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Volumn 50, Issue 9, 2010, Pages 727-736

Gene therapy for high-grade glioma

Author keywords

Clinical trial; Gene therapy; Glioma

Indexed keywords

ACICLOVIR; ADENOVIRUS VECTOR; BETA INTERFERON; CYTOMEGALOVIRUS ANTIGEN PP65; CYTOSINE DEAMINASE; FLUCYTOSINE; GANCICLOVIR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 12; INTERLEUKIN 13 RECEPTOR ALPHA2; INTERLEUKIN 2; INTERLEUKIN 4; LENTIVIRUS VECTOR; LIPOSOME; LYSOSOME ASSOCIATED MEMBRANE PROTEIN; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; MONOPHENOL MONOOXYGENASE; NAKED DNA; ONCOLYTIC VIRUS; ONYX 015; PLASMID DNA; PROTEIN P53; RETROVIRUS VECTOR; SMALL INTERFERING RNA; SOMATOMEDIN C; THYMIDINE KINASE; TRANSFORMING GROWTH FACTOR BETA2; TUMOR SUPPRESSOR PROTEIN; UNINDEXED DRUG; VALACICLOVIR;

EID: 77958110297     PISSN: 04708105     EISSN: 13498029     Source Type: Journal    
DOI: 10.2176/nmc.50.727     Document Type: Article
Times cited : (18)

References (87)
  • 1
    • 58149233970 scopus 로고    scopus 로고
    • Phase ib trial of oncolytic herpes virus G207 shows safety of multiple injections and documents viral replication
    • Aghi MK, Chiocca EA: Phase ib trial of oncolytic herpes virus G207 shows safety of multiple injections and documents viral replication. Mol Ther 17: 8-9, 2009
    • (2009) Mol Ther , vol.17 , pp. 8-9
    • Aghi, M.K.1    Chiocca, E.A.2
  • 2
    • 0026575130 scopus 로고
    • Expression of insulin-like growth factors I and II and their receptor mRNAs in primary human astrocytomas and meningiomas; in vivo studies using in situ hybridization and immunocytochemistry
    • Antoniades HN, Galanopoulos T, Neville-Golden J, Maxwell M: Expression of insulin-like growth factors I and II and their receptor mRNAs in primary human astrocytomas and meningiomas; in vivo studies using in situ hybridization and immunocytochemistry. Int J Cancer 50: 215-222, 1992
    • (1992) Int J Cancer , vol.50 , pp. 215-222
    • Antoniades, H.N.1    Galanopoulos, T.2    Neville-Golden, J.3    Maxwell, M.4
  • 3
    • 0028323573 scopus 로고
    • Develop-ment of anti-tumor immunity following thymidine kinase-mediated killing of experimental brain tumors
    • Barba D, Hardin J, Sadelain M, Gage FH: Develop-ment of anti-tumor immunity following thymidine kinase-mediated killing of experimental brain tumors. Proc Natl Acad Sci USA 91: 4348-4352,1994
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 4348-4352
    • Barba, D.1    Hardin, J.2    Sadelain, M.3    Gage, F.H.4
  • 12
    • 0026772206 scopus 로고
    • In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors
    • Culver KW, Ram Z, Wallbridge S, Ishii H, Oldfield EH, Blaese RM: In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science 256: 1550-1552, 1992
    • (1992) Science , vol.256 , pp. 1550-1552
    • Culver, K.W.1    Ram, Z.2    Wallbridge, S.3    Ishii, H.4    Oldfield, E.H.5    Blaese, R.M.6
  • 13
    • 37749029950 scopus 로고    scopus 로고
    • Insertional mutagenesis and clonal dominance: Biological and statistical considerations
    • Fehse B, Roeder I: Insertional mutagenesis and clonal dominance: biological and statistical considerations. Gene Ther 15: 143-153, 2008
    • (2008) Gene Ther , vol.15 , pp. 143-153
    • Fehse, B.1    Roeder, I.2
  • 15
