-
1
-
-
19344372271
-
Systems biology: Its practice and challenges
-
Aderem A. 2005. Systems biology: its practice and challenges. Cell 121:511-513.
-
(2005)
Cell
, vol.121
, pp. 511-513
-
-
Aderem, A.1
-
3
-
-
15944383395
-
Dose-response modeling in reproductive toxicology in the systems biology era
-
Andersen ME, Thomas RS, Gaido KW and Conolly RB. 2005b. Dose-response modeling in reproductive toxicology in the systems biology era. Reprod Toxicol 19:327-37
-
(2005)
Reprod Toxicol
, vol.19
, pp. 327-337
-
-
Andersen, M.E.1
Thomas, R.S.2
Gaido, K.W.3
Conolly, R.B.4
-
4
-
-
0029764075
-
Low-dose ionizing radiation decreases the frequency of neoplastic transformation to a level below the spontaneous rate in C3H 10T1/2 cells
-
Azzam EI, de Toledo SM, Raaphorst GP and Mitchel RE. 1996. Low-dose ionizing radiation decreases the frequency of neoplastic transformation to a level below the spontaneous rate in C3H 10T1/2 cells. Radiat Res 146:369-373
-
(1996)
Radiat Res
, vol.146
, pp. 369-373
-
-
Azzam, E.I.1
de Toledo, S.M.2
Raaphorst, G.P.3
Mitchel, R.E.4
-
5
-
-
22344449669
-
Constructing transcriptional regulatory networks
-
Blais A. and Dynlacht BD. 2005. Constructing transcriptional regulatory networks. Genes Dev 19:1499-511.
-
(2005)
Genes Dev
, vol.19
, pp. 1499-1511
-
-
Blais, A.1
Dynlacht, B.D.2
-
6
-
-
7644225837
-
Phenomena leading to cell survival values which deviate from linear-quadratic models
-
Bonner WM. 2004. Phenomena leading to cell survival values which deviate from linear-quadratic models. Mutat Res 568:33-39.
-
(2004)
Mutat Res
, vol.568
, pp. 33-39
-
-
Bonner, W.M.1
-
8
-
-
3343020085
-
Integrative analysis of cell cycle control in budding yeast
-
Chen KC, Calzone L, Csikasz-Nagy A, Cross FR, Novak B and Tyson JJ. 2004. Integrative analysis of cell cycle control in budding yeast. Mol Biol Cell 15:3841-3862.
-
(2004)
Mol Biol Cell
, vol.15
, pp. 3841-3862
-
-
Chen, K.C.1
Calzone, L.2
Csikasz-Nagy, A.3
Cross, F.R.4
Novak, B.5
Tyson, J.J.6
-
9
-
-
0025168534
-
Cell proliferation in carcinogenesis
-
Cohen SM and Ellwein LB. 1990. Cell proliferation in carcinogenesis. Science 249:1007-1011.
-
(1990)
Science
, vol.249
, pp. 1007-1011
-
-
Cohen, S.M.1
Ellwein, L.B.2
-
10
-
-
24644478241
-
Population variability in biological adaptive responses to DNA damage and the shapes of carcinogen dose-response curves
-
Conolly RB, Gaylor DW, Lutz WK. 2005. Population variability in biological adaptive responses to DNA damage and the shapes of carcinogen dose-response curves. Toxicol Appl Pharmacol 207(2 Suppl):570-575.
-
(2005)
Toxicol Appl Pharmacol
, vol.207
, Issue.2
, pp. 570-575
-
-
Conolly, R.B.1
Gaylor, D.W.2
Lutz, W.K.3
-
11
-
-
0141618447
-
Biologically motivated computational modeling of formaldehyde carcinogenicity in the F344 rat
-
Conolly RB, Kimbell JS, Janszen D, Schlosser PM, Kalisak D, Preston J and Miller FJ. 2003. Biologically motivated computational modeling of formaldehyde carcinogenicity in the F344 rat. Toxicol Sci 75:432-447.
