메뉴 건너뛰기




Volumn 78, Issue 10, 2010, Pages 4195-4205

Protein kinase C θ deficiency increases resistance of C57BL/6J mice to Plasmodium berghei infection-induced cerebral malaria

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; LYMPHOTOXIN; PROTEIN KINASE C THETA; TUMOR NECROSIS FACTOR ALPHA;

EID: 77957746730     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00465-10     Document Type: Article
Times cited : (14)

References (65)
  • 1
    • 0036697783 scopus 로고    scopus 로고
    • Breaking down the blood-brain barrier: Signaling a path to cerebral malaria?
    • Adams, S., H. Brown, and G. Turner. 2002. Breaking down the blood-brain barrier: signaling a path to cerebral malaria? Trends Parasitol. 18:360-366.
    • (2002) Trends Parasitol. , vol.18 , pp. 360-366
    • Adams, S.1    Brown, H.2    Turner, G.3
  • 2
    • 0033625869 scopus 로고    scopus 로고
    • Protein kinase Cθ: A new essential superstar on the T-cell stage
    • Altman, A., N. Isakov, and G. Baier. 2000. Protein kinase Cθ: a new essential superstar on the T-cell stage. Immunol. Today 21:567-573.
    • (2000) Immunol. Today , vol.21 , pp. 567-573
    • Altman, A.1    Isakov, N.2    Baier, G.3
  • 3
    • 0343618458 scopus 로고    scopus 로고
    • Involvement of IFN-gamma receptor-medicated signaling in pathology and anti-malarial immunity induced by Plasmodium berghei infection
    • Amani, V., A. M. Vigario, E. Belnoue, M. Marussig, L. Fonseca, D. Mazier, and L. Renia. 2000. Involvement of IFN-gamma receptor-medicated signaling in pathology and anti-malarial immunity induced by Plasmodium berghei infection. Eur. J. Immunol. 30:1646-1655.
    • (2000) Eur. J. Immunol. , vol.30 , pp. 1646-1655
    • Amani, V.1    Vigario, A.M.2    Belnoue, E.3    Marussig, M.4    Fonseca, L.5    Mazier, D.6    Renia, L.7
  • 5
    • 0027418818 scopus 로고
    • Molecular cloning and characterization of PKCθ, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells
    • Baier, G., D. Telford, L. Giampa, K. M. Coggeshall, G. Baier-Bitterlich, N. Isakov, and A. Altman. 1993. Molecular cloning and characterization of PKCθ, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells. J. Biol. Chem. 268:4997-5004.
    • (1993) J. Biol. Chem. , vol.268 , pp. 4997-5004
    • Baier, G.1    Telford, D.2    Giampa, L.3    Coggeshall, K.M.4    Baier-Bitterlich, G.5    Isakov, N.6    Altman, A.7
  • 7
    • 34748873441 scopus 로고    scopus 로고
    • Regulatory T cells and infection: A dangerous necessity
    • Belkaid, Y. 2007. Regulatory T cells and infection: a dangerous necessity. Nat. Rev. Immunol. 7:875-888.
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 875-888
    • Belkaid, Y.1
  • 11
    • 67049173014 scopus 로고    scopus 로고
    • Immune evasion by malaria parasites: A challenge for vaccine development
    • Casares, S., and T. L. Richie. 2009. Immune evasion by malaria parasites: a challenge for vaccine development. Curr. Opin. Immunol. 21:321-330.
    • (2009) Curr. Opin. Immunol. , vol.21 , pp. 321-330
    • Casares, S.1    Richie, T.L.2
  • 15
    • 0037141025 scopus 로고    scopus 로고
    • Locally upregulated lymphotoxin alpha, not systemic tumor necrosis factor alpha, is the principle mediator of murine cerebral malaria
    • Engwerda, C. R., T. L. Mynott, S. Sawhney, J. B. De Souza, Q. D. Bickle, and P. M. Kaye. 2002. Locally upregulated lymphotoxin alpha, not systemic tumor necrosis factor alpha, is the principle mediator of murine cerebral malaria. J. Exp. Med. 195:1371-1377.