    • 0028864786 scopus 로고
    • The extent of heterocellular communication mediated by gap junctions is predictive of bystander tumor cytotoxicity in vitro
    • Fick J, Barker FG 2nd, Dazin P, Westphale EM, Beyer EC, Israel MA: The extent of heterocellular communication mediated by gap junctions is predictive of bystander tumor cytotoxicity in vitro. Proc Natl Acad Sci USA 92: 11071-11075, 1995
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 11071-11075
    • Fick, J.1    Barker II, F.G.2    Dazin, P.3    Westphale, E.M.4    Beyer, E.C.5    Israel, M.A.6
  • 16
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis ele-gans
    • Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC: Potent and specific genetic interference by double-stranded RNA in Caenorhabditis ele-gans. Nature 391: 806-811, 1998
    • (1998) Nature , vol.391 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 18
    • 0025604195 scopus 로고
    • Retroviral vector-mediated gamma-inter-feron gene transfer into tumor cells generates potent and long lasting antitumor immunity
    • Gansbacher B, Bannerji R, Daniels B, Zier K, Cronin K, Gilboa E: Retroviral vector-mediated gamma-inter-feron gene transfer into tumor cells generates potent and long lasting antitumor immunity. Cancer Res 50: 7820-7825, 1990
    • (1990) Cancer Res , vol.50 , pp. 7820-7825
    • Gansbacher, B.1    Bannerji, R.2    Daniels, B.3    Zier, K.4    Cronin, K.5    Gilboa, E.6
  • 19
    • 0025000864 scopus 로고
    • Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity
    • Gansbacher B, Zier K, Daniels B, Cronin K, Bannerji R, Gilboa E: Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity. J Exp Med 172: 1217-1224, 1990
    • (1990) J Exp Med , vol.172 , pp. 1217-1224
    • Gansbacher, B.1    Zier, K.2    Daniels, B.3    Cronin, K.4    Bannerji, R.5    Gilboa, E.6
  • 22
    • 0029864009 scopus 로고    scopus 로고
    • Internal ribosomal entry site substitution eliminates neu-rovirulence in intergeneric poliovirus recombinants
    • Gromeier M, Alexander L, Wimmer E: Internal ribosomal entry site substitution eliminates neu-rovirulence in intergeneric poliovirus recombinants. Proc Natl Acad Sci USA 93: 2370-2375, 1996
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 2370-2375
    • Gromeier, M.1    Alexander, L.2    Wimmer, E.3
  • 24
    • 38949207486 scopus 로고    scopus 로고
    • Adenovirus vector induced innate immune responses: Impact upon efficacy and toxicity in gene therapy and vaccine applications
    • Hartman ZC, Appledorn DM, Amalfitano A: Adenovirus vector induced innate immune responses: impact upon efficacy and toxicity in gene therapy and vaccine applications. Virus Res 132: 1-14, 2008
    • (2008) Virus Res , vol.132 , pp. 1-14
    • Hartman, Z.C.1    Appledorn, D.M.2    Amalfitano, A.3
  • 28
    • 10844296758 scopus 로고    scopus 로고
    • Specific recognition and killing of glioblastoma multiforme by interleukin 13-zetakine redirected cytolytic T cells
    • Kahlon KS, Brown C, Cooper LJ, Raubitschek A, For-man SJ, Jensen MC: Specific recognition and killing of glioblastoma multiforme by interleukin 13-zetakine redirected cytolytic T cells. Cancer Res 64: 9160-9166, 2004
    • (2004) Cancer Res , vol.64 , pp. 9160-9166
    • Kahlon, K.S.1    Brown, C.2    Cooper, L.J.3    Raubitschek, A.4    For-Man, S.J.5    Jensen, M.C.6