-
(2003)
Toxicol Sci
, vol.75
, pp. 432-447
-
-
Conolly, R.B.1
Kimbell, J.S.2
Janszen, D.3
Schlosser, P.M.4
Kalisak, D.5
Preston, J.6
Miller, F.J.7
-
12
-
-
1642504765
-
Nonmonotonic dose-response relationships: Mechanistic basis, kinetic modeling, and implications for risk assessment
-
Conolly RB. and Lutz WK. 2004. Nonmonotonic dose-response relationships: mechanistic basis, kinetic modeling, and implications for risk assessment. Toxicol Sci 77:151-157.
-
(2004)
Toxicol Sci
, vol.77
, pp. 151-157
-
-
Conolly, R.B.1
Lutz, W.K.2
-
13
-
-
58549117870
-
Cell cycle regulation by feed-forward loops coupling transcription and phosphorylation
-
Csikasz-Nagy A, Kapuy O, Toth A, Pal C, Jensen LJ, Uhlmann F, Tyson JJ and Novak B. 2009. Cell cycle regulation by feed-forward loops coupling transcription and phosphorylation. Mol Syst Biol. 5:236.
-
(2009)
Mol Syst Biol
, vol.5
, pp. 236
-
-
Csikasz-Nagy, A.1
Kapuy, O.2
Toth, A.3
Pal, C.4
Jensen, L.J.5
Uhlmann, F.6
Tyson, J.J.7
Novak, B.8
-
14
-
-
0022702033
-
Dose-response models and methods of risk prediction and causation estimation
-
Edwards FM. 1986. Dose-response models and methods of risk prediction and causation estimation. Semin Nucl Med 16:118-130.
-
(1986)
Semin Nucl Med
, vol.16
, pp. 118-130
-
-
Edwards, F.M.1
-
15
-
-
0001424903
-
An amplified sensitivity arising from covalent modification in biological systems
-
Goldbeter A and Koshland DE Jr. 1981. An amplified sensitivity arising from covalent modification in biological systems. Proc Natl Acad Sci U S A 78:6840-6844.
-
(1981)
Proc Natl Acad Sci U S A
, vol.78
, pp. 6840-6844
-
-
Goldbeter, A.1
Koshland Jr., D.E.2
-
16
-
-
0021715523
-
Ultrasensitivity in biochemical systems controlled by covalent modification. Interplay between zero-order and multistep effects
-
Goldbeter A and Koshland DE Jr. 1984. Ultrasensitivity in biochemical systems controlled by covalent modification. Interplay between zero-order and multistep effects. J Biol Chem 259:14441-14447.
-
(1984)
J Biol Chem
, vol.259
, pp. 14441-14447
-
-
Goldbeter, A.1
Koshland Jr., D.E.2
-
17
-
-
21244491249
-
Hysteresis and cell cycle transition: How crutial is it?
-
Han Z, Yang L, MacLellan WR, Weiss JN and Qu Z. 2005. Hysteresis and cell cycle transition: How crutial is it? Biophys J 88:1626-1634.
-
(2005)
Biophys J
, vol.88
, pp. 1626-1634
-
-
Han, Z.1
Yang, L.2
Maclellan, W.R.3
Weiss, J.N.4
Qu, Z.5
-
18
-
-
0036842149
-
Multistage models and the incidence of cancer in the cohort of atomic bomb survivors
-
Heidenreich WF, Luebeck EG, Hazelton WD, Paretzke HG and Moolgavkar SH. 2002. Multistage models and the incidence of cancer in the cohort of atomic bomb survivors. Radiat Res 158:607-614.
