030737953
-
Physiological response to long-term peripheral and central leptin infusion in lean and obese mice
-
Halaas JL, Boozer C, Blair-West J, et al: Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc Natl Acad Sci USA 1997;94:8878-8883.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 8878-8883
-
-
Halaas, J.L.1
Boozer, C.2
Blair-West, J.3
-
6
-
-
0029066265
-
Effects of the obese gene product on body weight regulation in ob/ob mice
-
Pelleymounter MA, Cullen MJ, Baker MB, et al: Effects of the obese gene product on body weight regulation in ob/ob mice. Science 1995;269:540-543.
-
(1995)
Science
, vol.269
, pp. 540-543
-
-
Pelleymounter, M.A.1
Cullen, M.J.2
Baker, M.B.3
-
7
-
-
0033082380
-
From lesions to leptin: Hypothalamic control of food intake and body weight
-
Elmquist JK, Elias CF, Saper CB: From lesions to leptin: hypothalamic control of food intake and body weight. Neuron 1999;22:221-232.
-
(1999)
Neuron
, vol.22
, pp. 221-232
-
-
Elmquist, J.K.1
Elias, C.F.2
Saper, C.B.3
-
8
-
-
0034611732
-
Central nervous system control of food intake
-
Schwartz MW, Woods SC, Porte D Jr, et al: Central nervous system control of food intake. Nature 2000;404:661-671.
-
(2000)
Nature
, vol.404
, pp. 661-671
-
-
Schwartz, M.W.1
Woods, S.C.2
Porte Jr., D.3
-
9
-
-
0029864416
-
Leptin enters the brain by a saturable system independent of insu lin
-
Banks WA, Kastin AJ, Huang W, et al: Leptin enters the brain by a saturable system independent of insu lin. Peptides 1996;17:305-311.
-
(1996)
Peptides
, vol.17
, pp. 305-311
-
-
Banks, W.A.1
Kastin, A.J.2
Huang, W.3
-
10
-
-
0030942844
-
The leptin receptor
-
Tartaglia LA: The leptin receptor. J Biol Chem 1997;272:6093-6096.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 6093-6096
-
-
Tartaglia, L.A.1
-
11
-
-
0036828842
-
Regulation of Jak kinases by intracellular leptin receptor sequences
-
Kloek C, Haq AK, Dunn SL, et al: Regulation of Jak kinases by intracellular leptin receptor sequences. J Biol Chem 2002;277:41547-41555.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 41547-41555
-
-
Kloek, C.1
Haq, A.K.2
Dunn, S.L.3
-
12
-
-
0030028959
-
Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor
-
Chua SC Jr, Chung WK, Wu-Peng XS, et al: Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science 1996;271:994-996.
-
(1996)
Science
, vol.271
, pp. 994-996
-
-
Chua Jr., S.C.1
Chung, W.K.2
Wu-Peng, X.S.3
-
13
-
-
0030039272
-
Abnormal splicing of the leptin receptor in diabetic mice
-
Lee GH, Proenca R, Montez JM, et al: Abnormal splicing of the leptin receptor in diabetic mice. Nature 1996;379:632-635.
-
(1996)
Nature
, vol.379
, pp. 632-635
-
-
Lee, G.H.1
Proenca, R.2
Montez, J.M.3
-
15
-
-
0030928715
-
Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus
-
Cheung CC, Clifton DK, Steiner RA: Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus. Endocrinology 1997;138:4489-4492.
-
(1997)
Endocrinology
, vol.138
, pp. 4489-4492
-
-
Cheung, C.C.1
Clifton, D.K.2
Steiner, R.A.3
-
16
-
-
0033405582
-
Regulation of hypothalamic proopiomelanocortin by leptin in lean and obese rats
-
Kor ner J, Chua SC Jr, Williams JA, et al: Regulation of hypothalamic proopiomelanocortin by leptin in lean and obese rats. Neuroendocrinology 1999;70:377-383.
-
(1999)
Neuroendocrinology
, vol.70
, pp. 377-383
-
-
Ner, J.K.1
Chua Jr., S.C.2
Williams, J.A.3
-
17
-
-
0031040784
-
Regulation of leptin receptor and NPY gene expression in hypothalamus of leptin-treated obese (ob/ob) and cold-exposed lean mice
-
Mercer JG, Moar KM, Rayner DV, et al: Regulation of leptin receptor and NPY gene expression in hypothalamus of leptin-treated obese (ob/ob) and cold-exposed lean mice. FEBS Lett 1997;402:185-188.
-
(1997)
FEBS Lett.
