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Volumn 45, Issue 2, 2006, Pages 169-177

Chronic toxicity of diethyl phthalate in male Wistar rats-A dose-response study

Author keywords

Diethyl phthalate (DEP); Enzymes; Histology; Serum

Indexed keywords

CHOLESTEROL; CORN OIL; ENZYME; GLYCOGEN; PHTHALIC ACID DIETHYL ESTER; TRIACYLGLYCEROL; WATER;

EID: 33745217598     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2006.04.006     Document Type: Article
Times cited : (48)

References (39)
  • 1
    • 0035084122 scopus 로고    scopus 로고
    • Toxicological profile of diethyl phthalate: a vehicle for fragrance and cosmetic ingredients
    • Api A.M. Toxicological profile of diethyl phthalate: a vehicle for fragrance and cosmetic ingredients. Food Chem. Toxicol. 39 (2001) 97-108
    • (2001) Food Chem. Toxicol. , vol.39 , pp. 97-108
    • Api, A.M.1
  • 2
    • 33745196329 scopus 로고    scopus 로고
    • ATSDR., 1995. Toxicological profile for Diethyl Phthalate. Atlanta, GA: Agency for Toxic Substances and Disease Registry. Available from: (accessed 21 June 2005).
  • 3
    • 0000416021 scopus 로고
    • Lactate dehydrogenase
    • Bergmeyer H.U. (Ed), Verlag Chemie Weinheim, Academic Press, New York and London
    • Bergmeyer H.U., Bernt E., and Beneno H. Lactate dehydrogenase. In: Bergmeyer H.U. (Ed). Methods of Enzymatic Analysis Vol. 2 (1974), Verlag Chemie Weinheim, Academic Press, New York and London 736-738
    • (1974) Methods of Enzymatic Analysis , vol.2 , pp. 736-738
    • Bergmeyer, H.U.1    Bernt, E.2    Beneno, H.3
  • 4
    • 0001690532 scopus 로고
    • Glutathione and glutathione reductase
    • Bergmeyer H.U. (Ed), Verlag Chemie Weinheim, Academic Press, New York
    • Bernt E., and Bergmeyer H.U. Glutathione and glutathione reductase. In: Bergmeyer H.U. (Ed). Methods of Enzymatic Analysis Vol. 4 (1974), Verlag Chemie Weinheim, Academic Press, New York 1643-1647
    • (1974) Methods of Enzymatic Analysis , vol.4 , pp. 1643-1647
    • Bernt, E.1    Bergmeyer, H.U.2
  • 5
    • 0033693113 scopus 로고    scopus 로고
    • Levels of seven urinary phthalate metabolites in a human reference population
    • Blount B.C., Silva M.J., Caudill S.P., et al. Levels of seven urinary phthalate metabolites in a human reference population. Environ. Health Perspect. 108 (2000) 979-982
    • (2000) Environ. Health Perspect. , vol.108 , pp. 979-982
    • Blount, B.C.1    Silva, M.J.2    Caudill, S.P.3
  • 7
    • 0021800126 scopus 로고    scopus 로고
    • Cosmetic Ingredient Review (CIR) 1985. Final report on the safety assessment of dibutyl phthalate, dimethyl phthalate, and diethyl phthalate. Journal of the American College of Toxicology, 4(3), 267-303.
  • 8
    • 0018907441 scopus 로고
    • Functional and biochemical correlates of chlordecone exposure and its enhancement of CCl4 hepatoxicity
    • Davis M.E., and Mehendale H.M. Functional and biochemical correlates of chlordecone exposure and its enhancement of CCl4 hepatoxicity. Toxicology 15 (1980) 91-103
    • (1980) Toxicology , vol.15 , pp. 91-103
    • Davis, M.E.1    Mehendale, H.M.2
  • 9
    • 27744538788 scopus 로고    scopus 로고
    • Personal care product use predicts urinary concentrations of some phthalate monoesters
    • Duty S.M., Ackerman R.M., Calafat A.M., and Hauser R. Personal care product use predicts urinary concentrations of some phthalate monoesters. Environ. Health Perspect. 113 (2005) 1530-1535
    • (2005) Environ. Health Perspect. , vol.113 , pp. 1530-1535
    • Duty, S.M.1    Ackerman, R.M.2    Calafat, A.M.3    Hauser, R.4
  • 10
    • 33745222906 scopus 로고    scopus 로고
    • Environmental Protection Agency (EPA) 1981. Exposure and Risk Assessment for Phthalate Esters. EPA/440/4-81-020.
  • 11
