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Volumn 5, Issue 9, 2010, Pages

Low levels of physical activity increase metabolic responsiveness to cold in a rat (Rattus fuscipes)

Author keywords

[No Author keywords available]

Indexed keywords

CITRATE SYNTHASE; CYTOCHROME C OXIDASE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; TRANSCRIPTION FACTOR NRF1; UNCOUPLING PROTEIN 1; ION CHANNEL; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN; NRF1 PROTEIN, MOUSE; NUCLEAR RESPIRATORY FACTOR 1;

EID: 77958605757     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0013022     Document Type: Article
Times cited : (40)

References (55)
  • 1
    • 33748947179 scopus 로고    scopus 로고
    • The role of mitochondrial respiration in physiological and evolutionary adaptation
    • Das J (2006) The role of mitochondrial respiration in physiological and evolutionary adaptation. Bioessays 28: 890-901.
    • (2006) Bioessays , vol.28 , pp. 890-901
    • Das, J.1
  • 2
    • 0034611678 scopus 로고    scopus 로고
    • Towards a molecular understanding of adaptive thermogenesis
    • Lowell BB, Spiegelman BM (2000) Towards a molecular understanding of adaptive thermogenesis. Nature 404: 652-660.
    • (2000) Nature , vol.404 , pp. 652-660
    • Lowell, B.B.1    Spiegelman, B.M.2
  • 3
    • 85047700144 scopus 로고    scopus 로고
    • Relationship between juvenile obesity, dietary energy and fat intake and physical activity
    • Gillis LJ, Kennedy LC, Gillis AM, Bar-Or O (2002) Relationship between juvenile obesity, dietary energy and fat intake and physical activity. International J Obesity 26: 458-463.
    • (2002) International J Obesity , vol.26 , pp. 458-463
    • Gillis, L.J.1    Kennedy, L.C.2    Gillis, A.M.3    Bar-Or, O.4
  • 4
    • 67649841598 scopus 로고    scopus 로고
    • Fat storage and the biology of energy expenditure
    • Redinger RN (2009) Fat storage and the biology of energy expenditure. Transl Res 154: 52-60.
    • (2009) Transl Res , vol.154 , pp. 52-60
    • Redinger, R.N.1
  • 5
    • 0018785949 scopus 로고
    • Endothermy and activity in vertebrates
    • Bennett AF, Ruben JA (1979) Endothermy and activity in vertebrates. Science 206: 649-654.
    • (1979) Science , vol.206 , pp. 649-654
    • Bennett, A.F.1    Ruben, J.A.2
  • 6
    • 71249100778 scopus 로고    scopus 로고
    • Lack of adequate appreciation of physical exercise's complexities can pre-emp appropriate design and interpretation in scientific discovery
    • Booth FW, Laye MJ (2009) Lack of adequate appreciation of physical exercise's complexities can pre-emp appropriate design and interpretation in scientific discovery. J Physiol 587: 5527-5540.
    • (2009) J Physiol , vol.587 , pp. 5527-5540
    • Booth, F.W.1    Laye, M.J.2
  • 7
    • 58049195487 scopus 로고    scopus 로고
    • Linking performance and chronic disease risk: Indices of physical performance are surrogates for health
    • Booth FW, Roberts CK (2008) Linking performance and chronic disease risk: indices of physical performance are surrogates for health. Brit J Sport Med 42: 950-952.
    • (2008) Brit J Sport Med , vol.42 , pp. 950-952
    • Booth, F.W.1    Roberts, C.K.2
  • 8
    • 47949104798 scopus 로고    scopus 로고
    • The role of exercise and PGC1 alpha in inflammation and chronic disease
    • Handschin C, Spiegelman BM (2008) The role of exercise and PGC1 alpha in inflammation and chronic disease. Nature 454: 463-469.
