Quenching fire with fat: Phosphatidylinositides as putative regulators of pain

Trends in Pharmacological Sciences

Volumn 22, Issue 12, 2001, Pages 602-604

  Caterina, Michael J ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (8 AMINOMETHYL 6,7,8,9 TETRAHYDROPYRIDO[1,2 A]INDOL 3 YL) 3 (1 METHYL INDOL 3 YL)MALEIMIDE; BRADYKININ; DIACYLGLYCEROL; FAT; GUANINE NUCLEOTIDE BINDING PROTEIN; NERVE GROWTH FACTOR; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHATIDYLINOSITIDE; PHOSPHOLIPASE C; PHOSPHOLIPID; PROTEIN KINASE; PROTEIN KINASE C INHIBITOR; RESINIFERATOXIN; RO 318425; STAUROSPORINE; UNCLASSIFIED DRUG; VANILLOID RECEPTOR;

ENZYME ACTIVATION; HUMAN; HYPERALGESIA; INFLAMMATION; KNOCKOUT MOUSE; NONHUMAN; PAIN; PRIORITY JOURNAL; SHORT SURVEY; SIGNAL TRANSDUCTION; THERMAL STIMULATION; TISSUE INJURY; XENOPUS;

EID: 0035576828     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-6147(00)01862-9     Document Type: Review

References (19)

1. Peripheral mechanisms of inflammatory pain
2. Ion channels of nociception
3. 2-mediated inhibition
4. Induction of vanilloid receptor channel activity by protein kinase C
5. Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia
6. Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide
7. The vanilloid receptor: A molecular gateway to the pain pathway
8. Ion channels gated by heat
9. Neurotrophins and hyperalgesia
10. From worm to man: Three subfamilies of TRP channels
11. Activation of a TRPC3-dependent cation current through the neurotrophin BDNF
12. Specific involvement of PKC-ε in sensitization of the neuronal response to painful heat
13. A novel nociceptor signaling pathway revealed in protein kinase C ε mutant mice
14. Resiniferatoxin - An ultrapotent capsaicin analog
15. i in the ATP-induced heat sensitization process of rat nociceptive neurons
16. The cloned rat vanilloid receptor VR1 mediates both R-type binding and C-type calcium response in dorsal root ganglion neurons
17. Do phosphatidylinositides modulate vertebrate phototransduction?
18. 2 and its stabilization by Gβγ
19. Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol