Attenuated, replication-competent herpes simplex virus type 1 mutant G207: Safety evaluation of intracerebral injection in nonhuman primates

Journal of Virology

Volumn 73, Issue 8, 1999, Pages 6319-6326

  Hunter, William D ^a,b   Martuza, Robert L ^a   Feigenbaum, Frank ^a   Todo, Tomoki ^a   Mineta, Toshihiro ^a,c   Yazaki, Takahito ^a,d   Toda, Masahiro ^a,d   Newsome, Joseph T ^a   Platenberg, R Craig ^a   Manz, Herbert J ^a   Rabkin, Samuel D ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c SAGA UNIVERSITY   (Japan)

^d KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY TITER; ARTICLE; BASAL GANGLION; BRAIN HEMORRHAGE; CONTROLLED STUDY; FEVER; HEMIPARESIS; HERPES SIMPLEX VIRUS 1; HISTOPATHOLOGY; HUMORAL IMMUNITY; INOCULATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIMATE; PRIORITY JOURNAL; VIRUS ATTENUATION; VIRUS ENCEPHALITIS; VIRUS INFECTIVITY; VIRUS MENINGITIS; VIRUS MUTANT; VIRUS RECOMBINANT; VIRUS REPLICATION; VIRUS VIRULENCE;

EID: 0032789088     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.8.6319-6326.1999     Document Type: Article

References (69)