    • (2008) Nature , vol.454 , pp. 463-469
    • Handschin, C.1    Spiegelman, B.M.2
  • 9
    • 61849086539 scopus 로고    scopus 로고
    • A changing paradigm for prevention of cardiovascular disease: Emergence of the metabolic syndrome as a multiplex risk factor
    • Grundy SM (2008) A changing paradigm for prevention of cardiovascular disease: emergence of the metabolic syndrome as a multiplex risk factor. Eur Heart J Suppl 10: B16-B23.
    • (2008) Eur Heart J Suppl , vol.10
    • Grundy, S.M.1
  • 10
    • 45549108083 scopus 로고    scopus 로고
    • Reduced physical activity and risk of chronic disease: The biology behind the consequences
    • Booth FW, Laye MJ, Lees SJ, Rector RS, Thyfault JP (2008) Reduced physical activity and risk of chronic disease: the biology behind the consequences. Eur J Appl Physiol 102: 381-390.
    • (2008) Eur J Appl Physiol , vol.102 , pp. 381-390
    • Booth, F.W.1    Laye, M.J.2    Lees, S.J.3    Rector, R.S.4    Thyfault, J.P.5
  • 11
    • 68149137621 scopus 로고    scopus 로고
    • eNOS, metabolic syndrome and cardiovascular disease
    • Huang PL (2009) eNOS, metabolic syndrome and cardiovascular disease. Trends Endocrin Metabol 20: 295-302.
    • (2009) Trends Endocrin Metabol , vol.20 , pp. 295-302
    • Huang, P.L.1
  • 12
    • 0036712032 scopus 로고    scopus 로고
    • Exercise and gene expression: Physiological regulation of the human genome through physical activity
    • Booth FW, Chakravarthy MV, Spangenburg EE (2002) Exercise and gene expression: physiological regulation of the human genome through physical activity. J Physiol 543: 399-411.
    • (2002) J Physiol , vol.543 , pp. 399-411
    • Booth, F.W.1    Chakravarthy, M.V.2    Spangenburg, E.E.3
  • 13
    • 48449094498 scopus 로고    scopus 로고
    • AMPK and PPAR delta agonists are exercise mimetics
    • Narkar VA, Downes M, Yu RT, Embler E, Wang YX, et al. (2008) AMPK and PPAR delta agonists are exercise mimetics. Cell 134: 405-415.
    • (2008) Cell , vol.134 , pp. 405-415
    • Narkar, V.A.1    Downes, M.2    Yu, R.T.3    Embler, E.4    Wang, Y.X.5
  • 14
    • 0347660639 scopus 로고    scopus 로고
    • Controlling muscle mitochondrial content
    • Moyes CD (2003) Controlling muscle mitochondrial content. J Exp Biol 206: 4385-4391.
    • (2003) J Exp Biol , vol.206 , pp. 4385-4391
    • Moyes, C.D.1
  • 15
    • 72649089588 scopus 로고    scopus 로고
    • Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity
    • Hoehn KL, Turner N, Swarbrick MM, Wilks D, Preston E, et al. (2010) Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity. Cell Metabol 11: 70-76.
    • (2010) Cell Metabol , vol.11 , pp. 70-76
    • Hoehn, K.L.1    Turner, N.2    Swarbrick, M.M.3    Wilks, D.4    Preston, E.5
  • 16
    • 0019405046 scopus 로고
    • Influence of mild cold on 24 h energy expenditure, resting metabolism and diet-induced thermogenesis
    • Dauncey MJ (1981) Influence of mild cold on 24 h energy expenditure, resting metabolism and diet-induced thermogenesis. Brit J Nutr 45: 257-267.
    • (1981) Brit J Nutr , vol.45 , pp. 257-267
    • Dauncey, M.J.1
  • 17
    • 42049114034 scopus 로고    scopus 로고
    • Transcriptional paradigms in mammalian mitochondrial biogenesis and function
    • Scarpulla RC (2008) Transcriptional paradigms in mammalian mitochondrial biogenesis and function. Physiol Rev 88: 611-638.
