Spatiotemporal regulation of moesin phosphorylation and rear release by Rho and serine/threonine phosphatase during neutrophil migration

Experimental Cell Research

Volumn 278, Issue 1, 2002, Pages 112-122

  Yoshinaga Ohara, Naoko ^a   Takahashi, Atsushi ^a   Uchiyama, Takashi ^a   Sasada, Masataka ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Calyculin A; Ezrin; Moesin; Neutrophil migration; Radixin; Rear release; Rho; Uropod retraction

Indexed keywords

ACTIN; CALCYCLIN; CIPERMETHRIN; ENZYME INHIBITOR; GUANOSINE TRIPHOSPHATASE; MOESIN; PHOSPHATASE; RHO FACTOR; SERINE; THREONINE;

ACTIN FILAMENT; ARTICLE; BIOCHEMISTRY; CARBOXY TERMINAL SEQUENCE; CELL ASSAY; CELL FUNCTION; CELL MEMBRANE; CELL MIGRATION; CELL POLARITY; CELL SHAPE; CONTROLLED STUDY; CROSS LINKING; DOSE RESPONSE; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; HUMAN CELL; MICROSCOPY; NEUTROPHIL; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION;

UROPODA;

EID: 0036070518     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2002.5571     Document Type: Article

References (54)

1. Neutrophil actin dysfunction and abnormal neutrophil behavior
2. An inherited defect of neutrophil motility and microfilamentous cytoskeleton associated with abnormalities in 47-Kd and 89-Kd proteins
3. A novel syndrome of severe neutrophil dysfunction: Unresponsiveness confined to chemotaxin-induced functions
4. Regulatory dysfunction in leukotaxis
5. Lazy-leucocyte syndrome: A new disorder of neutrophil function
6. Immunodeficiency diseases caused by defects in phagocytes
7. Random migration of polymorphonuclear leukocytes induced by GM-CSF involving a signal transduction pathway different from that of fMLP
8. Rho-stimulated contractility drives the formation of stress fibers and focal adhesions
9. Role of Rho in chemoattractant-activated leukocyte adhesion through integrins
10. Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/ moesin (ERM) proteins and regulates their head-to-tail association
11. Cortical actin organization: Lessons from ERM (ezrin/radixin/moesin) proteins
12. Moesin interacts with the cytoplasmic region of intercellular adhesion molecule-3 and is redistributed to the uropod of T lymphocytes during cell polarization
13. Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2
14. Polarization and interaction of adhesion molecules P-selectin glycoprotein ligand 1 and intercellular adhesion molecule 3 with moesin and ezrin in myeloid cells
15. Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain
16. ADP-ribosylation of a small size GTP-binding protein in bovine neutrophils by the C3 exoenzyme of Clostridium botulinum and effect on the cell motility
17. Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
18. Evidence of ζ protein kinase C involvement in polymorphonuclear neutrophil integrin-dependent adhesion and chemotaxis
19. Cell migration: A physically integrated molecular process
20. Actin-based cell motility and cell locomotion
21. Ca2+-dependent myosin II activation is required for uropod retraction during neutrophil migration
22. Cell migration: Regulation of force on extracellular-matrix-integrin complexes
23. Adenosine diphosphate (ADP)-ribosylation of the guanosine triphosphatase (GTPase) Rho in resting peripheral blood human T lymphocytes results in pseudopodial extension and the inhibition of T cell activation
24. RhoA is required for monocyte tail retraction during transendothelial migration
25. Activation of RhoA and ROCK are essential for detachment of migrating leukocytes
26. Activation of ERM proteins in vivo by Rho involves phosphatidyl-inositol 4-phosphate 5-kinase and not ROCK kinases
27. Preparation of native and recombinant Clostridium botulinum C3 ADP-ribosyltrans-ferase and identification of Rho proteins by ADP-ribosylation
28. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
29. Specific accumulation of Rho-associated kinase at the cleavage furrow during cytokinesis: Cleavage furrow-specific phosphorylation of intermediate filaments
30. Transient calcium elevation in polymorphonuclear leukocytes triggered by thrombin-activated platelets
31. Biological defense mechanisms: The production by leukocytes of superoxide, a potential bactericidal agent
32. Down-regulation of CXCR2 expression on human polymorphonuclear leukocytes by TNF-α
33. Caspases mediate tumor necrosis factor-α-induced neutrophil apoptosis and downregulation of reactive oxygen production
34. Spatial control of actin polymerization during neutrophil chemotaxis
35. Immunofluorescence detection of ezrin/radixin/moesin (ERM) proteins with their carboxyl-terminal threonine phosphorylated in cultured cells and tissues
36. ERM (ezrin/radixin/moesin)-based molecular mechanism of microvillar breakdown at an early stage of apoptosis
37. Botulinum ADP-ribosyltrans-ferase C3: A new tool to study low molecular weight GTP-binding proteins
38. Role of the cytoskeleton in rapid activation of CD11b/CD18 function and its subsequent downregulation in neutrophils
39. Moesin, ezrin, and p205 are actin-binding proteins associated with neutrophil plasma membranes
40. Rho-kinase in human neutrophils: A role in signalling for myosin light chain phosphorylation and cell migration
41. Phosphorylation and the actin cytoskeleton in defective newborn neutrophil chemotaxis
42. Effect of okadaic acid on leukocyte movement
43. Phosphatase activity regulates superoxide anion generation and intracellular signaling in human neutrophils
44. Desensitization of the fMLP-induced NADPH-oxidase response in human neutrophils is lacking in okadaic acid-treated cells
45. A mechanical function of myosin II in cell motility
46. Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo
47. Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)
48. Rho GTPases control polarity, protrusion, and adhesion during cell movement
49. Indirect association of ezrin with F-actin: Isoform specificity and calcium sensitivity
50. Moesin, the major ERM protein of lymphocytes and platelets, differs from ezrin in its insensitivity to calpain
51. Protein phosphatase 2C inactivates F-actin binding of human platelet moesin
52. Normal development of mice and unimpaired cell adhesion/cell motility/actin-based cytoskeleton without compensatory up-regulation of ezrin or radixin in moesin gene knockout
53. Oriented endocytic recycling of α5β1 in motile neutrophils
54. Ca2+- and calcineurin-dependent recycling of an integrin to the front of migrating neutrophils