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Volumn 73, Issue 21-22, 2010, Pages 1560-1569

Functional role of phospholipase D (PLD) in di(2-ethylhexyl) phthalate-induced hepatotoxicity in Sprague-Dawley rats

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR; CYCLINE; CYTOCHROME P450; CYTOCHROME P450 2B1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PHOSPHOLIPASE D; PHOSPHOLIPASE D1; PHOSPHOLIPASE D2; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; PREGNANE X RECEPTOR; BIOLOGICAL MARKER; PLASTICIZER;

EID: 77958175690     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/15287394.2010.511582     Document Type: Article
Times cited : (16)

References (43)
  • 2
    • 1642433172 scopus 로고    scopus 로고
    • Phthalate-induced Leydig cell hyperplasia is associated with multiple endocrine disturbances
    • Akingbemi, B. T., Ge, R., Klinefelter, G. R., Zirkin, B. R., and Hardy, M. P. 2004. Phthalate-induced Leydig cell hyperplasia is associated with multiple endocrine disturbances. Proc. Natl. Acad. Sci. USA 101:775-780.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 775-780
    • Akingbemi, B.T.1    Ge, R.2    Klinefelter, G.R.3    Zirkin, B.R.4    Hardy, M.P.5
  • 4
    • 64249112729 scopus 로고    scopus 로고
    • Di (2-ethylhexyl) phthalate is a highly potent agonist for the human constitutive androstane receptor splice variant CAR2
    • DeKeyser, J. G., Stagliano, M. C., Auerbach, S. S., Prabhu, K. S., Jones, A. D., and Omiecinski, C. J. 2009. Di (2-ethylhexyl) phthalate is a highly potent agonist for the human constitutive androstane receptor splice variant CAR2. Mol. Pharmacol. 75:1005-1013.
    • (2009) Mol. Pharmacol. , vol.75 , pp. 1005-1013
    • DeKeyser, J.G.1    Stagliano, M.C.2    Auerbach, S.S.3    Prabhu, K.S.4    Jones, A.D.5    Omiecinski, C.J.6
  • 6
    • 0032775007 scopus 로고    scopus 로고
    • Regulation of phospholipase D
    • Exton, J. H. 1999. Regulation of phospholipase D. Biochim. Biophys. Acta 1439:121-133.
    • (1999) Biochim. Biophys. Acta , vol.1439 , pp. 121-133
    • Exton, J.H.1
  • 7
    • 0141542631 scopus 로고    scopus 로고
    • Phospholipase D in cell proliferation and cancer
    • Foster, D. A., and Xu, L. 2003. Phospholipase D in cell proliferation and cancer. Mol. Cancer Res. 1:789-800.
    • (2003) Mol. Cancer Res. , vol.1 , pp. 789-800
    • Foster, D.A.1    Xu, L.2
  • 8
    • 0033020809 scopus 로고    scopus 로고
    • Phospholipase D structure and regulation
    • Frohman, M. A., and Morris, A. J. 1999. Phospholipase D structure and regulation. Chem. Phys. Lipids 98:127-140.
    • (1999) Chem. Phys. Lipids , vol.98 , pp. 127-140
    • Frohman, M.A.1    Morris, A.J.2
  • 10
    • 34247143380 scopus 로고    scopus 로고
    • Phthalate ester toxicity in Leydig cells: Developmental timing and dosage considerations
    • Ge, R. S., Chen, G. R., Tanrikut, C., and Hardy, M. P. 2007b. Phthalate ester toxicity in Leydig cells: Developmental timing and dosage considerations. Reprod. Toxicol. 23:366-373.
    • (2007) Reprod. Toxicol , vol.23 , pp. 366-373
    • Ge, R.S.1    Chen, G.R.2    Tanrikut, C.3    Hardy, M.P.4
  • 11
    • 0020050214 scopus 로고
    • Peroxisome proliferation in cultured rat hepatocytes produced by clofibrate and phthalate ester metabolites
    • Gray, T. J., Beamand, J. A., Lake, B. G., Foster, J. R., and Gangolli, S. D. 1982. Peroxisome proliferation in cultured rat hepatocytes produced by clofibrate and phthalate ester metabolites. Toxicol. Lett. 10:273-279.