-
(2002)
Radiat Res
, vol.158
, pp. 607-614
-
-
Heidenreich, W.F.1
Luebeck, E.G.2
Hazelton, W.D.3
Paretzke, H.G.4
Moolgavkar, S.H.5
-
19
-
-
1642527139
-
DNA repair and cancer: Lessons from mutant mouse models
-
Ishikawa T, Zhang SS, Qin X, Takahashi Y, Oda H, Nakatsuru Y and Ide F. 2004. DNA repair and cancer: lessons from mutant mouse models. Cancer Sci 95:112-117.
-
(2004)
Cancer Sci
, vol.95
, pp. 112-117
-
-
Ishikawa, T.1
Zhang, S.S.2
Qin, X.3
Takahashi, Y.4
Oda, H.5
Nakatsuru, Y.6
Ide, F.7
-
20
-
-
71149116962
-
System-level feedbacks control cell cycle progression
-
Epub ahead of print
-
Kapuy O, He E, Lopez-Aviles S, Uhlmann F, Tyson J.J. and Novak B. 2009. System-level feedbacks control cell cycle progression. FEBS Lett. 22, Epub ahead of print.
-
(2009)
FEBS Lett
, vol.22
-
-
Kapuy, O.1
He, E.2
Lopez-Aviles, S.3
Uhlmann, F.4
Tyson, J.J.5
Novak, B.6
-
21
-
-
0037079054
-
Computational systems biology
-
Kitano H. 2002. Computational systems biology. Nature 420:206-210.
-
(2002)
Nature
, vol.420
, pp. 206-210
-
-
Kitano, H.1
-
22
-
-
0032568043
-
Functional capabilities of molecular network components controlling the mammalian G1/S cell cycle phase transition
-
Kohn KW. 1998. Functional capabilities of molecular network components controlling the mammalian G1/S cell cycle phase transition. Oncogene 168:1065-1075.
-
(1998)
Oncogene
, vol.168
, pp. 1065-1075
-
-
Kohn, K.W.1
-
23
-
-
70049114572
-
Temporal controls of the asymmetric cell division cycle in Caulobacter crescentus
-
Li S, Brazhnik P, Sobral B and Tyson J.J. 2009. Temporal controls of the asymmetric cell division cycle in Caulobacter crescentus. PLoS Comput Biol. 58:e1000463.
-
(2009)
PLoS Comput Biol
, vol.58
-
-
Li, S.1
Brazhnik, P.2
Sobral, B.3
Tyson, J.J.4
-
24
-
-
1342283106
-
Risks associated with ionizing radiation
-
Little MP. 2003. Risks associated with ionizing radiation. Br Med Bull 68:259-275.
-
(2003)
Br Med Bull
, vol.68
, pp. 259-275
-
-
Little, M.P.1
-
25
-
-
0036156007
-
Modelling lung tumour risk in radon-exposed uranium miners using generalizations of the two-mutation model of Moolgavkar, Venzon and Knudson
-
Little MP, Haylock RG, Muirhead CR. 2002. Modelling lung tumour risk in radon-exposed uranium miners using generalizations of the two-mutation model of Moolgavkar, Venzon and Knudson. Int J Radiat Biol 781:49-68.
-
(2002)
Int J Radiat Biol
, vol.781
, pp. 49-68
-
-
Little, M.P.1
Haylock, R.G.2
Muirhead, C.R.3
-
26
-
-
0037660900
-
The role of DNA breaks in genomic instability and tumori-genesis
-
Mills KD, Ferguson DO and Alt FW 2003. The role of DNA breaks in genomic instability and tumori-genesis. Immunol Rev 194:77-95.
-
(2003)
Immunol Rev
, vol.194
, pp. 77-95
-
-
Mills, K.D.1
Ferguson, D.O.2
Alt, F.W.3
-
27
-
-
0036180909
-
Testing extrapolation of a biologically based exposure-response model from in vitro to in vivo conditions
-
Mebust M, Crawford-Brown D, Hofmann W and Schollnberger H. 2002. Testing extrapolation of a biologically based exposure-response model from in vitro to in vivo conditions. Regul Toxicol Pharmacol 351:72-79.