    • 33745223371 scopus 로고    scopus 로고
    • Environmental Protection Agency (EPA) 1987. Health and environmental effects profile for phthalic acid esters. NTIS PB-89-120158.
  • 12
    • 0015366343 scopus 로고
    • Improved determination of total serum lipid by the sulphophospho vanillin reaction
    • Frings C.S., Fendly J.W., Dunn R.T., and Queen C.A. Improved determination of total serum lipid by the sulphophospho vanillin reaction. Clin. Chem. 18 (1972) 673
    • (1972) Clin. Chem. , vol.18 , pp. 673
    • Frings, C.S.1    Fendly, J.W.2    Dunn, R.T.3    Queen, C.A.4
  • 13
    • 0007651264 scopus 로고
    • Plasticizers in food
    • Giam C.S., and Wong M.K. Plasticizers in food. J. Food Prot. 50 (1987) 769-782
    • (1987) J. Food Prot. , vol.50 , pp. 769-782
    • Giam, C.S.1    Wong, M.K.2
  • 14
    • 10644277053 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in liver disease and organ transplantation
    • Hassanein T. Mitochondrial dysfunction in liver disease and organ transplantation. Mitochondrion 4 (2004) 609-620
    • (2004) Mitochondrion , vol.4 , pp. 609-620
    • Hassanein, T.1
  • 16
    • 0041352906 scopus 로고    scopus 로고
    • Activation of PPARalpha and PPARgamma by environmental phthalate monoesters
    • Hurst C.H., and Waxman D.J. Activation of PPARalpha and PPARgamma by environmental phthalate monoesters. Toxicol. Sci. 74 (2003) 297-308
    • (2003) Toxicol. Sci. , vol.74 , pp. 297-308
    • Hurst, C.H.1    Waxman, D.J.2
  • 17
    • 0029146597 scopus 로고
    • A variety of environmentally persistent chemicals, including some phthalate plasticizers, are weakly estrogenic
    • Joblings S., Reynolds T., White R., Parker M.G., and Sumpter J.P. A variety of environmentally persistent chemicals, including some phthalate plasticizers, are weakly estrogenic. Environ. Health Perspect. 103 (1995) 582-587
    • (1995) Environ. Health Perspect. , vol.103 , pp. 582-587
    • Joblings, S.1    Reynolds, T.2    White, R.3    Parker, M.G.4    Sumpter, J.P.5
  • 18
    • 1542498397 scopus 로고    scopus 로고
    • Mono(2-ethyl-5-hydroxyhexyl) phthalate and mono(2-ethyl-5-oxohexyl) phthalate as biomarkers for human exposure assessment to di-(2-ethylhexyl) phthalate
    • Kato K., Silva M.J., Reidy J.A., Hurtz D., et al. Mono(2-ethyl-5-hydroxyhexyl) phthalate and mono(2-ethyl-5-oxohexyl) phthalate as biomarkers for human exposure assessment to di-(2-ethylhexyl) phthalate. Environ. Health Perspect. 112 (2004) 327-330
    • (2004) Environ. Health Perspect. , vol.112 , pp. 327-330
    • Kato, K.1    Silva, M.J.2    Reidy, J.A.3    Hurtz, D.4
  • 19
    • 0036755741 scopus 로고    scopus 로고
    • NTP Center for the Evaluation of Risks to Human Reproduction: Phthalates expert panel report on the reproductive and Developmental toxicity of di(2-ethylhexyl) phthalate
    • Kavlock R., Boekelheide K., Chapin R., Cunningham M., Faustman E., Foster P., Golub M., Henderson R., Hinberg J., et al. NTP Center for the Evaluation of Risks to Human Reproduction: Phthalates expert panel report on the reproductive and Developmental toxicity of di(2-ethylhexyl) phthalate. Reprod. Toxicol. 16 (2002) 529-653
    • (2002) Reprod. Toxicol. , vol.16 , pp. 529-653
    • Kavlock, R.1    Boekelheide, K.2    Chapin, R.3    Cunningham, M.4    Faustman, E.5    Foster, P.6    Golub, M.7    Henderson, R.8    Hinberg, J.9
  • 20
    • 0036754969 scopus 로고    scopus 로고
    • NTP Center for the Evaluation of Risks to Human Reproduction: Phthalates expert panel report on the reproductive and Developmental toxicity of di-isononyl phthalate
    • Kavlock R., Boekelheide K., Chapin R., Cunningham M., Faustman E., Foster P., Golub M., Henderson R., Hinberg J., et al. NTP Center for the Evaluation of Risks to Human Reproduction: Phthalates expert panel report on the reproductive and Developmental toxicity of di-isononyl phthalate. Reprod. Toxicol. 16 (2002) 679-708
