Fat storage and the biology of energy expenditure

Translational Research

Volumn 154, Issue 2, 2009, Pages 52-60

  Redinger, Richard N ^a  

^a UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FARNESOID X RECEPTOR; GASTROINTESTINAL HORMONE; HORMONE RECEPTOR; LIPID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NRF1; TRANSCRIPTION FACTOR NRF2;

ADIPOCYTE; ADIPOGENESIS; ADIPOSE TISSUE; AUTONOMIC NERVOUS SYSTEM; BROWN ADIPOSE TISSUE; CELL MATURATION; CENTRAL NERVOUS SYSTEM; COMORBIDITY; CYTOLOGY; DIETARY INTAKE; ENERGY; ENERGY EXPENDITURE; FOOD INTAKE; GENE; GENE CONTROL; HEAT; HOMEOSTASIS; HUMAN; HYPOTHALAMUS; INTESTINE; INTRAABDOMINAL FAT; KNOWLEDGE; LIFESTYLE MODIFICATION; LIPID STORAGE; LIVER; LIVER CELL; LONGEVITY; METABOLIC SYNDROME X; MITOCHONDRION; MODULATION; MOLECULAR BIOLOGY; MUSCLE; MUSCLE CELL; NONHUMAN; OBESITY; OXIDATIVE PHOSPHORYLATION; PATHOPHYSIOLOGY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SATIETY; WHITE ADIPOSE TISSUE;

EID: 67649841598     PISSN: 19315244     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trsl.2009.05.003     Document Type: Review

References (53)

