Recent advances in protein transduction technology

Cell Transplantation

Volumn 19, Issue 6-7, 2010, Pages 649-654

  Noguchi, Hirofumi ^a   Matsushita, Masayuki ^b   Kobayashi, Naoya ^c   Levy, Marlon F ^a   Matsumoto, Shinichi ^a  

^a BAYLOR RESEARCH INSTITUTE   (United States)

^b MITSUBISHI KAGAKU INSTITUTE OF LIFE SCIENCES   (Japan)

^c OKAYAMA UNIVERSITY   (Japan)

Author keywords

Cell penetrating peptide; Endocytosis; Protein transduction domain; Protein transduction technology

Indexed keywords

CELL PENETRATING PEPTIDE; PROTEIN; PROTEIN P53; VIRUS GLYCOPROTEIN;

BLOOD BRAIN BARRIER; BRAIN; CELL MEMBRANE; CELL NUCLEUS; CELL ORGANELLE; CYTOPLASM; ENDOSOME; NEUROLOGIC DISEASE; NONHUMAN; PINOCYTOSIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN SECRETION; PROTEIN TRANSPORT; REVIEW; SIGNAL TRANSDUCTION; STATIC ELECTRICITY; UBIQUITINATION;

ANIMALS; CELL-PENETRATING PEPTIDES; DRUG DELIVERY SYSTEMS; ENDOSOMES; ORGAN SPECIFICITY; PROTEIN TRANSPORT; UBIQUITINATION;

ORTHOMYXOVIRIDAE;

EID: 77958533009     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/096368910X508744     Document Type: Review

References (55)

