Human Gene Therapy for Malignant Gliomas (Glioblastoma Multiforme and Anaplastic Astrocytoma) by In Vivo Transduction with Human Interferon β Gene Using Cationic Liposomes

Human Gene Therapy

Volumn 15, Issue 1, 2004, Pages 77-86

  Yoshida, Jun ^a   Mizuno, Masaaki ^a   Fujii, Masazumi ^a   Kajita, Yasukazu ^a   Nakahara, Norimoto ^a   Hatano, Manabu ^a   Saito, Ryuta ^a   Nobayashi, Misato ^a   Wakabayashi, Toshihiko ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CATION; LIPOSOME;

ADULT; ANEMIA; ANTINEOPLASTIC ACTIVITY; ARTICLE; BRAIN EDEMA; BRAIN HEMORRHAGE; CANCER PATIENT; CANCER REGRESSION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG RESPONSE; DRUG SAFETY; DRUG SCREENING; EVALUATION; EXPERIMENT; FEASIBILITY STUDY; FEMALE; GAMMA KNIFE; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER; GENETIC TRANSDUCTION; GLIOBLASTOMA; HEADACHE; HUMAN; IN VIVO STUDY; LIQUORRHEA; MALE; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PILOT STUDY; TRANSGENE;

ADULT; ASTROCYTOMA; BRAIN; GENE THERAPY; GLIOBLASTOMA; HUMANS; INTERFERON-BETA; LIPOSOMES; MAGNETIC RESONANCE IMAGING; MIDDLE AGED; PLASMIDS;

EID: 0742290161     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430340460732472     Document Type: Article

References (23)

