Inhibition of TRPV1 for the treatment of sensitive skin

Experimental Dermatology

Volumn 19, Issue 11, 2010, Pages 980-986

  Kueper, Thomas ^a   Krohn, Michael ^b   Haustedt, Lars Ole ^c   Hatt, Hanns ^d   Schmaus, Gerhard ^a   Vielhaber, Gabriele ^a  

^a SYMRISE AG   (Germany)

^b BRAIN AG   (Germany)

^c ANALYTICON DISCOVERY GMBH   (Germany)

^d RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

Capsaicin; Sensitive; Skin; TRPV1

Indexed keywords

4 TERT BUTYLCYCLOHEXANOL; CAPSAICIN; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 1 ANTAGONIST;

ANIMAL CELL; ARTICLE; CELL STRAIN HEK293; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ELECTROPHYSIOLOGY; FEMALE; HUMAN; IC 50; MALE; NONHUMAN; OOCYTE; PROTEIN EXPRESSION; SKIN ALLERGY; SKIN BURNING SENSATION; SKIN SENSITIVITY;

ADULT; ANIMALS; BORON COMPOUNDS; CALCIUM SIGNALING; CAPSAICIN; CELL LINE; CYCLOHEXANOLS; FEMALE; HUMANS; ION CHANNEL GATING; MEMBRANE TRANSPORT MODULATORS; OOCYTES; SENSATION DISORDERS; SKIN DISEASES; TRANSFECTION; TRPV CATION CHANNELS; XENOPUS LAEVIS;

EID: 77958535825     PISSN: 09066705     EISSN: 16000625     Source Type: Journal    
DOI: 10.1111/j.1600-0625.2010.01122.x     Document Type: Article

References (74)