    • (1982) Toxicol. Lett. , vol.10 , pp. 273-279
    • Gray, T.J.1    Beamand, J.A.2    Lake, B.G.3    Foster, J.R.4    Gangolli, S.D.5
  • 12
    • 0034065023 scopus 로고    scopus 로고
    • Species differences in response to diethylhexylphthalate: Suppression of apoptosis, induction of DNA synthesis and peroxisome proliferator activated receptor alphamediated gene expression
    • Hasmall, S. C., James, N. H., Macdonald, N., Soames, A. R., and Roberts, R. A. 2000. Species differences in response to diethylhexylphthalate: Suppression of apoptosis, induction of DNA synthesis and peroxisome proliferator activated receptor alphamediated gene expression. Arch. Toxicol. 74:85-91.
    • (2000) Arch. Toxicol , vol.74 , pp. 85-91
    • Hasmall, S.C.1    James, N.H.2    Macdonald, N.3    Soames, A.R.4    Roberts, R.A.5
  • 13
    • 4444352514 scopus 로고    scopus 로고
    • Environmental phthalate monoesters activate pregnane X receptor-mediated transcription
    • Hurst, C. H., and Waxman, D. J. 2004. Environmental phthalate monoesters activate pregnane X receptor-mediated transcription. Toxicol. Appl. Pharmacol. 199:266-274.
    • (2004) Toxicol. Appl. Pharmacol. , vol.199 , pp. 266-274
    • Hurst, C.H.1    Waxman, D.J.2
  • 14
    • 0026579621 scopus 로고
    • Nucleolar antigens and autoantibodies in hepatocellular carcinoma and other malignancies
    • Imai, H., Ochs, R. L., Kiyosawa, K., Furuta, S., Nakamura, R. M., and Tan, E. M. 1992. Nucleolar antigens and autoantibodies in hepatocellular carcinoma and other malignancies. Am. J. Pathol. 140:859-870.
    • (1992) Am. J. Pathol. , vol.140 , pp. 859-870
    • Imai, H.1    Ochs, R.L.2    Kiyosawa, K.3    Furuta, S.4    Nakamura, R.M.5    Tan, E.M.6
  • 15
    • 0035194767 scopus 로고    scopus 로고
    • Reversibility and persistence of di-2-ethylhexyl phthalate (DEHP) and phenobarbital-induced hepatocellular changes in rodents
    • Isenberg, J. S., Kamendulis, L. M., Ackley, D. C., Smith, J. H., Pugh, G. Jr., Lington, A. W., McKee, R. H., and Klaunig, J. E. 2001. Reversibility and persistence of di-2-ethylhexyl phthalate (DEHP) and phenobarbital-induced hepatocellular changes in rodents. Toxicol. Sci. 64:192-199.
    • (2001) Toxicol. Sci. , vol.64 , pp. 192-199
    • Isenberg, J.S.1    Kamendulis, L.M.2    Ackley, D.C.3    Smith, J.H.4    Pugh Jr., G.5    Lington, A.W.6    McKee, R.H.7    Klaunig, J.E.8
  • 16
    • 42949145115 scopus 로고    scopus 로고
    • Phorbol ester up-regulates phospholipase D1 but not phospholipase D2 expression through a PKC/Ras/ERK/NFkappaB-dependent pathway and enhances matrix metalloproteinase-9 secretion in colon cancer cells
    • Kang, D. W., Park, M. H., Lee, Y. J., Kim, H. S., Kwon, T. K., Park, W. S., and Min, D. S. 2008. Phorbol ester up-regulates phospholipase D1 but not phospholipase D2 expression through a PKC/Ras/ERK/NFkappaB-dependent pathway and enhances matrix metalloproteinase-9 secretion in colon cancer cells. J. Biol. Chem. 283:4094-4104.