1. Andreansky, S. S., B. He, G. Y. Gillespie, L. Soroceanu, J. Markert, J. Chou, B. Roizman, and R. J. Whitley. 1996. The application of genetically engineered herpes simplex viruses to the treatment of experimental brain tumors. Proc. Natl. Acad. Sci. USA 93:11313-11318.
2. Ashley, R., J. Benedetti, and L. Corey. 1985. Humoral immune response to HSV-1 and HSV-2 viral proteins in patients with primary genital herpes. J. Med. Virol. 17:153-166.
3. Boviatsis, E. J., J. M. Scharf, M. Chase, K. Harrington, N. W. Kowall, X. O. Breakefield, and E. A. Chiocca. 1994. Antitumor activity and reporter gene transfer into rat brain neoplasms inoculated with herpes simplex virus vectors defective in thymidine kinase or ribonucleotide reductase. Gene Ther. 1:323-331.
4. Budka, H., and T. Popow-Kraupp. 1981. Rabies and herpes simplex virus encephalitis. An immunohistological study on site and distribution of viral antigens. Virchows Arch. Abt. A 390:353-364.
5. Cameron, J. M., I. McDougall, H. S. Marsden, V. G. Preston, D. M. Ryan, and J. H. Subak-Sharpe. 1988. Ribonucleotide reductase encoded by herpes simplex virus is a determinant of the pathogenicity of the virus in mice and a valid antiviral target. J. Gen. Virol. 69:2607-2612.
6. Centifanto-Fitzgerald, Y. M., T. Yamaguchi, H. E. Kaufman, M. Tognon, and B. Roizman. 1982. Ocular disease pattern induced by herpes simplex virus is genetically determined by a specific region of viral DNA. J. Exp. Med. 155:475-489.
7. Chambers, R., G. Y. Gillespie, L. Soroceanu, S. Adreansky, S. Chatterjee, J. Chou, B. Rotzman, and R. J. Whitley. 1995. Comparison of genetically engineered herpes simplex viruses for the treatment of brain tumors in a seid mouse model of human malignant glioma. Proc. Natl. Acad. Sci. USA 92: 1411-1415.
8. Chou, J., E. R. Kern, R. J. Whitley, and B. Roizman. 1990. Mapping of herpes simplex virus-1 neurovirulence to gamma 34.5, a gene nonessential for growth in culture. Science 250:1262-1266.
9. Corey, L., and P. G. Spear. 1986. Infections with herpes simplex viruses (2). N. Engl. J. Med. 314:749-757.
10. Cowdry, E. V., and F. M. Nicholson. 1923. Inclusion bodies in experimental herpetic infection of rabbits. J. Exp. Med. 38:695-706.
11. Daumas-Duport, C., B. Scheithauer, J. O'Fallon, and P. Kelly. 1988. Grading of astrocytomas. A simple and reproducible method. Cancer 62:2152-2165.
12. Demaerel, P., G. Wilms, W. Robberecht, K. Johannik, P. Van Hecke, H. Carton, and A. L. Baert. 1992. MRI of herpes simplex encephalitis. Neuroradiology 34:490-493.
13. Dix, R. D., R. R. McKendall, and J. R. Baringer. 1983. Comparative neurovirulence of herpes simplex virus type 1 strains after peripheral or intracerebral inoculation of BALB/c mice. Infect. Immun. 40:103-112.
14. Dutt, M. K., and I. D. Johnston. 1982. Computed tomography and EEG in herpes simplex encephalitis. Their value in diagnosis and prognosis. Arch. Neurol. 39:99-102.
15. Field, H. J., and P. Wildy. 1978. The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice. J. Hyg. 81:267-277.
16. Goldstein, D. J., and S. K. Weller. 1988. Herpes simplex virus type 1-induced ribonucleotide reductase activity is dispensable for virus growth and DNA synthesis: isolation and characterization of an ICP6 lacZ insertion mutant. J. Virol. 62:196-205.
17. Gordon, Y. J., D. M. Gilden, and Y. Becker. 1983. HSV-1 thymidine kinase promotes virulence and latency in the mouse. Investig. Ophthalmol. Vis. Sci. 24:599-602.
18. Hershkovitz, P. 1983. Two new species of night monkeys, genus Aotus (Cebidae, Platyrhini): a preliminary report on Aotus taxonomy. Am. J. Primatol. 4:209-243.
19. Hindmarsh, T., M. Lindqvist, E. Olding-Stenkvist, B. Skoldenberg, and M. Forsgren. 1986. Accuracy of computed tomography in the diagnosis of herpes simplex encephalitis. Acta Radiol. Suppl. 369:192-196.
20. Hunt, R. D. 1993. Herpesvirus simplex infection, p. 82-86. In T. C. Jones, U. Mohr, and R. D. Hunt (ed.), Nonhuman primates I. Springer-Verlag KG, Berlin, Germany.
21. Jacobson, J. G., D. A. Leib, D. J. Goldstein, C. L. Bogard, P. A. Schaffer, S. K. Weller, and D. M. Coen. 1989. A herpes simplex virus ribonucleotide reductase deletion mutant is defective for productive acute and reactivatable latent infections of mice and for replication in mouse cells. Virology 173: 276-283.
22. Jia, W. W., M. McDermott, J. Goldie, M. Cyander, J. Tan, and F. Tufaro. 1994. Selective destruction of gliomas in immunocompetent rats by thymidine kinase-defective herpes simplex virus type 1. J. Natl. Cancer Inst. 86: 1209-1215.