1. Bonny, C.; Oberson, A.; Negri, S.; Sauser, C.; Schorderet, D. F. Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death. Diabetes 50:77-82; 2001.
2. Chatelin, L.; Volovitch, M.; Joliot, A. H.; Perez, F.; Prochiantz, A. Transcription factor hoxa-5 is taken up by cells in culture and conveyed to their nuclei. Mech. Dev. 55:111-117; 1996.
3. Del Gaizo, V.; Payne, R. M. A novel TAT-mitochondrial signal sequence fusion protein is processed, stays in mitochondria, and crosses the placenta. Mol. Ther. 7:720-730; 2003.
4. Deshayes, S.; Morris, M. C.; Divita, G.; Heitz, F. Cell-penetrating peptides: tools for intracellular delivery of therapeutics. Cell. Mol. Life Sci. 62:1839-1849; 2005.
5. Dietz, G. P.; Bähr, M. Delivery of bioactive molecules into the cell: The Trojan horse approach. Mol. Cell. Neurosci. 27:85-131; 2004.
6. Dietz, G. P.; Bähr, M. Peptide-enhanced cellular internalization of proteins in neuroscience. Brain Res. Bull. 68: 103-114; 2005.
7. Elliott, G.; O'Hare, P. Intercellular trafficking and protein delivery by a herpesvirus structural protein. Cell 88:223-233; 1997.
8. Embury, J.; Klein, D.; Pileggi, A.; Ribeiro, M.; Jayaraman, S.; Molano, R. D.; Fraker, C.; Kenyon, N.; Ricordi, C.; Inverardi, L.; Pastori, R. L. Proteins linked to a protein transduction domain efficiently transduce pancreatic islets. Diabetes 50:1706-1713; 2001.
9. Fischer, R.; Kohler, K.; Fotin-Mleczek, M.; Brock, R. A stepwise dissection of the intracellular fate of cationic cell-penetrating peptides. J. Biol. Chem. 279:12625-12635; 2004.
10. Frankel, A.; Pabo, C. Cellular uptake of the Tat protein from human immunodeficiency virus. Cell 55:1189-1193; 1988.
11. Futaki, S.; Suzuki, T.; Ohashi, W.; Yagami, T.; Tanaka, S.; Ueda, K.; Sugiura, Y. Arginine-rich peptides. An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery. J. Biol. Chem. 276:5836-5840; 2001.
12. Futaki, S.; Ohashi, W.; Suzuki, T.; Niwa, M.; Tanaka, S.; Ueda, K.; Harashima, H.; Sugiura, Y. Stearylated arginine-rich peptides: A new class of transfection systems. Bioconjug. Chem. 12:1005-1011; 2001.
13. Gammon, S. T.; Villalobos, V. M.; Prior, J. L.; Sharma, V.; Piwnica-Worms, D. Quantitative analysis of permeation peptide complexes labeled with Technetium-99m: Chiral and sequence-specific effects on net cell uptake. Bioconjug. Chem. 14:368-376; 2003.
14. Green, M.; Loewenstein, P. M. Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein. Cell 55:1179-1188; 1988.
15. Gupta, B.; Levchenko, T. S.; Torchilin, V. P. Intracellular delivery of large molecules and small particles by cell-penetrating proteins and peptides. Adv. Drug Deliv. Rev. 57:637-651; 2005.
16. Helland, D. E.; Welles, J. L.; Caputo, A.; Haseltine, W. A. Transcellular transactivation by the human immunodeficiency virus type 1 tat protein. J. Virol. 65:4547-4549; 1991.
17. Joliot, A.; Maizel, A.; Rosenberg, D.; Trembleau, A.; Dupas, S.; Volovitch, M.; Prochiantz, A. Identification of a signal sequence necessary for the unconventional secretion of engrailed homeoprotein. Curr. Biol. 8:856-863; 1998.
18. Joliot, A.; Pernelle, C.; Deagostini-Bazin, H.; Prochiantz, A. Antennapedia homeobox peptide regulates neural morphogenesis. Proc. Natl. Acad. Sci. USA 88:1864-1868; 1991.
19. Joliot, A.; Prochiantz, A. Transduction peptides: From technology to physiology. Nat. Cell Biol. 6:189-196; 2004.
20. Kaneto, H.; Nakatani, Y.; Miyatsuka, T.; Kawamori, D.; Matsuoka, T. A.; Matsuhisa, M.; Kajimoto, Y.; Ichijo, H.; Yamasaki, Y.; Hori, M. Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide. Nat. Med. 10:1128-1132; 2004.
21. Kumar, P.; Wu, H.; McBride, J. L.; Jung, K. E.; Kim, M. H.; Davidson, B. L.; Lee, S. K.; Shankar, P.; Manjunath, N. Transvascular delivery of small interfering RNA to the central nervous system. Nature 448:39-43; 2007.
