Enzymatic Targets in the Triglyceride Synthesis Pathway

Annual Reports in Medicinal Chemistry

Volumn 45, Issue C, 2010, Pages 109-122

  Koltun, Dmitry O ^a   Zablocki, Jeff ^a  

^a GILEAD SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77957764842     PISSN: 00657743     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-7743(10)45007-1     Document Type: Book

References (65)

1. World Health Organization: Obesity and Overweight (accessed July 2, 2010). http://www.who.int/dietphysicalactivity/publications/facts/obesity/en/.
2. Tirosh A., Shai I., Bitzur R., Kochba I., Tekes-Manova D., Israeli E., Shochat T., Rudich A. Diab. Care 2008, 31:2032.
3. Bloomfield D.K., Bloch K. Biochim. Biophys. Acta 1958, 30:220.
4. Bloomfield D.K., Bloch K. J. Biol. Chem. 1960, 235:337.
5. Ntambi J.M., Buhrow S.A., Kaestner K.H., Christy R.J., Sibley E., Kelly T.J., Lane M.D. J. Biol. Chem. 1988, 263:17291.
6. Wang J., Yu L., Schmidt R.E., Su C., Huang X., Gould K., Cao G. Biochem. Biophys. Res. Commun. 2005, 332:735.
7. Ntambi J.M., Miyazaki M., Stoehr J.P., Lan H., Kendziorski C., Yandell B.S., Song Y., Cohen P., Friedman J.M., Attie A.D. Proc. Natl. Acad. Sci. USA 2002, 99:11482.
8. Cohen P., Miyazaki M., Socci N.D., Hagge-Greenberg A., Liedtke W., Soukas A.A., Sharma R., Hudgins L.C., Ntambi J.M., Friedman J.M. Science 2002, 297:240.
9. Miyazaki M., Man W.C., Ntambi J.M. J. Nutr. 2001, 131:2260.
10. Miyazaki M., Kim Y.C., Ntambi J.M. J. Lipid Res. 2001, 42:1018.
11. Jiang G., Li Z., Liu F., Ellsworth K., Las-Yang Q., Wu M., Ronan J., Esau C., Murphy C., Szalkowski D., Bergeron R., Doebber T., Zhang B.B. J. Clin. Invest. 2005, 115:1030.
12. Ntambi J.M., Miyazaki M. Prog. Lipid Res. 2004, 43:91.
13. Dobrzyn A., Ntambi J.M. Prostaglandins Leukot. Essent. Fatty Acids 2005, 73:35.
14. Dobrzyn A., Ntambi J.M. Obes. Rev. 2005, 6:169.
15. Miyazaki M., Dobrzyn A., Sampath H., Lee S.H., Man W.C., Chu K., Peters J.M., Gonzalez F.J., Ntambi J.M. J. Biol. Chem. 2004, 279:35017.
16. Miyazaki M., Flowers M.T., Sampath H., Chu K., Otzelberger C., Liu X., Ntambi J.M. Cell Metab. 2007, 6:484.
17. Flowers J.B., Rabaglia M.E., Schueler K.L., Flowers M.T., Lan H., Keller M.P., Ntambi J.M., Attie A.D. Diabetes 2007, 56:1228.
18. Zheng Y., Eilertsen K.J., Ge L., Zhang L., Sundberg J.P., Prouty S.M., Stenn K.S., Parimoo S. Nat. Genet. 1999, 23:268.
19. Brown J.M., Chung S., Sawyer J.K., Degirolamo C., Alger H.M., Nguyen T., Zhu X., Duong M.N., Wibley A.L., Shah R., Davis M.A., Kelley K., Wilson M.D., Kent C., Parks J.S., Rudel L.L. Circulation 2008, 118:1467.
20. Brown J.M., Chung S., Sawyer J.K., Degirolamo C., Alger H.M., Nguyen T., Zhu X., Duong M.N., Brown A.L., Lord C., Shah R., Davis M.A., Kelley K., Wilson M.D., Madenspacher J., Fessler M.B., Parks J.S., Rudel L.L. Atheroscler. Thromb. Vasc. Biol. 2010, 30:24.
