Polarization and migration of hematopoietic stem and progenitor cells rely on the RhoA/ROCK I pathway and an active reorganization of the microtubule network

Journal of Biological Chemistry

Volumn 285, Issue 41, 2010, Pages 31661-31671

  Fonseca, Ana Violeta ^a   Freund, Daniel ^a   Bornhäuser, Martin ^b,c   Corbeil, Denis ^a,b  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b CENTER FOR REGENERATIVE THERAPIES DRESDEN   (Germany)

^c UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; MORPHOLOGY; RNA; ROCKS;

COCULTURE; EX-VIVO; MESENCHYMAL STROMAL CELLS; MICROTUBULE NETWORKS; MICROTUBULES; NOCODAZOLE; PROGENITOR CELL; RHO-KINASE INHIBITORS; RNA INTERFERENCE; STEM CELL RESEARCH; TIME-LAPSE VIDEO MICROSCOPY;

STEM CELLS;

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; CD34 ANTIGEN; EZRIN; MEMBRANE PROTEIN; NOCODAZOLE; PROMININ 1; RHO ASSOCIATED COILED COIL PROTEIN KINASE I; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; AMIDE; CD133 ANTIGEN; CYTOSKELETON PROTEIN; ENZYME INHIBITOR; GLYCOPROTEIN; LEUKOCYTE ANTIGEN; PEPTIDE; PYRIDINE DERIVATIVE; RHOA PROTEIN, HUMAN; ROCK1 PROTEIN, HUMAN;

ARTICLE; CELL ASSAY; CELL ISOLATION; CELL MIGRATION; CELL POLARITY; CELL STRUCTURE; CELL TYPE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOKINESIS; DOWN REGULATION; EX VIVO STUDY; GENETIC TRANSFECTION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; INTRACELLULAR SIGNALING; MESENCHYMAL STEM CELL; MICROTUBULE ORGANIZING CENTER; MIGRATION INHIBITION; PHENOTYPE; POLARIZATION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; RNA INTERFERENCE; STROMA CELL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CELL MOTION; CYTOLOGY; DRUG EFFECTS; GENE SILENCING; GENETICS; METABOLISM; MICROTUBULE; PHYSIOLOGY;

UROPODA;

AMIDES; ANTIGENS, CD; CELL MOVEMENT; CELL POLARITY; CELLS, CULTURED; CYTOSKELETAL PROTEINS; ENZYME INHIBITORS; GENE KNOCKDOWN TECHNIQUES; GLYCOPROTEINS; HEMATOPOIETIC STEM CELLS; HUMANS; MICROTUBULES; PEPTIDES; PYRIDINES; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN;

EID: 77957812911     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.145037     Document Type: Article

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