    • (2002) Reprod. Toxicol. , vol.16 , pp. 679-708
    • Kavlock, R.1    Boekelheide, K.2    Chapin, R.3    Cunningham, M.4    Faustman, E.5    Foster, P.6    Golub, M.7    Henderson, R.8    Hinberg, J.9
  • 21
    • 0036754969 scopus 로고    scopus 로고
    • NTP Center for the Evaluation of Risks to Human Reproduction: Phthalates expert panel report on the reproductive and Developmental toxicity of di-n-octyl phthalate
    • Kavlock R., Boekelheide K., Chapin R., Cunningham M., Faustman E., Foster P., Golub M., Henderson R., Hinberg J., et al. NTP Center for the Evaluation of Risks to Human Reproduction: Phthalates expert panel report on the reproductive and Developmental toxicity of di-n-octyl phthalate. Reprod. Toxicol. 16 (2002) 721-734
    • (2002) Reprod. Toxicol. , vol.16 , pp. 721-734
    • Kavlock, R.1    Boekelheide, K.2    Chapin, R.3    Cunningham, M.4    Faustman, E.5    Foster, P.6    Golub, M.7    Henderson, R.8    Hinberg, J.9
  • 22
    • 0000831015 scopus 로고
    • Acid Phosphatase
    • Bergmeyer H.U. (Ed), Verlag Chemie Weinheim, Academic Press, New York and London
    • Klaus W., and Christian S. Acid Phosphatase. In: Bergmeyer H.U. (Ed). Methods of Enzymatic Analysis vol. 2 (1974), Verlag Chemie Weinheim, Academic Press, New York and London 856-860
    • (1974) Methods of Enzymatic Analysis , vol.2 , pp. 856-860
    • Klaus, W.1    Christian, S.2
  • 24
    • 0032585881 scopus 로고    scopus 로고
    • Trans-activation of PPARalpha and PPARgamma by structurally diverse environmental chemicals
    • Maloney E.K., and Waxman D.J. Trans-activation of PPARalpha and PPARgamma by structurally diverse environmental chemicals. Toxicol. Appl. Pharmacol. 161 (1999) 209-218
    • (1999) Toxicol. Appl. Pharmacol. , vol.161 , pp. 209-218
    • Maloney, E.K.1    Waxman, D.J.2
  • 25
    • 0022296228 scopus 로고
    • The fall and rise of cellular glutathione levels: enzyme based approaches
    • Meister A. The fall and rise of cellular glutathione levels: enzyme based approaches. Curr. Top Cell Regul. 26 (1985) 383-394
    • (1985) Curr. Top Cell Regul. , vol.26 , pp. 383-394
    • Meister, A.1
  • 26
    • 8244237727 scopus 로고    scopus 로고
    • Analysis of the steroidogenic acute regulatory protein (StAR) gene in Japanese patients with congenital lipoid adrenal hyperplasia
    • Nakae J., Tajima T., Sugawara T., Arakane F., et al. Analysis of the steroidogenic acute regulatory protein (StAR) gene in Japanese patients with congenital lipoid adrenal hyperplasia. Human Mol. Genetics. 6 (1997) 571-576
    • (1997) Human Mol. Genetics. , vol.6 , pp. 571-576
    • Nakae, J.1    Tajima, T.2    Sugawara, T.3    Arakane, F.4
  • 27
    • 33745213661 scopus 로고    scopus 로고
    • National Center for Health Statistics. National Health and Nutritional Examination Survey. (NHANES web site). 1 July 2001. Available at: . Accessed 10 October 2005.
  • 28
    • 66349129125 scopus 로고
    • A colorimetric method for the determination of oxaloacetic acid glutamic pyruvic transaminase
    • Reitman S., and Frankel S. A colorimetric method for the determination of oxaloacetic acid glutamic pyruvic transaminase. Am. J. Clin. Pathol. 28 (1957) 53-56
    • (1957) Am. J. Clin. Pathol. , vol.28 , pp. 53-56
    • Reitman, S.1    Frankel, S.2
  • 29
    • 0036901692 scopus 로고    scopus 로고
    • Role of environmental estrogens in deterioration of male factor fertility
    • Rozati R., Reddy P.P., Reddanna P., and Mujtaba R. Role of environmental estrogens in deterioration of male factor fertility. Fert. Ster. 78 6 (2002) 1187-1194
    • (2002) Fert. Ster. , vol.78 , Issue.6 , pp. 1187-1194