21. Abreo M., Chafeev M., Chakka N., Chowdhury S., Fu J., Gschwend H.W., Holladay M.W., Hou D., Kamboj R., Kodumuru V., Li W., Liu S., Raina V., Sun S., Sun S., Sviridov S., Tu C., Winther M.D., Zhang Z. Patent Application WO 2005/011655 2005.
22. Xin Z., Zhao H., Serby M.D., Liu B., Liu M., Szczepankiewicz B.G., Nelson L.T.J., Smith H.T., Suhar T.S., Janis R.S., Cao N., Camp H.S., Collins C.A., Sham H.L., Surowy T.K., Liu G. Bioorg. Med. Chem. Lett. 2008, 18:4298.
23. G. Liu, Z. Xin, H. Zhao, M. D. Serby, H. T. Smith, N. Cao, T. K. Surowy, A. Adler, A. Mika, T. B. Farb, C. Keegan, K. Landschulz, M. Brune, C. A. Collins, H. L. Sham, and H. S. Camp, Abstracts of Papers, 233rd ACS National Meeting, Chicago, IL, United States, March 25-29, 2007, MEDI 232.
24. Ramtohul Y.K., Black C., Chan C.-C., Crane S., Guay J., Guiral S., Huang Z., Oballa R., Xu L.-J., Zhang L., Li C.S. Bioorg. Med. Chem. Lett. 2010, 20:1593.
25. Léger S., Black W.C., Deschenes D., Dolman S., Falgueyret J.-P., Gagnon M., Guiral S., Huang Z., Guay J., Leblanc Y., Li C.S., Mass F., Oballa R., Zhang L. Bioorg. Med. Chem. Lett. 2010, 20:499.
26. Uto Y., Ogata T., Kiyotsuka Y., Ueno Y., Miyawaza Y., Kurata H., Deguchi T., Yamada M., Watanabe N., Konishi M., Kurikawa N., Takagi T., Wakimoto S., Osumi J. Bioorg. Med. Chem. Lett. 2010, 20:341.
27. Uto Y., Kiyotsuka Y., Ueno Y., Miyawaza Y., Kurata H., Ogata T., Deguchi T., Watanabe N., Konishi M., Okuyama R., Kurikawa N., Takagi T., Wakimoto S., Kono K., Osumi J. Bioorg. Med. Chem. Lett. 2010, 20:746.
28. Koltun D.O., Parkhill E.Q., Vasilevich N.I., Glushkov A.I., Zilbershtein T.M., Ivanov A.V., Cole A.G., Henderson I., Zautke N.A., Brunn S.A., Mollova N., Leung K., Chisholm J.W., Zablocki J. Bioorg. Med. Chem. Lett. 2009, 19:2048.
29. Koltun D.O., Vasilevich N.I., Parkhill E.Q., Glushkov A.I., Zilbershtein T.M., Mayboroda E.I., Boze M.A., Cole A.G., Henderson I., Zautke N.A., Brunn S.A., Chu N., Hao J., Mollova N., Leung K., Chisholm J.W., Zablocki J. Bioorg. Med. Chem. Lett. 2009, 19:3050.
30. Koltun D.O., Zilbershtein T.M., Migulin V.A., Vasilevich N.I., Parkhill E.Q., Glushkov A.I., McGregor M.J., Brunn S.A., Chu N., Hao J., Mollova N., Leung K., Chisholm J.W., Zablocki J. Bioorg. Med. Chem. Lett. 2009, 19:4070.
31. E. Q. Parkhill, D. O. Koltun, S. A. Brunn, N. Mollova, K. Leung, J. W. Chisholm, and J. Zablocki, Abstracts of Papers, 238th ACS National Meeting, Washington, DC, United States, August 16-20, 2009, MEDI 147.
