Genetic and biochemical characterization of human AP endonuclease 1 mutants deficient in nucleotide incision repair activity

PLoS ONE

Volumn 5, Issue 8, 2010, Pages

  Gelin, Aurore ^a   Redrejo Rodríguez, Modesto ^b   Laval, Jacques ^b   Fedorova, Olga S ^c   Saparbaev, Murat ^b   Ishchenko, Alexander A ^b  

^a UMR 8126   (France)

^b Gustave Roussy Comprehensive Cancer Institute   (France)

^c INSTITUTE OF CHEMICAL BIOLOGY AND FUNDAMENTAL MEDICINE   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

APURINIC APYRIMIDINIC ENDONUCLEASE 1; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; DNA DIRECTED DNA POLYMERASE BETA; FLAP ENDONUCLEASE; PHOSPHODIESTERASE I; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; SPLEEN EXONUCLEASE; UNCLASSIFIED DRUG; 2'-DEOXYADENOSINE; APEX1 PROTEIN, HUMAN; DEOXYADENOSINE; DEOXYADENOSINE DERIVATIVE; MESYLIC ACID METHYL ESTER; MUTANT PROTEIN; NUCLEOTIDE;

AMINO ACID SUBSTITUTION; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; ENZYME ACTIVITY; ESCHERICHIA COLI; EXCISION REPAIR; GENETIC ANALYSIS; IN VITRO STUDY; NONHUMAN; NUCLEOTIDE INCISION REPAIR; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN ISOLATION; SITE DIRECTED MUTAGENESIS; ALKYLATION; BIOCATALYSIS; DRUG EFFECT; GENETICS; HUMAN; KINETICS; METABOLISM; MUTATION; NUCLEOTIDE SEQUENCE;

ALKYLATION; BASE SEQUENCE; BIOCATALYSIS; DEOXYADENOSINES; DNA DAMAGE; DNA REPAIR; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; ESCHERICHIA COLI; HUMANS; KINETICS; METHYL METHANESULFONATE; MUTAGENESIS, SITE-DIRECTED; MUTANT PROTEINS; MUTATION; NUCLEOTIDES;

EID: 77957879524     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0012241     Document Type: Article

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