    • (2002) J. Exp. Med. , vol.195 , pp. 1371-1377
    • Engwerda, C.R.1    Mynott, T.L.2    Sawhney, S.3    De Souza, J.B.4    Bickle, Q.D.5    Kaye, P.M.6
  • 16
    • 0025789023 scopus 로고
    • Late treatment with anti-LFA-1 (CD11a) antibody prevents cerebral malaria in a mouse model
    • Falanga, P. B., and E. C. Butcher. 1991. Late treatment with anti-LFA-1 (CD11a) antibody prevents cerebral malaria in a mouse model. Eur. J. Immunol. 21:2259-2263.
    • (1991) Eur. J. Immunol. , vol.21 , pp. 2259-2263
    • Falanga, P.B.1    Butcher, E.C.2
  • 17
    • 0025132263 scopus 로고
    • Interleukin 6 production in experimental cerebral malaria: Modulation by anticytokine antibodies and possible role in hypergammaglobulinemia
    • Grau, G. E., K. Frei, P. F. Piguet, A. Fontana, H. Heremans, A. Billiau, P. Vassalli, and P. H. Lambert. 1990. Interleukin 6 production in experimental cerebral malaria: modulation by anticytokine antibodies and possible role in hypergammaglobulinemia. J. Exp. Med. 172:1505-1508.
    • (1990) J. Exp. Med. , vol.172 , pp. 1505-1508
    • Grau, G.E.1    Frei, K.2    Piguet, P.F.3    Fontana, A.4    Heremans, H.5    Billiau, A.6    Vassalli, P.7    Lambert, P.H.8
  • 18
    • 0025781820 scopus 로고
    • Late administration of monoclonal antibody to leukocyte function-antigen 1 abrogates incipient murine cerebral malaria
    • Grau, G. E., P. Pointaire, P. F. Piguet, C. Vesin, H. Rosen, I. Stamenkovic, F. Takei, and P. Vassalli. 1991. Late administration of monoclonal antibody to leukocyte function-antigen 1 abrogates incipient murine cerebral malaria. Eur. J. Immunol. 21:2265-2267.
    • (1991) Eur. J. Immunol. , vol.21 , pp. 2265-2267
    • Grau, G.E.1    Pointaire, P.2    Piguet, P.F.3    Vesin, C.4    Rosen, H.5    Stamenkovic, I.6    Takei, F.7    Vassalli, P.8
  • 19
    • 0037341358 scopus 로고    scopus 로고
    • Regulation of murine cerebral malaria pathogenesis by CD1d-restricted NKT cells and the natural killer complex
    • Hansen, D. S., M. A. Siomos, L. Buckingham, A. A. Scalzo, and L. Schofield. 2003. Regulation of murine cerebral malaria pathogenesis by CD1d-restricted NKT cells and the natural killer complex. Immunity 18:391-402.
    • (2003) Immunity , vol.18 , pp. 391-402
    • Hansen, D.S.1    Siomos, M.A.2    Buckingham, L.3    Scalzo, A.A.4    Schofield, L.5
  • 20
    • 0037407318 scopus 로고    scopus 로고
    • Cytokine and chemokine responses in a cerebral malaria-susceptible or -resistant strain of mice to Plasmodium berghei ANKA infection: Early chemokine expression in the brain
    • Hanum, P. S., M. Hayano, and S. Kojima. 2003. Cytokine and chemokine responses in a cerebral malaria-susceptible or -resistant strain of mice to Plasmodium berghei ANKA infection: early chemokine expression in the brain. Int. Immunol. 15:633-640.
