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Volumn 38, Issue 12, 2010, Pages 1209-1218

Naturally occurring CD4+ CD25+ FOXP3+ T-regulatory cells are increased in chronic myeloid leukemia patients not in complete cytogenetic remission and can be immunosuppressive

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; CD4 ANTIGEN; GAMMA INTERFERON; GRANZYME B; HLA A3 ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 7 RECEPTOR; L SELECTIN; TRANSCRIPTION FACTOR FOXP3; TUBERCULIN; VIRUS PROTEIN;

EID: 78549290311     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2010.09.004     Document Type: Article
Times cited : (20)

References (38)
  • 1
    • 0016299728 scopus 로고
    • Immunological enhancement of tumor growth by syngeneic thymus-derived lymphocytes
    • Umiel T., Trainin N. Immunological enhancement of tumor growth by syngeneic thymus-derived lymphocytes. Transplantation 1974, 18:244-250.
    • (1974) Transplantation , vol.18 , pp. 244-250
    • Umiel, T.1    Trainin, N.2
  • 2
    • 0016588323 scopus 로고
    • A disquisition on suppressor T cells
    • Gershon R.K. A disquisition on suppressor T cells. Transplant Rev 1975, 26:170-185.
    • (1975) Transplant Rev , vol.26 , pp. 170-185
    • Gershon, R.K.1
  • 3
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi S., Sakaguchi N., Asano M., Itoh M., Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995, 155:1151-1164.
    • (1995) J Immunol , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 4
    • 0034665514 scopus 로고    scopus 로고
    • CD25 is a marker for CD4+ thymocytes that prevent autoimmune diabetes in rats, but peripheral T cells with this function are found in both CD25+ and CD25- subpopulations
    • Stephens L.A., Mason D. CD25 is a marker for CD4+ thymocytes that prevent autoimmune diabetes in rats, but peripheral T cells with this function are found in both CD25+ and CD25- subpopulations. J Immunol 2000, 165:3105-3110.
    • (2000) J Immunol , vol.165 , pp. 3105-3110
    • Stephens, L.A.1    Mason, D.2
  • 6
    • 0035806290 scopus 로고    scopus 로고
    • Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood
    • Jonuleit H., Schmitt E., Stassen M., Tuettenberg A., Knop J., Enk A.H. Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood. J Exp Med 2001, 193:1285-1294.
    • (2001) J Exp Med , vol.193 , pp. 1285-1294
    • Jonuleit, H.1    Schmitt, E.2    Stassen, M.3    Tuettenberg, A.4    Knop, J.5    Enk, A.H.6
  • 7
    • 0035806323 scopus 로고    scopus 로고
    • Human CD25(+)CD4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function
    • Levings M.K., Sangregorio R., Roncarolo M.G. Human CD25(+)CD4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J Exp Med 2001, 193:1295-1302.
    • (2001) J Exp Med , vol.193 , pp. 1295-1302
    • Levings, M.K.1    Sangregorio, R.2    Roncarolo, M.G.3
  • 8
    • 0035525739 scopus 로고    scopus 로고
    • Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells
    • Ng W.F., Duggan P.J., Ponchel F., et al. Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells. Blood 2001, 98:2736-2744.
    • (2001) Blood , vol.98 , pp. 2736-2744
    • Ng, W.F.1    Duggan, P.J.2    Ponchel, F.3
  • 9
    • 0035054606 scopus 로고    scopus 로고
    • Human CD4(+)CD25(+) thymocytes and peripheral T cells have immune suppressive activity in vitro
    • Stephens L.A., Mottet C., Mason D., Powrie F. Human CD4(+)CD25(+) thymocytes and peripheral T cells have immune suppressive activity in vitro. Eur J Immunol 2001, 31:1247-1254.
    • (2001) Eur J Immunol , vol.31 , pp. 1247-1254
    • Stephens, L.A.1    Mottet, C.2    Mason, D.3    Powrie, F.4
  • 10
    • 0037385314 scopus 로고    scopus 로고
    • An essential role for Scurfin in CD4+CD25+ T regulatory cells
    • Khattri R., Cox T., Yasayko S.A., Ramsdell F. An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat Immunol 2003, 4:337-342.
    • (2003) Nat Immunol , vol.4 , pp. 337-342
    • Khattri, R.1    Cox, T.2    Yasayko, S.A.3    Ramsdell, F.4
  • 11
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori S., Nomura T., Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003, 299:1057-1061.
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 12
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    • Fontenot J.D., Gavin M.A., Rudensky A.Y. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003, 4:330-336.