-
(2002)
Regul Toxicol Pharmacol
, vol.351
, pp. 72-79
-
-
Mebust, M.1
Crawford-Brown, D.2
Hofmann, W.3
Schollnberger, H.4
-
28
-
-
0019467329
-
Mutation and cancer:A model for human carcinogenesis
-
Moolgavkar SH. and Knudson AG, Jr. 1981. Mutation and cancer:a model for human carcinogenesis. J Natl Cancer Inst 666:1037-1052.
-
(1981)
J Natl Cancer Inst
, vol.666
, pp. 1037-1052
-
-
Moolgavkar, S.H.1
Knudson Jr., A.G.2
-
29
-
-
0344844367
-
Multistage carcinogenesis and the incidence of human cancer
-
Moolgavkar SH. and Luebeck EG. 2003. Multistage carcinogenesis and the incidence of human cancer. Genes Chromosomes Cancer 384:302-306.
-
(2003)
Genes Chromosomes Cancer
, vol.384
, pp. 302-306
-
-
Moolgavkar, S.H.1
Luebeck, E.G.2
-
30
-
-
7644221208
-
Radiation-induced bystander effects and adaptive responses- the Yin and Yang of low dose radiobiology?
-
Mothersill C. and Seymour C. 2004a. Radiation-induced bystander effects and adaptive responses- the Yin and Yang of low dose radiobiology? Mutat Res 5681:121-128.
-
(2004)
Mutat Res
, vol.5681
, pp. 121-128
-
-
Mothersill, C.1
Seymour, C.2
-
31
-
-
1042278763
-
Radiation-induced bystander effects-implications for cancer
-
Mothersill C. and Seymour CB. 2004b. Radiation-induced bystander effects-implications for cancer. Nat Rev Cancer 42:158-164.
-
(2004)
Nat Rev Cancer
, vol.42
, pp. 158-164
-
-
Mothersill, C.1
Seymour, C.B.2
-
32
-
-
0032485826
-
Mathematical model of the fission yeast cell cycle with checkpoint controls at the G1/S, G2/M and metaphase/anaphase transitions
-
Novak B, Csikasz-Nagy A, Gyorffy B, Chen K and Tyson JJ. 1998. Mathematical model of the fission yeast cell cycle with checkpoint controls at the G1/S, G2/M and metaphase/anaphase transitions. Biophys Chem 721-2:185-200.
-
(1998)
Biophys Chem
, vol.721-722
, pp. 185-200
-
-
Novak, B.1
Csikasz-Nagy, A.2
Gyorffy, B.3
Chen, K.4
Tyson, J.J.5
-
34
-
-
0035579883
-
Mathematical model of the cell division cycle of fission yeast
-
Novak B, Pataki Z, Ciliberto A and Tyson JJ. 2001. Mathematical model of the cell division cycle of fission yeast. Chaos 111:277-286.
-
(2001)
Chaos
, vol.111
, pp. 277-286
-
-
Novak, B.1
Pataki, Z.2
Ciliberto, A.3
Tyson, J.J.4
-
35
-
-
0034764752
-
A mathematical model of radiation carcinogenesis with induction of genomic instability and cell death
-
672-667
-
Ohtaki M. and Niwa O. 2001. A mathematical model of radiation carcinogenesis with induction of genomic instability and cell death. Radiat Res 1565 Pt 2:672-667.
-
(2001)
Radiat Res
, vol.1565
, Issue.2
-
-
Ohtaki, M.1
Niwa, O.2
-
36
-
-
0346753964
-
Mechanistic models for radiation carcinogenesis and the atomic bomb survivor data
-
Pierce DA. 2003. Mechanistic models for radiation carcinogenesis and the atomic bomb survivor data. Radiat Res 1606:718-723.
-
(2003)
Radiat Res
, vol.1606
, pp. 718-723
-
-
Pierce, D.A.1
-
37
-
-
18544385497
-
Radiation biology: Concepts for radiation protection
-
Preston RJ. 2005. Radiation biology: concepts for radiation protection. Health Phys 886:545-556.