    • (2003) Int. Immunol. , vol.15 , pp. 633-640
    • Hanum, P.S.1    Hayano, M.2    Kojima, S.3
  • 23
    • 27744563110 scopus 로고    scopus 로고
    • Pathogenesis, clinical features, and neurological outcome of cerebral malaria
    • Idro, R., N. E. Jenkins, and C. R. Newton. 2005. Pathogenesis, clinical features, and neurological outcome of cerebral malaria. Lancet Neurol. 4:827-840.
    • (2005) Lancet Neurol. , vol.4 , pp. 827-840
    • Idro, R.1    Jenkins, N.E.2    Newton, C.R.3
  • 24
    • 85047682875 scopus 로고    scopus 로고
    • Protein kinase Cθ in T-cell activation
    • Isakov, N., and A. Altman. 2002. Protein kinase Cθ in T-cell activation. Annu. Rev. Immunol. 20:761-794.
    • (2002) Annu. Rev. Immunol. , vol.20 , pp. 761-794
    • Isakov, N.1    Altman, A.2
  • 25
    • 0029041568 scopus 로고
    • Transcriptional regulation of the IL-2 gene
    • Jain, J., C. Loh, and A. Rao. 1995. Transcriptional regulation of the IL-2 gene. Curr. Opin. Immunol. 7:333-342.
    • (1995) Curr. Opin. Immunol. , vol.7 , pp. 333-342
    • Jain, J.1    Loh, C.2    Rao, A.3
  • 26
    • 0030841167 scopus 로고    scopus 로고
    • Interleukin-10 modulates susceptibility in experimental cerebral malaria
    • Kossodo, S., C. Monso, P. Juillard, T. Velu, M. Goldman, and G. E. Grau. 1997. Interleukin-10 modulates susceptibility in experimental cerebral malaria. Immunology 91:536-540.
    • (1997) Immunology , vol.91 , pp. 536-540
    • Kossodo, S.1    Monso, C.2    Juillard, P.3    Velu, T.4    Goldman, M.5    Grau, G.E.6
  • 30
    • 0032539562 scopus 로고    scopus 로고
    • A role for B cells in the development of T-cell helper function in a malaria infection in mice
    • Langhorne, J., C. Cross, E. Seixas, C. Li, and T. von der Weid. 1998. A role for B cells in the development of T-cell helper function in a malaria infection in mice. Proc. Natl. Acad. Sci. U. S. A. 95:1730-1734.
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 1730-1734
    • Langhorne, J.1    Cross, C.2    Seixas, E.3    Li, C.4    Von Der Weid, T.5
  • 32
    • 0041823567 scopus 로고    scopus 로고
    • Pathology of Plasmodium chabaudi chabaudi infection and mortality in interleukin-10-deficient mice are ameliorated by anti-tumor necrosis factor alpha and exacerbated by anti-transforming growth factor beta antibodies
    • Li, C., L. A. Sanni, F. Omer, E. Riley, and J. Langhorne. 2003. Pathology of Plasmodium chabaudi chabaudi infection and mortality in interleukin-10- deficient mice are ameliorated by anti-tumor necrosis factor alpha and exacerbated by anti-transforming growth factor beta antibodies. Infect. Immun. 71:4850-4856.
    • (2003) Infect. Immun. , vol.71 , pp. 4850-4856
    • Li, C.1    Sanni, L.A.2    Omer, F.3    Riley, E.4    Langhorne, J.5
  • 34
    • 4644337572 scopus 로고    scopus 로고
    • Serum levels of the proinflammatory cytokines interleukin-1β (IL-1β), IL-6, IL-8, IL-10, tumor necrosis factor alpha, and IL-12(p70) in Malian children with severe Plasmodium falciparum malaria and matched uncomplicated malaria or healthy controls
    • Lyke, K. E., R. Burges, Y. Cissoko, L. Sangare, M. Dao, I. Diarra, A. Kone, R. Harley, C. V. Plowe, O. K. Doumbo, and M. B. Sztein. 2004. Serum levels of the proinflammatory cytokines interleukin-1β (IL-1β), IL-6, IL-8, IL-10, tumor necrosis factor alpha, and IL-12(p70) in Malian children with severe Plasmodium falciparum malaria and matched uncomplicated malaria or healthy controls. Infect. Immun. 72:5630-5637.