    • (2008) J. Biol. Chem. , vol.283 , pp. 4094-4104
    • Kang, D.W.1    Park, M.H.2    Lee, Y.J.3    Kim, H.S.4    Kwon, T.K.5    Park, W.S.6    Min, D.S.7
  • 18
    • 0026724697 scopus 로고
    • Immunocytochemical identification of proliferative hepatocytes using monoclonal antibody to proliferating cell nuclear antigen (PCNA/cyclin). Comparison with immunocytochemical staining for DNA polymerase-alpha
    • Kawakita, N., Seki, S., Yanai, A., Sakaguch, H., Kuroki, T., Mizoguchi, Y., Kobayashi, K., and Monna, T. 1992. Immunocytochemical identification of proliferative hepatocytes using monoclonal antibody to proliferating cell nuclear antigen (PCNA/cyclin). Comparison with immunocytochemical staining for DNA polymerase-alpha. Am. J. Clin. Pathol. 97 (suppl. 1):14-20.
    • (1992) Am. J. Clin. Pathol. , vol.97 , Issue.1 SUPPL. , pp. 14-20
    • Kawakita, N.1    Seki, S.2    Yanai, A.3    Sakaguch, H.4    Kuroki, T.5    Mizoguchi, Y.6    Kobayashi, K.7    Monna, T.8
  • 19
    • 33846813514 scopus 로고    scopus 로고
    • Differential expression of phospholipases D1 and D2 in mouse tissues
    • DOI 10.1016/j.cellbi.2006.09.020, PII S1065699506002125
    • Kim, H., Lee, J., Kim, S., Shin, M. K., Min, D. S., and Shin, T. 2007. Differential expression of phospholipases D1 and D2 in mouse tissues. Cell Biol. Int. 31:148-155. (Pubitemid 46201910)
    • (2007) Cell Biology International , vol.31 , Issue.2 , pp. 148-155
    • Kim, H.1    Lee, J.2    Kim, S.3    Shin, M.K.4    Min, D.S.5    Shin, T.6
  • 20
    • 0020444298 scopus 로고
    • The carcinogenicity of dietary di (2-ethylhexyl) phthalate (DEHP) in Fischer 344 rats and B6C3F1 mice
    • Kluwe, W. M., Haseman, J. K., Douglas, J. F., and Huff, J. E. 1982. The carcinogenicity of dietary di (2-ethylhexyl) phthalate (DEHP) in Fischer 344 rats and B6C3F1 mice. J Toxicol. Environ. Health A 10:797-815.
    • (1982) J. Toxicol. Environ. Health A , vol.10 , pp. 797-815
    • Kluwe, W.M.1    Haseman, J.K.2    Douglas, J.F.3    Huff, J.E.4
  • 22
    • 0016698974 scopus 로고
    • Studies on the hepatic effects of orally administered di-(2-ethylhexyl) phthalate in the rat
    • Lake, B. G., Gangolli, S. D., Grasso, P., and Lloyd, A. G. 1975. Studies on the hepatic effects of orally administered di-(2-ethylhexyl) phthalate in the rat. Toxicol. Appl. Pharmacol. 32:355-367.
    • (1975) Toxicol. Appl. Pharmacol. , vol.32 , pp. 355-367
    • Lake, B.G.1    Gangolli, S.D.2    Grasso, P.3    Lloyd, A.G.4
  • 23
    • 0023234291 scopus 로고
    • Effect of prolonged administration of clofibric acid and di-(2-ethylhexyl) phthalate on hepatic enzyme activities and lipid peroxidation in the rat
    • Lake, B. G., Kozlen, S. L., Evans, J. G., Gray, T. J., Young, P. J., and Gangolli, S. D. 1987. Effect of prolonged administration of clofibric acid and di-(2-ethylhexyl) phthalate on hepatic enzyme activities and lipid peroxidation in the rat. Toxicology 44:213-228.
    • (1987) Toxicology , vol.44 , pp. 213-228
    • Lake, B.G.1    Kozlen, S.L.2    Evans, J.G.3    Gray, T.J.4    Young, P.J.5    Gangolli, S.D.6
  • 24
    • 0034142081 scopus 로고    scopus 로고
    • Phospholipase D: Molecular and cell biology of a novel gene family
    • Liscovitch, M., Czarny, M., Fiucci, G., and Tang, X. 2000. Phospholipase D: molecular and cell biology of a novel gene family. Biochem. J. 345:401-415.
