Evolution of the two-step model for UV-mutagenesis

Mutation Research - DNA Repair

Volumn 485, Issue 1, 2001, Pages 83-92

  Woodgate, R ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

DNA polymerase; Rad30; Rad30B; SOS mutagenesis; UmuC; UmuD

Indexed keywords

DNA DIRECTED DNA POLYMERASE GAMMA; DNA POLYMERASE; DNA POLYMERASE V; GENE PRODUCT; HOLOENZYME; PROTEIN UMUC; PROTEIN UMUD; UNCLASSIFIED DRUG;

CHROMOSOME DUPLICATION; CONFERENCE PAPER; DNA REPAIR; DNA SYNTHESIS; ENZYME ACTIVITY; ENZYME LOCALIZATION; ESCHERICHIA COLI; GENE ISOLATION; MOLECULAR GENETICS; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SPONTANEOUS MUTATION; ULTRAVIOLET RADIATION;

DNA POLYMERASE III; DNA-DIRECTED DNA POLYMERASE; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; EUKARYOTIC CELLS; GENES, BACTERIAL; HISTORY, 20TH CENTURY; MODELS, GENETIC; MUTAGENESIS; SOS RESPONSE (GENETICS); ULTRAVIOLET RAYS;

EMBRYOPHYTA; ESCHERICHIA COLI; EUKARYOTA; PROKARYOTA; SACCHAROMYCES CEREVISIAE;

EID: 0035946012     PISSN: 09218777     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0921-8777(00)00076-8     Document Type: Conference Paper

References (91)

