Health risks posed by use of di-2-ethylhexyl phthalate (DEHP) in PVC medical devices: A critical review

American Journal of Industrial Medicine

Volumn 39, Issue 1, 2001, Pages 100-111

  Tickner, Joel A ^a   Schettler, Ted ^b   Guidotti, Tee ^c   McCally, Michael ^d   Rossi, Mark ^e  

^a UNIVERSITY OF MASSACHUSETTS LOWELL   (United States)

^b BOSTON MEDICAL CENTER   (United States)

^c GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Di ethylhexyl phthalate; Medical device; Peroxisome proliferation; Polyvinyl chloride

Indexed keywords

PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; POLYVINYLCHLORIDE;

ARTICLE; CANCER RISK; CARCINOGENICITY; CARDIOTOXICITY; DISEASE ASSOCIATION; HEALTH HAZARD; HUMAN; LIVER CANCER; LIVER TOXICITY; LONG TERM EXPOSURE; LUNG TOXICITY; MEDICAL INSTRUMENTATION; METABOLISM; NEPHROTOXICITY; REPRODUCTIVE TOXICITY; TERATOGENICITY;

ANIMALS; BLOOD TRANSFUSION; CARCINOGENS; CHILD DEVELOPMENT; DIETHYLHEXYL PHTHALATE; DIFFUSION; EMBRYONIC AND FETAL DEVELOPMENT; ENVIRONMENTAL EXPOSURE; EQUIPMENT AND SUPPLIES; EQUIPMENT DESIGN; EQUIPMENT SAFETY; HAZARDOUS SUBSTANCES; HUMANS; INFANT, NEWBORN; OCCUPATIONAL EXPOSURE; PLASTICIZERS; PLASTICS; POLYVINYL CHLORIDE; RENAL DIALYSIS; RISK FACTORS;

EID: 0035153953     PISSN: 02713586     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0274(200101)39:1<100::AID-AJIM10>3.0.CO;2-Q     Document Type: Article

References (105)