  • 29
    • 0028805459 scopus 로고
    • Selective enhancement of radiation response of herpes simplex virus thymidine kinase transduced 9L gliosarcoma cells in vitro and in vivo by antiviral agents
    • Kim JH, Kim SH, Kolozsvary A, Brown SL, Kim OB, Freytag SO: Selective enhancement of radiation response of herpes simplex virus thymidine kinase transduced 9L gliosarcoma cells in vitro and in vivo by antiviral agents. Int J Radiat Oncol Biol Phys 33: 861-868, 1995
    • (1995) Int J Radiat Oncol Biol Phys , vol.33 , pp. 861-868
    • Kim, J.H.1    Kim, S.H.2    Kolozsvary, A.3    Brown, S.L.4    Kim, O.B.5    Freytag, S.O.6
  • 33
    • 1642474273 scopus 로고    scopus 로고
    • Persistence of a small subpopulation of cancer stem-like cells in the C6 glio-ma cell line
    • Kondo T, Setoguchi T, Taga T: Persistence of a small subpopulation of cancer stem-like cells in the C6 glio-ma cell line. Proc Natl Acad Sci USA 101: 781-786, 2004
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 781-786
    • Kondo, T.1    Setoguchi, T.2    Taga, T.3
  • 35
    • 0034855623 scopus 로고    scopus 로고
    • Glioma classification: A molecular reappraisal
    • Louis DN, Holland EC, Cairncross JG: Glioma classification: a molecular reappraisal. Am J Pathol 159: 779-786, 2001
    • (2001) Am J Pathol , vol.159 , pp. 779-786
    • Louis, D.N.1    Holland, E.C.2    Cairncross, J.G.3
  • 38
    • 0024041143 scopus 로고
    • Antiviral activity and mechanism of action of ganciclovir
    • Matthews T, Boehme R: Antiviral activity and mechanism of action of ganciclovir. Rev Infect Dis 10 Suppl 3: S490-S494, 1988
    • (1988) Rev Infect Dis , vol.10 , Issue.SUPPL. 3
    • Matthews, T.1    Boehme, R.2
  • 40
    • 0028174337 scopus 로고
    • Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant
    • Millauer B, Shawver LK, Plate KH, Risau W, Ullrich A: Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant. Nature 367: 576-579, 1994
    • (1994) Nature , vol.367 , pp. 576-579
    • Millauer, B.1    Shawver, L.K.2    Plate, K.H.3    Risau, W.4    Ullrich, A.5
  • 41
    • 0029023868 scopus 로고
    • Attenuated multi-mutated herpes simplex vi-rus-1 for the treatment of malignant gliomas
    • Mineta T, Rabkin SD, Yazaki T, Hunter WD, Martuza RL: Attenuated multi-mutated herpes simplex vi-rus-1 for the treatment of malignant gliomas. Nat Med 1: 938-943, 1995
    • (1995) Nat Med , vol.1 , pp. 938-943
    • Mineta, T.1    Rabkin, S.D.2    Yazaki, T.3    Hunter, W.D.4    Martuza, R.L.5
  • 42
    • 0033762762 scopus 로고    scopus 로고
    • RNA-transfected dendritic cells in cancer immunotherapy
    • Mitchell DA, Nair SK: RNA-transfected dendritic cells in cancer immunotherapy. J Clin Invest106: 1065-1069, 2000
    • (2000) J Clin Invest , vol.106 , pp. 1065-1069
    • Mitchell, D.A.1    Nair, S.K.2
  • 43
    • 0032442437 scopus 로고    scopus 로고
    • Effect of human interferon beta gene transfer upon human glioma, transplanted into nude mouse brain, involves induced natural killer cells
    • Mizuno M, Yoshida J: Effect of human interferon beta gene transfer upon human glioma, transplanted into nude mouse brain, involves induced natural killer cells. Cancer Immunol Immunother 47: 227-232, 1998
    • (1998) Cancer Immunol Immunother , vol.47 , pp. 227-232
