Error-free replicative bypass of (6-4) photoproducts by DNA polymerase ζ in mouse and human cells

Genes and Development

Volumn 24, Issue 2, 2010, Pages 123-128

  Yoon, Jung Hoon ^a   Prakash, Louise ^a   Prakash, Satya ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

(6 4) photoproducts; DNA repair; DNA replication; Replicative lesion bypass; UV damage

Indexed keywords

DEOXYRIBODIPYRIMIDINE PHOTOLYASE; DNA DIRECTED DNA POLYMERASE ETA; DNA POLYMERASE; DNA POLYMERASE IOTA; DNA POLYMERASE ZETA; GENE PRODUCT; PYRIMIDINE; PYRIMIDINE DIMER; PYRIMIDINONE DERIVATIVE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA REPLICATION; DNA SYNTHESIS; DNA TEMPLATE; EXCISION REPAIR; FIBROBLAST; HUMAN; HUMAN CELL; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; ULTRAVIOLET IRRADIATION;

ANIMALS; CELL LINE; CELLS, CULTURED; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DNA-DIRECTED DNA POLYMERASE; HUMANS; MICE; PYRIMIDINE DIMERS; ULTRAVIOLET RAYS;

EID: 75149164883     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.1872810     Document Type: Article

References (20)

1. Besaratinia A, Pfeifer GP. 2006. Investigating human cancer etiology by DNA lesion footprinting and mutagenicity analysis. Carcinogenesis 27: 1526-1537.
2. Bresson A, Fuchs RPP. 2002. Lesion bypass in yeast cells: Pol η participates in a multi-DNA polymerase process. EMBO J 21: 3881-3887.
3. Bullock PA, Seo YS, Hurwitz J. 1991. Initiation of simian virus 40 DNA synthesis in vitro. Mol Cell Biol 11: 2350-2361.
4. Danna KJ, Nathans D. 1972. Bidirectional replication of simian virus 40 DNA. Proc Natl Acad Sci 69: 3097-3100.
5. Fareed GC, Garon CF, Salzman NP. 1972. Origin and direction of simian virus 40 deoxyribonucleic acid replication. J Virol 10: 484-491.
6. Haracska L, Johnson RE, Unk I, Phillips BB, Hurwitz J, Prakash L, Prakash S. 2001. Targeting of human DNA polymerase i to the replication machinery via interaction with PCNA. Proc Natl Acad Sci 98: 14256-14261.
7. Jakubczak JL, Merlino G, French JE, Muller WJ, Paul B, Adhya S, Garges S. 1996. Analysis of genetic instability during mammary tumor progression using a novel selection-based assay for in vivo mutations in a bacteriophage l transgene target. Proc Natl Acad Sci 93: 9073-9078.
8. Johnson RE, Washington MT, Haracska L, Prakash S, Prakash L. 2000. Eukaryotic polymerases i and z act sequentially to bypass DNA lesions. Nature 406: 1015-1019.
9. Johnson RE, Haracska L, Prakash S, Prakash L. 2001. Role of DNA polymerase h in the bypass of a (6-4) TT photoproduct. Mol Cell Biol 21: 3558-3563.
10. Kemmink J, Boelens R, Koning T, van der Marel GA, van Boom JH, Kaptein R. 1987. 1H NMR study of the exchangeable protons of the duplex d(GCGTTGCG).d(CGCAACGC) containing a thymine photodimer. Nucleic Acids Res 15: 4645-4653.
11. Kim J-K, Choi B-S. 1995. The solution structure of DNA duplex-decamer containing the (6-4) photoproduct of thymidyl(3′ → 5′)thymidine by NMR and relaxation matrix refinement. Eur J Biochem 228: 849-854.
12. Kim J-K, Patel D, Choi B-S. 1995. Contrasting structural impacts induced by cis-syn cyclobutane dimer and (6-4) adduct in DNA duplex decamers: Implication in mutagenesis and repair activity. Photochem Photobiol 62: 44-50.
13. Lee J-H, Hwang G-S, Choi B-S. 1999. Solution structure of a DNA decamer duplex containing the stable 3′ T.G base pair of the pyrimidine(6-4) pyrimidone photoproduct [(6-4) adduct]: Implications for the highly specific 3′ T → C transition of the (6-4) adduct. Proc Natl Acad Sci 96: 6632-6636.
14. Li JJ, Kelly TJ. 1985. Simian virus 40 DNA replication in vitro: Specificity of initiation and evidence for bidirectional replication. Mol Cell Biol 5: 1238-1246.
15. Prakash S, Johnson RE, Prakash L. 2005. Eukaryotic translesion synthesis DNA polymerases: Specificity of structure and function. Annu Rev Biochem 74: 317-353.
16. Shachar S, Ziv O, Avkin S, Adar S, Wittschieben J, Reißner T, Chanev S, Friedberg EC, Wang Z, Carell T, et al. 2009. Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals. EMBO J 28: 383-393.
17. Yoon J-H, Lee CS, O'Connor TR, Yasui A, Pfeifer GP. 2000. The DNA damage spectrum produced by simulated sunlight. J Mol Biol 299: 681-693.
18. Yoon J-H, Prakash L, Prakash S. 2009. Highly error-free role of DNA polymerase h in the replicative bypass of UV induced pyrimidine dimers in mouse and human cells. Proc Natl Acad Sci 106: 18219-18224.
19. You Y-H, Pfeifer GP. 2001. Similarities in sunlight-induced mutational spectra of CpG-methylated transgenes and the p53 gene in skin cancer point to an important role of 5-methylcytosine rsidues in solar UV mutagenesis. J Mol Biol 305: 389-399.
20. You Y-H, Lee D-H, Yoon J-H, Nakajima S, Yasui A, Pfeifer GP. 2001. Cyclobutane pyrimidine dimers are responsible for the vast majority of mutations induced by UVB irradiation in mammalian cells. J Biol Chem 276: 44688-44694.