    • (2004) Infect. Immun. , vol.72 , pp. 5630-5637
    • Lyke, K.E.1    Burges, R.2    Cissoko, Y.3    Sangare, L.4    Dao, M.5    Diarra, I.6    Kone, A.7    Harley, R.8    Plowe, C.V.9    Doumbo, O.K.10    Sztein, M.B.11
  • 35
    • 3242790172 scopus 로고    scopus 로고
    • Protein kinase C theta is critical for the development of in vivo T helper (Th)2 cell but not Th1 cell responses
    • Marsland, B. J., T. J. Soos, G. Spath, D. R. Littman, and M. Kopf. 2004. Protein kinase C theta is critical for the development of in vivo T helper (Th)2 cell but not Th1 cell responses. J. Exp. Med. 200:181-189.
    • (2004) J. Exp. Med. , vol.200 , pp. 181-189
    • Marsland, B.J.1    Soos, T.J.2    Spath, G.3    Littman, D.R.4    Kopf, M.5
  • 36
    • 0025809384 scopus 로고
    • + T cells and B cells are necessary for the transfer of protective immunity to Plasmodium chabaudi chabaudi
    • + T cells and B cells are necessary for the transfer of protective immunity to Plasmodium chabaudi chabaudi. Eur. J. Immunol. 21:1433-1438.
    • (1991) Eur. J. Immunol. , vol.21 , pp. 1433-1438
    • Meding, S.J.1    Langhorne, J.2
  • 37
    • 0032938157 scopus 로고    scopus 로고
    • Protein kinase Cθ (PKCθ) distribution analysis in hematopoietic cells: Proliferating T cells exhibit high proportions of PKCθ in the particulate fraction
    • Meller, N., Y. Elitzur, and N. Isakov. 1999. Protein kinase Cθ (PKCθ) distribution analysis in hematopoietic cells: proliferating T cells exhibit high proportions of PKCθ in the particulate fraction. Cell. Immunol. 193:185-193.
    • (1999) Cell. Immunol. , vol.193 , pp. 185-193
    • Meller, N.1    Elitzur, Y.2    Isakov, N.3
  • 39
    • 0032480279 scopus 로고    scopus 로고
    • Three-dimensional segregation of supramolecular activation clusters in T cells
    • Monks, C. R., B. A. Freiberg, H. Kupfer, N. Sciaky, and A. Kupfer. 1998. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 395:82-86.
    • (1998) Nature , vol.395 , pp. 82-86
    • Monks, C.R.1    Freiberg, B.A.2    Kupfer, H.3    Sciaky, N.4    Kupfer, A.5
  • 40
    • 0031012266 scopus 로고    scopus 로고
    • Selective modulation of protein kinase C-theta during T-cell activation
    • Monks, C. R., H. Kupfer, I. Tamir, A. Barlow, and A. Kupfer. 1997. Selective modulation of protein kinase C-theta during T-cell activation. Nature 385:83-86.
    • (1997) Nature , vol.385 , pp. 83-86
    • Monks, C.R.1    Kupfer, H.2    Tamir, I.3    Barlow, A.4    Kupfer, A.5
  • 41
    • 72049100676 scopus 로고    scopus 로고
    • IL-10 plays a crucial role for the protection of experimental cerebral malaria by coinfection with non-lethal malaria parasites
    • Niikura, M., S. Kamiya, A. Nakane, K. Kita, and F. Kobayashi. 2010. IL-10 plays a crucial role for the protection of experimental cerebral malaria by coinfection with non-lethal malaria parasites. Int. J. Parasitol. 40:101-108.
