Evaluation of the impact of diabetes on retinal metabolites by NMR spectroscopy

Current Eye Research

Volumn 35, Issue 11, 2010, Pages 992-1001

  Santiago, A R ^a,b   Garrido, M J ^a   Cristovao A J ^a,c   Duarte, J M N ^a   Carvalho, R A ^a,d   Ambrosio A F ^a,b  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c UNIVERSITY OF COIMBRA   (Portugal)

^d UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

Diabetes; Diabetic retinopathy; Glucose uptake; Glycolysis; Lactate; Nuclear magnetic resonance; Streptozotocin

Indexed keywords

DEOXYGLUCOSE; GLUCOSE; LACTIC ACID; PYRUVIC ACID; TISSUE EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC RETINOPATHY; GLUCOSE METABOLISM; GLYCOLYSIS; MALE; METABOLIC DISORDER; METABOLITE; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; RETINA; STREPTOZOCIN DIABETES;

ANIMALS; BLOOD GLUCOSE; DEOXYGLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC RETINOPATHY; GLUCOSE; GLYCOLYSIS; LACTIC ACID; MAGNETIC RESONANCE SPECTROSCOPY; MALE; RATS; RATS, WISTAR; RETINA;

EID: 77958505485     PISSN: 02713683     EISSN: 14602202     Source Type: Journal    
DOI: 10.3109/02713683.2010.500113     Document Type: Article

References (47)

