메뉴 건너뛰기




Volumn 26, Issue 4-5, 2010, Pages 647-656

Rosuvastatin promotes osteoblast differentiation and regulates SLCO1A1 transporter gene expression in MC3T3-E1 cells

Author keywords

Bone morphogenetic protein 2 (BMP 2); In vitro; Osteoblast differentiation; Solute carrier (SLC) gene family transporter; Statin

Indexed keywords

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; CARRIER PROTEIN; COLLAGEN TYPE 1; LACTATE DEHYDROGENASE; MESSENGER RNA; MONOCARBOXYLATE TRANSPORTER 1; ORGANIC ANION TRANSPORTER; ORGANIC CATION TRANSPORTER; PROTEIN SLC22A8; PROTEIN SLCO1A1; PROTEIN SLCO2B1; ROSUVASTATIN; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG;

EID: 78149431109     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000322332     Document Type: Article
Times cited : (44)

References (52)
  • 1
    • 0031881755 scopus 로고    scopus 로고
    • Hydrophilicity/ lipophilicity: Relevance for the pharmacology and clinical effects of hmg-coa reductase inhibitors
    • Hamelin BA, Turgeon J: Hydrophilicity/ lipophilicity: Relevance for the pharmacology and clinical effects of hmg-coa reductase inhibitors. Trends Pharmacol Sci 1998;19:26-37.
    • (1998) Trends Pharmacol Sci , vol.19 , pp. 26-37
    • Hamelin, B.A.1    Turgeon, J.2
  • 6
    • 0035985804 scopus 로고    scopus 로고
    • The role of statins as potential targets for bone formation
    • Garrett IR, Mundy GR: The role of statins as potential targets for bone formation. Arthritis Res 2002;4:237-240.
    • (2002) Arthritis Res , vol.4 , pp. 237-240
    • Garrett, I.R.1    Mundy, G.R.2
  • 9
    • 36148999845 scopus 로고    scopus 로고
    • A comparison between the effects of hydrophobic and hydrophilic statins on osteoclast function in vitro and ovariec-tomy-induced bone loss in vivo
    • Hughes A, Rogers MJ, Idris AI, Crockett JC: A comparison between the effects of hydrophobic and hydrophilic statins on osteoclast function in vitro and ovariec-tomy-induced bone loss in vivo. Calcif Tissue Int 2007;81:403-413.
    • (2007) Calcif Tissue Int , vol.81 , pp. 403-413
    • Hughes, A.1    Rogers, M.J.2    Idris, A.I.3    Crockett, J.C.4
  • 10
    • 13544250565 scopus 로고    scopus 로고
    • Statins and osteoporosis: A clinical review
    • Gonyeau MJ: Statins and osteoporosis: A clinical review. Pharmacotherapy 2005;25:228-243.
    • (2005) Pharmacotherapy , vol.25 , pp. 228-243
    • Gonyeau, M.J.1
  • 11
    • 29944441329 scopus 로고    scopus 로고
    • Statins and osteoporosis: New role for old drugs
    • Jadhav SB, Jain GK: Statins and osteoporosis: New role for old drugs. J Pharm Pharmacol 2006;58:3-18.
    • (2006) J Pharm Pharmacol , vol.58 , pp. 3-18
    • Jadhav, S.B.1    Jain, G.K.2
  • 12
    • 3242883083 scopus 로고    scopus 로고
    • Osteoporosis requires bone-specific statins
    • Koida M, Fukuyama R, Nakamuta H: Osteoporosis requires bone-specific statins. Curr Pharm Des 2004;10:2605-2613.
    • (2004) Curr Pharm des , vol.10 , pp. 2605-2613
    • Koida, M.1    Fukuyama, R.2    Nakamuta, H.3
  • 13
    • 0035212177 scopus 로고    scopus 로고
    • Statins and their potential for osteoporosis
    • Mundy GR: Statins and their potential for osteoporosis. Bone 2001;29:495-497.
    • (2001) Bone , vol.29 , pp. 495-497
    • Mundy, G.R.1
  • 16
    • 33947508765 scopus 로고    scopus 로고
    • Statin-induced ras activation integrates the phosphatidy-linositol 3-kinase signal to akt and mapk for bone morphogenetic protein-2 expression in osteoblast differentiation
