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Volumn 204, Issue 13, 2007, Pages 3247-3256

Chromosomal position of a VH gene segment determines its activation and inactivation as a substrate for V(D)J recombination

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHROMOSOME POSITIONING; CONTROLLED STUDY; DNA SEQUENCE; GENE; GENE CLUSTER; GENE LOCUS; GENE TARGETING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; THYMOCYTE; VH GENE; ANIMAL; B LYMPHOCYTE; BIOLOGICAL MODEL; CELL LINEAGE; CHROMOSOME; CHROMOSOME MAP; GENE REARRANGEMENT; GENETICS; IMMUNOGLOBULIN GENE; METABOLISM; SIGNAL TRANSDUCTION; THYMUS; TRANSGENIC MOUSE;

EID: 37549065849     PISSN: 00221007     EISSN: 00221007     Source Type: Journal    
DOI: 10.1084/jem.20071787     Document Type: Article
Times cited : (28)

References (48)
  • 1
    • 0034969086 scopus 로고    scopus 로고
    • Factors and forces controlling V(D)J recombination
    • Hesslein, D.G., and D.G. Schatz. 2001. Factors and forces controlling V(D)J recombination. Adv. Immunol. 78:169-232.
    • (2001) Adv. Immunol , vol.78 , pp. 169-232
    • Hesslein, D.G.1    Schatz, D.G.2
  • 2
    • 0037625160 scopus 로고    scopus 로고
    • Gene segment selection in V(D)J recombination: Accessibility and beyond
    • Krangel, M.S. 2003. Gene segment selection in V(D)J recombination: accessibility and beyond. Nat. Immunol. 4:624-630.
    • (2003) Nat. Immunol , vol.4 , pp. 624-630
    • Krangel, M.S.1
  • 3
    • 33646181086 scopus 로고    scopus 로고
    • Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus
    • Jung, D., C. Giallourakis, R. Mostoslavsky, and F.W. Alt. 2006. Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus. Annu. Rev. Immunol. 24:541-570.
    • (2006) Annu. Rev. Immunol , vol.24 , pp. 541-570
    • Jung, D.1    Giallourakis, C.2    Mostoslavsky, R.3    Alt, F.W.4
  • 5
    • 0027305425 scopus 로고
    • Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the JH locus
    • Chen, J., M. Trounstine, F.W. Alt, F. Young, C. Kurahara, J.F. Loring, and D. Huszar. 1993. Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the JH locus. Int. Immunol. 5:647-656.
    • (1993) Int. Immunol , vol.5 , pp. 647-656
    • Chen, J.1    Trounstine, M.2    Alt, F.W.3    Young, F.4    Kurahara, C.5    Loring, J.F.6    Huszar, D.7
  • 8
    • 0026534145 scopus 로고
    • Chromosomal position of rearranging gene segments influences allelic exclusion in transgenic mice
    • Costa, T.E., H. Suh, and M.C. Nussenzweig. 1992. Chromosomal position of rearranging gene segments influences allelic exclusion in transgenic mice. Proc. Natl. Acad. Sci. USA. 89:2205-2208.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 2205-2208
    • Costa, T.E.1    Suh, H.2    Nussenzweig, M.C.3
  • 9
    • 0031038031 scopus 로고    scopus 로고
    • Essential functions of Pax5 (BSAP) in pro-B cell development: Difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus
    • Nutt, S.L., P. Urbanek, A. Rolink, and M. Busslinger. 1997. Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus. Genes Dev. 11:476-491.
    • (1997) Genes Dev , vol.11 , pp. 476-491
    • Nutt, S.L.1    Urbanek, P.2    Rolink, A.3    Busslinger, M.4
  • 10
    • 0037229028 scopus 로고    scopus 로고
    • Pax5 is required for recombination of transcribed, acetylated, 5′ IgH V gene segments
    • Hesslein, D.G., D.L. Pflugh, D. Chowdhury, A.L. Bothwell, R. Sen, and D.G. Schatz. 2003. Pax5 is required for recombination of transcribed, acetylated, 5′ IgH V gene segments. Genes Dev. 17:37-42.