    • Mizuno, M.1    Yoshida, J.2
  • 44
    • 0022485359 scopus 로고
    • Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: Paradigm for a prospective cancer control strategy
    • Moolten FL: Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy. Cancer Res 46: 5276-5281, 1986
    • (1986) Cancer Res , vol.46 , pp. 5276-5281
    • Moolten, F.L.1
  • 45
    • 0032877813 scopus 로고    scopus 로고
    • An-titumor effect and cellular immunity activation by murine interferon-beta gene transfer against in-tracerebral glioma in mouse
    • Natsume A, Mizuno M, Ryuke Y, Yoshida J: An-titumor effect and cellular immunity activation by murine interferon-beta gene transfer against in-tracerebral glioma in mouse. Gene Ther 6: 1626-1633, 1999
    • (1999) Gene Ther , vol.6 , pp. 1626-1633
    • Natsume, A.1    Mizuno, M.2    Ryuke, Y.3    Yoshida, J.4
  • 46
    • 0033848359 scopus 로고    scopus 로고
    • IFN-beta gene therapy induces systemic antitumor immunity against malignant glioma
    • Natsume A, Tsujimura K, Mizuno M, Takahashi T, Yoshida J: IFN-beta gene therapy induces systemic antitumor immunity against malignant glioma. J Neu-rooncol 47: 117-124, 2000
    • (2000) J Neu-rooncol , vol.47 , pp. 117-124
    • Natsume, A.1    Tsujimura, K.2    Mizuno, M.3    Takahashi, T.4    Yoshida, J.5
  • 49
    • 85047699172 scopus 로고    scopus 로고
    • The potential for efficacy of the modified (ICP 34.5(-)) herpes simplex virus HSV1716 following in-tratumoural injection into human malignant glioma: A proof of principle study
    • Papanastassiou V, Rampling R, Fraser M, Petty R, Hadley D, Nicoll J, Harland J, Mabbs R, Brown M: The potential for efficacy of the modified (ICP 34.5(-)) herpes simplex virus HSV1716 following in-tratumoural injection into human malignant glioma: a proof of principle study. Gene Ther 9: 398-406, 2002
    • (2002) Gene Ther , vol.9 , pp. 398-406
    • Papanastassiou, V.1    Rampling, R.2    Fraser, M.3    Petty, R.4    Hadley, D.5    Nicoll, J.6    Harland, J.7    Mabbs, R.8    Brown, M.9
  • 51
    • 0028067301 scopus 로고
    • Human neurological cancer cells express interleukin-4 (IL-4) receptors which are targets for the toxic effects of IL4-Pseudomonas exotoxin chimeric protein
    • Puri RK, Leland P, Kreitman RJ, Pastan I: Human neurological cancer cells express interleukin-4 (IL-4) receptors which are targets for the toxic effects of IL4-Pseudomonas exotoxin chimeric protein. Int J Cancer 58: 574-581, 1994
    • (1994) Int J Cancer , vol.58 , pp. 574-581
    • Puri, R.K.1    Leland, P.2    Kreitman, R.J.3    Pastan, I.4
  • 52
    • 0034694011 scopus 로고    scopus 로고
    • A phase III clinical evaluation of herpes simplex virus type 1 thymidine kinase and gan-ciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme
    • Rainov NG: A phase III clinical evaluation of herpes simplex virus type 1 thymidine kinase and gan-ciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme. Hum Gene Ther 11: 2389-2401, 2000
    • (2000) Hum Gene Ther , vol.11 , pp. 2389-2401
    • Rainov, N.G.1
  • 53
    • 0027531548 scopus 로고
    • In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats
    • Ram Z, Culver KW, Walbridge S, Blaese RM, Oldfield EH: In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats. Cancer Res 53: 83-88, 1993