23. Kahlon, J., F. D. Lakeman, M. Ackermann, and R. J. Whitly. 1986. Human antibody response to herpes simplex virus-specific polypeptides after primary and recurrent infection. J. Clin. Microbiol. 23:725-730.
24. Katzin, D. S., J. D. Connor, L. A. Wilson, and R. S. Sexton. 1967. Experimental herpes simplex infection in the owl monkey. Proc. Soc. Exp. Biol. Med. 125:391-398.
25. Kesari, S., B. P. Randazzo, T. Valyi-Nagy, Q. S. Huang, S. M. Brown, A. R. MacLean, V. Lee, J. Q. Trojanowski, and N. W. Fraser. 1995. Therapy of experimental human brain tumors using a neuroattenuated herpes simplex virus mutant. Lab. Investig. 73:636-648.
26. Kim, T. S., A. L. Halliday, E. T. Hedley-Whyte, and K. Convery. 1991. Correlates of survival and the Daumas-Duport grading system for astrocytomas. J. Neurosurg. 74:27-37.
27. Knipe, D. M., W. Batterson, C. Nosal, B. Roizman, and A. Buchan. 1981. Molecular genetics of herpes simplex virus. VI. Characterization of a temperature-sensitive mutant defective in the expression of all early viral gene products. J. Virol. 38:539-547.
28. Koelfen, W., M. Freund, F. Guckel, H. Rohr, and C. Schultze. 1996. MRI of encephalitis in children: comparison of CT and MRI in the acute stage with long-term follow-up. Neuroradiology 38:73-79.
29. Luna, L, G. 1968. Manual of histological staining methods of the Armed Forces Institute of Pathology, 3rd ed. McGraw-Hill, New York, N. Y.
30. + between immediate early gene 1 and the 'a' sequence. J. Gen. Virol. 72:631-639.
31. Mahaley, M. S., Jr., C. Mettlin, N. Natarajan, E. R Laws, Jr., and B. B. Peace. 1989. National survey of patterns of care for brain-tumor patients. J. Neurosurg. 71:826-836.
32. Mann, D. R., and M. D. Hilty. 1982. Antibody response to herpes simplex virus type 1 polypeptides and glycoproteins in primary and recurrent infection. Pediatr. Res. 16:176-180.
33. Markert, J. M., A. Malick, D. M. Coen, and R. L. Martuza. 1993. Reduction and elimination of encephalitis in an experimental glioma therapy model with attenuated herpes simplex mutants that retain susceptibility to acyclovir. Neurosurgery 32:597-603.
34. Martuza, R. L., A. Malick, J. M. Markert, K. L. Ruffner, and D. M. Coen. 1991. Experimental therapy of human glioma by means of a genetically engineered virus mutant. Science 252:854-856.
35. McGrath, N., N. E. Anderson, M. C. Croxson, and K. F. Powell. 1997. Herpes simplex encephalitis treated with acyclovir: diagnosis and long term outcome. J. Neurol. Neurosurg. Psychiatry 63:321-326.
36. Meignier, B., R. Longnecker, P. Mavromara-Nazos, A. E. Sears, and B. Roizman. 1988. Virulence of and establishment of latency by genetically engineered deletion mutants of herpes simplex virus 1. Virology 162:251-254.
37. Meignier, B., B. Martin, R. J. Whitley, and B. Roizman. 1990. In vivo behavior of genetically engineered herpes simplex viruses R7017 and R7020. II. Studies in immunocompetent and immunosuppressed owl monkeys (Aotus trivirgatus). J. Infect. Dis. 162:313-321.
38. Melendez, L. V., C. Espana, R. D. Hunt, M. D. Daniel, and F. G. Garcia. 1969. Natural herpes simplex infection in the owl monkey (Aotus trivirgatus). Lab. Anim. Care 19:38-45.
39. Mineta, T., S. D. Rabkin, and R. L. Martuza. 1994. Treatment of malignant gliomas using ganciclovir-hypersensitive, ribonucleotide reductase-deficient herpes simplex viral mutant. Cancer Res. 54:3963-3966.
40. Mineta, T., S. D. Rabkin, T. Yazaki, W. D. Hunter, and R. L. Martuza. 1995. Attenuated multi-mutated herpes simplex virus-1 for the treatment of malignant gliomas. Nat. Med. 1:938-943.
41. Mohr, I., and Y. Gluzman. 1996. A herpesvirus genetic element which affects translation in the absence of the viral GADD34 function. EMBO J. 15:4759-4766.
42. Neils, E. W., R. Lukin, T. A. Tomsick, and J. M. Tew. 1987. Magnetic resonance imaging and computerized tomography scanning of herpes simplex encephalitis. Report of two cases. J. Neurosurg. 67:592-594.
43. Nishlyama, Y. 1996. Herpesvirus genes: molecular basis of viral replication and pathogenicity. Nagoya J. Med. Sci. 59:107-119.
44. Pelosi, E., F. Rozenberg, D. M. Coen, and K. L. Tyler. 1998. A herpes simplex virus DNA polymerase mutation that specifically attenuates neurovirulence in mice. Virology 252:364-372.
45. Preston, V. G., J. W. Palfreyman, and B. M. Duita. 1984. Identification of a herpes simplex virus type 1 polypeptide which is a component of the virus-induced ribonucleotide reductase. J. Gen. Virol. 65:1457-1466.
46. Pyles, R. B., N. M. Sawtell, and R. L. Thompson. 1992. Herpes simplex virus type 1 dUTPase mutants are attenuated for neurovirulence, neuroinvasiveness, and reactivation from latency. J. Virol. 66:6706-6713.
