Gene transfer of CD154 and IL12 cDNA induces an anti-leukemic immunity in a murine model of acute leukemia

Leukemia

Volumn 16, Issue 9, 2002, Pages 1637-1644

  Saudemont, A ^a   Buffenoir, G ^a   Denys, A ^a   Desreumaux, P ^b   Jouy, N ^c   Hetuin, D ^a   Bauters, F ^b   Fenaux, P ^a,b   Quesnel, B ^a,b  

^a INSERM   (France)

^b LILLE UNIVERSITY HOSPITAL   (France)

^c EA 2691 Service de Neurologie et Pathologies Vasculaires   (France)

Author keywords

CD154; Gene therapy; IL12; Leukemia; Vaccine

Indexed keywords

CANCER VACCINE; CD4 ANTIGEN; CD40 ANTIGEN; CD40 LIGAND; CD8 ANTIGEN; COMPLEMENTARY DNA; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12; MESSENGER RNA;

ACUTE LEUKEMIA; ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTATION; ARTICLE; CANCER IMMUNOTHERAPY; CANCER INHIBITION; CELL ISOLATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; FEMALE; GENE THERAPY; GENE TRANSFER; GENETIC TRANSDUCTION; HELPER CELL; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; IN VIVO STUDY; IRRADIATION; LEUKEMIA CELL; LYMPHOCYTE DEPLETION; MOUSE; NATURAL KILLER CELL; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; NONHUMAN; PRIORITY JOURNAL; SPLEEN; TUMOR IMMUNITY;

EID: 0036736510     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2402590     Document Type: Article

References (27)

1. Role of B7-1 in mediating an immune response to myeloid leukemia cells
2. Irradiated B7-1 transduced primary acute myelogenous leukemia (AML) cells can be used as therapeutic vaccines in murine AML
3. B7-1 is superior to B7-2 costimulation in the induction and maintenance of T cell-mediated antileukemia immunity. Further evidence that B7-1 and B7-2 are functionally distinct
4. The role of B7 costimulation by murine acute myeloid leukemia in the generation and function of a CD8+ T-cell line with potent in vivo graft-versus-leukemia properties
5. CD40 ligand induces an antileukemia immune response in vivo
6. CD8+ T cells activated during the course of murine acute myelogenous leukemia elicit therapeutic responses to late B7 vaccines after cytoreductive treatment
7. Gene therapy with B7.1 and GM-CSF vaccines in a murine AML model
8. Enhanced immune costimulatory activity of primary acute myeloid leukaemia blasts after retrovirus-mediated gene transfer of B7.1
9. Gene immunotherapy in murine acute myeloid leukemia: Granulocyte-macrophage colony-stimulating factor tumor cell vaccines elicit more potent antitumor immunity compared with B7 family and other cytokine vaccines
10. CD80-transfected acute myeloid leukemia cells induce primary allogeneic T-cell responses directed at patient specific minor histocompatibility antigens and leukemia-associated antigens
11. Immune response to Philadelphia chromosome-positive acute lymphoblastic leukemia induced by expression of CD80, interleukin 2, and granulocyte-macrophage colony-stimulating factor
12. Combination of CD80 and granulocyte-macrophage colony-stimulating factor coexpression by a leukemia cell vaccine: Preclinical studies in a murine model recapitulating Philadelphia chromosome-positive acute lymphoblastic leukemia
13. Vaccines with interleukin-12-transduced acute myeloid leukemia cells elicit very potent therapeutic and long-lasting protective immunity
14. Interleukin-12: A cytokine at the interface of inflammation and immunity
15. Effective eradication of established murine tumors with IL-12 gene therapy using a polycistronic retroviral vector
16. Interleukin-12 and B7.1 co-stimulation cooperate in the induction of effective antitumor immunity and therapy of established tumors
17. Interleukin-12: A cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes
18. CD40 and CD154 in cell-mediated immunity
19. CD40-ligand (CD154) gene therapy for chronic lymphocytic leukemia
20. Dendritic cells directly trigger NK cell functions: Cross-talk relevant in innate anti-tumor immune responses in vivo
21. Activation of p65 NF-kappaB protein by p210BCR-ABL in a myeloid cell line (P210BCR-ABL activates p65 NF-kappaB)
22. A new murine aggressive leukemic model
23. Gene transfer of GM-CSF, CD80 and CD154 cDNA enhances survival in a murine model of acute leukemia with persistence of a minimal residual disease
24. Inflammatory alterations in mesenteric adipose tissue in Crohn's disease
25. IL-12 receptor beta 2 (IL-12R beta 2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding sites
26. Immunobiology of interleukin-12
27. Potentiated antitumor effectiveness of combined chemo-immunotherapy with interleukin-12 and 5-fluorouracil of L1210 leukemia in vivo