-
(2005)
Health Phys
, vol.886
, pp. 545-556
-
-
Preston, R.J.1
-
38
-
-
0344982141
-
Dynamics of the cell cycle: Checkpoints, sizers, and timers
-
Qu Z, MacLellan WR and Weiss JN. 2003a. Dynamics of the cell cycle: checkpoints, sizers, and timers. Biophys J 856:3600-3611.
-
(2003)
Biophys J
, vol.856
, pp. 3600-3611
-
-
Qu, Z.1
Maclellan, W.R.2
Weiss, J.N.3
-
39
-
-
0037302108
-
Regulation of the mammalian cell cycle: A model of the G1-to-S transition
-
Qu Z, Weiss JN and MacLellan WR. 2003b. Regulation of the mammalian cell cycle: a model of the G1-to-S transition. Am J Physiol Cell Physiol 2842:C349-364.
-
(2003)
Am J Physiol Cell Physiol
, vol.2842
-
-
Qu, Z.1
Weiss, J.N.2
Maclellan, W.R.3
-
40
-
-
4944259644
-
Coordination of cell growth and cell division: A mathematical study
-
Qu Z, Weiss JN, MacLellan WR. 2004. Coordination of cell growth and cell division: a mathematical study. J. Cell Sci 117:4199-4207.
-
(2004)
J. Cell Sci
, vol.117
, pp. 4199-4207
-
-
Qu, Z.1
Weiss, J.N.2
Maclellan, W.R.3
-
41
-
-
0031921399
-
Induction of an adaptive response against spontaneous neo-plastic transformation in vitro by low-dose gamma radiation
-
Redpath JL and Antoniono RJ. 1998. Induction of an adaptive response against spontaneous neo-plastic transformation in vitro by low-dose gamma radiation. Radiat Res 1495:517-520.
-
(1998)
Radiat Res
, vol.1495
, pp. 517-520
-
-
Redpath, J.L.1
Antoniono, R.J.2
-
42
-
-
0035663547
-
The shape of the dose-response curve for radiation-induced neoplastic transformation in vitro: Evidence for an adaptive response against neoplastic transformation at low doses of low-LET radiation
-
Redpath JL, Liang D, Taylor TH, Christie C and Elmore E. 2001. The shape of the dose-response curve for radiation-induced neoplastic transformation in vitro: evidence for an adaptive response against neoplastic transformation at low doses of low-LET radiation. Radiat Res 1566:700-707.
-
(2001)
Radiat Res
, vol.1566
, pp. 700-707
-
-
Redpath, J.L.1
Liang, D.2
Taylor, T.H.3
Christie, C.4
Elmore, E.5
-
43
-
-
78649430593
-
Changing regulatory risk paradigms can be good for our health: Phasic or linear and threshold dose-response models?
-
submitted
-
Ricci, PF, Straja S, and Cox, LA Jr., 2009, Changing regulatory risk paradigms can be good for our health: Phasic or linear and threshold dose-response models? Env. Int. (submitted)
-
(2009)
Env. Int
-
-
Ricci, P.F.1
Straja, S.2
Cox Jr., L.A.3
-
44
-
-
24144496216
-
Modeling Intercellular Interactions during Carcinogenesis
-
Sachs RK, Chan M, Hlatky L and Hahnfeldt P. 2005. Modeling Intercellular Interactions during Carcinogenesis. Radiat Res 1643:324-331.
-
(2005)
Radiat Res
, vol.1643
, pp. 324-331
-
-
Sachs, R.K.1
Chan, M.2
Hlatky, L.3
Hahnfeldt, P.4
-
45
-
-
15944363065
-
Application of a systems biology approach to developmental neu-rotoxicology
-
Slikker W, Xu Z and Wang C. 2005. Application of a systems biology approach to developmental neu-rotoxicology. Reprod Toxicol 193:305-319.