    • Ghosh-Choudhury N, Mandal CC, Choudhury GG: Statin-induced ras activation integrates the phosphatidy-linositol 3-kinase signal to akt and mapk for bone morphogenetic protein-2 expression in osteoblast differentiation. J Biol Chem 2007;282:4983-4993.
    • (2007) J Biol Chem , vol.282 , pp. 4983-4993
    • Ghosh-Choudhury, N.1    Mandal, C.C.2    Choudhury, G.G.3
  • 17
    • 0034805319 scopus 로고    scopus 로고
    • Simvastatin promotes oste-oblast differentiation and mineralization in mc3t3-e1 cells
    • Maeda T, Matsunuma A, Kawane T, Horiuchi N: Simvastatin promotes oste-oblast differentiation and mineralization in mc3t3-e1 cells. Biochem Biophys Res Commun 2001;280:874-877.
    • (2001) Biochem Biophys Res Commun , vol.280 , pp. 874-877
    • Maeda, T.1    Matsunuma, A.2    Kawane, T.3    Horiuchi, N.4
  • 20
    • 0042666802 scopus 로고    scopus 로고
    • Simvastatin induces osteob-lastic differentiation and inhibits adipocytic differentiation in mouse bone marrow stromal cells
    • Song C, Guo Z, Ma Q, Chen Z, Liu Z, Jia H, Dang G: Simvastatin induces osteob-lastic differentiation and inhibits adipocytic differentiation in mouse bone marrow stromal cells. Biochem Biophys Res Commun 2003;308:458-462.
    • (2003) Biochem Biophys Res Commun , vol.308 , pp. 458-462
    • Song, C.1    Guo, Z.2    Ma, Q.3    Chen, Z.4    Liu, Z.5    Jia, H.6    Dang, G.7
  • 22
    • 1642341604 scopus 로고    scopus 로고
    • Simvastatin treatment partially prevents ovariec-tomy-induced bone loss while increasing cortical bone formation
    • Oxlund H, Andreassen TT: Simvastatin treatment partially prevents ovariec-tomy-induced bone loss while increasing cortical bone formation. Bone 2004;34:609-618.
    • (2004) Bone , vol.34 , pp. 609-618
    • Oxlund, H.1    Andreassen, T.T.2
  • 24
    • 13444251203 scopus 로고    scopus 로고
    • Chemical, pharmaco-kinetic and pharmacodynamic properties of statins: An update
    • Schachter M: Chemical, pharmaco-kinetic and pharmacodynamic properties of statins: An update. Fundam Clin Phamacol 2005;19(1):117-125.
    • (2005) Fundam Clin Phamacol , vol.19 , Issue.1 , pp. 117-125
    • Schachter, M.1
  • 25
    • 0026641368 scopus 로고
    • Tissue selectivity of pravastatin sodium lovastatin and simvastatin. The relationship between inhibition of de novo sterol synthesis and active drug concentrations in the liver spleen and testis in rat
    • Koga T, Fukuda K, Shimada Y, Fukami M, Koike H, Tsujita Y: Tissue selectivity of pravastatin sodium, lovastatin and simvastatin. The relationship between inhibition of de novo sterol synthesis and active drug concentrations in the liver, spleen and testis in rat. Eur J Biochem 1992;209:315-319.
    • (1992) Eur J Biochem , vol.209 , pp. 315-319
    • Koga, T.1    Fukuda, K.2    Shimada, Y.3    Fukami, M.4    Koike, H.5    Tsujita, Y.6
  • 27
    • 48149093606 scopus 로고    scopus 로고
    • Involvement of organic anion transporting polypeptides in the toxicity of hy-drophilic pravastatin and lipophilic fluvastatin in rat skeletal myofibres
    • Sakamoto K, Mikami H, Kimura J: Involvement of organic anion transporting polypeptides in the toxicity of hy-drophilic pravastatin and lipophilic fluvastatin in rat skeletal myofibres. Br J Pharmacol 2008;154:1482-1490.
    • (2008) Br J Pharmacol , vol.154 , pp. 1482-1490
    • Sakamoto, K.1    Mikami, H.2    Kimura, J.3
  • 28
    • 33646536542 scopus 로고    scopus 로고
    • Drug and bile acid transporters in rosuvastatin hepatic uptake: Function, expression, and pharmacogenetics