1. Pons-Guiraud A. Sensitive skin: a complex and multifactorial syndrome. J Cosmet Dermatol 2004: 3: 145-148.
2. Coverly J, Peters L, Whittle E, Basketter D A. Susceptibility to skin stinging, non-immunologic contact urticaria and acute skin irritation; is there a relationship? Contact Dermatitis 1998: 38: 90-95.
3. Muizzuddin N, Marenus K D, Maes D H. Factors defining sensitive skin and its treatment. Am J Contact Dermat 1998: 9: 170-175.
4. Seidenari S, Francomano M, Mantovani L. Baseline biophysical parameters in subjects with sensitive skin. Contact Dermatitis 1998: 38: 311-315.
5. Misery L, Sibaud V, Ambronati M, Macy G, Boussetta S, Taieb C. Sensitive scalp: does this condition exist? An epidemiological study. Contact Dermatitis 2008: 58: 234-238.
6. Simion F A, Rhein L D, Morrison B M Jr et al. Self-perceived sensory responses to soap and synthetic detergent bars correlate with clinical signs of irritation. J Am Acad Dermatol 1995: 32: 205-211.
7. Farage M A. Enhancement of visual scoring of skin irritant reactions using cross-polarized light and parallel-polarized light. Contact Dermatitis 2008: 58: 147-155.
8. Saint-Martory C, Roguedas-Contios A M, Sibaud V, Degouy A, Schmitt A M, Misery L. Sensitive skin is not limited to the face. Br J Dermatol 2008: 158: 130-133.
9. Lee C H, Maibach H I. The sodium lauryl sulfate model: an overview. Contact Dermatitis 1995: 33: 1-7.
10. Effendy I, Loeffler H, Maibach H I. Baseline transepidermal water loss in patients with acute and healed irritant contact dermatitis. Contact Dermatitis 1995: 33: 371-374.
11. Ständer S, Schneider S W, Weishaupt C, Luger T A, Misery L. Putative neuronal mechanisms of sensitive skin. Exp Dermatol 2009: 18: 417-423.
12. Farage M A. Sensitive skin: closing in on a physiological cause. Contact Dermatitis 2010: 62: 137-149.
13. Frosch P, Kligman A M. Method for appraising the sting capacity of topically applied substances. J Soc Cosmet Chem 1977: 28: 197-209.
14. Green B G, Shaffer G S. Psychophysical assessment of the chemical irritability of human skin. J Soc Cosmet Chem 1992: 43: 131-147.
15. Jourdain R, De Lacharriere O, Bastien P, Maibach H I. Ethnic variations in self-perceived sensitive skin: epidemiological survey. Contact Dermatitis 2002: 46: 162-169.
16. Jourdain R, Bastien P, De Lacharriere O, Rubinstenn G. Detection thresholds of capsaicin: a new test to assess facial skin neurosensitivity. J Cosmet Sci 2005: 56: 153-166.
17. Caterina M J, Schumacher M A, Tominaga M, Rosen T A, Levine J D, Julius D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 1997: 389: 816-824.
18. Clapham D E. TRP channels as cellular sensors. Nature 2003: 426: 517-524.
19. Dhaka A, Viswanath V, Patapoutian A. Trp ion channels and temperature sensation. Annu Rev Neurosci 2006: 29: 135-161.
20. Chuang H H, Prescott E D, Kong H et al. Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4, 5)P2-mediated inhibition. Nature 2001: 411: 957-962.
21. Ständer S, Moormann C, Schumacher M et al. Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures. Exp Dermatol 2004: 13: 129-139.
22. Inoue K, Koizumi S, Fuziwara S, Denda S, Denda M. Functional vanilloid receptors in cultured normal human epidermal keratinocytes. Biochem Biophys Res Commun 2002: 291: 124-129.
23. Kim S J, Lee S A, Yun S J et al. Expression of vanilloid receptor 1 in cultured fibroblast. Exp Dermatol 2006: 15: 362-367.
24. Miyamoto R, Tokuda M, Sakuta T, Nagaoka S, Torii M. Expression and characterization of vanilloid receptor subtype 1 in human dental pulp cell cultures. J Endod 2005: 31: 652-658.
25. Yao X, Garland C J. Recent developments in vascular endothelial cell transient receptor potential channels. Circ Res 2005: 97: 853-863.
26. Denda M, Fuziwara S, Inoue K et al. Immunoreactivity of VR1 on epidermal keratinocyte of human skin. Biochem Biophys Res Commun 2001: 285: 1250-1252.
27. Zygmunt P M, Petersson J, Andersson D A et al. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature 1999: 400: 452-457.
28. Huang S M, Bisogno T, Trevisani M et al. An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors. Proc Natl Acad Sci U S A 2002: 99: 8400-8405.
29. Shin J, Cho H, Hwang S W et al. Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia. Proc Natl Acad Sci U S A 2002: 99: 10150-10155.
30. Moriyama T, Higashi T, Togashi K et al. Sensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandins. Mol Pain 2005: 1: 3.
31. Tominaga M, Wada M, Masu M. Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia. Proc Natl Acad Sci U S A 2001: 98: 6951-6956.
32. Camprubi-Robles M, Planells-Cases R, Ferrer-Montiel A. Differential contribution of SNARE-dependent exocytosis to inflammatory potentiation of TRPV1 in nociceptors. FASEB J 2009: 23: 3722-3733.
33. Cuypers E, Yanagihara A, Karlsson E, Tytgat J. Jellyfish and other cnidarian envenomations cause pain by affecting TRPV1 channels. FEBS Lett 2006: 580: 5728-5732.
34. Siemens J, Zhou S, Piskorowski R et al. Spider toxins activate the capsaicin receptor to produce inflammatory pain. Nature 2006: 444: 208-212.
35. Szallasi A, Cortright D N, Blum C A, Eid S R. The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept. Nat Rev Drug Discov 2007: 6: 357-372.
36. Bhave G, Zhu W, Wang H, Brasier D J, Oxford G S, Gereau R W IV. cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation. Neuron 2002: 35: 721-731.
37. Premkumar L S, Ahern G P. Induction of vanilloid receptor channel activity by protein kinase C. Nature 2000: 408: 985-990.
38. Jung J, Shin J S, Lee S Y et al. Phosphorylation of vanilloid receptor 1 by Ca2+/calmodulin-dependent kinase II regulates its vanilloid binding. J Biol Chem 2004: 279: 7048-7054.