47. Pyles, R. B., and R. L. Thompson. 1994. Evidence that the herpes simplex virus type 1 uracil DNA glycosylase is required for efficient viral replication and latency in the murine nervous system. J. Virol. 68:4963-4972.
48. Pyles, R. B., R. E. Warnick, C. L. Chalk, B. E. Szanti, and L. M. Parysek. 1997. A novel multiply-mutated HSV-1 strain for the treatment of human brain tumors. Hum. Gene Ther. 8:533-544.
49. Rabkin, S. D., T. Mineta, S. Miyatake, and T. Yazaki. 1996. Gene therapy: targeting tumor cells for destruction. Hum. Cell. 9:265-276.
50. Roizman, B., and A. E. Sears. 1995. Herpes simplex viruses and their replication, p. 2231-2296. In B. N. Fields, D. M. Knipe, and P. M. Howley (ed.), Fields virology, 3rd ed. Lippincott-Raven Publishers, Philadelphia, Pa.
51. Russell, S. J. 1994. Replicating vectors for gene therapy of cancer: risks, limitations and prospects. Eur. J. Cancer 30:1165-1171.
52. Schmidbauer, M., I. Podreka, D. Wimberger, W. Oder, G. Koch, S. Wenger, G. Goldenberg, S. Asenbaum. and L. Deecke, 1991. SPECT and MR imaging in herpes simplex encephalitis. J, Comput. Assisted Tomogr. 15:811-815.
53. Schroth, G., J. Gawehn, A. Thron, A. Vallbracht, and K. Voigt. 1987. Early diagnosis of herpes simplex encephalitis by MRI. Neurology 37:179-183.
54. Sköldenberg, B. 1996. Herpes simplex encephalitis. Scand. J. Infect. Dis. Suppl. 100:8-13.
55. Soong, S. J., N. E. Watson, G. R. Caddell, C. A. Alford, Jr., and R. J. Whitley. 1991. Use of brain biopsy for diagnostic evaluation of patients with suspected herpes simplex encephalitis: a statistical model and its clinical implications. NIAID Collaborative Antiviral Study Group. J. Infect. Dis. 163:17-22.
56. Taha, M. Y., G. B. Clements, and S. M. Brown. 1989. A variant of herpes simplex virus type 2 strain HG52 with a 1.5 kb deletion in RL between O to 0.02 and 0.81 to 0.83 map units is non-neurovirulent for mice. J. Gen. Virol. 70:705-716.
57. Tenser, R. B. 1983. Intracerebral inoculation of newborn and adult mice with thymidine kinase-deficient mutants of herpes simplex virus type 1. J. Infect. Dis. 147:956.
58. Thompson, R. L., E. K. Wagner, and J. G. Stevens. 1983. Physical location of a herpes simplex virus type-1 gene function(s) specifically associated with a 10 million-fold increase in HSV neurovirulence. Virology 131:180-192.
59. Tien, R. D., G. J. Felsberg, and A. K. Osumi. 1993. Herpesvirus infections of the CNS: MR findings. AJR Am. J. Roentgenol. 161:167-176.
60. Toda, M., S. D. Rabkin, and R. L. Martuza. 1998. Treatment of human breast cancer in a brain metastatic model by G207, a replication-competent multimutated herpes simplex virus 1. Hum. Gene Ther. 9:2177-2185.
61. Valyi-Nagy, T., M. U. Fareed, J. S. O'Keefe, R. M. Gesser, A. R. MacLean, S. M. Brown, J. G. Spivack, and N. W. Fraser. 1994. The herpes simplex virus type 1 strain 17+ gamma 34.5 deletion mutant 1716 is avirulent in SCID mice. J. Gen. Virol. 75:2059-2063.
62. Weller, R. E. 1994. Infectious and noninfectious disease of owl monkeys, p. 177-215. In J. F. Baer, R. E. Weller, and I. Kakoma (ed.), Aotus: the owl monkey. Academic Press, San Diego, Calif.
63. Whitley, R. J. 1995. Herpes simplex viruses, p. 2297-2342. In B. N. Fields, D. M. Knipe, and P. M. Howley (ed.), Fields virology, 3rd ed. Lippincott-Raven Publishers, Philadelphia, Pa.
64. Whitley, R. J., C. A. Alford, M. S. Hirsch, R. T. Schooley, J. P. Luby, F. Y. Aoki, D. Hanley, A. J. Nahmias, and S. J. Soong. 1986. Vidarabine versus acyclovir therapy in herpes simplex encephalitis. N. Engl. J. Med. 314:144-149.
65. Whitley, R. J., E. R. Kern, S. Chatterjee, J. Chou, and B. Roizman. 1993. Replication, establishment of latency, and induced reactivation of herpes simplex virus gamma 1 34.5 deletion mutants in rodent models. J. Clin. Investig. 91:2837-2843.
66. Whitley, R. J., and F. Lakeman. 1995. Herpes simplex virus infections of the central nervous system: therapeutic and diagnostic considerations. Clin. Infect. Dis. 20:414-420.
67. Yamada, Y., H. Kimura, T. Morishima, T. Daikoku, K. Maeno, and Y. Nishiyama. 1991. The pathogenicity of ribonucleotide reductase-null mutants of herpes simplex virus type 1 in mice. J. Infect. Dis. 164:1091-1097.
68. Yazaki, T., H. J. Manz, S. D. Rabkin, and R. L. Martuza. 1995. Treatment of human malignant meningiomas by G207, a replication-competent multimutated herpes simplex virus 1. Cancer Res. 55:4752-4756.
69. Zweerink, H. J., and L. Corey. 1982. Virus-specific antibodies in sera from patients with genital herpes simplex virus infection. Infect. Immun. 37:413-421.