    • Rozati, R.1    Reddy, P.P.2    Reddanna, P.3    Mujtaba, R.4
  • 30
    • 33745189009 scopus 로고    scopus 로고
    • SCCNFP, 2002. Opinion of the Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers concerning Diethyl Phthalate. 20th Plenary meeting of 4 June 2002. SCCNFP/0411/01, final.
  • 31
    • 33745210665 scopus 로고    scopus 로고
    • SCCNFP, 2003. Opinion of the Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers concerning Diethyl Phthalate. 26th Plenary meeting of 9 December 2003. SCCNFP/0767/03.
  • 32
    • 12144266466 scopus 로고
    • Estimation of glycogen with anthrone reagent
    • Seifter S., Dayton S., and Muntwyler B.E. Estimation of glycogen with anthrone reagent. Arch. Biochem. 25 (1950) 191-200
    • (1950) Arch. Biochem. , vol.25 , pp. 191-200
    • Seifter, S.1    Dayton, S.2    Muntwyler, B.E.3
  • 33
    • 1542686315 scopus 로고    scopus 로고
    • Urinary levels of seven phthalates metabolites in the U.S. population from the National Health and Nutrition Examination Survey (NHANES) 1999-2000
    • Silva M.J., Barr D.B., Reidy J.A., Malek N.A., Hodge C.C., and Caudill S.P. Urinary levels of seven phthalates metabolites in the U.S. population from the National Health and Nutrition Examination Survey (NHANES) 1999-2000. Environ. Health Perspect. 112 (2004) 331-338
    • (2004) Environ. Health Perspect. , vol.112 , pp. 331-338
    • Silva, M.J.1    Barr, D.B.2    Reidy, J.A.3    Malek, N.A.4    Hodge, C.C.5    Caudill, S.P.6
  • 34
    • 0034685740 scopus 로고    scopus 로고
    • Simultaneous administration of diethylphthalate and ethyl alcohol and its toxicity in male Sprague Dawley rats
    • Sonde V., D'Souza A., Tarapore R., Pereira L., Khare M.P., Sinkar P.U., Krishnan S., and Rao C.V. Simultaneous administration of diethylphthalate and ethyl alcohol and its toxicity in male Sprague Dawley rats. Toxicology 147 (2000) 23-31
    • (2000) Toxicology , vol.147 , pp. 23-31
    • Sonde, V.1    D'Souza, A.2    Tarapore, R.3    Pereira, L.4    Khare, M.P.5    Sinkar, P.U.6    Krishnan, S.7    Rao, C.V.8
  • 35
    • 0034899563 scopus 로고    scopus 로고
    • Tracking the role of a StAR in the sky of the new millennium
    • Stocco D.M. Tracking the role of a StAR in the sky of the new millennium. Mol. Endocrinol. 15 (2001) 1245-1254
    • (2001) Mol. Endocrinol. , vol.15 , pp. 1245-1254
    • Stocco, D.M.1
  • 36
    • 33745216333 scopus 로고    scopus 로고
    • US EPA (1993). Integrated Risk Information System: Diethyl Phthalate (CASRN: 84-66-2). Washington, DC, US Environmental Protection Agency, at website .
  • 37
    • 0033020938 scopus 로고    scopus 로고
    • Identification of plasticizers in medical products by a combined direct thermodesorption-cooled injection system and gas chromatography-mass spectrometry
    • Wahl H.G., Hoffmann A., Häring H.U., and Liebich H.M. Identification of plasticizers in medical products by a combined direct thermodesorption-cooled injection system and gas chromatography-mass spectrometry. J. Chromatogr., Part A 847 (1999) 1-7
    • (1999) J. Chromatogr., Part A , vol.847 , pp. 1-7
    • Wahl, H.G.1    Hoffmann, A.2    Häring, H.U.3    Liebich, H.M.4
  • 38
    • 33745217022 scopus 로고    scopus 로고
    • WHO, 2003. Concise International Chemical Assessment Document 52. Diethyl Phthalate.
  • 39
    • 0014906707 scopus 로고
    • Estimation of total serum/plasma cholesterol by sulphuric and ferric chloride reaction in acetic acid
    • Wybenga D.R., and Pileggi J.M. Estimation of total serum/plasma cholesterol by sulphuric and ferric chloride reaction in acetic acid. Clin. Chem. 16 (1970) 980-984
    • (1970) Clin. Chem. , vol.16 , pp. 980-984
    • Wybenga, D.R.1    Pileggi, J.M.2


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