    • Ho RH, Tirona RG, Leake BF, Glaeser H, Lee W, Lemke CJ, Wang Y, Kim RB: Drug and bile acid transporters in rosuvastatin hepatic uptake: Function, expression, and pharmacogenetics. Gas-troenterology 2006;130:1793-1806.
    • (2006) Gas-troenterology , vol.130 , pp. 1793-1806
    • Ho, R.H.1    Tirona, R.G.2    Leake, B.F.3    Glaeser, H.4    Lee, W.5    Lemke, C.J.6    Wang, Y.7    Kim, R.B.8
  • 30
    • 0036175127 scopus 로고    scopus 로고
    • Functional involvement of rat organic anion transporter 3 (roat3; Slc22a8) in the renal uptake of organic anions
    • Hasegawa M, Kusuhara H, Sugiyama D, Ito K, Ueda S, Endou H, Sugiyama Y: Functional involvement of rat organic anion transporter 3 (roat3; slc22a8) in the renal uptake of organic anions. J Pharmacol Exp Ther 2002;300:746-753.
    • (2002) J Pharmacol Exp Ther , vol.300 , pp. 746-753
    • Hasegawa, M.1    Kusuhara, H.2    Sugiyama, D.3    Ito, K.4    Ueda, S.5    Endou, H.6    Sugiyama, Y.7
  • 32
    • 53749107434 scopus 로고    scopus 로고
    • Overview of the proton-coupled mct (slc16a) family of transporters: Characterization, function and role in the transport of the drug of abuse gamma-hydroxybutyric acid
    • Morris ME, Felmlee MA: Overview of the proton-coupled mct (slc16a) family of transporters: Characterization, function and role in the transport of the drug of abuse gamma-hydroxybutyric acid. AAPS J 2008;10:311-321.
    • (2008) AAPS J , vol.10 , pp. 311-321
    • Morris, M.E.1    Felmlee, M.A.2
  • 33
    • 22344452137 scopus 로고    scopus 로고
    • Tissue distribution and ontogeny of mouse organic anion transporting polypeptides (oatps)
    • Cheng X, Maher J, Chen C, Klaassen CD: Tissue distribution and ontogeny of mouse organic anion transporting polypeptides (oatps). Drug Metab Dispos 2005;33:1062-1073.
    • (2005) Drug Metab Dispos , vol.33 , pp. 1062-1073
    • Cheng, X.1    Maher, J.2    Chen, C.3    Klaassen, C.D.4
  • 36
    • 33745039765 scopus 로고    scopus 로고
    • Transdermal application of lovastatin to rats causes profound increases in bone formation and plasma concentrations
    • Gutierrez GE, Lalka D, Garrett IR, Rossini G, Mundy GR: Transdermal application of lovastatin to rats causes profound increases in bone formation and plasma concentrations. Osteoporos Int 2006;17:1033-1042.
    • (2006) Osteoporos Int , vol.17 , pp. 1033-1042
    • Gutierrez, G.E.1    Lalka, D.2    Garrett, I.R.3    Rossini, G.4    Mundy, G.R.5
  • 37
    • 3042580179 scopus 로고    scopus 로고
    • Simvastatin promotes osteogenesis around titanium implants
    • Ayukawa Y, Okamura A, Koyano K: Simvastatin promotes osteogenesis around titanium implants. Clin Oral Implants Res 2004;15:346-350.
    • (2004) Clin Oral Implants Res , vol.15 , pp. 346-350
    • Ayukawa, Y.1    Okamura, A.2    Koyano, K.3
  • 38
    • 59649102438 scopus 로고    scopus 로고
    • Local application of statin promotes bone repair through the suppression of osteoclasts and the enhancement of osteoblasts at bone-healing sites in rats
    • Ayukawa Y, Yasukawa E, Moriyama Y, Ogino Y, Wada H, Atsuta I, Koyano K: Local application of statin promotes bone repair through the suppression of osteoclasts and the enhancement of osteoblasts at bone-healing sites in rats. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;107(3):336-42.
    • (2009) Oral Surg Oral Med Oral Pathol Oral Radiol Endod. , vol.107 , Issue.3 , pp. 336-342
    • Ayukawa, Y.1    Yasukawa, E.2    Moriyama, Y.3    Ogino, Y.4    Wada, H.5    Atsuta, I.6    Koyano, K.7
  • 39