    • (2003) Genes Dev , vol.17 , pp. 37-42
    • Hesslein, D.G.1    Pflugh, D.L.2    Chowdhury, D.3    Bothwell, A.L.4    Sen, R.5    Schatz, D.G.6
  • 12
    • 0032567938 scopus 로고    scopus 로고
    • Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor
    • Corcoran, A.E., A. Riddell, D. Krooshoop, and A.R. Venkitaraman. 1998. Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor. Nature. 391:904-907.
    • (1998) Nature , vol.391 , pp. 904-907
    • Corcoran, A.E.1    Riddell, A.2    Krooshoop, D.3    Venkitaraman, A.R.4
  • 13
    • 0035890244 scopus 로고    scopus 로고
    • Stepwise activation of the immunoglobulin mu heavy chain gene locus
    • Chowdhury, D., and R. Sen. 2001. Stepwise activation of the immunoglobulin mu heavy chain gene locus. EMBO J. 20:6394-6403.
    • (2001) EMBO J , vol.20 , pp. 6394-6403
    • Chowdhury, D.1    Sen, R.2
  • 14
    • 1542343974 scopus 로고    scopus 로고
    • Pax5 induces V-to-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene
    • Fuxa, M., J. Skok, A. Souabni, G. Salvagiotto, E. Roldan, and M. Busslinger. 2004. Pax5 induces V-to-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene. Genes Dev. 18:411-422.
    • (2004) Genes Dev , vol.18 , pp. 411-422
    • Fuxa, M.1    Skok, J.2    Souabni, A.3    Salvagiotto, G.4    Roldan, E.5    Busslinger, M.6
  • 15
    • 13244275244 scopus 로고    scopus 로고
    • Visualization of looping involving the immunoglobulin heavy-chain locus in developing B cells
    • Sayegh, C., S. Jhunjhunwala, R. Riblet, and C. Murre. 2005. Visualization of looping involving the immunoglobulin heavy-chain locus in developing B cells. Genes Dev. 19:322-327.
    • (2005) Genes Dev , vol.19 , pp. 322-327
    • Sayegh, C.1    Jhunjhunwala, S.2    Riblet, R.3    Murre, C.4
  • 16
    • 12344270023 scopus 로고    scopus 로고
    • Locus " decontraction" and centromeric recruitment contribute to allelic exclusion of the immunoglobulin heavy-chain gene
    • Roldan, E., M. Fuxa, W. Chong, D. Martinez, M. Novatchkova, M. Busslinger, and J.A. Skok. 2005. Locus " decontraction" and centromeric recruitment contribute to allelic exclusion of the immunoglobulin heavy-chain gene. Nat. Immunol. 6:31-41.
    • (2005) Nat. Immunol , vol.6 , pp. 31-41
    • Roldan, E.1    Fuxa, M.2    Chong, W.3    Martinez, D.4    Novatchkova, M.5    Busslinger, M.6    Skok, J.A.7
  • 17
    • 0037023361 scopus 로고    scopus 로고
    • Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development
    • Kosak, S.T., J.A. Skok, K.L. Medina, R. Riblet, M.M. Le Beau, A.G. Fisher, and H. Singh. 2002. Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development. Science. 296:158-162.
    • (2002) Science , vol.296 , pp. 158-162
    • Kosak, S.T.1    Skok, J.A.2    Medina, K.L.3    Riblet, R.4    Le Beau, M.M.5    Fisher, A.G.6    Singh, H.7
  • 18
    • 14844345051 scopus 로고    scopus 로고
    • Stat5 mediates the IL-7-induced accessibility of a representative D-Distal VH gene
    • Stanton, M.L., and P.H. Brodeur. 2005. Stat5 mediates the IL-7-induced accessibility of a representative D-Distal VH gene. J. Immunol. 174:3164-3168.
    • (2005) J. Immunol , vol.174 , pp. 3164-3168
    • Stanton, M.L.1    Brodeur, P.H.2
  • 20
    • 1642323620 scopus 로고    scopus 로고
    • Pax5 activates immunoglobulin heavy chain V to DJ rearrangement in transgenic thymocytes
    • Hsu, L.Y., H.E. Liang, K. Johnson, C. Kang, and M.S. Schlissel. 2004. Pax5 activates immunoglobulin heavy chain V to DJ rearrangement in transgenic thymocytes. J. Exp. Med. 199:825-830.