    • (2008) Physiol Rev , vol.88 , pp. 611-638
    • Scarpulla, R.C.1
  • 18
    • 0033538473 scopus 로고    scopus 로고
    • Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
    • Wu ZD, Puigserver P, Andersson U, Zhang CY, Adelmant G, et al. (1999) Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98: 115-124.
    • (1999) Cell , vol.98 , pp. 115-124
    • Wu, Z.D.1    Puigserver, P.2    Andersson, U.3    Zhang, C.Y.4    Adelmant, G.5
  • 19
    • 0032549811 scopus 로고    scopus 로고
    • A coldinducible coactivator of nuclear receptors linked to adaptive thermogenesis
    • Puigserver P, Wu Z, Park CW, Graves R, Wright M, et al. (1998) A coldinducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92: 829-839.
    • (1998) Cell , vol.92 , pp. 829-839
    • Puigserver, P.1    Wu, Z.2    Park, C.W.3    Graves, R.4    Wright, M.5
  • 20
    • 0037326196 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptorgamma coactivator 1 alpha (PGC-1 alpha): Transcriptional coactivator and metabolic regulator
    • Puigserver P, Spiegelman BM (2003) Peroxisome proliferator-activated receptorgamma coactivator 1 alpha (PGC-1 alpha): Transcriptional coactivator and metabolic regulator. Endocr Rev 24: 78-90.
    • (2003) Endocr Rev , vol.24 , pp. 78-90
    • Puigserver, P.1    Spiegelman, B.M.2
  • 21
    • 0036903174 scopus 로고    scopus 로고
    • Adaptations of skeletal muscle to exercise: Rapid increase in the transcriptional coactivator PGC-1
    • Baar K, Wende AR, Jones TE, Marison M, Nolte LA, et al. (2002) Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1. Faseb J 16: 1879-1886.
    • (2002) Faseb J , vol.16 , pp. 1879-1886
    • Baar, K.1    Wende, A.R.2    Jones, T.E.3    Marison, M.4    Nolte, L.A.5
  • 22
    • 0642303113 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor delta controls muscle development and oxydative capability
    • Luquet S, Lopez-Soriano J, Holst D, Fredenrich A, Melki J, et al. (2003) Peroxisome proliferator-activated receptor delta controls muscle development and oxydative capability. Faseb J 17: 2299-2301.
    • (2003) Faseb J , vol.17 , pp. 2299-2301
    • Luquet, S.1    Lopez-Soriano, J.2    Holst, D.3    Fredenrich, A.4    Melki, J.5
  • 23
    • 0037453718 scopus 로고    scopus 로고
    • Peroxisomeproliferator- activated receptor delta activates fat metabolism to prevent obesity
    • Wang YX, Lee CH, Tiep S, Yu RT, Ham JY, et al. (2003) Peroxisomeproliferator- activated receptor delta activates fat metabolism to prevent obesity. Cell 113: 159-170.
    • (2003) Cell , vol.113 , pp. 159-170
    • Wang, Y.X.1    Lee, C.H.2    Tiep, S.3    Yu, R.T.4    Ham, J.Y.5
  • 24
    • 8844276054 scopus 로고    scopus 로고
    • Regulation of muscle fiber type and running endurance by PPAR delta
    • Wang YX, Zhang CL, Yu RT, Cho HK, Nelson MC, et al. (2004) Regulation of muscle fiber type and running endurance by PPAR delta. PLoS Biol 2: 1532-1539.
    • (2004) PLoS Biol , vol.2 , pp. 1532-1539
    • Wang, Y.X.1    Zhang, C.L.2    Yu, R.T.3    Cho, H.K.4    Nelson, M.C.5
  • 26
    • 0037251008 scopus 로고    scopus 로고
    • Cold-induced recruitment of brown adipose tissue thermogenesis
    • Klingenspor M (2003) Cold-induced recruitment of brown adipose tissue thermogenesis. Exp Physiol 88: 141-148.
