Structural basis for cyclic Py-Im polyamide allosteric inhibition of nuclear receptor binding

Journal of the American Chemical Society

Volumn 132, Issue 41, 2010, Pages 14521-14529

  Chenoweth, David M ^a   Dervan, Peter B ^a  

^a California Institute of Technology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC INHIBITION; ALLOSTERIC MODULATORS; ANDROGEN RECEPTORS; BASE PAIRS; CHEMICAL CONTROLS; DNA HELIX; DNA STRUCTURE; DNA-BINDING; GENE NETWORKS; GLUCOCORTICOID RECEPTOR; HIGH RESOLUTION; MINOR GROOVES; MOLECULAR BASIS; NUCLEAR RECEPTORS; PYRROLE-IMIDAZOLE POLYAMIDES; SMALL MOLECULES; STRUCTURAL BASIS; STRUCTURAL PERTURBATION; X RAY CRYSTAL STRUCTURES;

AMIDES; BIOCHEMISTRY; CELL CULTURE; CRYSTAL STRUCTURE; DNA; GENES; TRANSCRIPTION; TRANSCRIPTION FACTORS;

DNA SEQUENCES;

ANDROGEN RECEPTOR; BETA AMINO ACID; CELL NUCLEUS RECEPTOR; GLUCOCORTICOID RECEPTOR; IMIDAZOLE; POLYAMIDE; PYRROLE;

ALLOSTERISM; ARTICLE; CRYSTAL STRUCTURE; DNA BINDING; DNA SEQUENCE; DNA STRUCTURE; MODULATION; PROTEIN BINDING; RECEPTOR BINDING; X RAY CRYSTALLOGRAPHY;

ALLOSTERIC REGULATION; CRYSTALLOGRAPHY, X-RAY; MODELS, MOLECULAR; NYLONS; PROTEIN CONFORMATION; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

EID: 77958046177     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja105068b     Document Type: Article

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