Diabetes downregulates GLUT1 expression in the retina and its microvessels but not in the cerebral cortex or its microvessels

Diabetes

Volumn 49, Issue 6, 2000, Pages 1016-1021

  Badr, Gamal A ^a   Tang, Jie ^a   Ismail Beigi, Faramarz ^a   Kern, Timothy S ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CAPILLARY; BRAIN CORTEX; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC RETINOPATHY; DOWN REGULATION; GENE EXPRESSION REGULATION; GLUCOSE TRANSPORT; HYPERGLYCEMIA; MALE; NONHUMAN; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; RETINA BLOOD VESSEL; RETINA CAPILLARY; STREPTOZOCIN DIABETES;

EID: 0034128197     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.49.6.1016     Document Type: Article

References (45)

1. Engerman RL, Kern TS: Experimental galactosemia produces diabetic-like retinopathy. Diabetes 33:97-100, 1984
2. Kador PF, Akagi Y, Takahashi Y, Ikebe H, Wyman M, Kinoshita JH: Prevention of retinal vessel changes associated with diabetic retinopathy in galactose-fed dogs by aldose reductase inhibitors. Arch Ophthalmol 108:1301-1309, 1990
3. Robison WG Jr, Tillis TN, Laver N, Kinoshita JH: Diabetes-related histopathologies of the rat retina prevented with an aldose reductase inhibitor. Exp Eye Res 50:355-366, 1990
4. Kern TS, Engerman RL: Comparison of retinal lesions in alloxan-diabetic rats and galactose-fed rats. Curr Eye Res 13:863-867, 1994
5. Kern TS, Engerman RL: A mouse model of diabetic retinopathy. Arch Ophthalmol 114:986-990, 1996
6. Engerman RL, Bloodworth JMB Jr, Nelson S: Relationship of microvascular disease in diabetes to metabolic control. Diabetes 26:760-769, 1977
7. Diabetes Control and Complications Trial Research Group: The effect of intensive treatment of diabetes on the development of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 329:977-986, 1993
8. U.K. Prospective Diabetes Study: Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes. Lancet 352:837-853, 1998
9. de Oliveira F: Pericytes in diabetic retinopathy. Br J Ophthalmol 50:134-143, 1966
10. Addison DJ, Garner A, Ashton N: Degeneration of intramural pericytes in diabetic retinopathy. Br Med J 1:264-266, 1970
11. Kern TS, Engerman RL: Capillary lesions develop in retina rather than cerebral cortex in diabetes and experimental galactosemia. Arch Ophthalmol 114:306-310, 1996
12. Choi TB, Boado RJ, Pardridge WM: Blood-brain barrier glucose transporter mRNA is increased in experimental diabetes mellitus. Biochem Biophys Res Comm 164:375-380, 1989
13. Pardridge WM, Triguero D, Farrell CR: Downregulation of blood-brain barrier glucose transporter in experimental diabetes. Diabetes 39:1040-1044, 1990
14. Pelligrino DA, LaManna JC, Duckrow RB, Bryan RM Jr, Harik SI: Hyperglycemia and blood-brain barrier glucose transport. J Cereb Blood Flow Metab 12:887-899, 1992
15. Taarnhoj J, Alm A: The effect of diabetes on transport through the blood-retinal and blood-brain barriers in rats. Graefes Arch Clin Exp Ophthalmol 229:291-293, 1991
16. Kainulainen H, Schurmann A, Vilja P, Joost HG: In vivo glucose uptake and glucose transporter proteins GLUT1 and GLUT3 in brain tissue from streptozotocin-diabetic rats. Acta Physiol Scand 149:221-225, 1993
17. Kumagai AK, Vinores SA, Pardridge WM: Pathological upregulation of inner blood-retinal barrier GLUT-1 glucose transporter expression in diabetes mellitus. Brain Res 706:313-317, 1996
18. Morgan CR, Lazarow A: Immunoassay of insulin: two-antibody system: plasma insulin levels of normal, sub-diabetic and diabetic rats. Diabetes 12:115-126, 1963
19. Cingle KA, Kalski RS, Bruner WE, O'Brien CM, Erhard P. Wyszynski RE: Age-related changes of glycosidases in human retinal pigment epithelium. Curr Eye Res 15:433-438, 1996
20. Shi J, Simpkins JW: 17 β-Estradiol modulation of glucose transporter 1 expression in blood-brain barrier. Am J Physiol 272:E1016-E1022, 1997
21. Sussman I, Carson MP, McCall AL, Schultz V, Ruderman NB, Tornheim K: Energy state of bovine cerebral microvessels: comparison of isolated methods. Microvasc Res 35:167-178, 1988