, vol.402
, pp. 185-188
-
-
Mercer, J.G.1
Moar, K.M.2
Rayner, D.V.3
-
18
-
-
13344280346
-
Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice
-
Schwartz MW, Baskin DG, Bukowski TR, et al: Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 1996;45:531-535.
-
(1996)
Diabetes
, vol.45
, pp. 531-535
-
-
Schwartz, M.W.1
Baskin, D.G.2
Bukowski, T.R.3
-
19
-
-
0030775971
-
Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus
-
Schwartz MW, Seeley RJ, Woods SC, et al: Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus. Diabetes 1997;46:2119-2123.
-
(1997)
Diabetes
, vol.46
, pp. 2119-2123
-
-
Schwartz, M.W.1
Seeley, R.J.2
Woods, S.C.3
-
20
-
-
0033180532
-
Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area
-
Elias CF, Aschkenasi C, Lee C, et al: Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron 1999;23:775-786.
-
(1999)
Neuron
, vol.23
, pp. 775-786
-
-
Elias, C.F.1
Aschkenasi, C.2
Lee, C.3
-
21
-
-
0034640508
-
Activation of downstream signals by the long form of the leptin receptor
-
Banks AS, Davis SM, Bates SH, Myers MG Jr: Activation of downstream signals by the long form of the leptin receptor. J Biol Chem 2000;275:14563-14572.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 14563-14572
-
-
Banks, A.S.1
Davis, S.M.2
Bates, S.H.3
Myers Jr., M.G.4
-
22
-
-
0038747134
-
Role of signal transducer and activator of transcription 3 in regulation of hypothalamic proopiomelanocortin gene expression by leptin
-
Munzberg H, Huo L, Nillni EA, et al: Role of signal transducer and activator of transcription 3 in regulation of hypothalamic proopiomelanocortin gene expression by leptin. Endocrinology 2003;144:2121-2131.
-
(2003)
Endocrinology
, vol.144
, pp. 2121-2131
-
-
Munzberg, H.1
Huo, L.2
Nillni, E.A.3
-
23
-
-
0030807358
-
Diet-induced obese mice develop peripheral, but not central, resistance to leptin
-
Van Heek M, Compton DS, France CF, et al: Diet-induced obese mice develop peripheral, but not central, resistance to leptin. J Clin Invest 1997;99:385-390.
-
(1997)
J. Clin. Invest.
, vol.99
, pp. 385-390
-
-
Van Heek, M.1
Compton, D.S.2
France, C.F.3
-
24
-
-
9244219587
-
Regionspecific leptin resistance within the hypothalamus of diet-induced obese mice
-
Munzberg H, Flier JS, Bjorbaek C: Regionspecific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology 2004;145:4880-4889.
-
(2004)
Endocrinology
, vol.145
, pp. 4880-4889
-
-
Munzberg, H.1
Flier, J.S.2
Bjorbaek, C.3
-
25
-
-
0030669288
-
Inhibition of food response to intracerebroventricular injection of leptin is attenuated in rats with diet-induced obesity
-
Widdowson PS, Upton R, Buckingham R, et al: Inhibition of food response to intracerebroventricular injection of leptin is attenuated in rats with diet-induced obesity. Diabetes 1997;46:1782-1785.
-
(1997)
Diabetes
, vol.46
, pp. 1782-1785
-
-
Widdowson, P.S.1
Upton, R.2
Buckingham, R.3
-
26
-
-
35048853939
-
Modulation of central leptin sensitivity and energy balance in a rat model of diet-induced obesity
-
Fam BC, Morris MJ, Hansen MJ, et al: Modulation of central leptin sensitivity and energy balance in a rat model of diet-induced obesity. Diabetes Obes Metab 2007;9:840-852.
-
(2007)
Diabetes Obes. Metab.
, vol.9
, pp. 840-852
-
-
Fam, B.C.1
Morris, M.J.2
Hansen, M.J.3
-
27
-
-
0037663897
-
Impaired transport of leptin across the blood-brain barrier in obesity is acquired and reversible
-
Banks WA, Farrell CL: Impaired transport of leptin across the blood-brain barrier in obesity is acquired and reversible. Am J Physiol Endocrinol Metab 2003;285: E10-E15.
-
(2003)
Am. J. Physiol. Endocrinol. Metab.
, vol.285
-
-
Banks, W.A.1
Farrell, C.L.2
-
28
-
-
0030594830
-
Decreased cerebrospinal-fluid/serum leptin ratio in obesity: A possible mechanism for leptin resistance
-
Caro JF, Kolaczynski JW, Nyce MR, et al: Decreased cerebrospinal-fluid/ serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet 1996;348:159-161.