    • (2003) Nat Immunol , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 13
    • 34548590227 scopus 로고    scopus 로고
    • Foxp3 expression in pancreatic carcinoma cells as a novel mechanism of immune evasion in cancer
    • Hinz S., Pagerols-Raluy L., Oberg H.H., et al. Foxp3 expression in pancreatic carcinoma cells as a novel mechanism of immune evasion in cancer. Cancer Res 2007, 67:8344-8350.
    • (2007) Cancer Res , vol.67 , pp. 8344-8350
    • Hinz, S.1    Pagerols-Raluy, L.2    Oberg, H.H.3
  • 14
    • 39049171753 scopus 로고    scopus 로고
    • Comprehensive analysis of FOXP3 mRNA expression in leukemia and transformed cell lines
    • Yamamoto M., Tsuji-Takayama K., Suzuki M., et al. Comprehensive analysis of FOXP3 mRNA expression in leukemia and transformed cell lines. Leuk Res 2008, 32:651-658.
    • (2008) Leuk Res , vol.32 , pp. 651-658
    • Yamamoto, M.1    Tsuji-Takayama, K.2    Suzuki, M.3
  • 15
    • 0033168037 scopus 로고    scopus 로고
    • Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody
    • Onizuka S., Tawara I., Shimizu J., Sakaguchi S., Fujita T., Nakayama E. Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody. Cancer Res 1999, 59:3128-3133.
    • (1999) Cancer Res , vol.59 , pp. 3128-3133
    • Onizuka, S.1    Tawara, I.2    Shimizu, J.3    Sakaguchi, S.4    Fujita, T.5    Nakayama, E.6
  • 16
    • 0033571105 scopus 로고    scopus 로고
    • Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity
    • Shimizu J., Yamazaki S., Sakaguchi S. Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity. J Immunol 1999, 163:5211-5218.
    • (1999) J Immunol , vol.163 , pp. 5211-5218
    • Shimizu, J.1    Yamazaki, S.2    Sakaguchi, S.3
  • 17
    • 0035874949 scopus 로고    scopus 로고
    • Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer
    • Woo E.Y., Chu C.S., Goletz T.J., et al. Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer. Cancer Res 2001, 61:4766-4772.
    • (2001) Cancer Res , vol.61 , pp. 4766-4772
    • Woo, E.Y.1    Chu, C.S.2    Goletz, T.J.3
  • 18
    • 1442283424 scopus 로고    scopus 로고
    • Immunosuppressive regulatory T cells are abundant in the reactive lymphocytes of Hodgkin lymphoma
    • Marshall N.A., Christie L.E., Munro L.R., et al. Immunosuppressive regulatory T cells are abundant in the reactive lymphocytes of Hodgkin lymphoma. Blood 2004, 103:1755-1762.
    • (2004) Blood , vol.103 , pp. 1755-1762
    • Marshall, N.A.1    Christie, L.E.2    Munro, L.R.3
  • 19
    • 24744432528 scopus 로고    scopus 로고
    • Reduced frequencies and suppressive function of CD4+CD25hi regulatory T cells in patients with chronic lymphocytic leukemia after therapy with fludarabine
    • Beyer M., Kochanek M., Darabi K., et al. Reduced frequencies and suppressive function of CD4+CD25hi regulatory T cells in patients with chronic lymphocytic leukemia after therapy with fludarabine. Blood 2005, 106:2018-2025.
    • (2005) Blood , vol.106 , pp. 2018-2025
    • Beyer, M.1    Kochanek, M.2    Darabi, K.3
  • 20
    • 3142737258 scopus 로고    scopus 로고
    • Foxp3 expressing CD4+CD25(high) regulatory T cells are overrepresented in human metastatic melanoma lymph nodes and inhibit the function of infiltrating T cells
    • Viguier M., Lemaitre F., Verola O., et al. Foxp3 expressing CD4+CD25(high) regulatory T cells are overrepresented in human metastatic melanoma lymph nodes and inhibit the function of infiltrating T cells. J Immunol 2004, 173:1444-1453.
    • (2004) J Immunol , vol.173 , pp. 1444-1453
    • Viguier, M.1    Lemaitre, F.2    Verola, O.3
  • 22
    • 33847189975 scopus 로고    scopus 로고
    • Increased frequencies of CD4(+)CD25(high) T(regs) correlate with disease relapse after allogeneic stem cell transplantation for chronic myeloid leukemia
    • Nadal E., Garin M., Kaeda J., Apperley J., Lechler R., Dazzi F. Increased frequencies of CD4(+)CD25(high) T(regs) correlate with disease relapse after allogeneic stem cell transplantation for chronic myeloid leukemia. Leukemia 2007, 21:472-479.
