NKT cells in sepsis

Clinical and Developmental Immunology

Volumn 2010, Issue , 2010, Pages

  Harris, Hobart W ^a   Leung, Briana ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; CD1 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; LIPOPOLYSACCHARIDE; LOW DENSITY LIPOPROTEIN RECEPTOR; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR;

ANTIGEN PRESENTING CELL; CELL TYPE; CLASSIFICATION; ENDOTOXEMIA; ENZYME POLYMORPHISM; GRAM NEGATIVE SEPSIS; HUMAN; HYPERLIPIDEMIA; IMMUNE RESPONSE; IMMUNOREGULATION; INFECTION; INFLAMMATION; INVARIANT NKT; LIPID METABOLISM; MORTALITY; NATURAL KILLER CELL; NONHUMAN; PATHOGENESIS; POLYMICROBIAL SEPSIS; PRIORITY JOURNAL; REVIEW; SEPSIS; SEPTIC SHOCK; T LYMPHOCYTE ACTIVATION; TH2 CELL;

ANIMALS; APOLIPOPROTEINS E; HUMANS; INFLAMMATION; MICE; NATURAL KILLER T-CELLS; SEPSIS;

EID: 78349290817     PISSN: 17402522     EISSN: 17402530     Source Type: Journal    
DOI: 10.1155/2010/414650     Document Type: Review

References (98)

1. Balato A., Unutmaz D., Gaspari A. A., Natural killer T cells: an unconventional t-cell subset with diverse effector and regulatory functions Journal of Investigative Dermatology 2009 129 7 1628 1642
2. Godfrey D. I., Hammond K. J. L., Poulton L. D., Smyth M. J., Baxter A. G., NKT cells: facts, functions and fallacies Immunology Today 2000 21 11 573 583
3. Godfrey D. I., MacDonald H. R., Kronenberg M., Smyth M. J., Van Kaer L., NKT cells: what's in a name? Nature Reviews Immunology 2004 4 3 231 237
4. Beckman E. M., Porcelli S. A., Morita C. T., Behar S. M., Furlong S. T., Brenner M. B., Recognition of lipid antigen by CD1-restricted + T cells Nature 1994 372 6507 691 694
5. Speak A. O., Salio M., Neville D. C. A., Fontaine J., Priestman D. A., Platt N., Heare T., Butters T. D., Dwek R. A., Trottein F., Exley M. A., Cerundolo V., Platt F. M., Implications for invariant natural killer T cell ligands due to the restricted presence of isoglobotrihexosylceramide in mammals Proceedings of the National Academy of Sciences of the United States of America 2007 104 14 5971 5976
6. Porubsky S., Speak A. O., Luckow B., Cerundolo V., Platt F. M., Grne H.-J., Normal development and function of invariant natural killer T cells in mice with isoglobotrihexosylceramide (iGb3) deficiency Proceedings of the National Academy of Sciences of the United States of America 2007 104 14 5977 5982
7. Natori T., Koezuka Y., Higa T., Agelasphins, novel -galactosylceramides from the marine sponge Agelas mauritianus Tetrahedron Letters 1993 34 35 5591 5592
8. Natori T., Morita M., Akimoto K., Koezuka Y., Agelasphins, novel antitumor and immunostimulatory cerebrosides from the marine sponge Agelas mauritianus Tetrahedron 1994 50 9 2771 2784
9. Jahng A., Maricic I., Aguilera C., Cardell S., Halder R. C., Kumar V., Prevention of autoimmunity by targeting a distinct, noninvariant CD1d-reactive T cell population reactive to sulfatide Journal of Experimental Medicine 2004 199 7 947 957
10. Zajonc D. M., Maricic I., Wu D., Halder R., Roy K., Wong C.-H., Kumar V., Wilson I. A., Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity Journal of Experimental Medicine 2005 202 11 1517 1526
11. Halder R. C., Aguilera C., Maricic I., Kumar V., Type II NKT cell-mediated anergy induction in type I NKT cells prevents inflammatory liver disease Journal of Clinical Investigation 2007 117 8 2302 2312
12. Bendelac A., Savage P. B., Teyton L., The biology of NKT cells Annual Review of Immunology 2007 25 297 336
13. Yoshimoto T., Paul W. E., CD4(pos), NK1.1(pos) T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3 Journal of Experimental Medicine 1994 179 4 1285 1295
