Novel, potent, selective, and metabolically stable stearoyl-CoA desaturase (SCD) inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 7, 2009, Pages 2048-2052

  Koltun, Dmitry O ^a   Parkhill, Eric Q ^a   Vasilevich, Natalya I ^b   Glushkov, Andrei I ^b   Zilbershtein, Timur M ^b   Ivanov, Alexei V ^b   Cole, Andrew G ^c   Henderson, Ian ^c   Zautke, Nathan A ^a   Brunn, Sandra A ^a   Mollova, Nevena ^a   Leung, Kwan ^a   Chisholm, Jeffrey W ^a   Zablocki, Jeff ^a  

^a CV THERAPEUTICS INC   (United States)

^b Asinex Ltd   (Russian Federation)

^c Ligand Pharmaceuticals Inc   (United States)

Author keywords

Desaturase; HEPG2 assay; Microsomal assay; Pteridinone; SCD; Stearoyl CoA

Indexed keywords

ACYL COENZYME A DESATURASE; ENZYME INHIBITOR; PYRIDINE DERIVATIVE;

ARTICLE; CELL STRAIN HEPG2; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELL LINE; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; MICROSOMES; PTERIDINES; QUINOXALINES; RATS; STEAROYL-COA DESATURASE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 61849145856     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.02.019     Document Type: Article

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