32. Uto Y., Ogata T., Harada J., Kiyotsuka Y., Ueno Y., Miyawaza Y., Kurata H., Deguchi T., Watanabe N., Takagi T., Wakimoto S., Okuyama R., Abe M., Kurikawa N., Kawamura S., Yamato M., Osumi J. Bioorg. Med. Chem. Lett. 2009, 19:4151.
33. Uto Y., Ogata T., Kiyotsuka Y., Miyawaza Y., Ueno Y., Kurata H., Deguchi T., Yamada M., Watanabe N., Takagi T., Wakimoto S., Okuyama R., Konishi M., Kurikawa N., Kono K., Osumi J. Bioorg. Med. Chem. Lett. 2009, 19:4159.
34. Scaglia N., Chisholm J.W., Igal R.A. PLoS ONE 2009, 4:e6812.
35. Zammit V.A., Buckett L.K., Turnbull A.V., Wure H., Proven A. Pharmacol. Ther. 2008, 188:295.
36. Cao J., Cheng L., Shi Y. J. Lipid Res. 2007, 48:583.
37. Cases S., Smith S.J., Zheng Y.-W., Myers H.M., Lear S.R., Sande E., Novak S., Collins C., Welch C.B., Lusis A.J., Erikson S.K., Farese R.V. Proc. Natl. Acad. Sci. USA 1998, 95:13018.
38. Buhman K.K., Smith S.J., Stone S.J., Repa J.J., Wong J.S., Knapp F.F., Burri B.J., Hamilton R.L., Abumrad N.A., Farese R.V. J. Biol. Chem. 2002, 277:25474.
39. Cases S., Stone S.J., Zhou P., Yen E., Tow B., Lardizabal K.D., Voelker T., Farese R.V. J. Biol. Chem. 2001, 276:38870.
40. Smith S.J., Cases S., Jensen D.R., Chen H.C., Sande E., Tow B., Sanan D.A., Raber J., Eckel R.J., Farese R.V. Nat. Genet. 2000, 87.
41. Chen H.C., Smith S.J., Ladha Z., Jensen D.R., Ferreira L.D., Pulawa L.K., McGuire J.G., Pitas R.E., Eckel R.J., Farese R.V. J. Clin. Invest. 2002, 109:1049.
42. Chen H.C., Farese R.V. Atheroscler. Thromb. Vasc. Biol. 2005, 25:482.
43. Chen H.C. Nutr. Metab. 2006, 3:10.
44. Stone S.J., Myers H.M., Watkins S.M., Brown B.E., Feingold K.R., Elias P.M., Farese R.V. J. Biol. Chem. 2004, 279:11767.
45. Yu X.X., Murray S.F., Pandey S.K., Booten S.L., Bao D., Song X.Z., Kelly S., Chen S., McKay R., Monia B.P., Bhanot S. Hepatology 2005, 42:362.
46. Fox B.M., Furukawa N., Hao X., Ho K., Inaba T., Jackson S., Kayser F., Labelle M., Li K., Matsui T., McMinn D.L., Ogawa N., Rubenstein S.M., Sagawa S., Sugimoto K., Suzuki M., Tanaka M., Ye G., Yoshida M., Zhang J. Patent Application WO 2004/047755 2004.
47. Smith R., Campbell A.-M., Coish P., Dai M., Jenkins S., Lower D., O'Connor S., Wang G., Zhang M., Zhu L.Z. Patent Application US 2006/7091288 2006.
48. Zhao G., Souers A.J., Voorbach M., Falls H.D., Droz B., Brodjian S., Lau Y.Y., Iyengar R.R., Gao J., Judd A.S., Wagaw S.H., Ravn M.M., Engstrom K.M., Lynch J.K., Mulhern M.M., Freeman J., Dayton B.D., Wang X., Grihalde N., Fry D., Beno D.W.A., Marsh K.C., Su Z., Diaz G.J., Collins C.A., Sham H., Reilly R.M., Brune M.E., Kym P.R. J. Med. Chem. 2008, 51:380.
