Downregulation of retinal GLUT1 in diabetes by ubiquitinylation

Molecular Vision

Volumn 10, Issue , 2004, Pages 618-628

  Fernandes, Rosa ^a,b   Carvalho, Ana Luisa ^c   Kumagai, Arno ^b   Seica, Raquel ^c   Hosoya, Ken Ichi ^d   Terasaki, Tetsuya ^e   Murta, Joaquim ^a   Pereira, Paulo ^a,f   Faro, Carlos ^c  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF COIMBRA   (Portugal)

^d UNIVERSITY OF TOYAMA   (Japan)

^e TOHOKU UNIVERSITY   (Japan)

^f UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOXAN; COMPLEMENTARY DNA; CROSS REACTING ANTIBODY; GLUCOSE; GLUCOSE TRANSPORTER 1; HEMAGGLUTININ; MESSENGER RNA; MONOCLONAL ANTIBODY; POLYCLONAL ANTIBODY; UBIQUITIN; GLUCOSE TRANSPORTER; SLC2A1 PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LYSATE; CONCENTRATION RESPONSE; CONJUGATION; CONTROLLED STUDY; DIABETIC RETINOPATHY; ENDOTHELIUM CELL; EXPERIMENTAL DIABETES MELLITUS; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VITRO STUDY; ISOTOPE LABELING; MOLECULAR WEIGHT; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN PROCESSING; RABBIT; RETINA CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUPERNATANT; UBIQUITINATION; WESTERN BLOTTING; ANIMAL; BLOOD RETINA BARRIER; CELL LINE; CHRONIC DISEASE; DOWN REGULATION; GENETICS; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; METABOLISM; RAT; RETINA BLOOD VESSEL; VASCULAR ENDOTHELIUM; WISTAR RAT;

ANIMALS; BLOOD GLUCOSE; BLOOD-RETINAL BARRIER; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELL LINE; CHRONIC DISEASE; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC RETINOPATHY; DOWN-REGULATION; ENDOTHELIUM, VASCULAR; GLUCOSE TRANSPORTER TYPE 1; HYPERGLYCEMIA; MONOSACCHARIDE TRANSPORT PROTEINS; RABBITS; RATS; RATS, WISTAR; RETINAL VESSELS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSFECTION; UBIQUITIN;