14. Arase H., Arase N., Kobayashi Y., Nishimura Y., Yonehara S., Onoe K., Cytotoxicity of fresh NK1.1+ T cell receptor / + thymocytes against a CD4+8+ thymocyte population associated with intact Fas antigen expression on the target Journal of Experimental Medicine 1994 180 2 423 432
15. Smyth M. J., Thia K. Y. T., Street S. E. A., Cretney E., Trapani J. A., Taniguchi M., Kawano T., Pelikan S. B., Crowe N. Y., Godfrey D. I., Differential tumor surveillance by natural killer (NK) and NKT cells Journal of Experimental Medicine 2000 191 4 661 668
16. Skld M., Behar S. M., Role of CD1D-restricted NKT cells in microbial immunity Infection and Immunity 2003 71 10 5447 5455
17. Angus D. C., Linde-Zwirble W. T., Lidicker J., Clermont G., Carcillo J., Pinsky M. R., Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care Critical Care Medicine 2001 29 7 1303 1310
18. Riedemann N. C., Guo R.-F., Ward P. A., Novel strategies for the treatment of sepsis Nature Medicine 2003 9 5 517 524
19. Ogasawara K., Takeda K., Hashimoto W., Satoh M., Okuyama R., Yanai N., Obinata M., Kumagai K., Takada H., Hiraide H., Seki S., Involvement of NK1+ T cells and their IFN- production in the generalized Shwartzman reaction Journal of Immunology 1998 160 7 3522 3527
20. Dieli F., Sireci G., Russo D., Taniguchi M., Ivanyi J., Fernandez C., Troye-Blomberg M., De Leo G., Salerno A., Resistance of natural killer T cell-deficient mice to systemic Shwartzman reaction Journal of Experimental Medicine 2000 192 11 1645 1651
21. Hermans I. F., Silk J. D., Gileadi U., Salio M., Mathew B., Ritter G., Schmidt R., Harris A. L., Old L., Cerundolo V., NKT cells enhance CD4+ and CD8+ T cell responses to soluble antigen in vivo through direct interaction with dendritic cells Journal of Immunology 2003 171 10 5140 5147
22. Hu C. K., Venet F., Heffernan D. S., Wang Y. L., Horner B., Huang X., Chung C. S., Gregory S. H., Ayala A., The role of hepatic invariant NKT cells in systemic/local inflammation and mortality during polymicrobial septic shock Journal of Immunology 2009 182 4 2467 2475
23. Nagarajan N. A., Kronenberg M., Invariant NKT cells amplify the innate immune response to lipopolysaccharide Journal of Immunology 2007 178 5 2706 2713
24. Wichterman K. A., Baue A. E., Chaudry I. H., Sepsis and septic shock: a review of laboratory models and a proposal Journal of Surgical Research 1980 29 2 189 201
25. Hubbard W. J., Choudhry M., Schwacha M. G., Kerby J. D., Rue L. W. III, Bland K. I., Chaudry I. H., Cecal ligation and puncture Shock 2005 24 supplement 1 52 57
26. Sherwood E. R., Lin C. Y., Tao W., Hartmann C. A., Dujon J. E., French A. J., Varma T. K., 2 microglobulin knockout mice are resistant to lethal intraabdominal sepsis American Journal of Respiratory and Critical Care Medicine 2003 167 12 1641 1649
27. Sweet M. J., Hume D. A., Endotoxin signal transduction in macrophages Journal of Leukocyte Biology 1996 60 1 8 26
28. Chow J. C., Young D. W., Golenbock D. T., Christ W. J., Gusovsky F., Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction Journal of Biological Chemistry 1999 274 16 10689 10692
29. Opal S. M., Scannon P. J., Vincent J.-L., White M., Carroll S. F., Palardy J. E., Parejo N. A., Pribble J. P., Lemke J. H., Relationship between plasma levels of lipopolysaccharide (LPS) and LPS- binding protein in patients with severe sepsis and septic shock Journal of Infectious Diseases 1999 180 5 1584 1589
30. Qureshi S. T., Larivire L., Leveque G., Clermont S., Moore K. J., Gros P., Malo D., Endotoxin-tolerant mice have mutations in toll-like receptor 4 (Tlr4) Journal of Experimental Medicine 1999 189 4 615 625
31. Yang R.-B., Mark M. R., Gray A., Huang A., Xie M. H., Zhang M., Goddard A., Wood W. I., Gurney A. L., Godowski P. J., Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling Nature 1998 395 6699 284 288