1. Aiello LM. Perspectives on diabetic retinopathy. Am J Ophthalmol. 2003;136:122-135.
2. Barber AJ. A new view of diabetic retinopathy: a neurodegenerative disease of the eye. Prog Neuropsychopharmacol Biol Psychiatry. 2003;27:283-290.
3. Fletcher EL, Phipps JA, Wilkinson-Berka JL. Dysfunction of retinal neurons and glia during diabetes. Clin Exp Optom. 2005;88:132-145.
4. Koya D, King GL. Protein kinase C activation and the development of diabetic complications. Diabetes. 1998;47:859-866.
5. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature. 2001;414:813-820.
6. Asnaghi V, Gerhardinger C, Hoehn T, et al. A role for the polyol pathway in the early neuroretinal apoptosis and glial changes induced by diabetes in the rat. Diabetes. 2003;52:506-511.
7. Heath H, Paterson RA, Hart JC. Changes in the hydroxyproline, hexosamine and sialic acid of the diabetic human and beta, beta'-iminodipropionitrile- treated rat retinal vascular systems. Diabetologia. 1967;3:515-518.
8. Kowluru RA. Diabetic retinopathy: mitochondrial dysfunction and retinal capillary cell death. Antioxid Redox Signal. 2005;7:1581-1587.
9. MacGregor LC, Matschinsky FM. Altered retinal metabolism in diabetes. II. Measurement of sodium-potassium ATPase and total sodium and potassium in individual retinal layers. J Biol Chem. 1986;261:4052-4058.
10. MacGregor LC, Rosecan LR, Laties AM, et al. Altered retinal metabolism in diabetes. I. Microanalysis of lipid, glucose, sorbitol, and myo-inositol in the choroid and in the individual layers of the rabbit retina. J Biol Chem. 1986;261:4046-4051.
11. Adachi-Uehara N, Kato M, Nimura Y, et al. Up-regulation of genes for oxidative phosphorylation and protein turnover in diabetic mouse retina. Exp Eye Res. 2006;83:849-857.
12. Fox TE, Han X, Kelly S, et al. Diabetes alters sphingolipid metabolism in the retina: A potential mechanism of cell death in diabetic retinopathy. Diabetes. 2006;55:3573-3580.
13. Santiago AR, Pereira TS, Garrido MJ, et al. High glucose and diabetes increase the release of [(3)H]-d-aspartate in retinal cell cultures and in rat retinas. Neurochem Int. 2006;48:453-458.
14. Ambati J, Chalam KV, Chawla DK, et al. Elevated gamma- aminobutyric acid, glutamate, and vascular endothelial growth factor levels in the vitreous of patients with proliferative diabetic retinopathy. Arch Ophthalmol. 1997;115:1161-1166.
15. Deng J, Wu DZ, Gao R. Detection of glutamate and gammaaminobutyric acid in vitreous of patients with proliferative diabetic retinopathy. Yan Ke Xue Bao. 2000;16:199-202.
16. Kowluru RA, Engerman RL, Case GL, et al. Retinal glutamate in diabetes and effect of antioxidants. Neurochem Int. 2001;38:385-390.
17. Lieth E, Barber AJ, Xu B, et al. Glial reactivity and impaired glutamate metabolism in short-term experimental diabetic retinopathy. Penn State Retina Research Group. Diabetes. 1998;47:815-820.
18. Vilchis C, Salceda R. Effect of diabetes on levels and uptake of putative amino acid neurotransmitters in rat retina and retinal pigment epithelium. Neurochem Res. 1996;21:1167-1171.
19. Brosnan JT, Man KC, Hall DE, et al. Interorgan metabolism of amino acids in streptozotocin-diabetic ketoacidotic rat. Am J Physiol. 1983;244:E151-E158.
20. Honda M, Inoue M, Okada Y, et al. Alteration of the GABAergic neuronal system of the retina and superior colliculus in streptozotocin-induced diabetic rat. Kobe J Med Sci. 1998;44:1-8.
21. Duarte JM, Cunha RA, Carvalho RA. Different metabolism of glutamatergic and GABAergic compartments in superfused hippocampal slices characterized by nuclear magnetic resonance spectroscopy. Neuroscience. 2007;144:1305-1313.
22. Fonseca CP, Jones JG, Carvalho RA, et al. Tricarboxylic acid cycle inhibition by Li+ in the human neuroblastoma SH-SY5Y cell line: A 13C NMR isotopomer analysis. Neurochem Int. 2005;47:385-393.
23. Carvalho RA, Sousa RP, Cadete VJ, et al. Metabolic remodeling associated with subchronic doxorubicin cardiomyopathy. Toxicology. 2010;270:92-98.
24. Vilchis C, Salceda R. Characterization of [2-3H]deoxy-Dglucose uptake in retina and retinal pigment epithelium of normal and diabetic rats. Neurochem Int. 1996;28:213-219.
25. Govindaraju V, Young K, Maudsley AA. Proton NMR chemical shifts and coupling constants for brain metabolites. NMR Biomed. 2000;13:129-153.
26. Duarte AI, Santos MS, Seica R, et al. Oxidative stress affects synaptosomal gamma-aminobutyric acid and glutamate transport in diabetic rats: The role of insulin. Diabetes. 2004;53:2110-2116.
27. Duarte AI, Santos MS, Seica R, et al. Insulin affects synaptosomal GABA and glutamate transport under oxidative stress conditions. Brain Res. 2003;977:23-30.
28. Van den Enden MK, Nyengaard JR, Ostrow E, et al. Elevated glucose levels increase retinal glycolysis and sorbitol pathway metabolism. Implications for diabetic retinopathy. Invest Ophthalmol Vis Sci. 1995;36:1675-1685.
29. Obrosova IG, Drel VR, Kumagai AK, et al. Early diabetesinduced biochemical changes in the retina: Comparison of rat and mouse models. Diabetologia. 2006;49:2525-2533.
30. LaNoue KF, Berkich DA, Conway M, et al. Role of specific aminotransferases in de novo glutamate synthesis and redox shuttling in the retina. J Neurosci Res. 2001;66: 914-922.
31. Carvalho RA, Rodrigues TB, Zhao P, et al. A (13)C isotopomer kinetic analysis of cardiac metabolism: Influence of altered cytosolic redox and [Ca(2+)](o). Am J Physiol Heart Circ Physiol. 2004;287:H889-H895.
32. Acosta ML, Fletcher EL, Azizoglu S, et al. Early markers of retinal degeneration in rd/rd mice. Mol Vis. 2005;11: 717-728.
33. Kumagai AK. Glucose transport in brain and retina: Implications in the management and complications of diabetes. Diabetes Metab Res Rev. 1999;15:261-273.
34. Puchowicz MA, Xu K, Magness D, et al. Comparison of glucose influx and blood flow in retina and brain of diabetic rats. J Cereb Blood Flow Metab. 2004;24:449-457.
35. Badr GA, Tang J, Ismail-Beigi F, et al. Diabetes downregulates GLUT1 expression in the retina and its microvessels but not in the cerebral cortex or its microvessels. Diabetes 2000;49:1016-1021.
36. Fernandes R, Carvalho AL, Kumagai A, et al. Downregulation of retinal GLUT1 in diabetes by ubiquitinylation. Mol Vis. 2004;10:618-628.
37. Kim DI, Lim SK, Park MJ, et al. The involvement of phosphatidylinositol 3-kinase /Akt signaling in high glucose- induced downregulation of GLUT-1 expression in ARPE cells. Life Sci. 2007;80:626-632.
38. Knott RM, Robertson M, Muckersie E, et al. Regulation of glucose transporters (GLUT-1 and GLUT-3) in human retinal endothelial cells. Biochem J. 1996;318(Pt 1):313-317. (Pubitemid 26283661)
39. Coffe V, Carbajal RC, Salceda R. Glucose metabolism in rat retinal pigment epithelium. Neurochem Res. 2006;31: 103-108.
40. Ola MS, Berkich DA, Xu Y, et al. Analysis of glucose metabolism in diabetic rat retinas. Am J Physiol Endocrinol Metab. 2006;290:E1057-E1067.
41. Paschen W, Djuricic B, Mies G, et al. Lactate and pH in the brain: Association and dissociation in different pathophysiological states. J Neurochem. 1987;48:154-159.
42. Obrosova I, Faller A, Burgan J, et al. Glycolytic pathway, redox state of NAD(P)-couples and energy metabolism in lens in galactose-fed rats: Effect of an aldose reductase inhibitor. Curr Eye Res. 1997;16:34-43.
43. Coffe V, Carbajal RC, Salceda R. Glycogen metabolism in the rat retina. J Neurochem. 2004;88:885-890.
44. Sanchez-Chavez G, Hernandez-Berrones J, Luna-Ulloa LB, et al. Effect of diabetes on glycogen metabolism in rat retina. Neurochem Res. 2008;33:1301-1308.
45. Lansel N, Rungger-Brandle E, Hitz-Kueng N, et al. [Effect of insulin on retinal glycogen content]. Klin Monatsbl Augenheilkd. 2000;216:316-317.
46. Diederen RM, Starnes CA, Berkowitz BA, et al. Reexamining the hyperglycemic pseudohypoxia hypothesis of diabetic oculopathy. Invest Ophthalmol Vis Sci. 2006;47:2726-2731.
47. Williamson JR, Chang K, Frangos M, et al. Hyperglycemic pseudohypoxia and diabetic complications. Diabetes. 1993;42:801-813.