    • (2003) Exp Physiol , vol.88 , pp. 141-148
    • Klingenspor, M.1
  • 27
    • 0347989317 scopus 로고    scopus 로고
    • Brown adipose tissue: Function and physiological significance
    • Cannon B, Nedergaard J (2004) Brown adipose tissue: Function and physiological significance. Physiol Rev 84: 277-359.
    • (2004) Physiol Rev , vol.84 , pp. 277-359
    • Cannon, B.1    Nedergaard, J.2
  • 28
    • 33745627066 scopus 로고    scopus 로고
    • Transverse aortic constriction leads to accelarated heart failure in mice lacking PPAR-c coactivator 1a
    • Arany Z, Novlkov M, Chin S, Rosenzweig A, Spiegelman BM (2006) Transverse aortic constriction leads to accelarated heart failure in mice lacking PPAR-c coactivator 1a. Proc Natl Acad Sci USA 103: 10086-10091.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 10086-10091
    • Arany, Z.1    Novlkov, M.2    Chin, S.3    Rosenzweig, A.4    Spiegelman, B.M.5
  • 29
    • 75849155745 scopus 로고    scopus 로고
    • The transcriptional coactivator PGC-1a mediates exercise-induced angiogenesis in skeletal muscle
    • Chinsomboon J, Ruas J, Gupta RK, Thom R, Shoag J, et al. (2009) The transcriptional coactivator PGC-1a mediates exercise-induced angiogenesis in skeletal muscle. Proc Natl Acad Sci USA 106: 21401-21406.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 21401-21406
    • Chinsomboon, J.1    Ruas, J.2    Gupta, R.K.3    Thom, R.4    Shoag, J.5
  • 30
    • 34547545892 scopus 로고    scopus 로고
    • AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1a
    • Jäger S, Handschirm C, St.-Pierre J, Spiegelman BM (2007) AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1a. Proc Natl Acad Sci USA 104: 12017-12022.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 12017-12022
    • Jäger, S.1    Handschirm, C.2    St.-Pierre, J.3    Spiegelman, B.M.4
  • 31
    • 34250740323 scopus 로고    scopus 로고
    • Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1a transcription coactivator
    • Li X, Monks B, Ge Q, Birnbaum MJ (2007) Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1a transcription coactivator. Nature 447: 1012-1017.
    • (2007) Nature , vol.447 , pp. 1012-1017
    • Li, X.1    Monks, B.2    Ge, Q.3    Birnbaum, M.J.4
  • 32
    • 0037102256 scopus 로고    scopus 로고
    • Transcription coactivator PGC-1a drives the formation of slow-twitch muscle fibres
    • Lin J, Wu H, Tarr PT, Zhang C-Y, Wu Z, et al. (2001) Transcription coactivator PGC-1a drives the formation of slow-twitch muscle fibres. Nature 418: 797-801.
    • (2001) Nature , vol.418 , pp. 797-801
    • Lin, J.1    Wu, H.2    Tarr, P.T.3    Zhang, C.-Y.4    Wu, Z.5
  • 33
    • 58149394230 scopus 로고    scopus 로고
    • Regulation of skeletal muscle mitochondrial fatty acid metabolism in lean and obese individuals
    • Holloway GP, Bonen A, Spriet LL (2009) Regulation of skeletal muscle mitochondrial fatty acid metabolism in lean and obese individuals. American J Clin Nutr 89: 455S-462S.
    • (2009) American J Clin Nutr , vol.89
    • Holloway, G.P.1    Bonen, A.2    Spriet, L.L.3
  • 34
    • 0037008157 scopus 로고    scopus 로고
    • BAR signaling required for diet-induced thermogenesis and obesity resistance
    • Bachman ES, Dhillon H, Zhang C-Y, Cinti S, Bianco AC (2002) bAR signaling required for diet-induced thermogenesis and obesity resistance. Nature 297: 843-845.
