Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors

Nature Structural and Molecular Biology

Volumn 16, Issue 1, 2009, Pages 63-70

  Rothenburg, Stefan ^a   Seo, Eun Joo ^a   Gibbs, James S ^b   Dever, Thomas E ^a   Dittmar, Katharina ^c  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; ENZYME INHIBITOR; PKR ENZYME; PROTEIN KINASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; DRUG SENSITIVITY; HUMAN; HUMAN CELL; MOLECULAR EVOLUTION; MOUSE; NONHUMAN; POXVIRUS; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; DNA, VIRAL; EIF-2 KINASE; EUKARYOTIC INITIATION FACTOR-2; EVOLUTION, MOLECULAR; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHORYLATION; PHYLOGENY; PROTEIN CONFORMATION; RNA, VIRAL; SUBSTRATE SPECIFICITY; VIRAL PROTEINS;

EUKARYOTA; VERTEBRATA;

EID: 58149234074     PISSN: 15459993     EISSN: 15459985     Source Type: Journal    
DOI: 10.1038/nsmb.1529     Document Type: Article

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