    • (2010) Int. J. Parasitol. , vol.40 , pp. 101-108
    • Niikura, M.1    Kamiya, S.2    Nakane, A.3    Kita, K.4    Kobayashi, F.5
  • 43
    • 77957731253 scopus 로고    scopus 로고
    • + T-cell polarization and mouse resistance to cutaneous leishmaniasis
    • N. Isakov (ed.), Transworld Research Network, Trivandrum, Kerala, India
    • + T-cell polarization and mouse resistance to cutaneous leishmaniasis, p. 221-238. In N. Isakov (ed.), Lymphocyte activation and signal transduction. Transworld Research Network, Trivandrum, Kerala, India.
    • (2007) Lymphocyte Activation and Signal Transduction , pp. 221-238
    • Ohayon, A.1    Dong, G.2    Isakov, N.3
  • 44
    • 0028113737 scopus 로고
    • Vascular clogging, mononuclear cell margination, and enhanced vascular permeability in the pathogenesis of human cerebral malaria
    • Patnaik, J. K., B. S. Das, S. K. Mishra, S. Mohanty, S. K. Satpathy, and D. Mohanty. 1994. Vascular clogging, mononuclear cell margination, and enhanced vascular permeability in the pathogenesis of human cerebral malaria. Am. J. Trop. Med. Hyg. 51:642-647.
    • (1994) Am. J. Trop. Med. Hyg. , vol.51 , pp. 642-647
    • Patnaik, J.K.1    Das, B.S.2    Mishra, S.K.3    Mohanty, S.4    Satpathy, S.K.5    Mohanty, D.6
  • 46
    • 66949146943 scopus 로고    scopus 로고
    • World Malaria Day 2009: What malaria knows about the immune system that immunologists still do not
    • Pierce, S. K., and L. H. Miller. 2009. World Malaria Day 2009: what malaria knows about the immune system that immunologists still do not. J. Immunol. 182:5171-5177.
    • (2009) J. Immunol. , vol.182 , pp. 5171-5177
    • Pierce, S.K.1    Miller, L.H.2
  • 47
    • 0025964164 scopus 로고
    • + T lymphocytes both contribute to acquired immunity to blood-stage Plasmodium chabaudi AS
    • + T lymphocytes both contribute to acquired immunity to blood-stage Plasmodium chabaudi AS. Infect. Immun. 59:51-58.
    • (1991) Infect. Immun. , vol.59 , pp. 51-58
    • Podoba, J.E.1    Stevenson, M.M.2
  • 48
    • 0031012981 scopus 로고    scopus 로고
    • Resistance to cerebral malaria in tumor necrosis factor-alpha/beta- deficient mice is associated with a reduction of intercellular adhesion molecule-1 upregulation and T helper type 1 response
    • Rudin, W., H. P. Eugster, G. Bordmann, J. Bonato, M. Muller, M. Yamage, and B. Ryffel. 1997. Resistance to cerebral malaria in tumor necrosis factor-alpha/beta-deficient mice is associated with a reduction of intercellular adhesion molecule-1 upregulation and T helper type 1 response. Am. J. Pathol. 150:257-266.
