Calculating a cure for cancer: Managing medulloblastoma MATH1-ematically

Expert Review of Neurotherapeutics

Volumn 10, Issue 10, 2010, Pages 1489-1492

  Dubuc, Adrian M ^a,b   Northcott, Paul A ^a,b   Kenney, Anna M ^c   Taylor, Michael D ^a,b  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

BMI1; brain tumors; cerebellum; external graule layer; genomics; granule cell precursors; MATH1; medulloblastoma; neuronal differentiation; Sonic Hedgehog

Indexed keywords

CYCLOPAMINE;

BRAIN DEVELOPMENT; CANCER THERAPY; CARCINOGENESIS; CELL PROLIFERATION; DRUG TARGETING; EDITORIAL; EPIGENETICS; GENE AMPLIFICATION; GENE OVEREXPRESSION; GENE TARGETING; GENOTYPE; HUMAN; MATH1 GENE; MEDULLOBLASTOMA; PATHOGENESIS;

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; HEDGEHOG PROTEINS; HUMANS; MEDULLOBLASTOMA; NEOPLASMS; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION;

EID: 77958012923     PISSN: 14737175     EISSN: 17448360     Source Type: Journal    
DOI: 10.1586/ern.10.126     Document Type: Editorial

References (33)

1. Northcott PA, Rutka JT, Taylor MD. Genomics of medulloblastoma: From Giemsa-banding to next generation sequencing in 20 years. Neurosurg Focus. 28(1), E6 (2010).
2. Kool M, Koster J, Bunt J et al. Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features. PLoS One 3(8), E3088 (2008).
3. Thompson M, Fuller C, Hogg TL et al. Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations. J. Clin. Oncol. 24(12), 1924-1931 (2006).
4. Northcott PA, Fernandez LA, Haggan J et al. The miR-17/92 polycistron is up-regulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehog-treated cerebellar neural precursors. Cancer Res. 69(8), 3249-3255 (2009).
5. Lee Y, Miller HL, Jensen P et al. A molecular fingerprint for medulloblastoma. Cancer Res. 63 (17), 5428-5437 (2003).
6. Fan X, Eberhart CG. Medulloblastoma stem cells. J. Clin. Oncol. 26(17), 2821-2827 (2008).
7. Kenney AM, Cole MD, Rowitch DH. Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors. Development 130(1), 15-28 (2003).
8. Ruiz i Altaba A, Palma V, Dahmane N. Hedgehog-Gli signalling and the growth of the brain. Nat. Rev. Neurosci. 3(1), 24-33 (2002).
9. Wechsler-Reya RJ, Scott MP. Control of neural proliferation in the cerebellum by Sonic Hedgehog. Neuron 22(1), 103-114 (1999).
10. Wallace VA. Purkinje-cell derived Sonic Hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum. Curr. Biol. 9(8), 445-448 (1999).
11. Dellovade T, Romer JT, Curran T, Rubin LL. The hedgehog pathway and neurological disorders. Annu. Rev. Neurosci. 29, 539-563 (2006).
12. Ben-Arie N, Bellen HJ, Armstrong DL et al. Math1 is essential for genesis of cerebellar granule neurons. Nature 390(6656), 169-172 (1997).
13. Kawauchi D, Saito T. Transcriptional cascade from Math1 to Mbh1 and Mbh2 is required for cerebellar granule cell differentiation. Dev. Bio. 322(2), 345-354 (2008).
14. Zhao H, Ayrault O, Zindy F, Kim JH, Roussel MF. Post-transcriptional downregulation of Atoh1/Math1 by bone morphogenic proteins suppresses medulloblastoma development. Genes Dev. 22(6), 722-727 (2008).
15. Grimmer MR, Weiss WA. BMPs oppose Math1 in cerebellar development in medulloblastoma. Genes Dev. 22(6), 693-699 (2008).
16. Gazit R, Krizhanovsky V, Ben-Arie N. Math1 controls cerebellar granule cell differentiation by regulating multiple components of the notch signaling pathway. Development 131(4), 903-913 (2004).
17. Flora A, Klisch TJ, Schuster G, Zoghbi HY. Deletion of atoh1 disrupts sonic hedgehog signaling in the developing cerebellum and prevents medulloblastoma. Science 326(5958), 1424-1427 (2009).
18. Helms AW, Gowan K, Abney A, Savage T, Johnson JE. Overexpression of math1 disrupts the coordination of neural differentiation in cerebellum development. Mol. Cell. Neurosci. 17(4), 671-682 (2001).
19. Salsano E, Pollo B, Eoli M, Giordana MT, Finocchiaro G. Expression of MATH1, a marker of cerebellar granule cell progenitors, identifies different medulloblastoma sub-types. Neurosci. Lett. 370(2-3), 180-185 (2004).
20. Yang ZJ, Ellis T, Markant SL et al. Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. Cancer Cell 14(2), 135-145 (2008).
21. Briggs KJ, Corcoran-Schwartz IM, Zhang W et al. Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma. Genes Dev. 22(6), 770-785 (2008).
22. Rood BR, Zhang H, Weitman DM, Cogen PH. Hypermethylation of HIC1 and 17p allelic loss in medulloblastoma. Cancer Res. 62(13), 3794-3797 (2002).
23. Ayrault O, Zhao H, Zindy F, Qu C, Sherr CJ, Roussel MF. Atoh1 inhibits neuronal differentiation and collaborates with gli1 to generate medulloblastoma-initiating cells. Cancer Res. 70(13), 5618-5627 (2010).
24. Stanton BZ, Peng LF. Small-molecule modulators of the Sonic Hedgehog signaling pathway. Mol. Biosyst. 6(1), 44-54 (2010).
25. -/- mice. Cancer Cell 6(3), 229-240 (2004).
26. Hallahan AR, Pritchard JL, Hansen S et al. The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastoma. Cancer Res. 64(21), 7794-7800 (2004).
27. Northcott PA, Nakahara Y, Wu X et al. Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma. Nat. Genet. 41(4), 465-472 (2009).
28. Taylor MD, Liu L, Raffel C et al. Mutations in SUFU predispose to medulloblastoma. Nat. Genet. 31(3), 306-310 (2002).
29. van Lohuizen M, Verbeek S, Scheijen B, Wientjens E, van der Gulden H, Berns A. Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging. Cell 65(5), 737-752 (1991).
30. Leung C, Lingbeek M, Shakhova O et al. Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas. Nature 428(6980), 337-341 (2004).
31. Michael LE, Westerman BA, Ermilov AN et al. Bmi1 is required for hedgehog pathway-driven medulloblastoma expansion. Neoplasia 10(12), 1343-1349 (2008).
32. He S, Iwashita T, Buchstaller J, Molofsky AV, Thomas D, Morrison SJ. Bmi-1 over-expression in neural stem/progenitor cells increases proliferation and neurogenesis in culture but has little effect on these functions in vivo. Dev. Bio. 328(2), 257-272 (2009).
33. Swartling FJ, Grimmer MR, Hackett CS et al. Pleiotropic role for MYCN in medulloblastoma. Genes Dev. 24(10), 1059-1072 (2010).