Discovery of small molecule inhibitors of the ph domain leucine-rich repeat protein phosphatase (PHLPP) by chemical and virtual screening

Journal of Medicinal Chemistry

Volumn 53, Issue 19, 2010, Pages 6899-6911

  Sierecki, Emma ^a   Sinko, William ^b   McCammon, J Andrew ^a,b   Newton, Alexandra C ^a  

^a University of California San Diego   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; NSC 11404; NSC 117079; NSC 119910; NSC 12509; NSC 13378; NSC 133896; NSC 134145; NSC 134149; NSC 13416; NSC 25247; NSC 3323; NSC 366218; NSC 42384; NSC 45586; NSC 45618; NSC 47754; NSC 47924; NSC 51532; NSC 601364; NSC 65541; NSC 74429; NSC 75913; NSC 79714; NSC 88915; PH DOMAIN LEUCINE RICH REPEAT PROTEIN PHOSPHATASE; PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; PROTEIN KINASE B; UNCLASSIFIED DRUG; UNINDEXED DRUG; 1,3-((4-(2,4-DIAMINO-5-METHYLPHENYL)DIAZENYLPHENYL)HYDRAZINYLIDENE)-6-OXOCYCLOHEXA-1,4-DIENE-1-CARBOXYLIC ACID; 1-AMINO-9,10-DIOXO-4-(3-SULFAMOYLANILINO)ANTHRACENE-2-SULFONIC ACID; ANTHRAQUINONE DERIVATIVE; AZO COMPOUND; ESCHERICHIA COLI PROTEIN; MOLECULAR LIBRARY; PHOSPHOPROTEIN PHOSPHATASE; SALICYLIC ACID DERIVATIVE;

APOPTOSIS; ARTICLE; CELL PROTECTION; CELL STRAIN COS7; DRUG PROTEIN BINDING; ENZYME INHIBITION; IC 50; IN VITRO STUDY; MOLECULAR DOCKING; MOLECULARLY TARGETED THERAPY; PROTEIN PHOSPHORYLATION; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; AGONISTS; AMINO ACID SEQUENCE; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; ENZYME ACTIVE SITE; HIGH THROUGHPUT SCREENING; HUMAN; METABOLISM; MOLECULAR GENETICS; MOLECULAR LIBRARY; PHOSPHORYLATION; SEQUENCE HOMOLOGY; SYNTHESIS; TUMOR CELL LINE;

AMINO ACID SEQUENCE; ANTHRAQUINONES; APOPTOSIS; AZO COMPOUNDS; CATALYTIC DOMAIN; CELL LINE, TUMOR; ESCHERICHIA COLI PROTEINS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHOSPHOPROTEIN PHOSPHATASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SALICYLATES; SEQUENCE HOMOLOGY, AMINO ACID; SMALL MOLECULE LIBRARIES;

EID: 77957930200     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100331d     Document Type: Article

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