    • (2004) J. Exp. Med , vol.199 , pp. 825-830
    • Hsu, L.Y.1    Liang, H.E.2    Johnson, K.3    Kang, C.4    Schlissel, M.S.5
  • 21
    • 0027521610 scopus 로고
    • Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus
    • Chen, J., F. Young, A. Bottaro, V. Stewart, R.K. Smith, and F.W. Alt. 1993. Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus. EMBO J. 12:4635-4645.
    • (1993) EMBO J , vol.12 , pp. 4635-4645
    • Chen, J.1    Young, F.2    Bottaro, A.3    Stewart, V.4    Smith, R.K.5    Alt, F.W.6
  • 22
    • 0027192988 scopus 로고
    • D)J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancer
    • Serwe, M., and F.V. Sablitzky. 1993. (D)J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancer. EMBO J. 12:2321-2327.
    • (1993) EMBO J , vol.12 , pp. 2321-2327
    • Serwe, M.1    Sablitzky, F.V.2
  • 23
    • 32044444420 scopus 로고    scopus 로고
    • Regulation of IgH gene assembly: Role of the intronic enhancer and 5′DQ52 region in targeting DHJH recombination
    • Afshar, R., S. Pierce, D.J. Bolland, A. Corcoran, and E.M. Oltz. 2006. Regulation of IgH gene assembly: role of the intronic enhancer and 5′DQ52 region in targeting DHJH recombination. J. Immunol. 176:2439-2447.
    • (2006) J. Immunol , vol.176 , pp. 2439-2447
    • Afshar, R.1    Pierce, S.2    Bolland, D.J.3    Corcoran, A.4    Oltz, E.M.5
  • 24
    • 0035865342 scopus 로고    scopus 로고
    • Deletion of the DQ52 element within the Ig heavy chain locus leads to a selective reduction in VDJ recombination and altered D gene usage
    • Nitschke, L., J. Kestler, T. Tallone, S. Pelkonen, and J. Pelkonen. 2001. Deletion of the DQ52 element within the Ig heavy chain locus leads to a selective reduction in VDJ recombination and altered D gene usage. J. Immunol. 166:2540-2552.
    • (2001) J. Immunol , vol.166 , pp. 2540-2552
    • Nitschke, L.1    Kestler, J.2    Tallone, T.3    Pelkonen, S.4    Pelkonen, J.5
  • 25
    • 33646071250 scopus 로고    scopus 로고
    • Complete sequence assembly and characterization of the C57BL/6 mouse Ig heavy chain v region
    • Johnston, C.M., A.L. Wood, D.J. Bolland, and A.E. Corcoran. 2006. Complete sequence assembly and characterization of the C57BL/6 mouse Ig heavy chain v region. J. Immunol. 176:4221-4234.
    • (2006) J. Immunol , vol.176 , pp. 4221-4234
    • Johnston, C.M.1    Wood, A.L.2    Bolland, D.J.3    Corcoran, A.E.4
  • 26
    • 0141705373 scopus 로고    scopus 로고
    • Antigen receptor loci poised for V(D)J rearrangement are broadly associated with BRG1 and flanked by peaks of histone H3 dimethylated at lysine 4
    • Morshead, K.B., D.N. Ciccone, S.D. Taverna, C.D. Allis, and M.A. Oettinger. 2003. Antigen receptor loci poised for V(D)J rearrangement are broadly associated with BRG1 and flanked by peaks of histone H3 dimethylated at lysine 4. Proc. Natl. Acad. Sci. USA. 100:11577-11582.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 11577-11582
    • Morshead, K.B.1    Ciccone, D.N.2    Taverna, S.D.3    Allis, C.D.4    Oettinger, M.A.5
  • 27
    • 0027769386 scopus 로고
    • Double-strand signal sequence breaks in V(D)J recombination are blunt, 5′-phosphorylated, RAG-dependent, and cell cycle regulated
    • Schlissel, M., A. Constantinescu, T. Morrow, M. Baxter, and A. Peng. 1993. Double-strand signal sequence breaks in V(D)J recombination are blunt, 5′-phosphorylated, RAG-dependent, and cell cycle regulated. Genes Dev. 7:2520-2532.