-
(1996)
Lancet
, vol.348
, pp. 159-161
-
-
Caro, J.F.1
Kolaczynski, J.W.2
Nyce, M.R.3
-
29
-
-
0037388560
-
Differential mechanisms and development of leptin resistance in A/J versus C57BL/6J mice during diet-induced obesity
-
Prpic V, Watson PM, Frampton IC, et al: Differential mechanisms and development of leptin resistance in A/J versus C57BL/6J mice during diet-induced obesity. Endocrinology 2003;144:1155-1163.
-
(2003)
Endocrinology
, vol.144
, pp. 1155-1163
-
-
Prpic, V.1
Watson, P.M.2
Frampton, I.C.3
-
30
-
-
2342444310
-
Leptin receptor signaling and the regulation of mammalian physiology
-
Myers MG Jr: Leptin receptor signaling and the regulation of mammalian physiology. Recent Prog Horm Res 2004;59:287-304.
-
(2004)
Recent Prog. Horm Res.
, vol.59
, pp. 287-304
-
-
Myers Jr., M.G.1
-
32
-
-
0033931981
-
Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity
-
El-Haschimi K, Pierroz DD, Hileman SM, et al: Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. J Clin Invest 2000;105:1827-1832.
-
(2000)
J. Clin. Invest.
, vol.105
, pp. 1827-1832
-
-
El-Haschimi, K.1
Pierroz, D.D.2
Hileman, S.M.3
-
33
-
-
45449097234
-
Effects of chronic central leptin infusion on proopiomelanocortin and neurotensin gene expression in the rat hypothalamus
-
Sahu A: Effects of chronic central leptin infusion on proopiomelanocortin and neurotensin gene expression in the rat hypothalamus. Neurosci Lett 2008;440:125-129.
-
(2008)
Neurosci. Lett.
, vol.440
, pp. 125-129
-
-
Sahu, A.1
-
34
-
-
0042922605
-
Leptin signaling in the hypothalamus during chronic central leptin infusion
-
Pal R, Sahu A: Leptin signaling in the hypothalamus during chronic central leptin infusion. Endocrinology 2003;144:3789-3798.
-
(2003)
Endocrinology
, vol.144
, pp. 3789-3798
-
-
Pal, R.1
Sahu, A.2
-
35
-
-
0032014178
-
Identification of SOCS-3 as a potential mediator of central leptin resistance
-
Bjorbaek C, Elmquist JK, Frantz JD, et al: Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol Cell 1998;1:619-625.
-
(1998)
Mol. Cell.
, vol.1
, pp. 619-625
-
-
Bjorbaek, C.1
Elmquist, J.K.2
Frantz, J.D.3
-
36
-
-
33847319765
-
Dietinduced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons
-
Enriori PJ, Evans AE, Sinnayah P, et al: Dietinduced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons. Cell Metab 2007;5:181-194.
-
(2007)
Cell. Metab.
, vol.5
, pp. 181-194
-
-
Enriori, P.J.1
Evans, A.E.2
Sinnayah, P.3
-
37
-
-
3142723983
-
Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity
-
Mori H, Hanada R, Hanada T, et al: Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity. Nat Med 2004;10:739-743.
-
(2004)
Nat. Med.
, vol.10
, pp. 739-743
-
-
Mori, H.1
Hanada, R.2
Hanada, T.3
-
38
-
-
33644803270
-
Altered hypothalamic signaling and responses to food deprivation in rats fed a low-carbohydrate diet
-
Kinzig KP, Scott KA, Hyun J, et al: Altered hypothalamic signaling and responses to food deprivation in rats fed a low-carbohydrate diet. Obes Res 2005;13:1672-1682.
-
(2005)
Obes. Res.
, vol.13
, pp. 1672-1682
-
-
Kinzig, K.P.1
Scott, K.A.2
Hyun, J.3
-
40
-
-
0025504280
-
Ketone bodies as substrates
-
Rich AJ: Ketone bodies as substrates. Proc Nutr Soc 1990;49:361-373.
-
(1990)
Proc. Nutr. Soc.
, vol.49
, pp. 361-373
-
-
Rich, A.J.1
-
41
-
-
0026509555
-
Interleukin-1-beta induces pituitary adrenocorticotropin secretion: Evidence for glucocorticoid modulation
-
Cambronero JC, Rivas FJ, Borrell J, Guaza C: Interleukin-1-beta induces pituitary adrenocorticotropin secretion: evidence for glucocorticoid modulation. Neuroendocrinology 1992;55:648-654.
-
(1992)
Neuroendocrinology
, vol.55
, pp. 648-654
-
-
Cambronero, J.C.1
Rivas, F.J.2
Borrell, J.3
Guaza, C.4
-
42
-
-
0032883806
-
Housekeeping genes as internal standards: Use and limits
-
Thellin O, Zorzi W, Lakaye B, et al: Housekeeping genes as internal standards: use and limits. J Biotechnol 1999;75:291-295.
