Effect of mitratapide on body composition, body measurements and glucose tolerance in obese Beagles

Veterinary Research Communications

Volumn 33, Issue 8, 2009, Pages 839-847

  Dobenecker, Britta ^a   De Bock, Manuelle ^b   Engelen, Marc ^b   Goossens, Lieve ^b   Scholz, Armin ^a   Kienzle, Ellen ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b JANSSEN RESEARCH FOUNDATION   (Belgium)

Author keywords

Body fat; Dog; Dual energy X ray absorptiometry; Mitratapide

Indexed keywords

ANTIOBESITY AGENT; MITRATAPIDE; UNCLASSIFIED DRUG; YARVITAN;

ANIMAL EXPERIMENT; ANIMAL FOOD; ANTHROPOMETRY; ARTICLE; BODY COMPOSITION; BODY FAT DISTRIBUTION; BODY WEIGHT; DOG; DRUG ACTIVITY; DRUG EFFICACY; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FOOD INTAKE; GLUCOSE TOLERANCE; INSULIN SENSITIVITY; NONHUMAN; OBESITY; PELVIS; WAIST CIRCUMFERENCE; WEIGHT REDUCTION;

ABSORPTIOMETRY, PHOTON; ADIPOSE TISSUE; ANIMALS; ANTI-OBESITY AGENTS; BODY COMPOSITION; BODY WEIGHT; DOG DISEASES; DOGS; EATING; FEMALE; GLUCOSE TOLERANCE TEST; OBESITY; PIPERAZINES; TRIAZOLES;

CANIS FAMILIARIS;

EID: 70949098592     PISSN: 01657380     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11259-009-9232-5     Document Type: Article

References (22)

1. A Anandacoomarasamy M Fransen L March 2009 Obesity and the musculoskeletal system Current Opinion in Rheumatology 21 1 71 77 10.1097/BOR.0b013e32831bc0d7 19093327
2. Armstrong PJ, Churchill JA (2008) Fat-the largest endocrine organ: not just energy storage after all! (abstract). 80 th Western Veterinary Conference, Las Vegas, NV, USA.
3. F Belfiore S Iannello M Camuto S Fagone A Cavaleri 2001 Insulin sensitivity of blood glucose versus insulin sensitivity of blood free fatty acids in normal, obese, and obese-diabetic subjects Metabolism 50 5 573 582 10.1053/meta.2001.22518 1:CAS:528:DC%2BD3MXjt1arurk%3D 11319720 (Pubitemid 32433048)
4. W Burkholder J Bauer 1998 Foods and techniques for managing obesity in companion animals Journal of the American Veterinary Medical Association 212 658 662 1:STN:280:DyaK1c7osFehtg%3D%3D 9524636
5. Burkholder W, Toll P (1997) Obesity. In: Hand, Tacher, Remillard, Roudebush (Ed.) Small Animal Clinical Nutrition, pp 401-430.
6. VD Dixit 2008 Adipose-immune interactions during obesity and caloric restriction: reciprocal mechanisms regulating immunity and health span Journal of Leukocyte Biology 84 4 882 892 10.1189/jlb.0108028 1:CAS:528: DC%2BD1cXht1amsbrP 18579754
7. A Edney P Smith 1986 Study of obesity in dogs visiting veterinary practices in the United Kingdom Veterinary Record 118 391 396 1:STN:280:DyaL283js12nsA%3D%3D 3716092
8. DJ Goldstein 1992 Beneficial health effects of modest weight loss International Journal of Obesity & Related Metabolic Disorders: Journal of the International Association for the Study of Obesity 16 397 415 1:STN:280:DyaK38zlsFWruw%3D%3D
9. H Goschke 1977 Mechanism of glucose intolerance during fasting: differences between lean and obese subjects Metabolism: Clinical & Experimental 26 1147 1153 1:STN:280:DyaE2s3lsVeisg%3D%3D
10. Greco DS (2008) Fat as an endocrine organ (abstract). 80 th Western Veterinary Conference, Las Vegas, NV, USA.
11. RD Kealy DF Lawler JM Ballam SL Mantz DN Biery EH Greeley G Lust M Segre GK Smith HD Stowe 2002 Effects of diet restriction on life span and age-related changes in dogs Journal of the American Veterinary Medical Association 220 1315 1320 10.2460/javma.2002.220.1315 11991408
12. DP Laflamme 1997 Development and validation of a body condition score system for dogs Canine Practice 22 4 10 15
13. R Lago R Gómez F Lago J Gómez-Reino O Gualillo 2008 Leptin beyond body weight regulation-current concepts concerning its role in immune function and inflammation Cellular Immunology 252 1-2 139 145 10.1016/j.cellimm.2007.09.004 1:CAS:528:DC%2BD1cXpt1Kjtr0%3D 18289518
14. DF Lawler RH Evans BT Larson EL Spitznagel MR Ellersieck RD Kealy 2005 Influence of lifetime food restriction on causes, time, and predictors of death in dogs Journal of the American Veterinary Medical Association 226 225 231 10.2460/javma.2005.226.225 15706972 (Pubitemid 40116744)
15. V Leray S Serisier S Khosniat L Martin H Dumon P Nguyen 2008 Adipose tissue gene expression in obese dogs after weight loss Journal of Animal Physiology and Animal Nutrition 92 3 390 398 10.1111/j.1439-0396.2008.00818.x 1:CAS:528:DC%2BD1cXnsVKqsr8%3D 18477322 (Pubitemid 351670184)
16. PD McGreevy PC Thomson C Pride A Fawcett T Grassi B Jones 2005 Prevalence of obesity in dogs examined by Australian veterinary practices and the risk factors involved Veterinary Record 156 22 695 702 1:STN:280: DC%2BD2M3otVShtQ%3D%3D 15923551
17. IL Mertens LF Van Gaal 2000 Overweight, obesity, and blood pressure: the effects of modest weight reduction Obesity Research 8 270 278 10.1038/oby.2000.32 1:STN:280:DC%2BD3cvjtlynug%3D%3D 10832771
18. NRC (2006) Nutrient requirements of dogs and cats. The national Research Council. National Academic Press, Washington D.C., USA.
19. FX Pi-Sunyer 1996 A review of long-term studies evaluating the efficacy of weight loss in ameliorating disorders associated with obesity Clinical Therapeutics 18 1006 1035 10.1016/S0149-2918(96)80057-9 1:STN:280: DyaK2s7lsFWjtQ%3D%3D 9001821 (Pubitemid 27077108)
20. JR Speakman D Booles R Butterwick 2001 Validation of dual energy X-ray absorptiometry (DXA) by comparison with chemical analysis of dogs and cats International Journal of Obesity & Related Metabolic Disorders 25 439 447 10.1038/sj.ijo.0801544 1:STN:280:DC%2BD3Mzit12juw%3D%3D (Pubitemid 32209822)
21. RR Wing R Koeske LH Epstein MP Nowalk W Gooding D Becker 1987 Long-term effects of modest weight loss in type II diabetic patients Archives of Internal Medicine 147 1749 1753 10.1001/archinte.147.10.1749 1:STN:280: DyaL1c%2FitlSquw%3D%3D 3310940 (Pubitemid 17159673)
22. JA Wren J Gossellin SJ Sunderland 2007 Dirlotapide: a review of its properties and role in the management of obesity on dogs Journal of Veterinary Pharmacology and Therapeutics Suppl 1 11 16 10.1111/j.1365-2885.2007.00864.x (Pubitemid 46850030)