32. Suffredini A. F., Fromm R. E., Parker M. M., Brenner M., Kovacs J. A., Wesley R. A., Parrillo J. E., The cardiovascular response of normal humans to the administration of endotoxin New England Journal of Medicine 1989 321 5 280 287
33. Taveira da Silva A. M., Kaulbach H. C., Chuidian F. S., Lambert D. R., Suffredini A. F., Danner R. L., Brief report: shock and multiple-organ dysfunction after self- administration of salmonella endotoxin New England Journal of Medicine 1993 328 20 1457 1460
34. Billiau A., Gamma-interferon: the match that lights the fire? Immunology Today 1988 9 2 37 40
35. Ozmen L., Pericin M., Hakimi J., Chizzonite R. A., Wysocka M., Trinchieri G., Gately M., Garotta G., Interleukin 12, interferon, and tumor necrosis factor are the key cytokines of the generalized Shwartzman reaction Journal of Experimental Medicine 1994 180 3 907 915
36. Wysocka M., Kubin M., Vieira L. Q., Ozmen L., Garotta G., Scott P., Trinchieri G., Interleukin-12 is required for interferon- production and lethality in lipopolysaccharide-induced shock in mice European Journal of Immunology 1995 25 3 672 676
37. Kawamura T., Takeda K., Mendiratta S. K., Kawamura H., Van Kaer L., Yagita H., Abo T., Okumura K., Cutting edge: critical role of NK1+ T cells in IL-12-induced immune responses in vivo Journal of Immunology 1998 160 1 16 19
38. Takahashi M., Ogasawara K., Takeda K., Hashimoto W., Sakihara H., Kumagai K., Anzai R., Satoh M., Seki S., LPS induces NK1.1+ T cells with potent cytotoxicity in the liver of mice via production of IL-12 from Kupffer cells Journal of Immunology 1996 156 7 2436 2442
39. Ito H., Koide N., Hassan F., Islam S., Tumurkhuu G., Mori I., Yoshida T., Kakumu S., Moriwaki H., Yokochi T., Lethal endotoxic shock using -galactosylceramide sensitization as a new experimental model of septic shock Laboratory Investigation 2006 86 3 254 261
40. Burdin N., Brossay L., Kronenberg M., Immunization with -galactosylceramide polarizes CD1-reactive NK T cells towards Th2 cytokine synthesis European Journal of Immunology 1999 29 6 2014 2025
41. Singh N., Hong S., Scherer D. C., Serizawa I., Burdin N., Kronenberg M., Koezuka Y., Van Kaer L., Cutting edge: activation of NK T cells by CD1d and -galactosylceramide directs conventional T cells to the acquisition of a Th2 phenotype Journal of Immunology 1999 163 5 2373 2377
42. Fujii S.-I., Shimizu K., Smith C., Bonifaz L., Steinman R. M., Activation of natural killer T cells by -galactosylceramide rapidly induces the full maturation of dendritic cells in vivo and thereby acts as an adjuvant for combined CD4 and CD8 T cell immunity to a coadministered protein Journal of Experimental Medicine 2003 198 2 267 279
43. Gonzalez-Aseguinolaza G., Van Kaer L., Bergmann C. C., Wilson J. M., Schmieg J., Kronenberg M., Nakayama T., Taniguchi M., Koezuka Y., Tsuji M., Natural killer T cell ligand -galactosylceramide enhances protective immunity induced by malaria vaccines Journal of Experimental Medicine 2002 195 5 617 624
44. Fujii S.-I., Shimizu K., Kronenberg M., Steinman R. M., Prolonged IFN- -producing NKT response induced with -galactosylceramide-loaded DCs Nature Immunology 2002 3 9 867 874
45. Parekh V. V., Wilson M. T., Olivares-Villagmez D., Singh A. K., Wu L., Wang C.-R., Joyce S., Van Kaer L., Glycolipid antigen induces long-term natural killer T cell anergy in mice Journal of Clinical Investigation 2005 115 9 2572 2583
46. Sireci G., La Manna M. P., Di Liberto D., Lo Dico M., Taniguchi M., Dieli F., Salerno A., Prophylaxis of lipopolysaccharide-induced shock by -galactosylceramide Journal of Leukocyte Biology 2008 84 2 550 560