    • (1993) Cancer Res , vol.53 , pp. 83-88
    • Ram, Z.1    Culver, K.W.2    Walbridge, S.3    Blaese, R.M.4    Oldfield, E.H.5
  • 54
    • 0028071271 scopus 로고
    • The effect of thymidine kinase transduction and ganciclovir therapy on tumor vas-culature and growth of 9L gliomas in rats
    • Ram Z, Walbridge S, Shawker T, Culver KW, Blaese RM, Oldfield EH: The effect of thymidine kinase transduction and ganciclovir therapy on tumor vas-culature and growth of 9L gliomas in rats. J Neu-rosurg 81: 256-260, 1994
    • (1994) J Neu-rosurg , vol.81 , pp. 256-260
    • Ram, Z.1    Walbridge, S.2    Shawker, T.3    Culver, K.W.4    Blaese, R.M.5    Oldfield, E.H.6
  • 56
    • 0028271497 scopus 로고
    • Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor-1 (IGF-1) receptor are nontumorigenic and induce regression of wild-type tumors
    • Resnicoff M, Sell C, Rubini M, Coppola D, Ambrose D, Baserga R, Rubin R: Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor-1 (IGF-1) receptor are nontumorigenic and induce regression of wild-type tumors. Cancer Res 54: 2218-2222, 1994
    • (1994) Cancer Res , vol.54 , pp. 2218-2222
    • Resnicoff, M.1    Sell, C.2    Rubini, M.3    Coppola, D.4    Ambrose, D.5    Baserga, R.6    Rubin, R.7
  • 57
    • 30044439886 scopus 로고    scopus 로고
    • Adenovirus p53 gene therapy
    • Roth JA: Adenovirus p53 gene therapy. Expert Opin Biol Ther 6: 55-61, 2006
    • (2006) Expert Opin Biol Ther , vol.6 , pp. 55-61
    • Roth, J.A.1
  • 60
    • 38449103630 scopus 로고    scopus 로고
    • Antisense therapeutics for tumor treatment: The TGF-beta2 inhibitor AP 12009 in clinical development against malignant tumors
    • Schlingensiepen KH, Fischer-Blass B, Schmaus S, Ludwig S: Antisense therapeutics for tumor treatment: the TGF-beta2 inhibitor AP 12009 in clinical development against malignant tumors. Recent Results Cancer Res 177: 137-150, 2008
    • (2008) Recent Results Cancer Res , vol.177 , pp. 137-150
    • Schlingensiepen, K.H.1    Fischer-Blass, B.2    Schmaus, S.3    Ludwig, S.4
  • 62
    • 28244458116 scopus 로고    scopus 로고
    • CD155/PVR enhances glioma cell dispersal by regulating adhesion signaling and focal adhesion dynamics
    • Sloan KE, Stewart JK, Treloar AF, Matthews RT, Jay DG: CD155/PVR enhances glioma cell dispersal by regulating adhesion signaling and focal adhesion dynamics. Cancer Res 65: 10930-10937, 2005
    • (2005) Cancer Res , vol.65 , pp. 10930-10937
    • Sloan, K.E.1    Stewart, J.K.2    Treloar, A.F.3    Matthews, R.T.4    Jay, D.G.5
  • 66
    • 0034517560 scopus 로고    scopus 로고
    • Human dendritic cells transfected with either RNA or DNA encoding influenza matrix protein M1 differ in their ability to stimulate cytotox-ic T lymphocytes
    • Strobel I, Berchtold S, Gotze A, Schulze U, Schuler G, Steinkasserer A: Human dendritic cells transfected with either RNA or DNA encoding influenza matrix protein M1 differ in their ability to stimulate cytotox-ic T lymphocytes. Gene Ther 7: 2028-2035, 2000
    • (2000) Gene Ther , vol.7 , pp. 2028-2035
    • Strobel, I.1    Berchtold, S.2    Gotze, A.3    Schulze, U.4    Schuler, G.5    Steinkasserer, A.6
  • 68
    • 0034035628 scopus 로고    scopus 로고
    • Attenuated, replication-competent herpes simplex virus type 1 mutant G207: Safety evaluation in mice