    • (2007) Leukemia , vol.21 , pp. 472-479
    • Nadal, E.1    Garin, M.2    Kaeda, J.3    Apperley, J.4    Lechler, R.5    Dazzi, F.6
  • 23
    • 0036038791 scopus 로고    scopus 로고
    • Serial Monitoring of BCR-ABL by peripheral blood real time polymerase chain reaction predicts the marrow cytogenetic response to imatinib mesylate in chronic myeloid leukaemia
    • Wang L., Pearson K., Pillitteri L., Ferguson J.E., Clark R.E. Serial Monitoring of BCR-ABL by peripheral blood real time polymerase chain reaction predicts the marrow cytogenetic response to imatinib mesylate in chronic myeloid leukaemia. Br J Haematol 2002, 118:771-777.
    • (2002) Br J Haematol , vol.118 , pp. 771-777
    • Wang, L.1    Pearson, K.2    Pillitteri, L.3    Ferguson, J.E.4    Clark, R.E.5
  • 24
    • 33745603988 scopus 로고    scopus 로고
    • Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: review and recommendations for 'harmonizing' current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results
    • Hughes T.P., Deininger M.W., Hochhaus A., et al. Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: review and recommendations for 'harmonizing' current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results. Blood 2006, 108:28-37.
    • (2006) Blood , vol.108 , pp. 28-37
    • Hughes, T.P.1    Deininger, M.W.2    Hochhaus, A.3
  • 25
    • 54049130762 scopus 로고    scopus 로고
    • A population study of imatinib in chronic myeloid leukaemia demonstrates lower efficacy than in clinical trials
    • Lucas C.M., Wang L., Austin G.M., et al. A population study of imatinib in chronic myeloid leukaemia demonstrates lower efficacy than in clinical trials. Leukemia 2008, 22:1963-1966.
    • (2008) Leukemia , vol.22 , pp. 1963-1966
    • Lucas, C.M.1    Wang, L.2    Austin, G.M.3
  • 26
    • 35449008469 scopus 로고    scopus 로고
    • Clinical evaluation of BCR-ABL peptide immunisation in chronic myeloid leukaemia: results of the EPIC study
    • Rojas J.M., Knight K., Wang L., Clark R.E. Clinical evaluation of BCR-ABL peptide immunisation in chronic myeloid leukaemia: results of the EPIC study. Leukemia 2007, 21:2287-2295.
    • (2007) Leukemia , vol.21 , pp. 2287-2295
    • Rojas, J.M.1    Knight, K.2    Wang, L.3    Clark, R.E.4
  • 27
    • 33745817085 scopus 로고    scopus 로고
    • CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells
    • Liu W., Putnam A.L., Xu-Yu Z., et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med 2006, 203:1701-1711.
    • (2006) J Exp Med , vol.203 , pp. 1701-1711
    • Liu, W.1    Putnam, A.L.2    Xu-Yu, Z.3
  • 28
    • 33745813929 scopus 로고    scopus 로고
    • Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells
    • Seddiki N., Santner-Nanan B., Martinson J., et al. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med 2006, 203:1693-1700.
    • (2006) J Exp Med , vol.203 , pp. 1693-1700
    • Seddiki, N.1    Santner-Nanan, B.2    Martinson, J.3
  • 29
    • 0025318094 scopus 로고
    • Rapid modulation of homing receptors (gp90MEL-14) induced by activators of protein kinase C. Receptor shedding due to accelerated proteolytic cleavage at the cell surface
    • Jung T.M., Dailey M.O. Rapid modulation of homing receptors (gp90MEL-14) induced by activators of protein kinase C. Receptor shedding due to accelerated proteolytic cleavage at the cell surface. J Immunol 1990, 144:3130-3136.
    • (1990) J Immunol , vol.144 , pp. 3130-3136
    • Jung, T.M.1    Dailey, M.O.2
  • 30
    • 0035892131 scopus 로고    scopus 로고
    • Direct evidence that leukaemic cells present HLA-associated immunogenic peptides derived from the BCR-ABL b3a2 fusion protein
    • Clark R.E., Dodi I.A., Hill S.C., et al. Direct evidence that leukaemic cells present HLA-associated immunogenic peptides derived from the BCR-ABL b3a2 fusion protein. Blood 2001, 98:2887-2893.
    • (2001) Blood , vol.98 , pp. 2887-2893
    • Clark, R.E.1    Dodi, I.A.2    Hill, S.C.3
  • 31
    • 34047174849 scopus 로고    scopus 로고
    • Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production
    • Allan S.E., Crome S.Q., Crellin N.K., et al. Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production. Int Immunol 2007, 19:345-354.
