Design, synthesis, and biological activity of potent and selective inhibitors of mast cell tryptase

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 11, 2005, Pages 2734-2737

  Hopkins, Corey R ^a   Czekaj, Mark ^a   Kaye, Steven S ^a   Gao, Zhongli ^a   Pribish, James ^a   Pauls, Henry ^a   Liang, Guyan ^a   Sides, Keith ^a   Cramer, Dona ^a   Cairns, Jennifer ^a   Luo, Yongyi ^a   Lim, Heng Keang ^a   Vaz, Roy ^a   Rebello, Sam ^a   Maignan, Sebastian ^a   Dupuy, Alain ^a   Mathieu, Magali ^a   Levell, Julian ^a  

^a SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BENZYLAMINE DERIVATIVE; INDOLE; PIPERIDINE DERIVATIVE; SERINE PROTEINASE; TRYPTASE INHIBITOR;

ARTICLE; COMPARATIVE STUDY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; HYDROPHOBICITY; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION;

ENZYME INHIBITORS; MAST CELLS; MODELS, MOLECULAR; SERINE ENDOPEPTIDASES; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPTASES;

EID: 21144450350     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.04.002     Document Type: Article

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