    • (1997) Am. J. Pathol. , vol.150 , pp. 257-266
    • Rudin, W.1    Eugster, H.P.2    Bordmann, G.3    Bonato, J.4    Muller, M.5    Yamage, M.6    Ryffel, B.7
  • 49
    • 8444243253 scopus 로고    scopus 로고
    • Differential regulation of Th2 and Th1 lung inflammatory responses by protein kinase C theta
    • Salek-Ardakani, S., T. So, B. S. Halteman, A. Altman, and M. Croft. 2004. Differential regulation of Th2 and Th1 lung inflammatory responses by protein kinase C theta. J. Immunol. 173:6440-6447. (Pubitemid 39487805)
    • (2004) Journal of Immunology , vol.173 , Issue.10 , pp. 6440-6447
    • Salek-Ardakani, S.1    So, T.2    Halteman, B.S.3    Altman, A.4    Croft, M.5
  • 50
    • 28244464872 scopus 로고    scopus 로고
    • Protein kinase Cθ controls Th1 cells in experimental autoimmune encephalomyelitis
    • Salek-Ardakani, S., T. So, B. S. Halteman, A. Altman, and M. Croft. 2005. Protein kinase Cθ controls Th1 cells in experimental autoimmune encephalomyelitis. J. Immunol. 175:7635-7641. (Pubitemid 41713463)
    • (2005) Journal of Immunology , vol.175 , Issue.11 , pp. 7635-7641
    • Salek-Ardakani, S.1    So, T.2    Halteman, B.S.3    Altman, A.4    Croft, M.5
  • 51
    • 2142711618 scopus 로고    scopus 로고
    • Cerebral Edema and Cerebral Hemorrhages in Interleukin-10-Deficient Mice Infected with Plasmodium chabaudi
    • DOI 10.1128/IAI.72.5.3054-3058.2004
    • Sanni, L. A., W. Jarra, C. Li, and J. Langhorne. 2004. Cerebral edema and cerebral hemorrhages in interleukin-10-deficient mice infected with Plasmodium chabaudi. Infect. Immun. 72:3054-3058. (Pubitemid 38542438)
    • (2004) Infection and Immunity , vol.72 , Issue.5 , pp. 3054-3058
    • Sanni, L.A.1    Jarra, W.2    Li, C.3    Langhorne, J.4
  • 52
    • 72149128886 scopus 로고    scopus 로고
    • Heroes or villains? T regulatory cells in malaria infection
    • Scholzen, A., G. Minigo, and M. Plebanski. 2009. Heroes or villains? T regulatory cells in malaria infection. Trends Parasitol. 26:16-25.
    • (2009) Trends Parasitol. , vol.26 , pp. 16-25
    • Scholzen, A.1    Minigo, G.2    Plebanski, M.3
  • 53
    • 0027324976 scopus 로고
    • Differential sequestration of parasitized erythrocytes in the cerebrum and cerebellum in human cerebral malaria
    • Sein, K. K., Y. Maeno, H. V. Thuc, T. K. Anh, and M. Aikawa. 1993. Differential sequestration of parasitized erythrocytes in the cerebrum and cerebellum in human cerebral malaria. Am. J. Trop. Med. Hyg. 48:504-511.
    • (1993) Am. J. Trop. Med. Hyg. , vol.48 , pp. 504-511
    • Sein, K.K.1    Maeno, Y.2    Thuc, H.V.3    Anh, T.K.4    Aikawa, M.5
  • 54
    • 0028263061 scopus 로고
    • Role of polymorphonuclear neutrophil leukocytes and their integrin CD11a (LFA-1) in the pathogenesis of severe murine malaria
    • Senaldi, G., C. Vesin, R. Chang, G. E. Grau, and P. F. Piguet. 1994. Role of polymorphonuclear neutrophil leukocytes and their integrin CD11a (LFA-1) in the pathogenesis of severe murine malaria. Infect. Immun. 62:1144-1149.
    • (1994) Infect. Immun. , vol.62 , pp. 1144-1149
    • Senaldi, G.1    Vesin, C.2    Chang, R.3    Grau, G.E.4    Piguet, P.F.5
  • 56
    • 33644512418 scopus 로고    scopus 로고
    • Resistance to experimental autoimmune encephalomyelitis and impaired IL-17 production in protein kinase Cθ-deficient mice
    • Tan, S. L., J. Zhao, C. Bi, X. C. Chen, D. L. Hepburn, J. Wang, J. D. Sedgwick, S. R. Chintalacharuvu, and S. Na. 2006. Resistance to experimental autoimmune encephalomyelitis and impaired IL-17 production in protein kinase Cθ-deficient mice. J. Immunol. 176:2872-2879. (Pubitemid 43306947)
    • (2006) Journal of Immunology , vol.176 , Issue.5 , pp. 2872-2879
    • Tan, S.-L.1    Zhao, J.2    Bi, C.3    Chen, X.C.4    Hepburn, D.L.5    Wang, J.6    Sedgwick, J.D.7    Chintalacharuvu, S.R.8    Na, S.9
  • 57
    • 0031053790 scopus 로고    scopus 로고
    • Cerebral malaria
    • Turner, G. 1997. Cerebral malaria. Brain Pathol. 7:569-582.