    • (1993) Genes Dev , vol.7 , pp. 2520-2532
    • Schlissel, M.1    Constantinescu, A.2    Morrow, T.3    Baxter, M.4    Peng, A.5
  • 28
    • 0035881859 scopus 로고    scopus 로고
    • Distinct control of the frequency and allelic exclusion of the V beta gene rearrangement at the TCR beta locus
    • Sieh, P., and J. Chen. 2001. Distinct control of the frequency and allelic exclusion of the V beta gene rearrangement at the TCR beta locus. J. Immunol. 167:2121-2129.
    • (2001) J. Immunol , vol.167 , pp. 2121-2129
    • Sieh, P.1    Chen, J.2
  • 30
    • 0029819322 scopus 로고    scopus 로고
    • Gene-targeted deletion and replacement mutations of the T-cell receptor beta-chain enhancer: The role of enhancer elements in controlling V(D)J recombination accessibility
    • Bories, J.C., J. Demengeot, L. Davidson, and F.W. Alt. 1996. Gene-targeted deletion and replacement mutations of the T-cell receptor beta-chain enhancer: the role of enhancer elements in controlling V(D)J recombination accessibility. Proc. Natl. Acad. Sci. USA. 93:7871-7876.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 7871-7876
    • Bories, J.C.1    Demengeot, J.2    Davidson, L.3    Alt, F.W.4
  • 32
    • 0034605064 scopus 로고    scopus 로고
    • Chromatin remodeling by the T cell receptor (TCR)-beta gene enhancer during early T cell development: Implications for the control of TCR-beta locus recombination
    • Mathieu, N., W.M. Hempel, S. Spicuglia, C. Verthuy, and P. Ferrier. 2000. Chromatin remodeling by the T cell receptor (TCR)-beta gene enhancer during early T cell development: Implications for the control of TCR-beta locus recombination. J. Exp. Med. 192:625-636.
    • (2000) J. Exp. Med , vol.192 , pp. 625-636
    • Mathieu, N.1    Hempel, W.M.2    Spicuglia, S.3    Verthuy, C.4    Ferrier, P.5
  • 33
    • 0038783581 scopus 로고    scopus 로고
    • Increase of TCR V beta accessibility within E beta regulatory region influences its recombination frequency but not allelic exclusion
    • Senoo, M., L. Wang, D. Suzuki, N. Takeda, Y. Shinkai, and S. Habu. 2003. Increase of TCR V beta accessibility within E beta regulatory region influences its recombination frequency but not allelic exclusion. J. Immunol. 171:829-835.
    • (2003) J. Immunol , vol.171 , pp. 829-835
    • Senoo, M.1    Wang, L.2    Suzuki, D.3    Takeda, N.4    Shinkai, Y.5    Habu, S.6
  • 35
    • 0037332014 scopus 로고    scopus 로고
    • Transient IL-7/IL-7R signaling provides a mechanism for feedback inhibition of immunoglobulin heavy chain gene rearrangements
    • Chowdhury, D., and R. Sen. 2003. Transient IL-7/IL-7R signaling provides a mechanism for feedback inhibition of immunoglobulin heavy chain gene rearrangements. Immunity. 18:229-241.
    • (2003) Immunity , vol.18 , pp. 229-241
    • Chowdhury, D.1    Sen, R.2
  • 36
    • 23944495647 scopus 로고    scopus 로고
    • Regulation of interleukin 7-dependent immunoglobulin heavy-chain variable gene rearrangements by transcription factor STAT5
    • Bertolino, E., K. Reddy, K.L. Medina, E. Parganas, J. Ihle, and H. Singh. 2005. Regulation of interleukin 7-dependent immunoglobulin heavy-chain variable gene rearrangements by transcription factor STAT5. Nat. Immunol. 6:836-843.
    • (2005) Nat. Immunol , vol.6 , pp. 836-843
    • Bertolino, E.1    Reddy, K.2    Medina, K.L.3    Parganas, E.4    Ihle, J.5    Singh, H.6
  • 40
    • 0025924685 scopus 로고
    • Coordination of immunoglobulin DJH transcription and D-to-JH rearrangement by promoter-enhancer approximation
    • Alessandrini, A., and S.V. Desiderio. 1991. Coordination of immunoglobulin DJH transcription and D-to-JH rearrangement by promoter-enhancer approximation. Mol. Cell. Biol. 11:2096-2107.