1. Jeffery R.W., Kelly K.M., Rothman A.J., Sherwood N.E., and Boutelle K.N. The weight loss experience: a descriptive analysis. Ann Behav Med 27 (2004) 100-106
2. Sacks F.M., Bray G.A., Carey V.J., et al. Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates. N Engl J Med 360 (2009) 859-873
3. Ahima R.S., and Flier J.S. Adipose tissue as an endocrine organ. Trends Endocrinol Metab 11 (2000) 327-332
4. Rajala M.W., and Scherer P. Minireview: The adipocyte-at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology 144 (2003) 3765-3773
5. Redinger R.N. The pathophysiology of obesity and its clinical manifestations. Gastroenterol Hepatol 3 (2007) 856-863
6. Tiraby C., Tavernier G., Lefort C., et al. Acquirement of brown fat cell features by human white adipocytes. J Biol Chem 278 (2003) 33370-33376
7. Gesta S., Tseng Y.H., and Kahn C.R. Developmental origin of fat: tracking obesity to its source. Cell 131 (2007) 242-256
8. Puigserver P., and Spiegelman B.M. Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Endocr Rev 24 (2003) 78-90
9. Ristow M., Muller-Wieland D., Pfeiffer A., Krone W., and Kahn C.R. Obesity associated with a mutation in a genetic regulator of adipocyte differentiation. N Engl J Med 339 (1998) 953-959
10. Cannon B., and Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol Rev 84 (2004) 277-359
11. Robidoux J., Martin T.L., and Collins S. Beta-adrenergic receptors and regulation of energy expenditure: a family affair. Annu Rev Pharmacol Toxicol 44 (2004) 297-323
12. Lafontan M., and Berlan M. Fat cell adrenergic receptors and the control of white and brown fat cell function. J Lipid Res 34 (1993) 1057-1091
13. Avram A.S., Avram M.M., and James W.D. Subcutaneous fat in normal and diseased states: 2. anatomy and physiology of white and brown adipose tissue. J Am Acad Dermatol 53 (2005) 671-683
14. Morrison R.F., and Farmer S.R. Hormonal signaling and transcriptional control of adipocyte differentiation. J Nutr 130 (2000) 3116S-3121S
15. Hany T.F., Gharehpapagh E., Kamel E.M., Buck A., and Himms-Hagen J. Brown adipose tissue: a factor to consider in symmetrical tracer uptake in the neck and upper chest region. Eur J Nucl Med 29 (2002) 1393-1397
16. Huttunen P., Hirvonen J., and Kinnula V. The occurrence of brown adipose tissue in outdoor workers. Eur J Appl Physiol Occup Physiol 46 (1981) 339-345
17. Huttunen P., and Kortelainen M.J. Long-term alcohol consumption and brown adipose tissue in man. Eur J Appl Physiol Occup Physiol 60 (1990) 418-424
18. Trayhurn P., and Beattie J.H. Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ. Proc Nutr Soc 60 (2001) 329-339
19. Unger R.H., and Zhou Y.T. Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover. Diabetes 50 (2001) S118-S121
20. Morton G.J., Cummings D.E., Baskin D.G., Barsh G.S., and Schwartz M.W. Central nervous system control of food intake and body weight. Nature 443 (2006) 289-295
21. Kreier F., Fliers E., Voshol P.J., et al. Selective parasympathetic innervation of subcutaneous and intra-abdominal fat and functional implications. J Clin Invest 110 (2002) 1243-1250
22. Schwartz M.W., Woods S.C., Porte Jr. D., Seeley R.J., and Baskin D.G. Central nervous system control of food intake. Nature 404 (2000) 661-671
23. Spiegelman B.M., and Flier J.S. Obesity and the regulation of energy balance. Cell 104 (2001) 531-543
24. Oberkofler H., Dallinger G., Liu Y.M., Hell E., Krempler F., and Patsch W. Uncoupling protein gene: quantification of expression levels in adipose tissues of obese and non-obese humans. J Lipid Res 38 (1997) 2125-2133
25. Van Marken Lichtenbelt W.D., Vanhommerig J.W., Smulders N.M., et al. Cold-activated brown adipose tissue in healthy men. N Engl J Med 360 (2009) 1500-1508
26. Morton G.J., Blevins J.E., Williams D.L., et al. Leptin action in the forebrain regulates the hindbrain response to satiety signals. J Clin Invest 115 (2005) 703-710
27. Wynne K., Stanley S., and Bloom S. The gut and regulation of body weight. J Clin Endocrinol Metab 89 (2004) 2576-2582
28. Margetic S., Gazzola C., Pegg G.G., and Hill R.A. Leptin: a review of its peripheral actions and interactions. Int J Obes Relat Metab Disord 26 (2002) 1407-1433
29. Yamauchi T., Kamon J., Waki H., et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 7 (2001) 941-946
30. Yamauchi T., Kamon J., Minokoshi Y., et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 8 (2002) 1288-1295
31. Tan G.D., Goossens G.H., Humphreys S.M., Vidal H., and Karpe F. Upper and lower body adipose tissue function: a direct comparison of fat mobilization in humans. Obes Res 12 (2004) 114-118
32. Broberger C., Johansen J., Johansson C., Schalling M., and Hökfelt T. The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice. Proc Natl Acad Sci U S A 95 (1998) 15043-15048
33. English P.J., Ghatei M.A., Malik I.A., Bloom S.R., and Wilding J.P. Food fails to suppress ghrelin levels in obese humans. J Clin Endocrinol Metab 87 (2002) 2984
34. Druce M.R., Small C.J., and Bloom S.R. Minireview: gut peptides regulating satiety. Endocriology 145 (2004) 2660-2665
35. Verdich C., Toubro S., Buemann B., Lysgard-Masden J., Juul-Holst J., and Astrup A. The role of postprandial releases of insulin and incretion hormones in meal-induced satiety-effect of obesity and weight reduction. Int J Obes Relat Metab Disord 25 (2001) 1206-1214
36. Vincent R.P., and le Roux C.W. The satiety hormone peptide YY as a regulator of appetite. J Clin Pathol 61 (2008) 548-552
37. Zhang Y., Castellani L.W., Sinal C.J., Gonzalez F.J., and Edwards P.A. Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) regulates triglyceride metabolism by activation of the nuclear receptor FXR. Genes Dev 18 (2004) 157-169
38. Dressel U., Allen T.L., Pippal J.B., Rohde P.R., Lau P., and Muscat G.E. The peroxisome proliferator-activated receptor beta/delta agonist, GW501516, regulates the expression of genes involved in lipid catabolism and energy uncoupling in skeletal muscle cells. Mol Endocrinol 17 (2003) 2477-2493
39. Luquet S., Lopez-Soriano J., Holst D., Fredenrich A., Melki J., Rassoulzadegan M., et al. Peroxisome proliferator-activated receptor delta controls muscle development and oxidative capability. FASEB J 17 (2003) 2299-2301
40. Grimaldi P.A. Roles of PPARdelta in the control of muscle development and metabolism. Biochem Soc Trans 31 (2003) 1130-1132
41. Liang H., and Ward W. PGC-1α: a key regulator of energy metabolism. Adv Physiol Educ 30 (2006) 145-151
42. Puigserver P., Wu Z., Park C.W., Graves R., Wright M., and Spiegelman B.M. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92 (1998) 829-839
43. Storlien L., Oakes N.D., and Kelley D.E. Metabolic flexibility. Proc Nutr Soc 63 (2004) 363-368
44. Tanner C.J., Barakat H.A., Dohm G.L., et al. Muscle fiber type is associated with obesity and weight loss. Am J Physiol Endocrinol Metab 282 (2002) e1191-e1196
45. Hickey M.S., Carey J.O., Azevedo J.L., et al. Skeletal muscle fiber composition is related to adiposity and in vitro glucose transport rate in humans. Am J Physiol 268 (1995) E453-E457
46. Wu Z., Puigserver P., Andersson U., et al. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98 (1999) 115-124
47. Lehman J.J., Barger P.M., Kovacs A., Saffitz J.E., Medeiros D.M., and Kelly D.P. Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. J Clin Invest 106 (2000) 847-856
48. Michael L.F., Wu Z., Cheatham R.B., et al. Restoration of insulin-sensitive glucose transporter (GLUT 4) gene expression in muscle cells by the transcriptional coactivator PGC-1. Proc Natl Acad Sci USA 98 (2001) 3820-3825
49. Lafleur S.E., Ji H., Manola S.L., et al. The hepatic vagus mediates fat-induced inhibition of diabetic hyperphagia. Diabetes (2003) 2321-2330
50. Ide T., Tsunoda M., Mochizuki T., and Murakami K. Enhancement of insulin signaling through inhibition of tissue lipid accumulation by activation of peroxisome proliferators-activated receptor (PPAR) alpha in obese mice. Med Sci Monit 10 (2004) BR388-BR395
51. Flordellis C.S., Ilias I., and Papavassiliou A.G. New therapeutic options for the metabolic syndrome: what's next?. Trends Endocrinol Metab 16 (2005) 254-260
52. Halford J.C. Obesity drugs in clinical development. Curr Opin Investig Drugs 7 (2006) 312-318
53. Bays H.E. Current and investigational antiobesity agents and obesity therapeutic treatment targets. Obes Res 12 (2004) 1197-1211