Breakdown products of neoglucobrassicin inhibit activation of Nrf2 target genes mediated by myrosinase-derived glucoraphanin hydrolysis products

Biological Chemistry

Volumn 391, Issue 11, 2010, Pages 1281-1293

  Haack, Michael ^a   Löwinger, Maria ^a   Lippmann, Doris ^a   Kipp, Anna ^a   Pagnotta, Eleonora ^b   Iori, Renato ^b   Monien, Bernhard H ^a   Glatt, Hansruedi ^a   Brauer, Martin N ^c   Wessjohann, Ludger A ^c   Brigelius Flohé, Regina ^a  

^a GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^b ISTITUTO NAZIONALE DELLA NUTRIZIONE   (Italy)

^c LEIBNIZ INSTITUTE OF PLANT BIOCHEMISTRY   (Germany)

Author keywords

aryl hydrocarbon receptor; glutathione peroxidase 2 (GPx2); indole glucosinolates; NAD(P)H:quinone oxidoreductase 1 (NQO1); sulforaphane

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; BENZO[A]PYRENE; GLUCORAPHANIN; GLUCOSINOLATE; GLUTATHIONE PEROXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SULFORAPHANE; THIOGLUCOSIDASE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; ENZYMATIC DEGRADATION; ENZYME ACTIVATION; ENZYME INHIBITION; GENE; GENE ACTIVITY; GPX 2 GENE; HUMAN; HYDROLYSIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; XENOBIOTIC METABOLISM;

BENZO(A)PYRENE; BRASSICA; CELL LINE, TUMOR; GENE EXPRESSION REGULATION; GLUCOSINOLATES; GLUTATHIONE PEROXIDASE; GLYCOSIDE HYDROLASES; HEP G2 CELLS; HUMANS; HYDROLYSIS; IMIDOESTERS; INDOLES; MUTAGENESIS, SITE-DIRECTED; NAD(P)H DEHYDROGENASE (QUINONE); NF-E2-RELATED FACTOR 2; PROMOTER REGIONS, GENETIC; RECEPTORS, ARYL HYDROCARBON; THIOCYANATES; TRANSCRIPTIONAL ACTIVATION; XENOBIOTICS;

BRASSICA;

EID: 78649365818     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/BC.2010.134     Document Type: Article

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