    • (1991) Mol. Cell. Biol , vol.11 , pp. 2096-2107
    • Alessandrini, A.1    Desiderio, S.V.2
  • 41
    • 0021983551 scopus 로고
    • Developmentally controlled and tissue-specific expression of unrearranged VH gene segments
    • Yancopoulos, G.D., and F.W. Alt. 1985. Developmentally controlled and tissue-specific expression of unrearranged VH gene segments. Cell. 40:271-281.
    • (1985) Cell , vol.40 , pp. 271-281
    • Yancopoulos, G.D.1    Alt, F.W.2
  • 42
    • 0030483542 scopus 로고    scopus 로고
    • Identification of the earliest B lineage stage in mouse bone marrow
    • Li, Y.S., R. Wasserman, K. Hayakawa, and R.R. Hardy. 1996. Identification of the earliest B lineage stage in mouse bone marrow. Immunity. 5:527-535.
    • (1996) Immunity , vol.5 , pp. 527-535
    • Li, Y.S.1    Wasserman, R.2    Hayakawa, K.3    Hardy, R.R.4
  • 43
    • 0027406812 scopus 로고
    • Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes
    • Shinkai, Y., S. Koyasu, K. Nakayama, K.M. Murphy, D.Y. Loh, E.L. Reinherz, and F.W. Alt. 1993. Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes. Science. 259:822-825.
    • (1993) Science , vol.259 , pp. 822-825
    • Shinkai, Y.1    Koyasu, S.2    Nakayama, K.3    Murphy, K.M.4    Loh, D.Y.5    Reinherz, E.L.6    Alt, F.W.7
  • 44
    • 0029119248 scopus 로고
    • Characterization of immature thymocyte lines derived from T-cell receptor or recombination activating gene 1 and p53 double mutant mice
    • Mombaerts, P., C. Terhorst, T. Jacks, S. Tonegawa, and J. Sancho. 1995. Characterization of immature thymocyte lines derived from T-cell receptor or recombination activating gene 1 and p53 double mutant mice. Proc. Natl. Acad. Sci. USA. 92:7420-7424.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 7420-7424
    • Mombaerts, P.1    Terhorst, C.2    Jacks, T.3    Tonegawa, S.4    Sancho, J.5
  • 45
    • 0027997502 scopus 로고
    • Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP
    • Urbanek, P., Z.Q. Wang, I. Fetka, E.F. Wagner, and M. Busslinger. 1994. Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP. Cell. 79:901-912.
    • (1994) Cell , vol.79 , pp. 901-912
    • Urbanek, P.1    Wang, Z.Q.2    Fetka, I.3    Wagner, E.F.4    Busslinger, M.5
  • 46
    • 0034750803 scopus 로고    scopus 로고
    • Matrix attachment region-dependent function of the immunoglobulin mu enhancer involves histone acetylation at a distance without changes in enhancer occupancy
    • Fernandez, L.A., M. Winkler, and R. Grosschedl. 2001. Matrix attachment region-dependent function of the immunoglobulin mu enhancer involves histone acetylation at a distance without changes in enhancer occupancy. Mol. Cell. Biol. 21:196-208.
    • (2001) Mol. Cell. Biol , vol.21 , pp. 196-208
    • Fernandez, L.A.1    Winkler, M.2    Grosschedl, R.3
  • 47
    • 0031019217 scopus 로고    scopus 로고
    • Changes in locus-specific V(D)J recombinase activity induced by immunoglobulin gene products during B cell development
    • Constantinescu, A., and M.S. Schlissel. 1997. Changes in locus-specific V(D)J recombinase activity induced by immunoglobulin gene products during B cell development. J. Exp. Med. 185:609-620.
    • (1997) J. Exp. Med , vol.185 , pp. 609-620
    • Constantinescu, A.1    Schlissel, M.S.2
  • 48
    • 0036850786 scopus 로고    scopus 로고
    • The "dispensable" portion of RAG2 is necessary for efficient V-to-DJ rearrangement during B and T cell development
    • Liang, H.E., L.Y. Hsu, D. Cado, L.G. Cowell, G. Kelsoe, and M.S. Schlissel. 2002. The "dispensable" portion of RAG2 is necessary for efficient V-to-DJ rearrangement during B and T cell development. Immunity. 17:639-651.
    • (2002) Immunity , vol.17 , pp. 639-651
    • Liang, H.E.1    Hsu, L.Y.2    Cado, D.3    Cowell, L.G.4    Kelsoe, G.5    Schlissel, M.S.6


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