22. Lewin, M.; Carlesso, N.; Tung, C. H.; Tang, X. W.; Cory, D.; Scadden, D. T.; Weissleder, R. Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells. Nat. Biotechnol. 18:410-414; 2000.
23. Lord, J. M.; Roberts, L. M. Toxin entry: Retrograde transport through the secretory pathway. J. Cell Biol. 140:733-736; 1998.
24. Matsushita, M.; Noguchi, H.; Lu, Y. F.; Tomizawa, K.; Michiue, H.; Li, S. T.; Hirose, K.; Bonner-Weir, S.; Matsui, H. Photo-acceleration of protein release from endosome in the protein transduction system. FEBS Lett. 572:221-226; 2004.
25. Matsushita, M.; Tomizawa, K.; Moriwaki, A.; Li, S. T.; Terada, H.; Matsui, H. A high-efficiency protein transduction system demonstrating the role of PKA in long-lasting long-term potentiation. J. Neurosci. 21:6000-6007; 2001.
26. Mi, Z.; Lu, X.; Mai, J. C.; Ng, B. G.; Wang, G.; Lechman, E. R.; Watkins, S. C.; Rabinowich, H.; Robbins, P. D. Identification of a synovial fibroblast-specific protein transduction domain for delivery of apoptotic agents to hyperplastic synovium. Mol. Ther. 8:295-305; 2003.
27. Michiue, H.; Tomizawa, K.; Matsushita, M.; Tamiya, T.; Lu, Y. F.; Ichikawa, T.; Date, I.; Matsui, H. Ubiquitination-resistant p53 protein transduction therapy facilitates anti-cancer effect on the growth of human malignant glioma cells. FEBS Lett. 579:3965-3969; 2005. (Pubitemid 40961896)
28. Michiue, H.; Tomizawa, K.; Wei, F. Y.; Matsushita, M.; Lu, Y. F.; Ichikawa, T.; Tamiya, T.; Date, I.; Matsui, H. The NH2 terminus of influenza virus hemagglutinin-2 subunit peptides enhances the antitumor potency of polyarginine-mediated p53 protein transduction. J. Biol. Chem. 280:8285-8289; 2005.
29. Morris, M. C.; Vidal, P.; Chaloin, L.; Heitz, F.; Divita, G. A new peptide vector for efficient delivery of oligonucleotides into mammalian cells. Nucleic Acids Res. 25:2730-2736; 1997.
30. Noguchi, H.; Bonner-Weir, S.; Wei, F. Y.; Matsushita, M.; Matsumoto, S. BETA2/NeuroD protein can be transduced into cells due to an arginine- and lysine-rich sequence. Diabetes 54:2859-2866; 2005.
31. Noguchi, H.; Kaneto, H.; Weir, G. C.; Bonner-Weir, S. PDX-1 protein containing its own antennapedia-like protein transduction domain can transduce pancreatic duct and islet cells. Diabetes 52:1732-1737; 2003.
32. Noguchi, H.; Matsumoto, S. Protein transduction technology offers a novel therapeutic approach for diabetes. J. Hepatobiliary Pancreat. Surg. 13:306-313; 2006.
33. Noguchi, H.; Matsumoto, S.; Kobayashi, N.; Hayashi, S.; Iwanaga, Y.; Nagata, H.; Jackson, A.; Naziruddin, B.; Okitsu, T.; Levy, M. F. Effect of JNK inhibitor during islet isolation and transplantation. Transplant. Proc. 40: 379-381; 2008.
34. Noguchi, H.; Matsumoto, S.; Okitsu, T.; Iwanaga, Y.; Yonekawa, Y.; Nagata, H.; Matsushita, M.; Wei, F. Y.; Matsui, H.; Minami, K.; Seino, S.; Masui, Y.; Futaki, S.; Tanaka, K. PDX-1 protein is internalized by lipid raft-dependent macropinocytosis. Cell Transplant. 14:637- 645; 2005.
35. Noguchi, H.; Matsumoto, S.; Onaca, N.; Naziruddin, B.; Jackson, A.; Ikemoto, T.; Shimoda, M.; Fujita, Y.; Chujo, D.; Iwanaga, Y.; Nagata, H.; Okitsu, T.; Kobayashi, N.; Ueno, H.; Chaussabel, D.; Grayburn, P.; Banchereau, J.; Levy, M. F. Ductal injection of JNK inhibitors before pancreas preservation prevents islet apoptosis and improves islet graft function. Hum. Gene Ther. 20:73-83; 2009.
36. Noguchi, H.; Matsushita, M.; Matsumoto, S.; Lu, Y. F.; Matsui, H.; Bonner-Weir, S. Mechanism of PDX-1 protein transduction. Biochem. Biophys. Res. Commun. 332:68-74; 2005.
37. Noguchi, H.; Matsushita, M.; Okitsu, T.; Moriwaki, A.; Tomizawa, K.; Kang, S.; Li, S. T.; Kobayashi, N.; Matsumoto, S.; Tanaka, K.; Tanaka, N.; Matsui, H. A new cell-permeable peptide allows successful allogeneic islet transplantation in mice. Nat. Med. 10:305-309; 2004.