    • (2007) Int Immunol , vol.19 , pp. 345-354
    • Allan, S.E.1    Crome, S.Q.2    Crellin, N.K.3
  • 32
    • 3042802079 scopus 로고    scopus 로고
    • Imatinib mesylate affects the development and function of dendritic cells generated from CD34+ peripheral blood progenitor cells
    • Appel S., Boehmler A.M., Grunebach F., et al. Imatinib mesylate affects the development and function of dendritic cells generated from CD34+ peripheral blood progenitor cells. Blood 2004, 103:538-544.
    • (2004) Blood , vol.103 , pp. 538-544
    • Appel, S.1    Boehmler, A.M.2    Grunebach, F.3
  • 33
    • 33746418579 scopus 로고    scopus 로고
    • Imatinib mesylate minimally affects bcr-abl+ and normal monocyte-derived dendritic cells but strongly inhibits T cell expansion despite reciprocal dendritic cell-T cell activation
    • Boissel N., Rousselot P., Raffoux E., et al. Imatinib mesylate minimally affects bcr-abl+ and normal monocyte-derived dendritic cells but strongly inhibits T cell expansion despite reciprocal dendritic cell-T cell activation. J Leukoc Biol 2006, 79:747-756.
    • (2006) J Leukoc Biol , vol.79 , pp. 747-756
    • Boissel, N.1    Rousselot, P.2    Raffoux, E.3
  • 34
    • 10744232318 scopus 로고    scopus 로고
    • The effects of STI571 on antigen presentation of dendritic cells generated from patients with chronic myelogenous leukemia
    • Sato N., Narita M., Takahashi M., et al. The effects of STI571 on antigen presentation of dendritic cells generated from patients with chronic myelogenous leukemia. Hematol Oncol 2003, 21:67-75.
    • (2003) Hematol Oncol , vol.21 , pp. 67-75
    • Sato, N.1    Narita, M.2    Takahashi, M.3
  • 35
    • 0346150377 scopus 로고    scopus 로고
    • Increased IFN-gamma synthesis by T cells from patients on imatinib therapy for chronic myeloid leukemia
    • Aswald J.M., Lipton J.H., Aswald S., Messner H.A. Increased IFN-gamma synthesis by T cells from patients on imatinib therapy for chronic myeloid leukemia. Cytokines Cell Mol Ther 2002, 7:143-149.
    • (2002) Cytokines Cell Mol Ther , vol.7 , pp. 143-149
    • Aswald, J.M.1    Lipton, J.H.2    Aswald, S.3    Messner, H.A.4
  • 36
    • 38449083810 scopus 로고    scopus 로고
    • Imatinib impairs the proliferation and function of CD4+CD25+ regulatory T cells in a dose-dependent manner
    • Chen J., Schmitt A., Giannopoulos K., et al. Imatinib impairs the proliferation and function of CD4+CD25+ regulatory T cells in a dose-dependent manner. Int J Oncol 2007, 31:1133-1139.
    • (2007) Int J Oncol , vol.31 , pp. 1133-1139
    • Chen, J.1    Schmitt, A.2    Giannopoulos, K.3
  • 37
    • 58149187113 scopus 로고    scopus 로고
    • Imatinib mesylate inhibits CD4+ CD25+ regulatory T cell activity and enhances active immunotherapy against BCR-ABL- tumors
    • Larmonier N., Janikashvili N., LaCasse C.J., et al. Imatinib mesylate inhibits CD4+ CD25+ regulatory T cell activity and enhances active immunotherapy against BCR-ABL- tumors. J Immunol 2008, 181:6955-6963.
    • (2008) J Immunol , vol.181 , pp. 6955-6963
    • Larmonier, N.1    Janikashvili, N.2    LaCasse, C.J.3
  • 38
    • 78549235705 scopus 로고    scopus 로고
    • Effect of tyrosine kinase inhibitors on regulatory T-cells (TREGS) in patients with chronic myeloid leukaemia (CML)
    • [abstract]
    • Rohon P., Porkka K., Mustjoki S. Effect of tyrosine kinase inhibitors on regulatory T-cells (TREGS) in patients with chronic myeloid leukaemia (CML). Haematologica 2008, 93(suppl 1):44-45. [abstract].
    • (2008) Haematologica , vol.93 , Issue.SUPPL. 1 , pp. 44-45
    • Rohon, P.1    Porkka, K.2    Mustjoki, S.3


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