    • (2000) Biochem. J. , vol.345 , pp. 401-415
    • Liscovitch, M.1    Czarny, M.2    Fiucci, G.3    Tang, X.4
  • 25
    • 0027182431 scopus 로고
    • DNA hypomethylation of proliferating cell nuclear antigen gene in human hepatocellular carcinoma is not due to cell proliferation
    • Liu, Y. W., Chang, K. J., and Liu, Y. C. 1993. DNA hypomethylation of proliferating cell nuclear antigen gene in human hepatocellular carcinoma is not due to cell proliferation. Cancer Lett. 70:189-196.
    • (1993) Cancer Lett. , vol.70 , pp. 189-196
    • Liu, Y.W.1    Chang, K.J.2    Liu, Y.C.3
  • 26
    • 1542283630 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor α target genes
    • Mandard, S., Muller, M., and Kersten, S. 2004. Peroxisome proliferator-activated receptor α target genes. Cell Mol. Life Sci. 61:393-416.
    • (2004) Cell. Mol. Life Sci. , vol.61 , pp. 393-416
    • Mandard, S.1    Muller, M.2    Kersten, S.3
  • 29
    • 0018172473 scopus 로고
    • Hepatic peroxisome (microbody) proliferation in rats fed plasticizers and related compounds
    • Moody, D. E., and Reddy, J. K. 1978. Hepatic peroxisome (microbody) proliferation in rats fed plasticizers and related compounds. Toxicol Appl Pharmacol. 45:497-504.
    • (1978) Toxicol Appl. Pharmacol. , vol.45 , pp. 497-504
    • Moody, D.E.1    Reddy, J.K.2
  • 30
    • 0021858935 scopus 로고
    • Rapid induction of cirrhosis by administration of carbon tetrachloride plus phospholipase D
    • Ozeki, T., Funakoshi, K., and Iwaki, K. 1985. Rapid induction of cirrhosis by administration of carbon tetrachloride plus phospholipase D. Br. J. Exp. Pathol. 66:385-390.
    • (1985) Br. J. Exp. Pathol. , vol.66 , pp. 385-390
    • Ozeki, T.1    Funakoshi, K.2    Iwaki, K.3
  • 31
    • 33745217598 scopus 로고    scopus 로고
    • Chronic toxicity of diethyl phthalate in male Wistar rats - A dose-response study
    • Pereira, C., Mapuskar, K., and Rao, C. V. 2006. Chronic toxicity of diethyl phthalate in male Wistar rats-a dose-response study. Regul. Toxicol. Pharmacol. 45:169-177.
    • (2006) Regul. Toxicol. Pharmacol. , vol.45 , pp. 169-177
    • Pereira, C.1    Mapuskar, K.2    Rao, C.V.3
  • 33
    • 75249083175 scopus 로고    scopus 로고
    • Characterization of peroxisome proliferator-activated receptor alpha-independent effects of PPARalpha activators in the rodent liver: Di-(2-ethylhexyl) phthalate also activates the constitutive-activated receptor
    • Ren, H., Aleksunes, L. M., Wood, C., Vallanat, B., George, M. H., Klaassen, C. D., and Corton, J. C. 2010. Characterization of peroxisome proliferator-activated receptor alpha-independent effects of PPARalpha activators in the rodent liver: Di-(2-ethylhexyl) phthalate also activates the constitutive-activated receptor. Toxicol. Sci. 113:45-59.
    • (2010) Toxicol. Sci. , vol.113 , pp. 45-59
    • Ren, H.1    Aleksunes, L.M.2    Wood, C.3    Vallanat, B.4    George, M.H.5    Klaassen, C.D.6    Corton, J.C.7
  • 34
    • 0033753210 scopus 로고    scopus 로고
    • Novel role of oxidants in the molecular mechanism of action of peroxisome proliferators
    • Rusyn, I., Rose, M. L., and Bojes, H. K. 2000. Thurman RG. 2001. Novel role of oxidants in the molecular mechanism of action of peroxisome proliferators. Antioxid. Redox Signal. 2:607-621.
    • (2000) Antioxid. Redox Signal , vol.2 , pp. 607-621
    • Rusyn, I.1    Rose, M.L.2    Bojes, H.K.3    Thurman, R.G.4
  • 35
    • 33745204653 scopus 로고    scopus 로고
    • Modes of action and species-specific effects of di-(2-ethylhexyl) phthalate in the liver
    • Rusyn, I., Peters, J. M., and Cunningham, M. L. 2006. Modes of action and species-specific effects of di-(2-ethylhexyl) phthalate in the liver. Crit. Rev. Toxicol. 36:459-479.