1. Isolation of an E. coli strain with a mutation affecting DNA polymerase
2. DNA polymerase II
3. Purification and DNA synthesis in cell-free extracts: Properties of DNA polymerase II
4. Analysis of DNA polymerases II and III in mutants of Escherichia coli thermosensitive for DNA synthesis
5. A phenotype for enigmatic DNA polymerase II. A pivotal role for pol II in replication restart in UV-irradiated Escherichia coli
6. Escherichia coli mutants temperature-sensitive for DNA synthesis
7. Isolation and characterization of thermosensitive Escherichia coli mutants defective in deoxyribonucleic acid replication
8. Increased spontaneous mutation rates in mutants of E. coli with altered DNA polymerase III
9. Mutagenic repair in Escherichia coli. III. Requirement for a function of DNA polymerase III in ultraviolet light mutagenesis
10. DNA polymerase III of Escherichia coli is required for UV and ethyl methanesulfonate mutagenesis
11. Mutagenic DNA repair in Escherichia coli. XVIII. Involvement of DNA polymerase III α-subunit (DnaE protein) in mutagenesis after exposure to UV light
12. Isolation and characterization of mutants of Escherichia coli deficient in induction of mutations by ultraviolet light
13. Phenomenology of an inducible mutagenic DNA repair pathway in Escherichia coli: SOS repair hypothesis
14. Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli
15. uvm mutants of Escherichia coli K-12 deficient in UV mutagenesis. I. Isolation of uvm mutants and their phenotypical characterization in DNA repair and mutagenesis
16. Cloning and characterization of the umu operon responsible for inducible mutagenesis in Escherichia coli
17. Proteins required for ultraviolet light and chemical mutagenesis. Identification of the products of the umuC locus of Escherichia coli
18. Escherichia coli umuDC mutants: DNA sequence alterations and UmuD cleavage
19. Mutagenesis and repair deficiencies of Escherichia coli umuC mutants are suppressed by the plasmid pKM101
20. Role of the E. coli umuC gene product in the repair of single-stranded DNA phage
21. Induction of mutation in a bacterial virus
22. Molecular mechanisms of induced mutagenesis. Replication in vivo of bacteriophage φX174 single-stranded, ultraviolet light-irradiated DNA in intact and irradiated host cells
23. Sites of inhibition of in vitro DNA synthesis in carcinogen- and UV-treated φX174 DNA
24. Sites of termination of in vitro DNA synthesis on ultraviolet- and N-acetylaminofluorene-treated φX174 templates by prokaryotic and eukaryotic DNA polymerases
25. Mutagenic repair in Escherichia coli. X. The umuC gene product may be required for replication past pyrimidine dimers but not for the coding error in UV mutagenesis
26. Mutagenic repair in Escherichia coli: Products of the recA gene and of the umuD and umuC genes act at different steps in UV-induced mutagenesis
27. The two-step model of bacterial UV mutagenesis
28. Mutagenic DNA repair in Escherichia coli. XVI. Mutagenesis by ultraviolet light plus delayed photoreversal in recA strains
29. Mutagenic DNA repair in Escherichia coli. XVII. Effect of temperature-sensitive DnaE proteins on the induction of streptomycin-resistant mutations by UV light
30. UmuD mutagenesis protein of Escherichia coli: Overproduction, purification and cleavage by RecA
31. RecA protein-dependent cleavage of UmuD protein and SOS mutagenesis
32. RecA-mediated cleavage activates UmuD for mutagenesis: Mechanistic relationship between transcriptional derepression and posttranslational activation
33. UmuC mutagenesis protein of Escherichia coli: Purification and interaction with UmuD and UmuD′
34. Activity of the purified mutagenesis proteins UmuC, UmuD′ and RecA in replicative bypass of an abasic DNA lesion by DNA polymerase III
35. Construction of a umuDC operon substitution mutation in Escherichia coli
36. Purification of a soluble UmuD′C complex from Escherichia coli: Cooperative binding of UmuD′C to single-stranded DNA
37. 2/′C mutagenic complex and RecA
38. The mutagenesis proteins UmuD′ and UmuC prevent lethal frameshifts while increasing base substitution mutations
39. 2/′C is an error-prone DNA polymerase, Escherichia coli, DNA pol V
40. The mutagenesis protein UmuC is a DNA polymerase activated by UmuD′, RecA, and SSB and is specialized for translesion replication
41. The dinB gene encodes an novel Escherichia coli DNA polymerase (DNA pol IV) involved in mutagenesis
42. Roles of E. coli DNA polymerases IV and V in lesion-targeted and untargeted SOS mutagenesis
43. The Escherichia coli SOS mutagenesis proteins UmuD and UmuD′ interact physically with the replicative DNA polymerase
44. DNA polymerases and SOS mutagenesis: Can one reconcile the biochemical and genetic data
45. Levels of chromosomally encoded Umu proteins and requirements for in vivo UmuD cleavage
46. Specific RecA amino acid changes affect RecA-UmuD′C interaction
47. Regulation of SOS mutagenesis by proteolysis
48. Lon-mediated proteolysis of the Escherichia coli UmuD mutagenesis protein: In vitro degradation and identification of residues required for proteolysis
49. Structural insights into the regulation of SOS mutagenesis
50. Subunit-specific degradation of the UmuD/D′ heterodimer by the ClpXP protease: The role of trans recognition in UmuD′ stability
51. Minimizing proteolysis in Escherichia coli: Genetic solutions
52. Proteases and their targets in Escherichia coli
53. Constitutive expression of SOS functions and modulation of mutagenesis resulting from resolution of genetic instability at or near the recA locus of Escherichia coli
54. In vivo stability of the Umu mutagenesis proteins: A major role for RecA
55. Frequency and spectrum of mutations produced by a single cis-syn thymine-thymine dimer in a single-stranded vector
56. Efficient translesion replication in the absence of Escherichia coli Umu proteins and 3′-5′ exonuclease proofreading function
57. Contribution of 3′ to 5′ exonuclease activity of DNA polymerase III holoenzyme from Escherichia coli to specificity
58. Capacity of RecA protein to bind preferentially to UV lesions and inhibit the editing subunit of DNA polymerase III: A possible mechanism for SOS-induced targeted mutagenesis
59. The base substitution and frameshift fidelity of Escherichia coli DNA polymerase III holoenzyme in vitro
60. A rapid method for cloning mutagenic DNA repair genes: Isolation of umu-complementing genes from multidrug resistance plasmids R391, R446b, and R471a
61. Characterization of the umu-complementing operon from R391
62. Unusual insertion element polymorphisms in the promoter and terminator regions of the mucAB-like genes of R471a and R446b
63. Identification of mucAB-like homologs on two IncT plasmids, R394 and Rts-1
64. Identification of a DinB/UmuC homolog in the archeon Sulfolobus solfataricus
65. The Saccharomyces cerevisiae RAD30 gene, a homologue of Escherichia coli dinB and umuC, is DNA damage inducible and functions in a novel error-free postreplication repair mechanism
66. Novel human and mouse homologs of Saccharomyces cerevisiae DNA polymerase η
67. The REV1 gene of Saccharomyces cerevisiae: Isolation, sequence and functional analysis
68. dinP, a new gene in Escherichia coli, whose product shows similarities to UmuC and its homologues
69. Deletion of the Saccharomyces cerevisiae gene RAD30 encoding an Escherichia coli DinB homolog confers UV radiation sensitivity and altered mutability
70. Human and mouse homologs of Escherichia coli DinB (DNA polymerase IV), members of the UmuC/DinB superfamily
71. Deoxycytidyl transferase activity of yeast REV1 protein
72. Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, pol η
73. Xeroderma pigmentosum variant (XPV) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity
74. The human DINB1 gene encodes the DNA polymerase pol θ
75. Error-prone bypass of certain DNA lesions by the human DNA polymerase κ
76. pol ι, a remarkably error-prone human DNA polymerase
77. The XPV (Xeroderma pigmentosum variant) gene encodes human DNA polymerase η
78. hRAD30 mutations in the variant form of Xeroderma pigmentosum
79. Fidelity of human DNA polymerase η
80. Xeroderma pigmentosum variants: Influence of temperature on DNA repair
81. Eukaryotic polymerases ι and ζ act sequentially to bypass DNA lesions
82. Preferential incorporation of G opposite template T by the low-fidelity human DNA polymerase ι
83. Misinsertion and bypass of thymine-thymine dimers by human DNA polymerase ι
84. DNA polymerase (and related Rad30-like enzymes
85. Thymine-thymine dimer bypass by yeast DNA polymerase ζ
86. DNA polymerase ζ and the control of DNA damage induced mutagenesis in eukaryotes
87. Roles of DNA polymerase ζ and Rev1 protein in eukaryotic mutagenesis and translesion replication
88. A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase ζ
89. 2/′C)
90. A "cowcatcher" model for SOS-lesion targeted mutations in E. coli involving pol V, RecA, SSB and β sliding clamp
91. Mechanisms of accurate translesion synthesis by human DNA polymerase η