1. CHEN, H.-S., SHINE, H.D., GOODMAN, J.C., GROSSMAN, R.G., and WOO, S.L. (1994). Gene therapy for brain tumor: Regression of experimental gliomas by adenovirus-mediated gene transfer in vivo. Proc. Natl. Acad. Sci. U.S.A. 91, 3054-3057.
2. CULVER, K.W., RAM, Z., WALLBRIDGE, S., ISHII, H., OLDFIELD, E.H., and BLAESE, R.M. (1992). In vivo gene transfer with retroviral vector-producing cells for treatment of experimental brain tumors. Science 256, 1550-1552.
3. FELGNER, P.L., and RINGOLD, G.M. (1989). Cationic liposome-mediated transfection. Nature 337, 387-388.
4. FELGNER, P.L., GADEK, T.R., HOLM, M., ROMAN, R., CHAN, H.W., WENZ, M., NORTHROP, J.R., RINGOLD, G.M., and DANIELSON, M. (1987). Lipofection: A highly efficient, lipid-mediated DNA-transfection procedure. Proc. Natl. Acad. Sci. U.S.A. 84, 7413-7414.
5. KAMB, A., GRUIS, N.A., WEAVER-FELDHAUS, J., LIU, Q., HARSHMAN, K., TAVTIGIAN, S.V., STOCKERT, E., DAY, R.S., III, JOHNSON, B.E., and SKOLNICK, M.H. (1994). A cell cycle regulator potentially involved in genesis of many tumor types. Science 264, 436-440.
6. MERCHANT, R.E., MERCHANT, L.H., COOK, S.H.S., MCVICAR, D.W., and YOUNG, H.F. (1988). Intralesional infusion of lymphokine-activated killer (LAK) cells and recombinant interteukin-2 (rIL-2) for the treatment of patients with malignant brain tumor. Neurosurgery 23, 725-732.
7. MIZUNO, M., and YOSHIDA, J. (1998). Effect of human interferon-β gene transfer upon human glioma transplanted into nude mouse brain involves induced natural killer cells. Cancer Immunol. Immunother. 47, 227-232.
8. MIZUNO, M., YOSHIDA, J., SUGITA, K., INOUE, I., SEO, H., HAYASHI, Y., KOSHIZAKA, T., and YAGI, K. (1990a). Growth inhibition of glioma cells transfected with the human β-interferon gene by liposomes coupled with a monoclonal antibody. Cancer Res. 50, 7826-7829.
9. MIZUNO, M., YOSHIDA, J., SUGITA, K., and YAGI, K. (1990b). Growth inhibition of glioma cells of different cell lines by human interferon-β produced in the cells transfected with its gene by means of liposomes. J. Clin. Biochem. Nutr. 9, 73-77.
10. MIZUNO, M., YOSHIDA, J., OYAMA, H., and SUGITA, K. (1992). Growth inhibition of glioma cells by liposome-mediated cell transfection with tumor necrosis factor-α gene: Its enhancement by prior γ-interferon treatment. Neurol. Med. Chir. (Tokyo) 32, 873-876.
11. NATSUME, A., MIZUNO, M., RYUKE, Y., and YOSHIDA, J. (1999). Antitumor effect and cellular immunity activation by murine interferon-β gene transfer against intracerebral glioma in mouse. Gene Ther. 6, 1626-1633.
12. NATSUME, A., TSUJIMURA, K., MIZUNO, M., TAKAHASHI, T., and YOSHIDA, J. (2000). IFN-β gene therapy induces systemic antitumor immunity against malignant glioma. J. Neurooncol. 47, 117-124.
13. RAM, Z., CULVER, K.W., OSHIRO, E.M., VIOLA, J.J., DEVROOM, H.L., OTTO, E., LONG, Z., CHIANG, Y., MCGARRITY, G.J., MUUL, L.M., KATZ, D., BLAESE, R.M., and OLDFIELD, E.H. (1997). Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells. Nat. Med. 3, 1354-1361.
14. TAKAKURA, K. (1993). Brain Tumor Registry of Japan, Vol. 8 [in Japanese]. (Committee of Brain Tumor Registry of Japan, Tokyo) pp. 66-73.
15. VON HOEGEN, P. (1995). Synergistic role of type I interferons in the induction of protective cytotoxic T lymphocytes. Immunol. Lett. 47, 157-162.
16. WAKER, M.D., GREEN, S.B., BYAR, D.P., ALEXANDER, E., Jr., BATZDORF, U., BROOKS, W.H., HUNT, W.E., MACCARTY, C.S., MAHALEY, M.S., MEALEY, J., JR., OWENS, G., RANSOHOFF, J., II, ROSERTSON, J.T., SHAPIRO, W.R., SMITH, K.R., JR., WILSON, C.B., and STRIKE, T.A. (1980). Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery. N. Engl. J. Med. 303, 1323-1329.
17. YAGI, K., NODA, H., KURONO, M., and OHISHI, N. (1993). Efficient gene transfer with less than cytotoxicity by means of cationic multilamellar liposomes. Biochem. Biophys. Res. Commun. 196, 1042-1048.
18. YAGI, K., HAYASHI, Y., ISHIDA, N., OHBAYASHI, M., OHISHI, N., MIZUNO, M., and YOSHIDA, J. (1994). Interferon-β endogenously produced by intratumoral injection of cationic liposome-encapsulated gene: Cytocidal effect on glioma transplanted into nude mouse brain. Biochem. Mol. Biol. Int. 32, 167-171.
19. YOSHIDA, J., MIZUNO, M., and YAGI, K. (1991). Secretion of human β-interferon into the cystic fluid of glioma transfected with the interferon gene. J. Clin. Biochem. Nutr. 11, 123-128.
20. YOSHIDA, J., MIZUNO, M., and YAGI, K. (1992a). Antitumor effect of endogenous human β-interferon on malignant glioma and augmentation of the effect by tumor necrosis factor-α. J. Clin. Biochem. Nutr. 12, 153-160.
21. YOSHIDA, J., WAKABAYASHI, T., MIZUNO, M., SUGITA, K., YOSHIDA, T., HORI, S., MORI, T., SATO, T., KARASHIMA, A., KURISU, K., KIYA, K., and UOZUMI, T. (1992b). Clinical effect of intra-arterial tumor necrosis factor-α for malignant glioma. J. Neurosurg. 77, 78-83.
22. YOSHIDA, J., WAKABAYASHI, T., MIZUNO, M., SUGITA, K., SEO, H., OSHIMA, M., TADOKORO, M., and SAKUMA, S. (1992c). Tumor specific binding of radiolabeled G-22 monoclonal antibody in glioma patients. Neurol. Med. Chir. 32, 125-129.
23. YOSHIDA, J., KAJITA, T., WAKABAYASHI, T., and SUGITA, K. (1994). Long-term follow-up results of 175 patients with malignant glioma: Importance of radical tumor resection with interferon, ACNU and radiation. Acta Neurochir. 127, 55-59.