38. Noguchi, H.; Nakai, Y.; Matsumoto, S.; Kawaguchi, M.; Ueda, M.; Okitsu, T.; Iwanaga, Y.; Yonekawa, Y.; Nagata, H.; Minami, K.; Masui, Y.; Futaki, S.; Tanaka, K. Cell permeable peptide of JNK inhibitor prevents islet apoptosis immediately after isolation and improves islet graft function. Am. J. Transplant. 5:1848-1855; 2005.
39. Noguchi, H.; Nakai, Y.; Ueda, M.; Masui, Y.; Futaki, S.; Kobayashi, N.; Hayashi, S.; Matsumoto, S. Activation of c-Jun NH(2)-terminal kinase (JNK) pathway during islet transplantation and prevention of islet graft loss by intraportal injection of JNK inhibitor. Diabetologia 50:612-619; 2007.
40. Noguchi, H.; Oishi, K.; Ueda, M.; Yukawa, H.; Hayashi, S.; Kobayashi, N.; Levy, M. F.; Matsumoto, S. Establishment of mouse pancreatic stem cell line. Cell Transplant. 18:563-571; 2009.
41. Noguchi, H.; Ueda, M.; Matsumoto, S.; Kobayashi, N.; Hayashi, S. BETA2/NeuroD protein transduction requires cell surface heparan sulfate proteoglycans. Hum. Gene Ther. 18:10-17; 2007.
42. Ostenson, C. G.; Sandberg-Nordqvist, A. C.; Chen, J.; Hallbrink, M.; Rotin, D.; Langel, U.; Efendic, S. Overexpression of protein-tyrosine phosphatase PTP sigma is linked to impaired glucose-induced insulin secretion in hereditary diabetic Goto-Kakizaki rats. Biochem. Biophys. Res. Commun. 291:945-950; 2002.
43. Pooga, M.; Soomets, U.; Hallbrink, M.; Valkna, A.; Saar, K.; Rezaei, K.; Kahl, U.; Hao, J. X.; Xu, X. J.; Wiesenfeld-Hallin, Z.; Hokfelt, T.; Bartfai, T.; Langel, U. Cell penetrating PNA constructs regulate galanin receptor levels and modify pain transmission in vivo. Nat. Biotechnol. 16:857-861; 1998.
44. Prochiantz, A. Messenger proteins: Homeoproteins, TAT and others. Curr. Opin. Cell. Biol. 12:400-406; 2000.
45. Prochiantz, A.; Joliot, A. Can transcription factors function as cell-cell signalling molecules? Nat. Rev. Mol. Cell Biol. 4:814-819; 2003.
46. Rodriguez, M. S.; Desterro, J. M.; Lain, S.; Lane, D. P.; Hay, R. T. Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation. Mol. Cell. Biol. 20:8458-8467; 2000.
47. Sakaguchi, M.; Nukui, T.; Sonegawa, H.; Murata, H.; Futami, J.; Yamada, H.; Huh, N. H. Targeted disruption of transcriptional regulatory function of p53 by a novel efficient method for introducing a decoy oligonucleotide into nuclei. Nucleic Acids Res. 33:e88; 2005.
48. Sandvig, K.; van Deurs, B. Entry of ricin and Shiga toxin into cells: Molecular mechanisms and medical perspectives. EMBO J. 19:5943-5950; 2000.
49. Schwarze, S. R.; Ho, A.; Vocero-Akbani, A.; Dowdy, S. F. In vivo protein transduction: Delivery of a biologically active protein into the mouse. Science 285:1569-1572; 1999.
50. Simeoni, F.; Morris, M. C.; Heitz, F.; Divita, G. Insight into the mechanism of the peptide-based gene delivery system MPG: Implications for delivery of siRNA into mammalian cells. Nucleic Acids Res. 31:2717-2724; 2003.
51. Skehel, J. J.; Cross, K.; Steinhauer, D.; Wiley, D. C. Influenza fusion peptides. Biochem. Soc. Trans. 29:623-626; 2001.
52. Torchilin, V. P.; Rammohan, R.; Weissig, V.; Levchenko, T. S. TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors. Proc. Natl. Acad. Sci. USA 98:8786-8791; 2001.
53. Ueda, M.; Matsumoto, S.; Hayashi, S.; Kobayashi, N.; Noguchi, H. Cell surface heparan sulfate proteoglycans mediate the internalization of PDX-1 protein. Cell Transplant. 17:91-97; 2008.
54. Wadia, J. S.; Stan, R. V.; Dowdy, S. F. Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis. Nat. Med. 10:310-315; 2004.
55. Wender, P. A.; Mitchell, D. J.; Pattabiraman, K.; Pelkey, E. T.; Steinman, L.; Rothbard, J. B. The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: Peptoid molecular transporters. Proc. Natl. Acad. Sci. USA 97:13003-13008; 2000.