A phase I clinical trial of interferon-beta gene therapy for high-grade glioma: Novel findings from gene expression profiling and autopsy

Journal of Gene Medicine

Volumn 10, Issue 4, 2008, Pages 329-339

  Wakabayashi, Toshihiko ^a   Natsume, Atsushi ^b   Hashizume, Yoshio ^c   Fujii, Masazumi ^b   Mizuno, Masaaki ^b   Yoshida, Jun ^a,b  

^a NAGOYA UNIVERSITY HOSPITAL   (Japan)

^b NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c AICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CATION; CD34 ANTIGEN; LIPOSOME;

ADULT; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPSY; CANCER CELL; CANCER GENE THERAPY; CANCER GRADING; CANCER REGRESSION; CD8+ T LYMPHOCYTE; CELL DEATH; CELL INFILTRATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GLIOMA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MALE; MICROARRAY ANALYSIS; NEOVASCULARIZATION (PATHOLOGY); NUCLEOTIDE SEQUENCE; OUTCOME ASSESSMENT; PHASE 1 CLINICAL TRIAL; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; TREATMENT DURATION; TREATMENT RESPONSE;

ADULT; APOPTOSIS; AUTOPSY; BRAIN NEOPLASMS; CLUSTER ANALYSIS; FEMALE; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GLIOMA; HUMANS; IMMUNITY; INTERFERON-BETA; LIPOSOMES; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; TREATMENT OUTCOME;

EID: 42049112450     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.1160     Document Type: Article

References (35)

1. Fine HA, Dear KB, Loeffler JS, et al. Meta-analysis of radiation therapy with and without adjuvant chemotherapy for malignant gliomas in adults. Cancer 1993; 71: 2585-2597.
2. Culver KW, Ram Z, Wallbridge S, et al. In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science 1992; 256: 1550-1552.
3. http://www.wiley.co.uk/genetherapy/clinical/.
4. Mizuno M, Yoshida J, Sugita K, et al. Growth inhibition of glioma cells transfected with the human beta-interferon gene by liposomes coupled with a monoclonal antibody. Cancer Res 1990; 50:7826-7829.
5. Yagi K, Hayashi Y, Ishida N, et al. Interferon-beta endogenously produced by intratumoral injection of cationic liposome-encapsulated gene: cytocidal effect on glioma transplanted into nude mouse brain. Biochem Mol Biol Int 1994; 32: 167-171.
6. Mizuno M, Yoshida J. Effect of human interferon beta gene transfer upon human glioma, transplanted into nude mouse brain, involves induced natural killer cells. Cancer Immunol Immunother 1998; 47: 227-232.
7. Natsume A, Mizuno M, Ryuke Y, et al. Antitumor effect and cellular immunity activation by murine interferon-beta gene transfer against intracerebral glioma in mouse. Gene Ther 1999; 6: 1626-1633.
8. Natsume A, Tsujimura K, Mizuno M, et al. IFN-beta gene therapy induces systemic antitumor immunity against malignant glioma. J Neurooncol 2000; 47: 117-124.
9. Borden EC, Lindner D, Dreicer R, et al. Second-generation interferons for cancer: clinical targets. Semin Cancer Biol 2000; 10: 125-144.
10. Yoshida J, Mizuno M, Fujii M, et al. Human gene therapy for malignant gliomas (glioblastoma multiforme and anaplastic astrocytoma) by in vivo transduction with human interferon beta gene using cationic liposomes. Hum Gene Ther 2004; 15: 77-86.
11. Therasse P, Arbuck SG, Eisenhauer EA, et al. New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 2000; 92: 205-216.
12. Natsume A, Ishii D, Wakabayashi T, et al. IFN-beta down-regulates the expression of DNA repair gene MGMT and sensitizes resistant glioma cells to temozolomide. Cancer Res 2005; 65:7573-7579.
13. Stupp R, Reni M, Gatta G, et al. Anaplastic astrocytoma in adults. Crit Rev Oncol Hematol 2007, 63: 72-80.
14. Ishii D, Natsume A, Wakabayashi T, et al. Efficacy of temozolomide is correlated with 1p loss and methylation of the deoxyribonucleic acid repair gene MGMT in malignant gliomas. Neurol Med Chir (Tokyo) 2007; 47: 341-349; discussion 350.
15. Nakanishi H, Mizutani Y, Kawauchi A, et al. Significant antitumoral activity of cationic multilamellar liposomes containing human IFN-beta gene against human renal cell carcinoma. Clin Cancer Res 2003; 9: 1129-1135.
16. Saito R, Mizuno M, Hatano M, et al. Two different mechanisms of apoptosis resistance observed in interferon-beta induced apoptosis of human glioma cells. J Neurooncol 2004; 67: 273-280.
17. Takaoka A, Hayakawa S, Yanai H, et al. Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence. Nature 2003; 424: 516-523.
18. Smith ML, Chen IT, Zhan Q, et al. Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. Science 1994; 266: 1376-1380.
19. Chung HK, Yi YW, Jung NC, et al. CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle. J Biol Chem 2003; 278: 28079-28088.
20. Pitti RM, Marsters SA, Ruppert S, et al. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J Biol Chem 1996; 271: 12687-12690.
21. Kischkel FC, Lawrence DA, Chuntharapai A, et al. Apo2L/ TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5. Immunity 2000; 12: 611-620.
22. Baldwin AS Jr. The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol 1996; 14: 649-683.
23. Chen FE, Ghosh G. Regulation of DNA binding by Rel/NF-kappaB transcription factors: structural views. Oncogene 1999; 18: 6845-6852.
24. de Martin R, Schmid JA, Hofer-Warbinek R. The NF-kappaB/Rel family of transcription factors in oncogenic transformation and apoptosis. Mutat Res 1999; 437: 231-243.
25. Aggarwal BB. Apoptosis and nuclear factor-kappa B: a tale of association and dissociation. Biochem Pharmacol 2000; 60: 1033-1039.
26. Laviola L, Natalicchio A, Giorgino F. The IGF-I signaling pathway. Curr Pharm Des 2007; 13: 663-669.
27. Santer FR, Bacher N, Moser B, et al. Nuclear insulin-like growth factor binding protein-3 induces apoptosis and is targeted to ubiquitin/ proteasome-dependent proteolysis. Cancer Res 2006; 66: 3024-3033.
28. Dranoff G. GM-CSF-based cancer vaccines. Immunol Rev 2002; 188: 147-154.
29. Eager R, Nemunaitis J. GM-CSF gene-transduced tumor vaccines. Mol Ther 2005; 12: 18-27.
30. Xie K. Interleukin-8 and human cancer biology. Cytokine Growth Factor Rev 2001; 12: 375-391.
31. Yeh M, Gharavi NM, Choi J, et al. Oxidized phospholipids increase interleukin 8 (IL-8) synthesis by activation of the csrc/signal transducers and activators of transcription (STAT)3 pathway. J Biol Chem 2004; 279: 30175-30181.
32. Leon SP, Folkerth RD, Black PM. Microvessel density is a prognostic indicator for patients with astroglial brain tumors. Cancer 1996; 77: 362-372.
33. Fidler IJ. Regulation of neoplastic angiogenesis. J Natl Cancer Inst Monogr 2001; 10-14.
34. Ren B, Yee KO, Lawler J, et al. Regulation of tumor angiogenesis by thrombospondin-1. Biochim Biophys Acta 2006; 1765: 178-188.
35. Kargiotis O, Rao JS, Kyritsis AP. Mechanisms of angiogenesis in gliomas. J Neurooncol 2006; 78: 281-293.