    • (2006) Crit. Rev. Toxicol , vol.36 , pp. 459-479
    • Rusyn, I.1    Peters, J.M.2    Cunningham, M.L.3
  • 37
    • 0020334775 scopus 로고
    • Hepatic effects of phthalate esters
    • Seth, P. K. 1982. Hepatic effects of phthalate esters. Environ. Health Perspect. 45:27-34.
    • (1982) Environ. Health Perspect , vol.45 , pp. 27-34
    • Seth, P.K.1
  • 38
    • 0035153953 scopus 로고    scopus 로고
    • Health risks posed by use of di-2-ethylhexyl phthalate (DEHP) in PVC medical devices: A critical review
    • Tickner, J. A., Schettler, T., Guidotti, T., McCally, M., and Rossi, M. 2001. Health risks posed by use of di-2-ethylhexyl phthalate (DEHP) in PVC medical devices: A critical review. Am. J. Ind. Med. 39:100-111.
    • (2001) Am. J. Ind. Med. , vol.39 , pp. 100-111
    • Tickner, J.A.1    Schettler, T.2    Guidotti, T.3    McCally, M.4    Rossi, M.5
  • 39
    • 0032813328 scopus 로고    scopus 로고
    • Phospholipase D in cellular senescence
    • Venable, M. E., and Obeid, L. M. 1999. Phospholipase D in cellular senescence. Biochim. Biophys. Acta 1439:291-298.
    • (1999) Biochim. Biophys. Acta , vol.1439 , pp. 291-298
    • Venable, M.E.1    Obeid, L.M.2
  • 40
    • 0031969263 scopus 로고    scopus 로고
    • Receptor and nonreceptor-mediated organ-specific toxicity of di (2-ethylhexyl) phthalate (DEHP) in peroxisome proliferator-activated receptor α-null mice
    • Ward, J. M., Peters, J. M., Perella, C. M., and Gonzalez, F. J. 1998. Receptor and nonreceptor-mediated organ-specific toxicity of di (2-ethylhexyl) phthalate (DEHP) in peroxisome proliferator-activated receptor α-null mice. Toxicol. Pathol. 26:240-246.
    • (1998) Toxicol. Pathol. , vol.26 , pp. 240-246
    • Ward, J.M.1    Peters, J.M.2    Perella, C.M.3    Gonzalez, F.J.4
  • 41
    • 0020334777 scopus 로고
    • Phthalate esters as peroxisome proliferator carcinogens
    • Warren, J. R., Lalwani, N. D., and Reddy, J. K. 1982. Phthalate esters as peroxisome proliferator carcinogens. Environ. Health Perspect. 45:35-40.
    • (1982) Environ. Health Perspect , vol.45 , pp. 35-40
    • Warren, J.R.1    Lalwani, N.D.2    Reddy, J.K.3
  • 42
    • 0035132641 scopus 로고    scopus 로고
    • Nuclear receptor CAR as a regulatory factor for the sexually dimorphic induction of CYP2B1 gene by phenobarbital in rat livers
    • Yoshinari, K., Sueyoshi, T., Moore, R., and Negishi, M. 2001. Nuclear receptor CAR as a regulatory factor for the sexually dimorphic induction of CYP2B1 gene by phenobarbital in rat livers. Mol. Phamacol. 59:278-284.
    • (2001) Mol. Phamacol , vol.59 , pp. 278-284
    • Yoshinari, K.1    Sueyoshi, T.2    Moore, R.3    Negishi, M.4
  • 43
    • 0033167086 scopus 로고    scopus 로고
    • Phospholipase D activity of cytochrome P450 in human liver endoplasmic reticulum
    • Yun, C. H., Ahn, T., Guengerich, F. P., Yamazaki, H., and Shimada, T. 1999. Phospholipase D activity of cytochrome P450 in human liver endoplasmic reticulum. Arch. Biochem. Biophys. 367:81-88.
    • (1999) Arch. Biochem. Biophys. , vol.367 , pp. 81-88
    • Yun, C.H.1    Ahn, T.2    Guengerich, F.P.3    Yamazaki, H.4    Shimada, T.5


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