    • Sundaresan P, Hunter WD, Martuza RL, Rabkin SD: Attenuated, replication-competent herpes simplex virus type 1 mutant G207: safety evaluation in mice. J Virol 74: 3832-3841, 2000
    • (2000) J Virol , vol.74 , pp. 3832-3841
    • Sundaresan, P.1    Hunter, W.D.2    Martuza, R.L.3    Rabkin, S.D.4
  • 70
    • 0027997532 scopus 로고
    • Use of suicide genes in gene therapy
    • Tiberghien P: Use of suicide genes in gene therapy. J Leukoc Biol 56: 203-209, 1994
    • (1994) J Leukoc Biol , vol.56 , pp. 203-209
    • Tiberghien, P.1
  • 73
    • 27944496521 scopus 로고    scopus 로고
    • Retroviral insertional mutagenesis: Past, present and future
    • Uren AG, Kool J, Berns A, van Lohuizen M: Retroviral insertional mutagenesis: past, present and future. Oncogene 24: 7656-7672, 2005
    • (2005) Oncogene , vol.24 , pp. 7656-7672
    • Uren, A.G.1    Kool, J.2    Berns, A.3    van Lohuizen, M.4
  • 74
    • 68149094346 scopus 로고    scopus 로고
    • Trabedersen, a TGFbeta2-specific an-tisense oligonucleotide for the treatment of malignant gliomas and other tumors overexpressing TGFbeta2
    • Vallieres L: Trabedersen, a TGFbeta2-specific an-tisense oligonucleotide for the treatment of malignant gliomas and other tumors overexpressing TGFbeta2. IDrugs 12: 445-453, 2009
    • (2009) IDrugs , vol.12 , pp. 445-453
    • Vallieres, L.1
  • 75
    • 0035412401 scopus 로고    scopus 로고
    • Highly efficient gene delivery by mRNA electroporation in human hematopoietic cells: Superiority to lipofection and passive pulsing of mRNA and to electroporation of plasmid cDNA for tumor antigen loading of dendritic cells
    • Van Tendeloo VF, Ponsaerts P, Lardon F, Nijs G, Lenjou M, Van Broeckhoven C, Van Bockstaele DR, Berneman ZN: Highly efficient gene delivery by mRNA electroporation in human hematopoietic cells: superiority to lipofection and passive pulsing of mRNA and to electroporation of plasmid cDNA for tumor antigen loading of dendritic cells. Blood 98: 49-56, 2001
    • (2001) Blood , vol.98 , pp. 49-56
    • van Tendeloo, V.F.1    Ponsaerts, P.2    Lardon, F.3    Nijs, G.4    Lenjou, M.5    van Broeckhoven, C.6    van Bockstaele, D.R.7    Berneman, Z.N.8
  • 76
    • 0030928619 scopus 로고    scopus 로고
    • Gene therapy-promises, problems and prospects
    • Verma IM, Somia N: Gene therapy-promises, problems and prospects. Nature 389: 239-242, 1997
    • (1997) Nature , vol.389 , pp. 239-242
    • Verma, I.M.1    Somia, N.2
  • 78
    • 42049112450 scopus 로고    scopus 로고
    • A phase I clinical trial of inter-feron-beta gene therapy for high-grade glioma: Novel findings from gene expression profiling and autopsy
    • Wakabayashi T, Natsume A, Hashizume Y, Fujii M, Mizuno M, Yoshida J: A phase I clinical trial of inter-feron-beta gene therapy for high-grade glioma: novel findings from gene expression profiling and autopsy. J Gene Med 10: 329-339, 2008
    • (2008) J Gene Med , vol.10 , pp. 329-339
    • Wakabayashi, T.1    Natsume, A.2    Hashizume, Y.3    Fujii, M.4    Mizuno, M.5    Yoshida, J.6
  • 79
    • 0028991827 scopus 로고
    • Enhancement of interleukin-4-mediated tumor regression in athymic mice by in situ retroviral gene transfer