EID: 16544391719     PISSN: 10900535     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. King GL, Kunisaki M, Nishio Y, Inoguchi T, Shiba T, Xia P. Biochemical and molecular mechanisms in the development of diabetic vascular complications. Diabetes 1996; 45:S105-8.
2. Lorenzi M. Glucose toxicity in the vascular complications of diabetes: the cellular perspective. Diabetes Metab Rev 1992; 8:85-103.
3. Kumagai AK, Glasgow BJ, Pardridge WM. GLUT1 glucose transporter expression in the diabetic and nondiabetic human eye. Invest Ophthalmol Vis Sci 1994; 35:2887-94.
4. Badr GA, Tang J, Ismail-Beigi F, Kern TS. Diabetes downregulates GLUT1 expression in the retina and its microvessels but not in the cerebral cortex or its microvessels. Diabetes 2000; 49:1016-21.
5. Mandarino LJ, Finlayson J, Hassell JR. High glucose downregulates glucose transport activity in retinal capillary pericytes but not endothelial cells. Invest Ophthalmol Vis Sci 1994; 35:964-72.
6. Busik JV, Olson LK, Grant MB, Henry DN. Glucose-induced activation of glucose uptake in cells from the inner and outer blood-retinal barrier. Invest Ophthalmol Vis Sci 2002; 43:2356-63.
7. Hosoya K, Tomi M, Ohtsuki S, Takanaga H, Ueda M, Yanai N, Obinata M, Terasaki T. Conditionally immortalized retinal capillary endothelial cell lines (TR-iBRB) expressing differentiated endothelial cell functions derived from a transgenic rat. Exp Eye Res 2001; 72:163-72.
8. Hershko A, Ciechanover A, Heller H, Haas AL, Rose IA. Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis. Proc Natl Acad Sci U S A 1980; 77:1783-6.
9. Kumagai AK, Kang YS, Boado RJ, Pardridge WM. Upregulation of blood-brain barrier GLUT1 glucose transporter protein and mRNA in experimental chronic hypoglycemia. Diabetes 1995; 44:1399-404.
10. Boado RJ, Pardridge WM. The brain-type glucose transporter mRNA is specifically expressed at the blood-brain barrier. Biochem Biophys Res Commun 1990; 166:174-9.
11. Goto Y, Suzuki K, Ono T, Sasaki M, Toyota T. Development of diabetes in the non-obese NIDDM rat (GK rat). Adv Exp Med Biol 1988; 246:29-31.
12. Agardh CD, Agardh E, Zhang H, Ostenson CG. Altered endothelial/pericyte ratio in Goto-Kakizaki rat retina. J Diabetes Complications 1997; 11:158-62.
13. Miyamoto K, Ogura Y, Nishiwaki H, Matsuda N, Honda Y, Kato S, Ishida H, Seino Y. Evaluation of retinal microcirculatory alterations in the Goto-Kakizaki rat. A spontaneous model of non-insulin-dependent diabetes. Invest Ophthalmol Vis Sci 1996; 37:898-905.
14. Sone H, Kawakami Y, Okuda Y, Sekine Y, Honmura S, Matsuo K, Segawa T, Suzuki H, Yamashita K. Ocular vascular endothelial growth factor levels in diabetic rats are elevated before observable retinal proliferative changes. Diabetologia 1997; 40:726-30.
15. Goto Y, Kakizaki M, Masaki N. Spontaneous diabetes produced by selective breeding of normal wistar rats. Proc Jpn Acad 1975; 51:80-5.
16. Engerman RL, Bloodworth JM Jr. Experimental diabetic retinopathy in dogs. Arch Ophthalmol 1965; 73:205-10.
17. Vinores SA, Derevjanik NL, Mahlow J, Berkowitz BA, Wilson CA. Electron microscopic evidence for the mechanism of blood-retinal barrier breakdown in diabetic rabbits: comparison with magnetic resonance imaging. Pathol Res Pract 1998; 194:497-505.
18. Horak J. The role of ubiquitin in down-regulation and intracellular sorting of membrane proteins: insights from yeast. Biochim Biophys Acta 2003; 1614:139-55.
19. Desterro JM, Rodriguez MS, Hay RT. Regulation of transcription factors by protein degradation. Cell Mol Life Sci 2000; 57:1207-19.
20. Kumagai AK, Vinores SA, Pardridge WM. Pathological upregulation of inner blood-retinal barrier Glut1 glucose transporter expression in diabetes mellitus. Brain Res 1996; 706:313-7.
21. Tang J, Zhu XW, Lust WD, Kern TS. Retina accumulates more glucose than does the embryologically similar cerebral cortex in diabetic rats. Diabetologia 2000; 43:1417-23.
22. Fernandes R, Suzuki K, Kumagai AK. Inner blood-retinal barrier GLUT1 in long-term diabetic rats: an immunogold electron microscopic study. Invest Ophthalmol Vis Sci 2003; 44:3150-4.
23. Rodriguez T, Busquets S, Alvarez B, Carb N, Agell N, Lpez-Soriano FJ, Argils JM. Protein turnover in skeletal muscle of the diabetic rat: activation of ubiquitin-dependent proteolysis. Int J Mol Med 1998; 1:971-7.
24. Galban VD, Evangelista EA, Migliorini RH, do Carmo Kettelhut I. Role of ubiquitin-proteasome-dependent proteolytic process in degradation of muscle protein from diabetic rabbits. Mol Cell Biochem 2001; 225:35-41.
25. Liu Z, Miers WR, Wei L, Barrett EJ. The ubiquitin-proteasome proteolytic pathway in heart vs skeletal muscle: effects of acute diabetes. Biochem Biophys Res Commun 2000; 276:1255-60.
26. Akarsu E, Pirim I, Capoglu I, Deniz O, Akcay G, Unuvar N. Relationship between electroneurographic changes and serum ubiquitin levels in patients with type 2 diabetes. Diabetes Care 2001; 24:100-3.
27. Kornitzer D, Ciechanover A. Modes of regulation of ubiquitin-mediated protein degradation. J Cell Physiol 2000; 182:1-11.
28. Hicke L. A new ticket for entry into budding vesicles-ubiquitin. Cell 2001; 106:527-30.
29. Hicke L, Dunn R. Regulation of membrane protein transport by ubiquitin and ubiquitin-binding proteins. Annu Rev Cell Dev Biol 2003; 19:141-72.
30. Matunis MJ, Coutavas E, Blobel G. A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex. J Cell Biol 1996; 135:1457-70.
31. Matunis MJ, Wu J, Blobel G. SUMO-1 modification and its role in targeting the Ran GTPase-activating protein, RanGAP1, to the nuclear pore complex. J Cell Biol 1998; 140:499-509.
32. Giorgino F, de Robertis O, Laviola L, Montrone C, Perrini S, McCowen KC, Smith RJ. The sentrin-conjugating enzyme mUbc9 interacts with GLUT4 and GLUT1 glucose transporters and regulates transporter levels in skeletal muscle cells. Proc Natl Acad Sci U S A 2000; 97:1125-30.