47. Sireci G., La Manna M. P., Di Sano C., Di Liberto D., Porcelli S. A., Kronenberg M., Dieli F., Salerno A., Pivotal advance: -galactosylceramide induces protection against lipopolysaccharide-induced shock Journal of Leukocyte Biology 2007 81 3 607 622
48. Yu K. O. A., Porcelli S. A., The diverse functions of CD1d-restricted NKT cells and their potential for immunotherapy Immunology Letters 2005 100 1 42 55
49. Lisbonne M., Diem S., De Castro Keller A., Lefort J., Araujo L. M., Hachem P., Fourneau J.-M., Sidobre S., Kronenberg M., Taniguchi M., Van Endert P., Dy M., Askenase P., Russo M., Vargaftig B. B., Herbelin A., Leite-de-Moraes M. C., Cutting edge: invariant V 14 NKT cells are required for allergen-induced airway inflammation and hyperreactivity in an experimental asthma model Journal of Immunology 2003 171 4 1637 1641
50. Teng M. W., Yue S., Sharkey J., Exley M. A., Smyth M. J., CD1d activation and blockade: a new antitumor strategy Journal of Immunology 2009 182 6 3366 3371
51. Zeng D., Liu Y., Sidobre S., Kronenberg M., Strober S., Activation of natural killer T cells in NZB/W mice induces Th1-type immune responses exacerbating lupus Journal of Clinical Investigation 2003 112 8 1211 1222
52. Rhee R. J., Carlton S., Lomas J. L., Lane C., Brossay L., Cioffi W. G., Ayala A., Inhibition of CD1d activation suppresses septic mortality: a role for NK-T cells in septic immune dysfunction Journal of Surgical Research 2003 115 1 74 81
53. Yue S. C., Nowak M., Shaulov-Kask A., Wang R., Yue D., Balk S. P., Exley M. A., Direct CD1d-mediated stimulation of APC IL-12 production and protective immune response to virus infection in vivo Journal of Immunology 2010 184 1 268 276
54. Kinjo Y., Wu D., Kim G., Xing G.-W., Poles M. A., Ho D. D., Tsuji M., Kawahara K., Wong C.-H., Kronenberg M., Recognition of bacterial glycosphingolipids by natural killer T cells Nature 2005 434 7032 520 525
55. Mattner J., DeBord K. L., Ismail N., Goff R. D., Cantu C. III, Zhou D., Saint-Mezard P., Wang V., Gao Y., Yin N., Hoebe K., Schneewind O., Walker D., Beutler B., Teyton L., Savage P. B., Bendelac A., Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections Nature 2005 434 7032 525 529
56. Sriram V., Du W., Gervay-Hague J., Brutkiewicz R. R., Cell wall glycosphingolipids of Sphingomonas paucimobilis are CD1d-specific ligands for NKT cells European Journal of Immunology 2005 35 6 1692 1701
57. Brigl M., Bry L., Kent S. C., Gumperz J. E., Brenner M. B., Mechanism of CD1d-restricted natural killer T cell activation during microbial infection Nature Immunology 2003 4 12 1230 1237
58. Taniguchi M., Seino K.-I., Nakayama T., The NKT cell system: bridging innate and acquired immunity Nature Immunology 2003 4 12 1164 1165
59. Etogo A. O., Nunez J., Lin C. Y., Toliver-Kinsky T. E., Sherwood E. R., NK but not CD1-restricted NKT cells facilitate systemic inflammation during polymicrobial intra-abdominal sepsis Journal of Immunology 2008 180 9 6334 6345
60. Emoto M., Miyamoto M., Yoshizawa I., Emoto Y., Schaible U. E., Kita E., Kaufmann S. H. E., Critical role of NK cells rather than V 14+NKT cells in lipopolysaccharide-induced lethal shock in mice Journal of Immunology 2002 169 3 1426 1432
61. Carnaud C., Lee D., Donnars O., Park S.-H., Beavis A., Koezuka Y., Bendelac A., Cutting edge: cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells Journal of Immunology 1999 163 9 4647 4650
62. Banerjee S., Bhaduri J. N., Serum protein-bound carbohydrates and lipids in cholera Proceedings of the Society for Experimental Biology and Medicine 1959 101 2 340 341
63. Gallin J. I., Kaye D., O'Leary W. M., Serum lipids in infection New England Journal of Medicine 1969 281 20 1081 1086
