Topical administration of simvastatin recovers alveolar bone loss in rats

Journal of Periodontal Research

Volumn 43, Issue 3, 2008, Pages 261-267

  Seto, H ^a   Ohba, H ^a   Tokunaga, K ^a   Hama, H ^a   Horibe, M ^a   Nagata, T ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Alveolar bone formation; Rat periodontitis; Simvastatin; Topical administration

Indexed keywords

ALKALINE PHOSPHATASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; SIMVASTATIN;

ANIMAL; ARTICLE; BIOSYNTHESIS; BONE REGENERATION; CELL CULTURE; DRUG EFFECT; FISCHER 344 RAT; MALE; OSTEOBLAST; OSTEOLYSIS; PERIODONTITIS; RAT; SKULL; TOMOGRAPHY; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; ALKALINE PHOSPHATASE; ALVEOLAR BONE LOSS; ANIMALS; BONE REGENERATION; CELLS, CULTURED; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; OSTEOBLASTS; PERIODONTITIS; RATS; RATS, INBRED F344; SIMVASTATIN; SKULL; TOMOGRAPHY;

EID: 43049103810     PISSN: 00223484     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0765.2007.01024.x     Document Type: Article

References (28)

1. Pihlstrom BL, Michalowicz BS. Periodontal diseases. Lancet 2005 366 : 1809 1820.
2. Mundy G, Garrett R, Harris S et al. Stimulation of bone formation in vitro and in rodents by statins. Science 1999 286 : 1946 1949.
3. Maeda T, Matsunuma A, Kawane T, Horiuchi N. Simvastatin promotes osteoblast differentiation and mineralization in MC3T3-E1 cells. Biochem Biophys Res Commun 2001 280 : 874 877.
4. Chan KA, Andrade SE, Boles M et al. Inhibitors of hydroxymethylglutaryl- coenzyme A reductase and risk of fracture among older women. Lancet 2000 355 : 2185 2188.
5. Bellows CG, Aubin JE, Heersche JN, Antosz ME. Mineralized bone nodules formed in vitro from enzymatically released rat calvaria cell populations. Calcif Tissue Int 1986 38 : 143 154.
6. Azuma H, Kido J, Ikedo D, Kataoka M, Nagata T. Substance P enhances the inhibition of osteoblastic cell differentiation induced by lipopolysaccharide from Porphyromonas gingivalis. J Periodontol 2004 75 : 974 981.
7. Lowry OH, Roberts NR, Wu ML, Hixon WS, Crawford EJ. The quantitative histochemistry of brain. II. Enzyme measurements. J Biol Chem 1954 207 : 19 37.
8. Ikedo D, Ohishi K, Yamauchi N, Kataoka M, Kido J, Nagata T. Stimulatory effects of phenytoin on osteoblastic differentiation of fetal rat calvaria cells in culture. Bone 1999 25 : 653 660.
9. Villanueva AR, Lundin KD. A versatile new mineralized bone stain for simultaneous assessment of tetracycline and osteoid seams. Stain Technol 1989 64 : 129 138.
10. Lohinai Z, Benedek P, Feher E et al. Protective effects of mercaptoethylguanidine, a selective inhibitor of inducible nitric oxide synthase, in ligature-induced periodontitis in the rat. Br J Pharmacol 1998 123 : 353 360.
11. Di Paola R, Marzocco S, Mazzon E et al. Effect of aminoguanidine in ligature-induced periodontitis in rats. J Dent Res 2004 83 : 343 348.
12. Lima V, Bezerra M, Alencar V et al. Effects of chlorpromazine on alveolar bone loss in experimental periodontal disease in rats. Eur J Oral Sci 2000 108 : 123 129.
13. Bezerra MM, de Lima V, Alencar VB et al. Selective cyclooxygenase-2 inhibition prevents alveolar bone loss in experimental periodontitis in rats. J Periodontol 2000 71 : 1009 1014.
14. Seto H, Toba Y, Takada Y et al. Milk basic protein (MBP) increases alveolar bone formation in rat experimental periodontitis. J Periodont Res 2007 42 : 85 89.
15. Amstad-Jossi M, Schroeder HE. Age-related alterations of periodontal structures around the cemento-enamel junction and of the gingival connective tissue composition in germ-free rats. J Periodont Res 1978 13 : 76 90.
16. Mitsuta T, Horiuchi H, Shinoda H. Effects of topical administration of clodronate on alveolar bone resorption in rats with experimental periodontitis. J Periodontol 2002 73 : 479 486.
17. Goya JA, Paez HA, Mandalunis PM. Effect of topical administration of monosodium olpadronate on experimental periodontitis in rats. J Periodontol 2006 77 : 1 6.
18. Adachi H, Igarashi K, Mitani H, Shinoda H. Effects of topical administration of a bisphosphonate (risedronate) on orthodontic tooth movements in rats. J Dent Res 1994 73 : 1478 1486.
19. Igarashi K, Adachi H, Mitani H, Shinoda H. Inhibitory effect of the topical administration of a bisphosphonate (risedronate) on root resorption incident to orthodontic tooth movement in rats. J Dent Res 1996 75 : 1644 1649.
20. Stein D, Lee Y, Schmid MJ et al. Local simvastatin effects on mandibular bone growth and inflammation. J Periodontol 2005 76 : 1861 1870.
21. Thylin MR, McConnell JC, Schmid MJ et al. Effects of simvastatin gels on murine calvarial bone. J Periodontol 2002 73 : 1141 1148.
22. Oxlund H, Andreassen TT. Simvastatin treatment partially prevents ovariectomy-induced bone loss while increasing cortical bone formation. Bone 2004 34 : 609 618.
23. Staal A, Frith JC, French MH et al. The ability of statins to inhibit bone resorption is directly related to their inhibitory effect on HMG-CoA reductase activity. J Bone Miner Res 2003 18 : 88 96.
24. Ramirez-Yanez GO, Seymour GJ, Walsh LJ, Forwood MR, Symons AL. Prostaglandin E2 enhances alveolar bone formation in the rat mandible. Bone 2004 35 : 1361 1368.
25. Takagi M, Santavirta S, Ida H et al. High-turnover periprosthetic bone remodeling and immature bone formation around loose cemented total hip joints. J Bone Miner Res 2001 16 : 79 88.
26. Petersson U, Somogyi E, Reinholt FP, Karlsson T, Sugars RV, Wendel M. Nucleobindin is produced by bone cells and secreted into the osteoid, with a potential role as a modulator of matrix maturation. Bone 2004 34 : 949 960.
27. Poole KE, van Bezooijen RL, Loveridge N et al. Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation. FASEB J 2005 19 : 1842 1844.
28. Yazawa H, Zimmermann B, Asami Y, Bernimoulin JP. Simvastatin promotes cell metabolism, proliferation, and osteoblastic differentiation in human periodontal ligament cells. J Periodontol 2005 76 : 295 302.