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Volumn 12, Issue 7, 2009, Pages 445-453

Trabedersen, a TGFβ2-specific antisense oligonucleotide for the treatment of malignant gliomas and other tumors overexpressing TGFβ2

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ANTISENSE OLIGONUCLEOTIDE; AP 11014; AP 12009; BELAGENPUMATUCEL L; CARMUSTINE; GC 1008; LOMUSTINE; LY 2157299; PROCARBAZINE; RANAGENGLIOTUCEL T; TEMOZOLOMIDE; TRANSFORMING GROWTH FACTOR BETA2; UNCLASSIFIED DRUG; VINCRISTINE; NUCLEOTIDE; OLIGODEOXYRIBONUCLEOTIDE;

EID: 68149094346     PISSN: 13697056     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (30)

References (93)
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    • 668092 Results of G004, a phase IIb actively controlled clinical trial with the TGF-β 2 targeted compound AP 12009 for recurrent anaplastic astrocytoma. Hau P, Stockhammer G, Kunst M, Mahapatra A, Sastry KV, Parfenov VE, Leshinsky VG, Jachimczak P, Bogdahn U, Schlingensiepen K J CLIN ONCOL 2006 2418S Abs 1566
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    • 671306 Suppression of TGF-β 2 in pancreatic cancer by the antisense oligonucleotide AP 12009: Preclinical efficacy data as basis for clinical studies. Stauder G, Jachimczak P, Schlingensiepen R, Goldbrunner M, Graf K, Kielmanowicz M, Hafner M, Szyrach M, Bischof A, Schlingensiepen KH EJC SUPPL 2003 15 Abs 229
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    • 671320 The TGF-β 2 antisense oligonucleotide AP 12009 as a therapeutic agent in recurrent high-grade glioma: Safety and efficacy results of phase I/II clinical trials. Hau P, Bogdahn U, Schlaier J, Mehdorn M, Wurm G, Pichler J, Kunst M, Goldbrunner M, Schlingensiepen KH, Stauder G EJC SUPPL 2003 15 Abs 34
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    • 671324 Antisense-TGF-β -2 oligonucleotide AP 12009: Results of safety pharmacology and toxicity studies. Schlingensiepen R, Goldbrunner M, Bischof A, Kunst M, Schulmeyer F, Jachimczak P, Stauder G, Schlingensiepen KH J CANCER RES CLIN ONCOL 2002 128Suppl 1 Abs P673
  • 33
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    • 671327 Intracerebral and intrathecal infusion of the TGF-β 2-specificantisense phosphorothioate oligonucleotide AP 12009 in rabbits and primates: Toxicology and safety. Schlingensiepen R, Goldbrunner M, Szyrach MNI, Stauder G, Jachimczak P, Bogdahn U, Schulmeyer F, Hau P, Schlingensiepen KH OLIGONUCLEOTIDES 2005 152 94-104. A preclinical safety and toxicity study demonstrating that trabedersen can be administered chronically to rabbits, rats and monkeys via the intracerebral or intravenous route without causing major side effects
    • 671327 Intracerebral and intrathecal infusion of the TGF-β 2-specificantisense phosphorothioate oligonucleotide AP 12009 in rabbits and primates: Toxicology and safety. Schlingensiepen R, Goldbrunner M, Szyrach MNI, Stauder G, Jachimczak P, Bogdahn U, Schulmeyer F, Hau P, Schlingensiepen KH OLIGONUCLEOTIDES 2005 152 94-104. A preclinical safety and toxicity study demonstrating that trabedersen can be administered chronically to rabbits, rats and monkeys via the intracerebral or intravenous route without causing major side effects.
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.