64. Samra J. S., Summers L. K. M., Frayn K. N., Sepsis and fat metabolism British Journal of Surgery 1996 83 9 1186 1196
65. Ulevitch R. J., Johnston A. R., The modification of biophysical and endotoxic properties of bacterial lipopolysaccharides by serum Journal of Clinical Investigation 1978 62 6 1313 1324
66. Ulevitch R. J., Johnston A. R., Weinstein D. B., New function for high density lipoproteins. Their participation in intravascular reactions of bacterial lipopolysaccharides Journal of Clinical Investigation 1979 64 5 1516 1524
67. Ulevitch R. J., Johnston A. R., Weinstein D. B., New function for high density lipoproteins. Isolation and characterization of a bacterial lipopolysaccharide-high density lipoprotein complex formed in rabbit plasma Journal of Clinical Investigation 1981 67 3 827 837
68. Eichbaum E. B., Harris H. W., Kane J. P., Rapp J. H., Chylomicrons can inhibit endotoxin activity in vitro Journal of Surgical Research 1991 51 5 413 416
69. Harris H. W., Eichbaum E. B., Kane J. P., Rapp J. H., Detection of endotoxin in triglyceride-rich lipoproteins in vitro Journal of Laboratory and Clinical Medicine 1991 118 2 186 193
70. Harris H. W., Grunfeld C., Feingold K. R., Rapp J. H., Human very low density lipoproteins and chylomicrons can protect against endotoxin-induced death in mice Journal of Clinical Investigation 1990 86 3 696 702
71. Feingold K. R., Funk J. L., Moser A. H., Shigenaga J. K., Rapp J. H., Grunfeld C., Role for circulating lipoproteins in protection from endotoxin toxicity Infection and Immunity 1995 63 5 2041 2046
72. Read T. E., Grunfeld C., Kumwenda Z., Calhoun M. C., Kane J. P., Feingold K. R., Rapp J. H., Triglyceride-rich lipoproteins improve survival when given after endotoxin in rats Surgery 1995 117 1 62 67
73. Read T. E., Grunfeld C., Kumwenda Z. L., Calhoun M. C., Kane J. P., Feingold K. R., Rapp J. H., Triglyceride-rich lipoproteins prevent septic death in rats Journal of Experimental Medicine 1995 182 1 267 272
74. Casas A. T., Hubsch A. P., Doran J. E., Effects of reconstituted high-density lipoprotein in persistent gram-negative bacteremia American Surgeon 1996 62 5 350 355
75. Cue J. I., DiPiro J. T., Brunner L. J., Doran J. E., Blankenship M. E., Mansberger J. R., Hawkins M. L., Peck M., Reconstituted high density lipoprotein inhibits physiologic and tumor necrosis factor responses to lipopolysaccharide in rabbits Archives of Surgery 1994 129 2 193 197
76. Hubsch A. P., Powell F. S., Lerch P. G., Doran J. E., A reconstituted, apolipoprotein A-I containing lipoprotein reduces tumor necrosis factor release and attenuates shock in endotoxemic rabbits Circulatory Shock 1993 40 1 14 23
77. Pajkrt D., Doran J. E., Koster F., Lerch P. G., Arnet B., Van Der Poll T., Ten Cate J. W., Van Deventer S. J. H., Antiinflammatory effects of reconstituted high-density lipoprotein during human endotoxemia Journal of Experimental Medicine 1996 184 5 1601 1608
78. Parker T. S., Levine D. M., Chang J. C. C., Laxer J., Coffin C. C., Rubin A. L., Reconstituted high-density lipoprotein neutralizes gram-negative bacterial lipopolysaccharides in human whole blood Infection and Immunity 1995 63 1 253 258
79. Rensen P. C. N., Van Oosten M., De Van Bilt E., Van Eck M., Kuiper J., Van Berkel T. J. C., Human recombinant apolipoprotein E redirects lipopolysaccharide from Kupffer cells to liver parenchymal cells in rats in vivo Journal of Clinical Investigation 1997 99 10 2438 2445
80. Levine D. M., Parker T. S., Donnelly T. M., Walsh A., Rubin A. L., In vivo protection against endotoxin by plasma high density lipoprotein Proceedings of the National Academy of Sciences of the United States of America 1993 90 24 12040 12044
