New azole antifungals. 3. Synthesis and antifungal activity of 3- substituted-4(3H)-quinazolinones

Journal of Medicinal Chemistry

Volumn 41, Issue 11, 1998, Pages 1869-1882

  Bartroli, Javier ^a   Turmo, Enric ^a   Algueró, Mònica ^a   Boncompte, Eulàlia ^a   Vericat, Maria L ^a   Conte, Lourdes ^a   Ramis, Joaquim ^a   Merlos, Manuel ^a   García Rafanell, Julián ^a   Forn, Javier ^a  

^a Research Center   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

2 [2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 1 METHYL 3 (1H 1,2,4 TRIAZOL 1 YL)PROPYL] 4 [4 (2,2,3,3 TETRAFLUOROPROPOXY)PHENYL] 1,2,4 TRIAZOL 3(2H) ONE; 3 [4 (4 CYANOPHENYL)THIAZOL 2 YL ] 2 (2,4 DIFLUOROPHENYL) 1 ( 1H 1,2,4 TRIAZOL 1 YL) 2 BUTANOL; 7 CHLORO 3 [2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 1 METHYL 3 (1H 1,2,4 TRIAZOL 1 YL)PROPYL]QUINAZOLIN 4(3H) ONE; AMPHOTERICIN; ANTIFUNGAL AGENT; FLUCONAZOLE; ITRACONAZOLE; QUINAZOLINONE DERIVATIVE; SCH 42427; UNCLASSIFIED DRUG; VORICONAZOLE;

ANIMAL MODEL; ANTIFUNGAL ACTIVITY; ANTIMICROBIAL THERAPY; ARTICLE; ASPERGILLOSIS; CANDIDIASIS; DRUG HALF LIFE; HYDROPHOBICITY; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; STEREOCHEMISTRY; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SYSTEMIC MYCOSIS; TOXICITY TESTING;

ANIMALS; ANTIFUNGAL AGENTS; ASPERGILLOSIS; ASPERGILLUS FUMIGATUS; CANDIDIASIS; COLONY COUNT, MICROBIAL; FUNGI; MALE; MICE; MOLECULAR CONFORMATION; QUINAZOLINES; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 14444286696     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9707277     Document Type: Article

References (24)

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