    • (1997) Brain Pathol. , vol.7 , pp. 569-582
    • Turner, G.1
  • 58
    • 33749266350 scopus 로고    scopus 로고
    • A unified hypothesis for the genesis of cerebral malaria: Sequestration, inflammation, and hemostasis leading to microcirculatory dysfunction
    • van der Heyde, H. C., J. Nolan, V. Combes, I. Gramaglia, and G. E. Grau. 2006. A unified hypothesis for the genesis of cerebral malaria: sequestration, inflammation, and hemostasis leading to microcirculatory dysfunction. Trends Parasitol. 22:503-508.
    • (2006) Trends Parasitol. , vol.22 , pp. 503-508
    • Van Der Heyde, H.C.1    Nolan, J.2    Combes, V.3    Gramaglia, I.4    Grau, G.E.5
  • 59
    • 0037092038 scopus 로고    scopus 로고
    • Translocation of PKCθ in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase C
    • DOI 10.1083/jcb.200201097
    • Villalba, M., K. Bi, J. Hu, Y. Altman, P. Bushway, E. Reits, J. Neefjes, G. Baier, R. T. Abraham, and A. Altman. 2002. Translocation of PKCθ in T cells is mediated by a nonconventional, PI3K- and Vav-dependent pathway, but does not absolutely require phospholipase C. J. Cell Biol. 157:253-263. (Pubitemid 34839822)
    • (2002) Journal of Cell Biology , vol.157 , Issue.2 , pp. 253-263
    • Villalba, M.1    Bi, K.2    Hu, J.3    Altman, Y.4    Bushway, P.5    Reits, E.6    Neefjes, J.7    Baier, G.8    Abraham, R.T.9    Altman, A.10
  • 60
    • 0030001823 scopus 로고    scopus 로고
    • Gene-targeted mice lacking B cells are unable to eliminate a blood stage malaria infection
    • von der Weid, T., N. Honarvar, and J. Langhorne. 1996. Gene-targeted mice lacking B cells are unable to eliminate a blood stage malaria infection. J. Immunol. 156:2510-2516.
    • (1996) J. Immunol. , vol.156 , pp. 2510-2516
    • Von Der Weid, T.1    Honarvar, N.2    Langhorne, J.3
  • 64
    • 0030586620 scopus 로고    scopus 로고
    • Participation of lymphocyte subpopulations in the pathogenesis of experimental murine cerebral malaria
    • Yanez, D. M., D. D. Manning, A. J. Cooley, W. P. Weidanz, and H. C. van der Heyde. 1996. Participation of lymphocyte subpopulations in the pathogenesis of experimental murine cerebral malaria. J. Immunol. 157:1620-1624.
    • (1996) J. Immunol. , vol.157 , pp. 1620-1624
    • Yanez, D.M.1    Manning, D.D.2    Cooley, A.J.3    Weidanz, W.P.4    Van Der Heyde, H.C.5
  • 65
    • 75649091127 scopus 로고    scopus 로고
    • Why does immunity to parasites take so long to develop?
    • Yazdanbakhsh, M. 2010. Why does immunity to parasites take so long to develop? Nat. Immunol. Rev. 10:80-81.
    • (2010) Nat. Immunol. Rev. , vol.10 , pp. 80-81
    • Yazdanbakhsh, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.