Novel spiropiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 1′-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-5-(trifluoromethyl)-3,4-dihydrospiro[chromene-2,4′-piperidine]

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 2, 2010, Pages 746-754

  Uto, Yoshikazu ^a   Kiyotsuka, Yohei ^a   Ueno, Yuko ^a   Miyazawa, Yuriko ^a   Kurata, Hitoshi ^a   Ogata, Tsuneaki ^a   Deguchi, Tsuneo ^a   Yamada, Makiko ^a   Watanabe, Nobuaki ^a   Konishi, Masahiro ^a   Kurikawa, Nobuya ^a   Takagi, Toshiyuki ^a   Wakimoto, Satoko ^a   Kono, Keita ^a   Ohsumi, Jun ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

Desaturation index; Spiropiperidine; Stearoyl CoA desaturase (SCD)

Indexed keywords

1' [6 [5 (PYRIDIN 3 YLMETHYL) 1,3,4 OXADIAZOL 2 YL]PYRIDAZIN 3 YL] 5 (TRIFLUOROMETHYL) 3,4 DIHYDROSPIRO[CHROMENE 2,4' PIPERIDINE]; ACYL COENZYME A DESATURASE; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; C57BL 6 MOUSE; CYCLIZATION; DRUG ACTIVITY; DRUG HALF LIFE; DRUG IDENTIFICATION; DRUG POTENCY; EYE; FATTY ACID DESATURATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; SKIN;

ADMINISTRATION, ORAL; ANIMALS; BENZOPYRANS; CELL LINE, TUMOR; HUMANS; MICE; MICE, INBRED C57BL; MICROSOMES, LIVER; PIPERIDINES; STEAROYL-COA DESATURASE;

MUS;

EID: 72249112330     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.11.043     Document Type: Article

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