    • (2002) Nature , vol.297 , pp. 843-845
    • Bachman, E.S.1    Dhillon, H.2    Zhang, C.-Y.3    Cinti, S.4    Bianco, A.C.5
  • 35
    • 77949328118 scopus 로고    scopus 로고
    • Thermogenesis challenges the adipostat hypothesis for body-weight control
    • Cannon B, Nedergaard J (2009) Thermogenesis challenges the adipostat hypothesis for body-weight control. Proc Nutr Soc 68: 401-407.
    • (2009) Proc Nutr Soc , vol.68 , pp. 401-407
    • Cannon, B.1    Nedergaard, J.2
  • 36
    • 77958535632 scopus 로고    scopus 로고
    • Lower body temperatures are advantageous for a small mammal (bush rat, Rattus fuscipes) experiencing chronic cold
    • in press
    • Glanville EJ, Seebacher F (2010) Lower body temperatures are advantageous for a small mammal (bush rat, Rattus fuscipes) experiencing chronic cold. J Mammal, in press.
    • (2010) J Mammal
    • Glanville, E.J.1    Seebacher, F.2
  • 37
    • 74449091178 scopus 로고    scopus 로고
    • Plasticity in body temperature and metabolic capacity sustains winter activity in a small endotherm (Rattus fuscipes)
    • Glanville EJ, Seebacher F (2010) Plasticity in body temperature and metabolic capacity sustains winter activity in a small endotherm (Rattus fuscipes). Comp Biochem Physiol A 155: 383-391.
    • (2010) Comp Biochem Physiol A , vol.155 , pp. 383-391
    • Glanville, E.J.1    Seebacher, F.2
  • 38
    • 33744910824 scopus 로고    scopus 로고
    • Contribution of thermal and nonthermal factors to the regulation of body temperature in humans
    • Mekjavic IB, Eiken O (2006) Contribution of thermal and nonthermal factors to the regulation of body temperature in humans. J Appl Physiol 100: 2065-2072.
    • (2006) J Appl Physiol , vol.100 , pp. 2065-2072
    • Mekjavic, I.B.1    Eiken, O.2
  • 39
    • 65549096847 scopus 로고    scopus 로고
    • Lifestyle-induced metabolic inflexibility and accelerated ageing syndrome: Insulin resistance, friend or foe?
    • Nunn AVW, Bell JD, Guy GW (2009) Lifestyle-induced metabolic inflexibility and accelerated ageing syndrome: insulin resistance, friend or foe? Nutr Metabol 6.
    • (2009) Nutr Metabol , pp. 6
    • Nunn, A.V.W.1    Bell, J.D.2    Guy, G.W.3
  • 41
    • 9144262378 scopus 로고    scopus 로고
    • Cardiomyocyterestricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy
    • Cheng L, Ding G, Qin Q, Huang Y, Lewis W, et al. (2004) Cardiomyocyterestricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy. Nature Med 10: 1245-1250.
    • (2004) Nature Med , vol.10 , pp. 1245-1250
    • Cheng, L.1    Ding, G.2    Qin, Q.3    Huang, Y.4    Lewis, W.5
  • 42
    • 63649121321 scopus 로고    scopus 로고
    • Regulation by exercise of skeletal muscle content of mitochondria and GLUT4
    • Holloszy JO (2008) Regulation by exercise of skeletal muscle content of mitochondria and GLUT4. J Physiol Pharmacol 59: 5-18.
    • (2008) J Physiol Pharmacol , vol.59 , pp. 5-18
    • Holloszy, J.O.1
  • 44
    • 0028865142 scopus 로고
    • Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity
    • Kopecky J, Clarke G, Enerback S, Spiegelman B, Kozak LP (1995) Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity. J Clin Invest 96: 2914-2923.