81. Harris H. W., Rockey D. C., Young D. M., Welch W. J., Diet-induced protection against lipopolysaccharide includes increased hepatic NO production Journal of Surgical Research 1999 82 2 339 345
82. Liberopoulos E., Siamopoulos K., Elisaf M., Apolipoprotein E and renal disease American Journal of Kidney Diseases 2004 43 2 223 233
83. Mahley R. W., Rall S. C. Jr., Apolipoprotein E: far more than a lipid transport protein Annual Review of Genomics and Human Genetics 2000 1 2000 507 537
84. Moore R. J., Chamberlain R. M., Khuri F. R., Apolipoprotein E and the risk of breast cancer in African-American and non-Hispanic white women: a review Oncology 2004 66 2 79 93
85. Rensen P., Van Oosten M., Van Amersfoort E., Apolipoprotein E is increased by bacterial LPS in vivo and protects against LPS-induced lethality Circulation 1998 98 supplement 1 305
86. De Bont N., Netea M. G., Demacker P. N. M., Verschueren I., Kullberg B. J., Van Dijk K. W., Van Der Meer J. W. M., Stalenhoef A. F. H., Apolipoprotein E knock-out mice are highly susceptible to endotoxemia and Klebsiella pneumoniae infection Journal of Lipid Research 1999 40 4 680 685
87. Van Oosten M., Rensen P. C. N., Van Amersfoort E. S., Van Eck M., Van Dam A.-M., Brev J. J. P., Vogel T., Panet A., Van Berkel T. J. C., Kuiper J., Apolipoprotein E protects against bacterial lipopolysaccharide-induced lethality: a new therapeutic approach to treat gram-negative sepsis Journal of Biological Chemistry 2001 276 12 8820 8824
88. Kattan O. M., Kasravi F. B., Elford E. L., Schell M. T., Harris H. W., Apolipoprotein E-mediated immune regulation in sepsis Journal of Immunology 2008 181 2 1399 1408
89. Van Den Elzen P., Garg S., Len L., Brigl M., Leadbetter E. A., Gumperz J. E., Dascher C. C., Cheng T.-Y., Sacks F. M., Illarionov P. A., Besra G. S., Kent S. C., Moody D. B., Brenner M. B., Apolipoprotein-mediated pathways of lipid antigen presentation Nature 2005 437 7060 906 910
90. Raffa R. L., Weisgraber K. H., Hypomorphic apolipoprotein E mice. A new model of conditional gene repair to examine apolipoprotein E-mediated metabolism Journal of Biological Chemistry 2002 277 13 11064 11068
91. Harris H. W., Apolipoprotein E: from Alzheimer's to sepsis Critical Care Medicine 2005 33 11 2696 2697
92. Moretti E. W., Morris R. W., Podgoreanu M., Schwinn D. A., Newman M. F., Bennett E., Moulin V. G., Mba U. U., Laskowitz D. T., APOE polymorphism is associated with risk of severe sepsis in surgical patients Critical Care Medicine 2005 33 11 2521 2526
93. Lynch J. R., Tang W., Wang H., Vitek M. P., Bennett E. R., Sullivan P. M., Warner D. S., Laskowitz D. T., APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response Journal of Biological Chemistry 2003 278 49 48529 48533
94. Wang H., Christensen D. J., Vitek M. P., Sulivan P. M., Laskowitz D. T., APOE genotype affects outcome in a murine model of sepsis: implications for a new treatment strategy Anaesthesia and Intensive Care 2009 37 1 38 45
95. Dong J., Peters-Libeu C. A., Weisgraber K. H., Segelke B. W., Rupp B., Capila I., Herniz M. J., LeBrun L. A., Linhardt R. J., Interaction of the N-terminal domain of apolipoprotein E4 with heparin Biochemistry 2001 40 9 2826 2834
96. Chuang K., Elford E. L., Tseng J., Leung B., Harris H. W., An expanding role for apolipoprotein E in sepsis and inflammation American Journal of Surgery 2010 200 3 391 397
97. Fujii S.-I., Exploiting dendritic cells and natural killer T cells in immunotherapy against malignancies Trends in Immunology 2008 29 5 242 249
98. Vincent J.-L., Sun Q., Dubois M.-J., Clinical trials of immunomodulatory therapies in severe sepsis and septic shock Clinical Infectious Diseases 2002 34 8 1084 1093