Transcriptional upregulation of Nrf2-dependent phase II detoxification genes in the involved epidermis of vitiligo vulgaris

Journal of Investigative Dermatology

Volumn 130, Issue 12, 2010, Pages 2781-2789

  Natarajan, Vivek T ^a   Singh, Archana ^b   Kumar, Avinash A ^b   Sharma, Pankaj ^c   Kar, Hemanta K ^c   Marrot, Laurent ^d   Meunier, Jean Roch ^d   Natarajan, Krishnamurthy ^e   Rani, Rajni ^b   Gokhale, Rajesh S ^a,b,f  

^a CSIR INSTITUTE OF GENOMICS AND INTEGRATIVE BIOLOGY   (India)

^b NATIONAL INSTITUTE OF IMMUNOLOGY   (India)

^c DR RAM MANOHAR LOHIA HOSPITAL   (India)

^d L'Oréal Research and Innovation   (France)

^e JAWAHARLAL NEHRU UNIVERSITY   (India)

^f JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CURCUMIN; GAMMA GLUTAMYLCYSTINE LIGASE; LIGASE; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE QUINONE OXIDASE 1; SANTALOL; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; APOPTOSIS; ARTICLE; CHILD; CLINICAL ARTICLE; CONCENTRATION RESPONSE; DETOXIFICATION; EPIDERMIS; FEMALE; GENE CONTROL; HOMEOSTASIS; HUMAN; HUMAN TISSUE; KERATINOCYTE; MALE; MELANOCYTE; OXIDATIVE STRESS; PRIORITY JOURNAL; PUNCH BIOPSY; TRANSCRIPTION REGULATION; VITILIGO;

EID: 78149466029     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2010.201     Document Type: Article

References (42)