-
(2005)
Reprod Toxicol
, vol.193
, pp. 305-319
-
-
Slikker, W.1
Xu, Z.2
Wang, C.3
-
48
-
-
0036905483
-
The dynamics of cell cycle regulation
-
Tyson JJ, Csikasz-Nagy A and Novak B. 2002. The dynamics of cell cycle regulation. Bioessays 2412:1095-1109.
-
(2002)
Bioessays
, vol.2412
, pp. 1095-1109
-
-
Tyson, J.J.1
Csikasz-Nagy, A.2
Novak, B.3
-
49
-
-
0035926571
-
Regulation of the eukaryotic cell cycle: Molecular antagonism, hysteresis, and irreversible transitions
-
Tyson JJ and Novak B. 2001. Regulation of the eukaryotic cell cycle: molecular antagonism, hysteresis, and irreversible transitions. J Theor Biol 2102:249-263.
-
(2001)
J Theor Biol
, vol.2102
, pp. 249-263
-
-
Tyson, J.J.1
Novak, B.2
-
50
-
-
0036861315
-
Carcinogenic effects of low-level ionizing radiation: Problems and prospects
-
Upton AC. 2002. Carcinogenic effects of low-level ionizing radiation: problems and prospects. In Vivo 166:527-533.
-
(2002)
Vivo
, vol.166
, pp. 527-533
-
-
Upton, A.C.1
-
51
-
-
0034081305
-
The dose-response relationship for cancer incidence in a two-stage radiation carcinogenesis model incorporating cellular repopulation
-
Wheldon EG, Lindsay KA and Wheldon TE. 2000. The dose-response relationship for cancer incidence in a two-stage radiation carcinogenesis model incorporating cellular repopulation. Int J Radiat Biol 765:699-710.
-
(2000)
Int J Radiat Biol
, vol.765
, pp. 699-710
-
-
Wheldon, E.G.1
Lindsay, K.A.2
Wheldon, T.E.3
-
52
-
-
0030046784
-
A diversity of responses displayed by a stochastic model of radiation car-cinogenesis allowing for cell death
-
Yakovlev A and Polig E. 1996. A diversity of responses displayed by a stochastic model of radiation car-cinogenesis allowing for cell death. Math Biosci 1321:1-33.
-
(1996)
Math Biosci
, vol.1321
, pp. 1-33
-
-
Yakovlev, A.1
Polig, E.2
-
53
-
-
36148997654
-
Computational analysis of mammalian cell division gated by a circadian clock: Quantized cell cycle and cell size control
-
Zamborszky J, Hong CI, Csikasz NA. 2007. Computational analysis of mammalian cell division gated by a circadian clock: quantized cell cycle and cell size control. J Biol Rhythms. 226:542-553.
-
(2007)
J Biol Rhythms
, vol.226
, pp. 542-553
-
-
Zamborszky, J.1
Hong, C.I.2
Csikasz, N.A.3
-
54
-
-
78649424176
-
Computational Modeling of Biochemical Pathways Linking Ionizing Radiation to Cell Cycle Arrest and Apoptosis
-
to be submitted
-
Zhao Y. and Conolly RB. 2010. Computational Modeling of Biochemical Pathways Linking Ionizing Radiation to Cell Cycle Arrest and Apoptosis. Environment Health Perspectives, to be submitted.
-
(2010)
Environment Health Perspectives
-
-
Zhao, Y.1
Conolly, R.B.2
-
55
-
-
13444270529
-
Parameter estimation for a mathematical model of the cell cycle in frog eggs
-
Zwolak JW, Tyson JJ and Watson LT. 2005. Parameter estimation for a mathematical model of the cell cycle in frog eggs. J Comput Biol 121:48-63.
-
(2005)
J Comput Biol
, vol.121
, pp. 48-63
-
-
Zwolak, J.W.1
Tyson, J.J.2
Watson, L.T.3
|