22. Kowluru RA, Jirousek MR, Stramm LE, Farid NA, Engerman RL, Kern TS: Abnormalities of retinal metabolism in diabetes or experimental galactosemia. V. Relationship between protein kinase C and ATPases. Diabetes 47:464-469, 1998
23. Elias H, Hennig A, Schwartz DE: Stereology: applications to biomedical research. Physiol Rev 51:158-200, 1971
24. Engerman RL, Kern TS: Hyperglycemia as a cause of diabetic retinopathy. Metabolism 35 (Suppl. 1):20-23, 1986
25. Hammes H-P, Martin S, Federlin K, Geisen K, Brownlee M: Aminoguanidine treatment inhibits the development of experimental diabetic retinopathy. Proc Natl Acad Sci U S A 88:11555-11558, 1991
26. Engerman RL, Kern TS: Aldose reductase inhibition fails to prevent retinopathy in diabetic and galactosemic dogs. Diabetes 42:820-825, 1993
27. Kern TS, Kowluru R, Engerman RL: Abnormalities of retinal metabolism in diabetes or galactosemia: ATPases and glutathione. Invest Ophthalmol Vis Sci 35:2962-2967, 1994
28. Kowluru R, Kern TS, Engerman RL: Abnormalities of retinal metabolism in diabetes or galactosemia. II. Comparison of γ-glutamyl transpeptidase in retina and cerebral cortex, and effects of antioxidant therapy. Curr Eye Res 13:891-896, 1994
29. Xia P, Inoguchi T, Kern TS, Engerman RL, Oates PJ, King GL: Characterization of the mechanism for the chronic activation of DAG-PKC pathway in diabetes and hypergalactosemia. Diabetes 43:1122-1129, 1994
30. Kowluru RA, Kern TS, Engerman RL, Armstrong D: Abnormalities of retinal metabolism in diabetes or experimental galactosemia. III. Effects of antioxidants. Diabetes 45:1233-1237, 1996
31. Kowluru RA, Kern TS, Engerman RL: Abnormalities of retinal metabolism in diabetes or experimental galactosemia. IV. Antioxidant defense system. Free Radic Biol Med 22:587-592, 1996
32. Xia P, Aiello LP, Ishil H, Jiang ZY, Park DJ, Robinson GS, Takagi H, Newsome WP, Jirousek MR, King GL: Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth. J Clin Invest 98:2018-2026, 1996
33. Goldstein GW, Csejtey J, Diamond I: Carrier-mediated glucose transport in capillaries isolated from rat brain. J Neurochem 28:725-728, 1977
34. Betz AL, Csejtey J, Goldstein GW: Hexose transport and phosphorylation by capillaries isolated from rat brain. Am J Physiol 236:C96-C102, 1979
35. Betz AL, Goldstein GW: Transport of hexoses, potassium, and neutral amino acids into capillaries isolated from bovine retina. Exp Eye Res 30:593-605, 1980
36. Betz AL, Bowman PD, Goldstein GW: Hexose transport in microvascular endothelial cells cultured from bovine retina. Exp Eye Res 36:269-277, 1983
37. Mueckler M: Family of glucose-transporter genes: implication for glucose homeostasis and diabetes. Diabetes 36:6-11, 1990
38. Vannucci SJ, Maher F, Simpson IA: Glucose transporter proteins in brain: delivery of glucose to neurons and glia. Glia 21:2-21, 1997
39. Kumagai AK, Glasgow BJ, Pardridge WM: GLUT1 glucose transporter expression in the diabetic and nondiabetic human eye. Invest Ophthalmol Vis Sci 35:2887-2894, 1994
40. Takata K, Kasahara T, Kasahara M, Ezaki O, Hirano H: Ultracytochemical localization of the erythrocyte/HepG2-type glucose transporter (GLUT1) in cells of the blood-retinal barrier in the rat. Invest Ophthalmol Vis Sci 33:377-383, 1992
41. 3H]deoxy-D-glucose uptake in retina and retinal pigment epithelium or normal and diabetic rats. Neurochem Int 28:213-219, 1996
42. Badr GA, Zhang J-Z, Tang J, Kern TS, Ismail-Beigi F: Glut1 and Glut3 expression, but not capillary density, is increased by cobalt chloride in rat cerebrum and retina. Brain Res Mol Brain Res 64:24-33, 1999
43. Knott RM, Kobertson M, Muckersie E, Forrester JV: Regulation of glucose transporters (GLUT-1 and GLUT-3) in human retinal endothelial cells. Biochem J 318:313-317, 1996
44. Vannucci SJ, Seaman LB, Vannucci RC: Effects of hypoxia-ischemia on GLUT1 and GLUT3 glucose transporters in immature rat brain. J Cereb Blood Flow Metab 16:77-81, 1996
45. Vannucci SJ, Gibbs EM, Simpson IA: Glucose utilization and glucose transporter proteins GLUT-1 and GLUT-3 in brains of diabetic (db/db) mice. Am J Physiol 272:E267-E274, 1997