-
(1999)
J. Biotechnol.
, vol.75
, pp. 291-295
-
-
Thellin, O.1
Zorzi, W.2
Lakaye, B.3
-
43
-
-
0035710746
-
Analysis of relative gene expression data using real-time quantitative PCR and the 2 (-Delta Delta C (T)) method
-
Livak KJ, Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2 (-Delta Delta C (T)) method. Methods 2001;25:402-408.
-
(2001)
Methods
, vol.25
, pp. 402-408
-
-
Livak, K.J.1
Schmittgen, T.D.2
-
44
-
-
0032747280
-
Recombinant leptin for weight loss in obese and lean adults: A randomized, controlled, dose-escalation trial
-
Heymsfield SB, Greenberg AS, Fujioka K, et al: Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. JAMA 1999;282:1568-1575.
-
(1999)
JAMA
, vol.282
, pp. 1568-1575
-
-
Heymsfield, S.B.1
Greenberg, A.S.2
Fujioka, K.3
-
45
-
-
17844401180
-
Molecular and anatomical determinants of central leptin resistance
-
Munzberg H, Myers MG Jr: Molecular and anatomical determinants of central leptin resistance. Nat Neurosci 2005;8:566-570.
-
(2005)
Nat. Neurosci.
, vol.8
, pp. 566-570
-
-
Munzberg, H.1
Myers Jr., M.G.2
-
46
-
-
2342449315
-
Triglycerides induce leptin resistance at the blood-brain ba rrier
-
Banks WA, Coon AB, Robinson SM, et al: Triglycerides induce leptin resistance at the blood-brain ba rrier. Diabetes 2004;53:1253-1260.
-
(2004)
Diabetes
, vol.53
, pp. 1253-1260
-
-
Banks, W.A.1
Coon, A.B.2
Robinson, S.M.3
-
48
-
-
38149134457
-
Effects of a high-protein ketogenic diet on hunger, appetite, and weight loss in obese men feeding ad libitum
-
Johnstone AM, Horgan GW, Murison SD, et al: Effects of a high-protein ketogenic diet on hunger, appetite, and weight loss in obese men feeding ad libitum. Am J Clin Nutr 2008;87:44-55.
-
(2008)
Am. J. Clin. Nutr.
, vol.87
, pp. 44-55
-
-
Johnstone, A.M.1
Horgan, G.W.2
Murison, S.D.3
-
49
-
-
20144368234
-
Comparison of energy-restricted very low-carbohydrate and low-fat diets on weight loss and body composition in overweight men and women
-
Volek J, Sharman M, Gómez A, et al: Comparison of energy-restricted very low-carbohydrate and low-fat diets on weight loss and body composition in overweight men and women. Nutr Metab (Lond) 2004;1:13.
-
(2004)
Nutr. Metab. (Lond)
, vol.1
, pp. 13
-
-
Volek, J.1
Sharman, M.2
Gómez, A.3
-
50
-
-
2442615980
-
A low-carbohydrate, ketogenic diet versus a low-fat diet to treat obesity and hyperlipidemia: A randomized, controlled trial
-
Yancy WS Jr, Olsen MK, Guyton JR, et al: A low-carbohydrate, ketogenic diet versus a low-fat diet to treat obesity and hyperlipidemia: a randomized, controlled trial. Ann Intern Med 2004;140:769-777.
-
(2004)
Ann. Intern. Med.
, vol.140
, pp. 769-777
-
-
Yancy Jr., W.S.1
Olsen, M.K.2
Guyton, J.R.3
-
52
-
-
58849098399
-
Lowcarbohydrate high-fat diets: Regulation of energy balance and body weight regain in rats
-
Caton SJ, Yinglong B, Burget L, et al: Lowcarbohydrate high-fat diets: regulation of energy balance and body weight regain in rats. Obesity (Silver Spring) 2009;17:283-289.
-
(2009)
Obesity (Silver Spring)
, vol.17
, pp. 283-289
-
-
Caton, S.J.1
Yinglong, B.2
Burget, L.3
-
53
-
-
0031831194
-
Acute hyperleptinemia does not modify insulin sensitivity in vivo in the rat
-
Widdowson PS, Upton R, Pickavance L, et al: Acute hyperleptinemia does not modify insulin sensitivity in vivo in the rat. Horm Metab Res 1998;30:259-262.
-
(1998)
Horm Metab. Res.
, vol.30
, pp. 259-262
-
-
Widdowson, P.S.1
Upton, R.2
Pickavance, L.3
|