    • 76949089977 scopus 로고    scopus 로고
    • In vivo performance of absorbable collagen sponges with rosuvastatin in critical-size cortical bone defects
    • Monjo M, Rubert M, Wohlfahrt JC, Ronold HJ, Ellingsen JE, Lyngstadaas SP: In vivo performance of absorbable collagen sponges with rosuvastatin in critical-size cortical bone defects. Acta Biomater 2010;6:1405-1412.
    • (2010) Acta Biomater , vol.6 , pp. 1405-1412
    • Monjo, M.1    Rubert, M.2    Wohlfahrt, J.C.3    Ronold, H.J.4    Ellingsen, J.E.5    Lyngstadaas, S.P.6
  • 41
    • 34548499895 scopus 로고    scopus 로고
    • Bone formation with the combination of simvastatin and calcium sulfate in critical-sized rat calvarial defect
    • Nyan M, Sato D, Oda M, Machida T, Kobayashi H, Nakamura T, Kasugai S: Bone formation with the combination of simvastatin and calcium sulfate in critical-sized rat calvarial defect. J Pharmacol Sci 2007;104:384-386.
    • (2007) J Pharmacol Sci , vol.104 , pp. 384-386
    • Nyan, M.1    Sato, D.2    Oda, M.3    MacHida, T.4    Kobayashi, H.5    Nakamura, T.6    Kasugai, S.7
  • 44
    • 11844306556 scopus 로고    scopus 로고
    • Early healing pattern of statin-induced osteogenesis
    • Wong RW, Rabie AB: Early healing pattern of statin-induced osteogenesis. Br J Oral Maxillofac Surg 2005;43:46-50.
    • (2005) Br J Oral Maxillofac Surg , vol.43 , pp. 46-50
    • Wong, R.W.1    Rabie, A.B.2
  • 45
    • 35748962429 scopus 로고    scopus 로고
    • The safety of statins in clinical practice
    • Armitage J: The safety of statins in clinical practice. Lancet 2007;370:1781-1790.
    • (2007) Lancet , vol.370 , pp. 1781-1790
    • Armitage, J.1
  • 46
    • 3042794762 scopus 로고    scopus 로고
    • Safety and efficacy of rosuvastatin
    • Olsson GO: Safety and efficacy of rosuvastatin. Lancet 2004;364:135.
    • (2004) Lancet , vol.364 , pp. 135
    • Olsson, G.O.1
  • 49
    • 0033957938 scopus 로고    scopus 로고
    • Statins: Lower lipids and better bones?
    • Rogers MJ: Statins: Lower lipids and better bones? Nat Med 2000;6:21-23.
    • (2000) Nat Med , vol.6 , pp. 21-23
    • Rogers, M.J.1
  • 50
    • 22244460553 scopus 로고    scopus 로고
    • Stimulatory effects of statins on bone marrow-derived mesenchymal stem cells.Study of a new therapeutic agent for fracture
    • Sonobe M, Hattori K, Tomita N, Yoshikawa T, Aoki H, Takakura Y, Suguro T: Stimulatory effects of statins on bone marrow-derived mesenchymal stem cells. Study of a new therapeutic agent for fracture. Biomed Mater Eng 2005;15:261-267.
    • (2005) Biomed Mater Eng , vol.15 , pp. 261-267
    • Sonobe, M.1    Hattori, K.2    Tomita, N.3    Yoshikawa, T.4    Aoki, H.5    Takakura, Y.6    Suguro, T.7
  • 51
    • 34547178337 scopus 로고    scopus 로고
    • Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (oatp) substrates on oatp1b1, oatp2b1, and oatp1b3
    • Noe J, Portmann R, Brun ME, Funk C: Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (oatp) substrates on oatp1b1, oatp2b1, and oatp1b3. Drug Metab Dispos 2007;35:1308-1314.
    • (2007) Drug Metab Dispos , vol.35 , pp. 1308-1314
    • Noe, J.1    Portmann, R.2    Brun, M.E.3    Funk, C.4
  • 52
    • 0037131885 scopus 로고    scopus 로고
    • Pharmacogenomics of organic anion-transporting polype-ptides (oatp)
    • Tirona RG, Kim RB: Pharmacogenomics of organic anion-transporting polype-ptides (oatp). Adv Drug Deliv Rev 2002;54:1343-1352.
    • (2002) Adv Drug Deliv Rev , vol.54 , pp. 1343-1352
    • Tirona, R.G.1    Kim, R.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.