49. Birch A.M., Birtles S., Buckett L.K., Kemmitt P.D., Smith G.J., Smith T.J.D., Turnbull A.V., Wang S.J.Y. J. Med. Chem. 2009, 52:1558.
50. J. T. M. Linders, P. Roevens, M. Berwaer, S. Boeckx, J.-P. Bongartz, H. Borghys, C. Buyck, E. Coesemans, P. V. Davidenko, R.A.H.J. Gilissen, T. Govaerts, P. Haspeslagh, B. Hrupka, A. Klochkova, K. Kolodziejczyk, G. Van Lommen, J. Peeters, K. De Waepenaert, and G. H. M. Willemsens, Abstracts of Papers, 238th ACS National Meeting, Washington, DC, United States, August 16-20, 2009, MEDI 372.
51. R. L. Dow, J.-C. Li, L. Patel, C. Perreault, M. J. Munchhof, D.W. Piotrowski, E. M. Gibbs, W. J. Zavadoski, T. B. Manion, J. L. Treadway, and J. L. LaPerle, Abstracts of Papers, 239th ACS National Meeting, San Francisco, CA, United States, March 20-24, 2010, MEDI 315.
52. Shoulders C.C., Brett D.J., Bayliss J.D., Narcisi T.M., Jarmuz A., Grantham T.T., Leoni P.R., Bhattacharya S., Pease R.J., Cullen P.M., Levi S., Byfield P.G.H., Purkiss P., Scott J. Hum. Mol. Genet. 1993, 2:2109.
53. Hussain M.M., Shi J., Dreizen P. J. Lipid Res. 2003, 42:22.
54. Chandler C.E., Wilder D.E., Pettini J.L., Savoy Y.E., Petras S.F., Chang G., Vincent J., Harwood H.J. J. Lipid Res. 2003, 44:1887.
55. Freedom of Information Summary is available from FDA at (accessed July 2, 2010). http://www.fda.gov/downloads/AnimalVeterinary/Products/ApprovedAnimalDrugProducts/FOIADrugSummaries/UCM050063.pdf.
56. Public Assessment Report is available from EMEA at (accessed July 2, 2010). http://www.ema.europa.eu/vetdocs/PDFs/EPAR/yarvitan/V-113-en1.pdf.
57. Li J., Bronk B.S., Dirlam J.P., Blize A.E., Bertinato P., Jaynes B.H., Hickman A., Miskell C., Pillai U.A., Tibbitts J.S., Haven M.L., Kolosko N.L., Barry C.J., Manion T.B. Bioorg. Med. Chem. Lett. 2007, 17:1996.
58. Dobenecker B., De Bock M., Engelen M., Goossens L., Scholz A., Kienzle E. Vet. Res. Commun. 2009, 33:839.
59. Source: FDA http://www.clinicaltrials.gov.
60. Source: Prous Integrity http://integrity.prous.com.
61. D. J. Rader, W. J. Sasiela, M. Davidson, H. E. Bays, M. Parris, E. Meagher, C. Price, and S. L. Schwartz, 69th Annual Meeting Scientific Session of the American Diabetes Association. (ADA), New Orleans, LA, June 5-9, Abstract 471-P.
62. Vu C.B., Milne J.C., Carney D.P., Song J., Choy W., Lambert P.D., Gagne D.J., Hirsch M., Cote A., Davis M., Lainez E., Meade N., Normington K., Jirousek M.R., Perni R.B. Bioorg. Med. Chem. Lett. 2009, 19:1416.
63. Popescu C.-I., Dubuisson J. Biol. Cell. 2010, 102:63.
64. Gastaminza P., Cheng G., Wieland S., Zhong J., Liao W., Chisari F.V. J. Virology 2008, 82:2120.
65. Source: Xenon Pharmaceuticals http://www.xenon-pharma.com/pages/index%5Fobesity.php.