    • (1995) J Clin Invest , vol.96 , pp. 2914-2923
    • Kopecky, J.1    Clarke, G.2    Enerback, S.3    Spiegelman, B.4    Kozak, L.P.5
  • 45
    • 58149529580 scopus 로고    scopus 로고
    • UCP1: Its involvement and utility in obesity
    • Kozak LP, Anunciado-Koza R (2008) UCP1: its involvement and utility in obesity. Int J Obesity 32: S32-S38.
    • (2008) Int J Obesity , vol.32
    • Kozak, L.P.1    Anunciado-Koza, R.2
  • 46
    • 58749091645 scopus 로고    scopus 로고
    • UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality
    • Feldman HM, Golozoubova V, Cannon B, Nedergaard J (2009) UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab 9: 203-209.
    • (2009) Cell Metab , vol.9 , pp. 203-209
    • Feldman, H.M.1    Golozoubova, V.2    Cannon, B.3    Nedergaard, J.4
  • 48
    • 77950221998 scopus 로고    scopus 로고
    • Human brown adipose tissue
    • Enerbäck S (2010) Human brown adipose tissue. Cell Metab 11: 248-252.
    • (2010) Cell Metab , vol.11 , pp. 248-252
    • Enerbäck, S.1
  • 49
    • 34249730751 scopus 로고    scopus 로고
    • Transient receptor potential ion channels control thermoregulatory behaviour in reptiles
    • Seebacher F, Murray, SA (2007) Transient receptor potential ion channels control thermoregulatory behaviour in reptiles. PLoS One 2: e281.
    • (2007) PLoS One , vol.2
    • Seebacher, F.1    Murray, S.A.2
  • 50
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for the relative quantification in real-time RT-PCR
    • Pfaffl MW (2001) A new mathematical model for the relative quantification in real-time RT-PCR. Nucl Acid Res 29: 2002-2007.
    • (2001) Nucl Acid Res , vol.29 , pp. 2002-2007
    • Pfaffl, M.W.1
  • 51
    • 0037386379 scopus 로고    scopus 로고
    • Seasonal acclimatisation of muscle metabolic enzymes in a reptile (Alligator mississippiensis)
    • Seebacher F, Guderley H, Elsey RM, Trosclair PL (2003) Seasonal acclimatisation of muscle metabolic enzymes in a reptile (Alligator mississippiensis). J Exp Biol 206: 1193-1200.
    • (2003) J Exp Biol , vol.206 , pp. 1193-1200
    • Seebacher, F.1    Guderley, H.2    Elsey, R.M.3    Trosclair, P.L.4
  • 52
    • 0034779544 scopus 로고    scopus 로고
    • Design, calibration and calculation for flow-through respirometry systems
    • Withers PC (2001) Design, calibration and calculation for flow-through respirometry systems. Aust J Zool 49: 445-461.
    • (2001) Aust J Zool , vol.49 , pp. 445-461
    • Withers, P.C.1
  • 53
    • 0001495141 scopus 로고
    • The respiratory metabolism and swimming performance of young sockeye salmon
    • Brett JR (1964) The respiratory metabolism and swimming performance of young sockeye salmon. J Fish Res 21: 1183-1226.
    • (1964) J Fish Res , vol.21 , pp. 1183-1226
    • Brett, J.R.1
  • 54
    • 10344249454 scopus 로고    scopus 로고
    • Voluntary running in deer mice: Speed, distance, energy costs and temperature effects
    • Chappell MA, Garland T, Rezende EL, Gomes FR (2004) Voluntary running in deer mice: speed, distance, energy costs and temperature effects. J Exp Biology 207: 3839-3854.
    • (2004) J Exp Biology , vol.207 , pp. 3839-3854
    • Chappell, M.A.1    Garland, T.2    Rezende, E.L.3    Gomes, F.R.4


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