Structure-aided drug design's next generation

Nature Biotechnology

Volumn 22, Issue 5, 2004, Pages 513-519

  Thiel, Karl A ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL INDUSTRY; DRUG PRODUCTS; SOCIETIES AND INSTITUTIONS;

BIOINFORMATICS; DRUG DISCOVERY;

CHEMICAL ANALYSIS;

DIPEPTIDYL PEPTIDASE IV;

BIOTECHNOLOGICAL PROCEDURES; COMPUTER AIDED DESIGN; DRUG BINDING; DRUG DESIGN; DRUG RESEARCH; FINANCIAL MANAGEMENT; HIGH THROUGHPUT SCREENING; PRIORITY JOURNAL; PROCESS DESIGN; PROCESS OPTIMIZATION; PROTEIN STRUCTURE; REVIEW; STRUCTURE AIDED DRUG DESIGN; X RAY CRYSTALLOGRAPHY;

COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; DRUG DESIGN; GENOMICS; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 2342517401     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/nbt0504-513     Document Type: Review

References (5)

1. Goldstein, J.L. Remarks at the Awards Ceremony, Albert Lasker Award for Clinical Research, 1999, http://www.laskerfoundation.org/awards/library/1999rem arksgsclin2.shtml
2. Shuker, S.R. et al. Discovering high-affinity ligands for proteins: SAR by NMR. Science 274, 1531-1534 (1996).
3. Palczewski, K. et al. Crystal structure of rhodopsin: a G protein-coupled receptor. Science 289, 739-745 (2000).
4. Levinthal, C. How to fold graciously in Mössbauer Spectroscopy in Biological Systems. Proceedings of a Meeting Held at Allerton House, Monticello, Illinois. (eds. DeBrunner, J.T.P. & Munck, E.) 22-24 (University of Illinois Press, Chicago, IL, USA, 1969).
5. Williams, P. et al. Crystal structure of human cytochrome P450 2C9 with bound warfarin. Nature 424, 464-468 (2003).