39. Ramsey I S, Delling M, Clapham D E. An introduction to TRP channels. Annu Rev Physiol 2006: 68: 619-647.
40. Conway S J. TRPing the switch on pain: an introduction to the chemistry and biology of capsaicin and TRPV1. Chem Soc Rev 2008: 37: 1530-1545.
41. De Lacharriere O. Sensitive Skin - A Neurological Perspective. Osaka, Japan: 24th IFSCC, 2006.
42. Facer P, Casula M A, Smith G D et al. Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy. BMC Neurol 2007: 7: 11.
43. Planells-Cases R, Garcia-Sanz N, Morenilla-Palao C, Ferrer-Montiel A. Functional aspects and mechanisms of TRPV1 involvement in neurogenic inflammation that leads to thermal hyperalgesia. Pflugers Arch 2005: 451: 151-159.
44. Pei L, Lin C Y, Dai J P, Yin G F. Facial pain induces the alteration of transient receptor potential vanilloid receptor 1 expression in rat trigeminal ganglion. Neurosci Bull 2007: 23: 92-100.
45. Kawamata T, Ji W, Yamamoto J, Niiyama Y, Furuse S, Namiki A. Contribution of transient receptor potential vanilloid subfamily 1 to endothelin-1-induced thermal hyperalgesia. Neuroscience 2008: 154: 1067-1076.
46. Hu H Z, Gu Q, Wang C et al. 2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3. J Biol Chem 2004: 279: 35741-35748.
47. Ma S, G G, Ak V E, Jf D, H H. Menthol derivative WS-12 selectively activates transient receptor potential melastatin-8 (TRPM8) ion channels. Pak J Pharm Sci 2008: 21: 370-378.
48. Jordt S E, Julius D. Molecular basis for species-specific sensitivity to "hot" chili peppers. Cell 2002: 108: 421-430.
49. Price T J, Patwardhan A M, Flores C M, Hargreaves K M. A role for the anandamide membrane transporter in TRPV1-mediated neurosecretion from trigeminal sensory neurons. Neuropharmacology 2005: 49: 25-39.
50. Crandall M, Miaskowski C, Kools S, Savedra M. The pain experience of adolescents after acute blunt traumatic injury. Pain Manag Nurs 2002: 3: 104-114.
51. Caterina M J. Quenching fire with fat: phosphatidylinositides as putative regulators of pain. Trends Pharmacol Sci 2001: 22: 602-604.
52. Caterina M J, Julius D. The vanilloid receptor: a molecular gateway to the pain pathway. Annu Rev Neurosci 2001: 24: 487-517.
53. Julius D, Basbaum A I. Molecular mechanisms of nociception. Nature 2001: 413: 203-210.
54. Nagy I, Santha P, Jancso G, Urban L. The role of the vanilloid (capsaicin) receptor (TRPV1) in physiology and pathology. Eur J Pharmacol 2004: 500: 351-369.
55. Southall M D, Li T, Gharibova L S, Pei Y, Nicol G D, Travers J B. Activation of epidermal vanilloid receptor-1 induces release of proinflammatory mediators in human keratinocytes. J Pharmacol Exp Ther 2003: 304: 217-222.
56. Li W H, Lee Y M, Kim J Y et al. Transient receptor potential vanilloid-1 mediates heat-shock-induced matrix metalloproteinase-1 expression in human epidermal keratinocytes. J Invest Dermatol 2007: 127: 2328-2335.
57. Mandadi S, Sokabe T, Shibasaki K et al. TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP. Pflugers Arch 2009: 458: 1093-1102.
58. Peier A M, Reeve A J, Andersson D A et al. A heat-sensitive TRP channel expressed in keratinocytes. Science 2002: 296: 2046-2049.
59. Dallos A, Kiss M, Polyanka H, Dobozy A, Kemeny L, Husz S. Effects of the neuropeptides substance P, calcitonin gene-related peptide, vasoactive intestinal polypeptide and galanin on the production of nerve growth factor and inflammatory cytokines in cultured human keratinocytes. Neuropeptides 2006: 40: 251-263.
60. Boulais N, Misery L. The epidermis: a sensory tissue. Eur J Dermatol 2008: 18: 119-127.
61. Caterina M J, Leffler A, Malmberg A B et al. Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 2000: 288: 306-313.
62. Davis J B, Gray J, Gunthorpe M J et al. Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia. Nature 2000: 405: 183-187.
63. Garcia-Martinez C, Humet M, Planells-Cases R et al. Attenuation of thermal nociception and hyperalgesia by VR1 blockers. Proc Natl Acad Sci U S A 2002: 99: 2374-2379.
64. Denda M, Sokabe T, Fukumi-Tominaga T, Tominaga M. Effects of skin surface temperature on epidermal permeability barrier homeostasis. J Invest Dermatol 2007: 127: 654-659.
65. Choi E H, Man M Q, Xu P et al. Stratum corneum acidification is impaired in moderately aged human and murine skin. J Invest Dermatol 2007: 127: 2847-2856.
66. Prahl S, Kueper T, Biernoth T et al. Aging skin is functionally anaerobic: importance of coenzyme Q10 for anti aging skin care. Biofactors 2008: 32: 245-255.
67. Lee Y M, Kim Y K, Chung J H. Increased expression of TRPV1 channel in intrinsically aged and photoaged human skin in vivo. Exp Dermatol 2009: 18: 431-436.
68. Cua A B, Wilhelm K P, Maibach H I. Cutaneous sodium lauryl sulphate irritation potential: age and regional variability. Br J Dermatol 1990: 123: 607-613.
69. Besne I, Descombes C, Breton L. Effect of age and anatomical site on density of sensory innervation in human epidermis. Arch Dermatol 2002: 138: 1445-1450.
70. Lee Y M, Kim Y K, Kim K H, Park S J, Kim S J, Chung J H. A novel role for the TRPV1 channel in UV-induced matrix metalloproteinase (MMP)-1 expression in HaCaT cells. J Cell Physiol 2009: 219: 766-775.
71. Holzer P. The pharmacological challenge to tame the transient receptor potential vanilloid-1 (TRPV1) nocisensor. Br J Pharmacol 2008: 155: 1145-1162.
72. Gunthorpe M J, Rami H K, Jerman J C et al. Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist. Neuropharmacology 2004: 46: 133-149.
73. Gavva N R, Tamir R, Klionsky L et al. Proton activation does not alter antagonist interaction with the capsaicin-binding pocket of TRPV1. Mol Pharmacol 2005: 68: 1524-1533.
74. Ständer S, Weisshaar E, Luger T A. Neurophysiological and neurochemical basis of modern pruritus treatment. Exp Dermatol 2008: 17: 161-169.