1. Arican O, Kurutas EB (2008) Oxidative stress in the blood of patients with active localized vitiligo. Acta Dermatovenerol Alp Panonica Adriat 17:12-6
2. Baglole CJ, Sime PJ, Phipps RP (2008) Cigarette smoke-induced expression of heme oxygenase-1 in human lung fibroblasts is regulated by intracellular glutathione. Am J Physiol Lung Cell Mol Physiol 295:L624-36
3. Bickers DR, Athar M (2006) Oxidative stress in the pathogenesis of skin disease. J Invest Dermatol 126:2565-75
4. Brenner M, Hearing VJ (2008) The protective role of melanin against UV damage in human skin. Photochem Photobiol 84:539-49
5. Chung WO, Dale BA (2004) Innate immune response of oral and foreskin keratinocytes: utilization of different signaling pathways by various bacterial species. Infect Immun 72:352-8
6. Dell'anna ML, Picardo M (2006) A review and a new hypothesis for non-immunological pathogenetic mechanisms in vitiligo. Pigment Cell Res 19:406-11
7. Gauthier Y, Cario Andre M, Taieb A (2003) A critical appraisal of vitiligo etiologic theories. Is melanocyte loss a melanocytorrhagy? Pigment Cell Res 16:322-32
8. Gomez-Lechon MJ, O'Connor E, Castell JV et al. (2002) Sensitive markers used to identify compounds that trigger apoptosis in cultured hepato-cytes. Toxicol Sci 65:299-308
9. Gong P, Cederbaum AI (2006) Nrf2 is increased by CYP2E1 in rodent liver and HepG2 cells and protects against oxidative stress caused by CYP2E1. Hepatology 43:144-53
10. Guan CP, Wei XD, Chen HY et al. (2008a) [Abnormal nuclear translocation of nuclear factor-E2 related factor 2 in the lesion of vitiligo]. Zhonghua Yi Xue Za Zhi 88:2403-6
11. Guan CP, Zhou MN, Xu AE et al. (2008b) The susceptibility to vitiligo is associated with NF-E2-related factor2 (Nrf2) gene polymorphisms: a study on Chinese Han population. Exp Dermatol 17:1059-62
12. Ines D, Sonia B, Riadh BM et al. (2006) A comparative study of oxidant-antioxidant status in stable and active vitiligo patients. Arch Dermatol Res 298:147-52
13. Jeong SO, Oh GS, Ha HY et al. (2009) Dimethoxycurcumin, a synthetic curcumin analogue, induces heme oxygenase-1 expression through Nrf2 activation in RAW264.7 macrophages. J Clin Biochem Nutr 44:79-84
14. Kensler TW, Wakabayashi N, Biswal S (2007) Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol 47:89-116
15. Kovacs D, Raffa S, Flori E et al. (2009) Keratinocyte growth factor down-regulates intracellular ROS production induced by UVB. J Dermatol Sci 54:106-13
16. Lateef H, Stevens MJ, Varani J (2004) All-trans-retinoic acid suppresses matrix metalloproteinase activity and increases collagen synthesis in diabetic human skin in organ culture. Am J Pathol 165:167-74
17. Le Poole IC, Luiten RM (2008) Autoimmune etiology of generalized vitiligo. Curr Dir Autoimmun 10:227-43
18. Lei TC, Vieira WD, Hearing VJ (2002) In vitro migration of melanoblasts requires matrix metalloproteinase-2: implications to vitiligo therapy by photochemotherapy. Pigment Cell Res 15:426-32
19. Marrot L, Jones C, Perez P et al. (2008) The significance of Nrf2 pathway in (photo)-oxidative stress response in melanocytes and keratinocytes of the human epidermis. Pigment Cell Melanoma Res 21:79-88
20. Miao W, Hu L, Scrivens PJ et al. (2005) Transcriptional regulation of NF-E2 p45-related factor (NRF2) expression by the aryl hydrocarbon receptor-xenobiotic response element signaling pathway: direct cross-talk between phase I and II drug-metabolizing enzymes. J Biol Chem 280:20340-8
21. Motohashi H, Yamamoto M (2004) Nrf2-Keap1 defines a physiologically important stress response mechanism. Trends Mol Med 10:549-57
22. Namazi MR (2007) Neurogenic dysregulation, oxidative stress, autoimmu-nity, and melanocytorrhagy in vitiligo: can they be interconnected? Pigment Cell Res 20:360-3
23. Nguyen T, Nioi P, Pickett CB (2009) The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J Biol Chem 284:13291-5
24. Numata I, Okuyama R, Memezawa A et al. (2009) Functional expression of heme oxygenase-1 in human differentiated epidermis and its regulation by cytokines. J Invest Dermatol 129:2594-603
25. Passi S, Grandinetti M, Maggio F et al. (1998) Epidermal oxidative stress in vitiligo. Pigment Cell Res 11:81-5
26. Rokos H, Beazley WD, Schallreuter KU (2002) Oxidative stress in vitiligo: photo-oxidation of pterins produces H(2)O(2) and pterin-6-carboxylic acid. Biochem Biophys Res Commun 292:805-11
27. Rushmore TH, King RG, Paulson KE et al. (1990) Regulation of glutathione S-transferase Ya subunit gene expression: identification of a unique xenobiotic-responsive element controlling inducible expression by planar aromatic compounds. Proc Natl Acad Sci USA 87:3826-30
28. Schallreuter KU (1999) Successful treatment of oxidative stress in vitiligo. Skin Pharmacol Appl Skin Physiol 12:132-8
29. Schallreuter KU, Bahadoran P, Picardo M et al. (2008a) Vitiligo pathogenesis: autoimmune disease, genetic defect, excessive reactive oxygen species, calcium imbalance, or what else? Exp Dermatol 17:139-40
30. Schallreuter KU, Gibbons NC, Zothner C et al. (2006) Butyrylcholinesterase is present in the human epidermis and is regulated by H2O2: more evidence for oxidative stress in vitiligo. Biochem Biophys Res Commun 349:931-8
31. Schallreuter KU, Kruger C, Wurfel BA et al. (2008b) From basic research to the bedside: efficacy of topical treatment with pseudocatalase PC-KUS in 71 children with vitiligo. Int J Dermatol 47:743-53
32. Shalbaf M, Gibbons NC, Wood JM et al. (2008) Presence of epidermal allantoin further supports oxidative stress in vitiligo. Exp Dermatol 17:761-70
33. Spencer JD, Gibbons NC, Rokos H et al. (2007) Oxidative stress via hydrogen peroxide affects proopiomelanocortin peptides directly in the epidermis of patients with vitiligo. J Invest Dermatol 127:411-20
34. Spritz RA (2008) The genetics of generalized vitiligo. Curr Dir Autoimmun 10:244-57
35. Tirumalai R, Rajesh Kumar T, Mai KH et al. (2002) Acrolein causes transcriptional induction of phase II genes by activation of Nrf2 in human lung type II epithelial (A549) cells. Toxicol Lett 132:27-36
36. Tobin DJ, Swanson NN, Pittelkow MR et al. (2000) Melanocytes are not absent in lesional skin of long duration vitiligo. J Pathol 191:407-16
37. Wakabayashi N, Itoh K, Wakabayashi J et al. (2003) Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation. Nat Genet 35:238-45
38. Westerhof W, d'Ischia M (2007) Vitiligo puzzle: the pieces fall in place. Pigment Cell Res 20:345-59
39. Yang C, Zhang X, Fan H et al. (2009) Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia. Brain Res 1282:133-41
40. Zhang J, Ohta T, Maruyama A et al. (2006) BRG1 interacts with Nrf2 to selectively mediate HO-1 induction in response to oxidative stress. Mol Cell Biol 26:7942-52
41. Zhou MN, Xu AE, Lu LJ et al. (2008) [Association of single nucleotide polymorphisms of Nrf2 promoter region with susceptibility to vitiligo]. Zhonghua Yi Xue Za Zhi 88:969-72
42. Zou CG, Banerjee R (2005) Homocysteine and redox signaling. Antioxid Redox Signal 7:547-59