A conformationally constrained inhibitor with an enhanced potency for β-tryptase and stability against semicarbazide-sensitive amine oxidase (SSAO)

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 22, 2010, Pages 6721-6724

  Liang, Guyan ^a   Choi Sledeski, Yong Mi ^a   Poli, Gregory ^a   Chen, Xin ^a   Shum, Patrick ^a   Minnich, Anne ^a   Wang, Qingping ^a   Tsay, Joseph ^a   Sides, Keith ^a   Cairns, Jennifer ^a   Stoklosa, Gregory ^a   Nieduzak, Thaddeus ^a   Zhao, Zhicheng ^a   Wang, Jie ^a   Vaz, Roy J ^a  

^a SANOFI   (France)

Author keywords

Benzylamine; Inhibitor; Molecular modeling; SSAO; Structure based drug design; Tryptase; X ray

Indexed keywords

AMINE OXIDASE (COPPER CONTAINING); TRYPTASE INHIBITOR;

AMINO ACID SUBSTITUTION; ARTICLE; CONFORMATIONAL TRANSITION; DRUG DESIGN; ENTROPY; ENZYME ACTIVITY; ENZYME STABILITY; HUMAN; MOLECULAR DYNAMICS; MOLECULAR MODEL; NONHUMAN; X RAY;

AMINE OXIDASE (COPPER-CONTAINING); ANIMALS; ENZYME INHIBITORS; HUMANS; MOLECULAR CONFORMATION; MOLECULAR DYNAMICS SIMULATION; TRYPTASES; X-RAY DIFFRACTION;

EID: 77958032471     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.08.141     Document Type: Article

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