1. Effects of di(2-ethylhexyl) phthalate on the gonadal pathophysiology, sperm morphology, and reproductive performance of male rats
2. Pharmacokinetics, interactions with macromolecules and species differences in metabolism of DEHP
3. Oral toxicity of DEHP during pregnancy and suckling in the Long-Evans rat
4. Elevated 8-hydroxydeoxyguanosine in hepatic DNA of rats following exposure to peroxisome proliferators: Relationship to carcinogenesis and nuclear localization
5. Leaching of plasticizers from and surface characterization of PVC blood platelet bags
6. Perplexing peroxisome proliferators
7. Proliferation of Sertoli cells during development of the human testis assessed by stereological methods
8. Effects of chronic phthalate exposure on the kidney
9. PVC replacement in medical devices
10. Di-(2-ethylhexyl) phthalate suppresses estradiol and ovulation in cycling rats
11. Glucuronidation in humans. Pharmacogenetic and developmental aspects
12. Metabolites of the plasticizer di(2-ethylhexyl) phthalate in urine samples of workers in polyvinylchloride processing industries
13. Genetic toxicology of phthalate esters: Mutagenic and other genotoxic effects
14. A cancer risk assessment of di(2-ethylhexyl)phthalate: Application of the new U.S. EPA risk assessment guidelines
15. Spatial variations and correlations in the distribution of PCDDs and PCDFs and related compounds in sediments from the river Rhine
16. Maker of IV system to stop using a plastic
17. Phthalate esters and their effect on the liver
18. Effects of prolonged administration of phthalate ester on the liver
19. Delivery of di-2-ethylhexyl phthalate to patients during hemodialysis
20. Impaired metabolism of di(2-ethylhexyl) phthalate (DEHP) in old rat - An in vitro study
21. Mechanism of action of the nongenotoxic peroxisome proliferators: Role of the peroxisome proliferator-activated receptor-alpha
22. Effect of some phthalate esters and other testicular toxins on primary cultures of testicular cells
23. Aspects of the testicular toxicity of phthalate esters
24. Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinate, p,p′-DDE, and ketoconazole) and toxic substances (dibutyl- and diethylhexyl phthalate, PCB 169, and ethane dimethane sulphonate) during sexual differentiation produces diverse profiles of reproductive malformations in the rat
25. The future of medical waste incineration
26. Morphine glucuronidation in premature neonates
27. Identification and measurement of plasticizer in neonatal tissues after umbilical catheters and blood products
28. Hepatocarcinogenic potential of DEHP in rodents and its implications on human risk
29. Di(2-ethylhexyl) phthalate
30. Interior surface materials in the home and the development of bronchial obstruction in young children in Oslo, Norway
31. Effects of a plasticizer leached from PVC on the subhuman primate: A consequence of chronic transfusion therapy
32. Plasticizers from PVC
33. Migration of a phthalate ester plasticizer from polyvinyl chloride blood bags into stored human blood and its localization in human tissues
34. Prenatal and post-developmental UDP-glucuronyltransferases in the human liver
35. Hepatic effects of a phthalate ester plasticizer leached from poly(vinyl chloride) blood bags following transfusion
36. Vinyl chloride: Still a cause for concern
37. Overview of phthalate ester pharmacokinetics in mammalian species
38. Subchronic toxicity of DEHP in common marmosets: Lack of hepatic peroxisome proliferation, testicular atrophy, or pancreatic acinar cell hyperplasia
39. The in vitro hydrolysis of some phthalate diesters by hepatic and intestinal preparations from various species
40. The effect of mono(2-ethylhexyl)phthalate on an isolated perfused rat heart-lung preparation
41. Reproductive effects of four phthalic acid esters in the mouse
42. Materials degradation in endotracheal tubes: A potential contributor to bronchopulmonary disease
43. Bis(2-ethylhexyl) phthalate concentrations in the serum of hemodialysis patients
44. Effects of relatively low levels of mono-(2-ethylhexyl) phthalate on cocultured sertoli cells and gonocytes from neonatal rats
45. Medical device films: Performance properties of metallocene polyethylene films, EVA Films and flexible PVC films
46. Effect of mono(2-ethylhexyl) phthalate on follicle-stimulating hormone responsiveness of cultured rat sertoli cells
47. Trans-activation of PPAR-alpha and PPAR-gamma by structurally diverse environmental chemicals
48. Compatibility of docetaxel and paclitaxel in intravenous solutions with polyvinyl chloride infusion materials
49. Implications for risk assessment of suggested nongenotoxic mechanisms of chemical carcinogenesis
50. Phthalic acid is the main metabolite of the plasticizer di(2-ethylhexyl) phthalate in peritoneal dialysis patients
51. Nonadditive developmental toxicity in mixtures of trichloroethylene, di(2-ethylhexyl) phthalate and heptachlor in a 5 × 5 × 5 design
52. Residential exposure to plasticizers and its possible role in the pathogenesis of asthma
53. Leaching of diethylhexyl phthalate from polyvinyl chloride containers by selected drugs and formulation components
54. Toxic potential of the plasticizer di(2-ethylhexyl) phthalate in the context of its disposition and metabolism in primates and man
55. DEHP induces a functional zinc deficiency during pregnancy and teratogenesis that is independent of peroxisome proliferator-activated receptor-alpha
56. Exposure of newborn infants to di-(2-ethylhexyl) phthalate and 2-ethylhexanoic acid following exchange transfusion with polyvinylchloride catheters
57. Effects of route of administration and repetitive dosing on the disposition kinetics of di(2-ethylhexyl) phthalate and its mono-de-esterified metabolite in rats
58. Circulating concentrations of di(2-ethylhexyl) phthalate and its deesterified phthalic acid products following plasticizer exposure in patients receiving hemodialysis
59. Subchronic oral toxicity of di-n-octyl phthalate and DEHP in the rat
60. Carcinogenesis by hepatic peroxisome proliferators: Evaluation of the risk of hypolipidemic drugs and industrial plasticizers to humans
61. Induction of hepatic peroxisome proliferation in nonrodent species, including primates
62. Comparison of hepatic peroxisome proliferative effect and its implication for hepatocarcinogenicity of phthalate esters, di(2-ethylhexyl) phthalate, and di(2-ethylhexyl) adipate with a hypolipidemic drug
63. Comparative pharmacokinetics and subacute toxicity of di(2-ethylhexyl) phthalate (DEHP in rats and marmosets: Extrapolation of effects in rodents to man
64. Teratogenicity of di(2-ethylhexyl) phthalate, 2-ethylhexanol, 2-ethylhexanoic acid, and valproic acid, and potentiation by caffeine
65. Hypotension and cardiac arrest in rats after infusion of mono(2-ethylhexyl)phthalate (MEHP) a contaminant of stored blood
66. Distribution of di(2-ethylhexyl) phthalate and products in blood and blood components
67. DEHP as plasticizer in PVC respiratory tubing systems: Indications of hazardous effects on pulmonary function in mechanically ventilated, preterm infants
68. Metallocene polyolefins
69. A prospective analysis of cholestasis in infants supported with extracorporeal membrane oxygenation
70. Exposure to di(2-ethylhexyl) phthalate in infants receiving extracorporeal membrane oxygenation
71. Acute and subacute toxicity of di(2-ethylhexyl) phthalate with note upon its metabolism
72. Maternal-fetal transfer of 14C-di-2-ethylhexyl phthalate and 14C-diethyl phthalate in rats
73. Exposure of newborn infants to plasticizers: Plasma levels of di-(2-ethylhexyl) phthalate and mono-(2-ethylhexyl) phthalate during exchange transfusion
74. Dispositions of di- and mono-(2-ethylhexyl) phthalate in newborn infants subjected to exchange transfusions
75. Dioxin prevention and medical waste incinerators
76. Teratogenicity/fetotoxicity of DEHP in mice
77. Fetotoxic effects of mono-2-ethylhexyl phthalate (MEHP) in mice
78. Developmental toxicity evaluation of dietary di(2-ethylhexyl) phthalate in Fischer 344 rats and CD-1 mice
79. Formation of mono(ethylhexyl) phthalate from di(ethylhexyl) phthalate in human plasma stored in PVC bags and it's presence in fractionated plasma proteins
80. Polymer substitutes for medical grade polyvinyl chloride (PVC)
81. Receptor and nonreceptor mediated organ-specific toxicity of DEHP in peroxisome proliferator-activated receptor alpha-null mice
82. The impact of metallocenes on PVC