    • Wei MX, Tamiya T, Hurford RK Jr, Boviatsis EJ, Tep-per RI, Chiocca EA: Enhancement of interleukin-4-mediated tumor regression in athymic mice by in situ retroviral gene transfer. Hum Gene Ther 6: 437-443, 1995
    • (1995) Hum Gene Ther , vol.6 , pp. 437-443
    • Wei, M.X.1    Tamiya, T.2    Hurford Jr, R.K.3    Boviatsis, E.J.4    Tep-Per, R.I.5    Chiocca, E.A.6
  • 80
    • 0029610610 scopus 로고
    • The failure of current im-munotherapy for malignant glioma. Tumor-derived TGF-beta, T-cell apoptosis, and the immune privilege of the brain
    • Weller M, Fontana A: The failure of current im-munotherapy for malignant glioma. Tumor-derived TGF-beta, T-cell apoptosis, and the immune privilege of the brain. Brain Res Brain Res Rev 21: 128-151, 1995
    • (1995) Brain Res Brain Res Rev , vol.21 , pp. 128-151
    • Weller, M.1    Fontana, A.2
  • 81
    • 0027166647 scopus 로고
    • Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment
    • Wickham TJ, Mathias P, Cheresh DA, Nemerow GR: Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment. Cell 73: 309-319, 1993
    • (1993) Cell , vol.73 , pp. 309-319
    • Wickham, T.J.1    Mathias, P.2    Cheresh, D.A.3    Nemerow, G.R.4
  • 82
    • 0031435653 scopus 로고    scopus 로고
    • Reversal of tumor-induced im-munosuppression: A new approach to cancer therapy
    • Wojtowicz-Praga S: Reversal of tumor-induced im-munosuppression: a new approach to cancer therapy. J Immunother 20: 165-177, 1997
    • (1997) J Immunother , vol.20 , pp. 165-177
    • Wojtowicz-Praga, S.1
  • 83
    • 0028258785 scopus 로고
    • Interferon-beta endogenously produced by intratumoral injection of cationic liposome-encapsulated gene: Cytocidal effect on glio-ma transplanted into nude mouse brain
    • Yagi K, Hayashi Y, Ishida N, Ohbayashi M, Ohishi N, Mizuno M, Yoshida J: Interferon-beta endogenously produced by intratumoral injection of cationic liposome-encapsulated gene: cytocidal effect on glio-ma transplanted into nude mouse brain. Biochem Mol Biol Int 32: 167-171, 1994
    • (1994) Biochem Mol Biol Int , vol.32 , pp. 167-171
    • Yagi, K.1    Hayashi, Y.2    Ishida, N.3    Ohbayashi, M.4    Ohishi, N.5    Mizuno, M.6    Yoshida, J.7
  • 84
    • 0742290161 scopus 로고    scopus 로고
    • Human gene therapy for malignant gliomas (gliob-lastoma multiforme and anaplastic astrocytoma' by in vivo transduction with human interferon beta gene using cationic liposomes
    • Yoshida J, Mizuno M, Fujii M, Kajita Y, Nakahara N, Hatano M, Saito R, Nobayashi M, Wakabayashi T: Human gene therapy for malignant gliomas (gliob-lastoma multiforme and anaplastic astrocytoma' by in vivo transduction with human interferon beta gene using cationic liposomes. Hum Gene Ther 15: 77-86, 2004
    • (2004) Hum Gene Ther , vol.15 , pp. 77-86
    • Yoshida, J.1    Mizuno, M.2    Fujii, M.3    Kajita, Y.4    Nakahara, N.5    Hatano, M.6    Saito, R.7    Nobayashi, M.8    Wakabayashi, T.9
  • 85
    • 31144475398 scopus 로고    scopus 로고
    • Viral gene therapy strategies: From basic science to clinical application
    • Young LS, Searle PF, Onion D, Mautner V: Viral gene therapy strategies: from basic science to clinical application. JPathol208: 299-318, 2006
    • (2006) JPathol , vol.208 , pp. 299-318
    • Young, L.S.1    Searle, P.F.2    Onion, D.3    Mautner, V.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.