Design and evaluation of novel bivalent thrombin inhibitors based on amidinophenylalanines

European Journal of Biochemistry

Volumn 265, Issue 2, 1999, Pages 598-605

  Steinmetzer, Torsten ^a   Renatus, Martin ^b   Künzel, Sebastian ^a   Eichinger, Andreas ^b   Bode, Wolfram ^b   Wikström, Peter ^c   Hauptmann, Jörg ^a   Stürzebecher, Jörg ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^c Pentapharm Ltd   (Switzerland)

Author keywords

Anticoagulants; Bivalent inhibitor; Enzyme kinetics; Hirudin; Thrombin

Indexed keywords

4 AMINOBUTYRIC ACID; BENZAMIDINE; BLOOD CLOTTING FACTOR 10A; CARBOXYL GROUP; FIBRINOGEN; GLUTAMIC ACID; HIRULOG; PHENYLALANINE DERIVATIVE; PLASMIN; SERINE PROTEINASE; THROMBIN INHIBITOR; UROKINASE;

ANIMAL EXPERIMENT; ANTICOAGULATION; ARTICLE; CRYSTALLIZATION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DESIGN; DRUG STABILITY; DRUG STRUCTURE; ENZYME KINETICS; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; PROTHROMBIN TIME; RAT; THROMBIN TIME;

AMINO ACID SEQUENCE; ANIMALS; ANTITHROMBINS; BENZAMIDINES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; GUANIDINES; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PEPTIDES; PHENYLALANINE; RATS;

ANIMALIA;

EID: 0033569798     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.1999.00742.x     Document Type: Article

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